{"id":"https://openalex.org/W2802231733","doi":"https://doi.org/10.1093/bioinformatics/bty322","title":"Spatial quantification of the synaptic activity phenotype across large populations of neurons with Markov random fields","display_name":"Spatial quantification of the synaptic activity phenotype across large populations of neurons with Markov random fields","publication_year":2018,"publication_date":"2018-04-19","ids":{"openalex":"https://openalex.org/W2802231733","doi":"https://doi.org/10.1093/bioinformatics/bty322","mag":"2802231733","pmid":"https://pubmed.ncbi.nlm.nih.gov/29897415"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/bty322","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bty322","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/34/18/3196/25731673/bty322.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/34/18/3196/25731673/bty322.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032005041","display_name":"Sean M. Robinson","orcid":"https://orcid.org/0000-0003-3957-1735"},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I155660961","display_name":"University of Turku","ror":"https://ror.org/05vghhr25","country_code":"FI","type":"education","lineage":["https://openalex.org/I155660961"]},{"id":"https://openalex.org/I2738703131","display_name":"Commissariat \u00e0 l'\u00c9nergie Atomique et aux \u00c9nergies Alternatives","ror":"https://ror.org/00jjx8s55","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131"]},{"id":"https://openalex.org/I3020098449","display_name":"CEA Grenoble","ror":"https://ror.org/02mg6n827","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131","https://openalex.org/I3020098449"]},{"id":"https://openalex.org/I899635006","display_name":"Universit\u00e9 Grenoble Alpes","ror":"https://ror.org/02rx3b187","country_code":"FR","type":"education","lineage":["https://openalex.org/I899635006"]}],"countries":["FI","FR"],"is_corresponding":true,"raw_author_name":"Sean Robinson","raw_affiliation_strings":["Department of Mathematics and Statistics, University of Turku, Turku, Finland","Universit\u00e9 Grenoble Alpes, CEA, INSERM, Biology of Cancer and Infection UMR S 1036, Grenoble, France"],"affiliations":[{"raw_affiliation_string":"Department of Mathematics and Statistics, University of Turku, Turku, Finland","institution_ids":["https://openalex.org/I155660961"]},{"raw_affiliation_string":"Universit\u00e9 Grenoble Alpes, CEA, INSERM, Biology of Cancer and Infection UMR S 1036, Grenoble, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I899635006","https://openalex.org/I3020098449","https://openalex.org/I2738703131"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049640837","display_name":"Michael J. Courtney","orcid":"https://orcid.org/0000-0001-8693-3933"},"institutions":[{"id":"https://openalex.org/I130217899","display_name":"\u00c5bo Akademi University","ror":"https://ror.org/029pk6x14","country_code":"FI","type":"education","lineage":["https://openalex.org/I130217899"]},{"id":"https://openalex.org/I155660961","display_name":"University of Turku","ror":"https://ror.org/05vghhr25","country_code":"FI","type":"education","lineage":["https://openalex.org/I155660961"]},{"id":"https://openalex.org/I4210140120","display_name":"Turku Centre for Biotechnology","ror":"https://ror.org/0421ba211","country_code":"FI","type":"facility","lineage":["https://openalex.org/I4210140120"]}],"countries":["FI"],"is_corresponding":true,"raw_author_name":"Michael J Courtney","raw_affiliation_strings":["Neuronal Signalling Lab, Turku Centre for Biotechnology, University of Turku and \u00c5bo Akademi University, Turku, Finland","Screening Unit, Turku Centre for Biotechnology, University of Turku and \u00c5bo Akademi University, and Institute of Biomedicine, University of Turku, Turku, Finland","Turku Brain and Mind Center, University of Turku and \u00c5bo Akademi University, Turku, Finland"],"affiliations":[{"raw_affiliation_string":"Neuronal Signalling Lab, Turku Centre for Biotechnology, University of Turku and \u00c5bo Akademi University, Turku, Finland","institution_ids":["https://openalex.org/I155660961","https://openalex.org/I130217899","https://openalex.org/I4210140120"]},{"raw_affiliation_string":"Screening Unit, Turku Centre for Biotechnology, University of Turku and \u00c5bo Akademi University, and Institute of Biomedicine, University of Turku, Turku, Finland","institution_ids":["https://openalex.org/I155660961","https://openalex.org/I130217899","https://openalex.org/I4210140120"]},{"raw_affiliation_string":"Turku Brain and Mind Center, University of Turku and \u00c5bo Akademi University, Turku, Finland","institution_ids":["https://openalex.org/I130217899","https://openalex.org/I155660961"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5032005041","https://openalex.org/A5049640837"],"corresponding_institution_ids":["https://openalex.org/I130217899","https://openalex.org/I154526488","https://openalex.org/I155660961","https://openalex.org/I2738703131","https://openalex.org/I3020098449","https://openalex.org/I4210140120","https://openalex.org/I899635006"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.04637575,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"34","issue":"18","first_page":"3196","last_page":"3204"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9947999715805054,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.9894000291824341,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/markov-chain","display_name":"Markov chain","score":0.5960077047348022},{"id":"https://openalex.org/keywords/phenotype","display_name":"Phenotype","score":0.531694769859314},{"id":"https://openalex.org/keywords/markov-random-field","display_name":"Markov random field","score":0.5078418850898743},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4342588782310486},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.36529040336608887},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3604692816734314},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.3405511677265167},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2949690818786621},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.2115200161933899},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.13676244020462036}],"concepts":[{"id":"https://openalex.org/C98763669","wikidata":"https://www.wikidata.org/wiki/Q176645","display_name":"Markov chain","level":2,"score":0.5960077047348022},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.531694769859314},{"id":"https://openalex.org/C2778045648","wikidata":"https://www.wikidata.org/wiki/Q176827","display_name":"Markov random field","level":4,"score":0.5078418850898743},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4342588782310486},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.36529040336608887},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3604692816734314},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.3405511677265167},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2949690818786621},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.2115200161933899},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13676244020462036},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.0},{"id":"https://openalex.org/C124504099","wikidata":"https://www.wikidata.org/wiki/Q56933","display_name":"Image segmentation","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002415","descriptor_name":"Cats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002415","descriptor_name":"Cats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002415","descriptor_name":"Cats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/bioinformatics/bty322","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bty322","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/34/18/3196/25731673/bty322.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:29897415","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29897415","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:6137993","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6137993","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"Text"},{"id":"pmh:oai:www.utupub.fi:10024/187229","is_oa":false,"landing_page_url":"https://www.utupub.fi/handle/10024/187229","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/bty322","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bty322","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/34/18/3196/25731673/bty322.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1250795336","display_name":null,"funder_award_id":"R01CA200417","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G1481482654","display_name":null,"funder_award_id":"CA200417","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1573715304","display_name":null,"funder_award_id":"CA20041","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G1672991332","display_name":null,"funder_award_id":"CA200417","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2723775281","display_name":null,"funder_award_id":"R01CA200417","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320321726","display_name":"Suomen Kulttuurirahasto","ror":"https://ror.org/027xav248"},{"id":"https://openalex.org/F4320323313","display_name":"Turun Yliopisto","ror":"https://ror.org/05vghhr25"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320335019","display_name":"Varsinais-Suomen Rahasto","ror":"https://ror.org/027xav248"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2802231733.pdf","grobid_xml":"https://content.openalex.org/works/W2802231733.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W143236119","https://openalex.org/W1512624479","https://openalex.org/W1520053542","https://openalex.org/W1591127859","https://openalex.org/W1803919009","https://openalex.org/W1962432205","https://openalex.org/W1963989925","https://openalex.org/W1967463041","https://openalex.org/W1971960993","https://openalex.org/W1978822608","https://openalex.org/W1979161825","https://openalex.org/W1981856505","https://openalex.org/W1995831678","https://openalex.org/W2003037085","https://openalex.org/W2017539895","https://openalex.org/W2017941065","https://openalex.org/W2020371238","https://openalex.org/W2020573425","https://openalex.org/W2021510996","https://openalex.org/W2023681729","https://openalex.org/W2039489843","https://openalex.org/W2040311875","https://openalex.org/W2057375178","https://openalex.org/W2081432059","https://openalex.org/W2082648159","https://openalex.org/W2091015360","https://openalex.org/W2094368363","https://openalex.org/W2094795912","https://openalex.org/W2103421493","https://openalex.org/W2114100577","https://openalex.org/W2126334242","https://openalex.org/W2141660740","https://openalex.org/W2147238273","https://openalex.org/W2165045267","https://openalex.org/W2268568430","https://openalex.org/W2394641095","https://openalex.org/W2401629147","https://openalex.org/W2469389540","https://openalex.org/W2512878401","https://openalex.org/W2525326847","https://openalex.org/W2538939159","https://openalex.org/W2547554208","https://openalex.org/W2568039432","https://openalex.org/W2590144118","https://openalex.org/W2591673237","https://openalex.org/W2607122245","https://openalex.org/W2731197081","https://openalex.org/W2746359368"],"related_works":["https://openalex.org/W1660242800","https://openalex.org/W2077211377","https://openalex.org/W3152686072","https://openalex.org/W1840542775","https://openalex.org/W1006270037","https://openalex.org/W2416830231","https://openalex.org/W3129238073","https://openalex.org/W2056274461","https://openalex.org/W179926425","https://openalex.org/W162527578"],"abstract_inverted_index":{"Supplementary":[0],"data":[1],"are":[2],"available":[3],"at":[4],"Bioinformatics":[5],"online.":[6]},"counts_by_year":[],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}