{"id":"https://openalex.org/W2808475704","doi":"https://doi.org/10.1093/bioinformatics/bty246","title":"Association mapping in biomedical time series via statistically significant shapelet mining","display_name":"Association mapping in biomedical time series via statistically significant shapelet mining","publication_year":2018,"publication_date":"2018-04-13","ids":{"openalex":"https://openalex.org/W2808475704","doi":"https://doi.org/10.1093/bioinformatics/bty246","mag":"2808475704","pmid":"https://pubmed.ncbi.nlm.nih.gov/29949972"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/bty246","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bty246","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/34/13/i438/25098133/bty246.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/34/13/i438/25098133/bty246.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047048637","display_name":"Christian Bock","orcid":"https://orcid.org/0000-0002-0701-5868"},"institutions":[{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Christian Bock","raw_affiliation_strings":["Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland","SIB Swiss Institute of Bioinformatics, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland","institution_ids":["https://openalex.org/I35440088"]},{"raw_affiliation_string":"SIB Swiss Institute of Bioinformatics, Switzerland","institution_ids":["https://openalex.org/I12708293"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050458847","display_name":"Thomas Gumbsch","orcid":null},"institutions":[{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Thomas Gumbsch","raw_affiliation_strings":["Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland","SIB Swiss Institute of Bioinformatics, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland","institution_ids":["https://openalex.org/I35440088"]},{"raw_affiliation_string":"SIB Swiss Institute of Bioinformatics, Switzerland","institution_ids":["https://openalex.org/I12708293"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021730842","display_name":"Michael Moor","orcid":"https://orcid.org/0000-0003-4911-6437"},"institutions":[{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Michael Moor","raw_affiliation_strings":["Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland","SIB Swiss Institute of Bioinformatics, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland","institution_ids":["https://openalex.org/I35440088"]},{"raw_affiliation_string":"SIB Swiss Institute of Bioinformatics, Switzerland","institution_ids":["https://openalex.org/I12708293"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003031729","display_name":"Bastian Rieck","orcid":"https://orcid.org/0000-0003-4335-0302"},"institutions":[{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Bastian Rieck","raw_affiliation_strings":["Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland","SIB Swiss Institute of Bioinformatics, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland","institution_ids":["https://openalex.org/I35440088"]},{"raw_affiliation_string":"SIB Swiss Institute of Bioinformatics, Switzerland","institution_ids":["https://openalex.org/I12708293"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047763166","display_name":"Damian Roqueiro","orcid":"https://orcid.org/0000-0002-9195-5915"},"institutions":[{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Damian Roqueiro","raw_affiliation_strings":["Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland","SIB Swiss Institute of Bioinformatics, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland","institution_ids":["https://openalex.org/I35440088"]},{"raw_affiliation_string":"SIB Swiss Institute of Bioinformatics, Switzerland","institution_ids":["https://openalex.org/I12708293"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074540538","display_name":"Karsten Borgwardt","orcid":"https://orcid.org/0000-0001-7221-2393"},"institutions":[{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Karsten Borgwardt","raw_affiliation_strings":["Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland","SIB Swiss Institute of Bioinformatics, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland","institution_ids":["https://openalex.org/I35440088"]},{"raw_affiliation_string":"SIB Swiss Institute of Bioinformatics, Switzerland","institution_ids":["https://openalex.org/I12708293"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5074540538"],"corresponding_institution_ids":["https://openalex.org/I12708293","https://openalex.org/I35440088"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":2.8251,"has_fulltext":true,"cited_by_count":23,"citation_normalized_percentile":{"value":0.91799322,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"34","issue":"13","first_page":"i438","last_page":"i446"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12205","display_name":"Time Series Analysis and Forecasting","score":0.8610000014305115,"subfield":{"id":"https://openalex.org/subfields/1711","display_name":"Signal Processing"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12205","display_name":"Time Series Analysis and Forecasting","score":0.8610000014305115,"subfield":{"id":"https://openalex.org/subfields/1711","display_name":"Signal Processing"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13702","display_name":"Machine Learning in Healthcare","score":0.056699998676776886,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.013000000268220901,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/discriminative-model","display_name":"Discriminative model","score":0.7605783939361572},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6243165731430054},{"id":"https://openalex.org/keywords/ranking","display_name":"Ranking (information retrieval)","score":0.5686976909637451},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.5154052972793579},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.45875951647758484},{"id":"https://openalex.org/keywords/pruning","display_name":"Pruning","score":0.43851256370544434},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.38434356451034546},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.3622874617576599},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.1219167709350586}],"concepts":[{"id":"https://openalex.org/C97931131","wikidata":"https://www.wikidata.org/wiki/Q5282087","display_name":"Discriminative model","level":2,"score":0.7605783939361572},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6243165731430054},{"id":"https://openalex.org/C189430467","wikidata":"https://www.wikidata.org/wiki/Q7293293","display_name":"Ranking (information retrieval)","level":2,"score":0.5686976909637451},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.5154052972793579},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.45875951647758484},{"id":"https://openalex.org/C108010975","wikidata":"https://www.wikidata.org/wiki/Q500094","display_name":"Pruning","level":2,"score":0.43851256370544434},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.38434356451034546},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.3622874617576599},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1219167709350586},{"id":"https://openalex.org/C6557445","wikidata":"https://www.wikidata.org/wiki/Q173113","display_name":"Agronomy","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056726","descriptor_name":"Genetic Association Studies","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D056726","descriptor_name":"Genetic Association Studies","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D056726","descriptor_name":"Genetic Association Studies","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D057225","descriptor_name":"Data Mining","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D057225","descriptor_name":"Data Mining","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D057225","descriptor_name":"Data Mining","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1093/bioinformatics/bty246","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bty246","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/34/13/i438/25098133/bty246.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:29949972","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29949972","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:www.research-collection.ethz.ch:20.500.11850/279088","is_oa":true,"landing_page_url":"http://hdl.handle.net/20.500.11850/279088","pdf_url":"http://hdl.handle.net/20.500.11850/279088","source":{"id":"https://openalex.org/S4306402302","display_name":"Repository for Publications and Research Data (ETH Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I35440088","host_organization_name":"ETH Zurich","host_organization_lineage":["https://openalex.org/I35440088"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics, 34 (13)","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:doc.rero.ch:332614","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":{"id":"https://openalex.org/S4306400148","display_name":"reroDoc Digital Library","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":""},{"id":"pmh:oai:europepmc.org:4991104","is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6022601","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"doi:10.3929/ethz-b-000279088","is_oa":true,"landing_page_url":"https://doi.org/10.3929/ethz-b-000279088","pdf_url":null,"source":{"id":"https://openalex.org/S7407051236","display_name":"ETH Z\u00fcrich Research Collection","issn_l":null,"issn":[],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/bty246","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bty246","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/34/13/i438/25098133/bty246.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6100000143051147,"id":"https://metadata.un.org/sdg/10","display_name":"Reduced inequalities"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320320924","display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","ror":"https://ror.org/00yjd3n13"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2808475704.pdf","grobid_xml":"https://content.openalex.org/works/W2808475704.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W18854425","https://openalex.org/W748993927","https://openalex.org/W1843659499","https://openalex.org/W1898928487","https://openalex.org/W1943063538","https://openalex.org/W1973590682","https://openalex.org/W1978371851","https://openalex.org/W1989415069","https://openalex.org/W2005896876","https://openalex.org/W2014093593","https://openalex.org/W2015329932","https://openalex.org/W2031648200","https://openalex.org/W2036703787","https://openalex.org/W2041486528","https://openalex.org/W2084416969","https://openalex.org/W2104579579","https://openalex.org/W2132996843","https://openalex.org/W2280404143","https://openalex.org/W2282181907","https://openalex.org/W2290195878","https://openalex.org/W2295959708","https://openalex.org/W2372800617","https://openalex.org/W2396881363","https://openalex.org/W2402972623","https://openalex.org/W2442246762","https://openalex.org/W2468738844","https://openalex.org/W2523834880","https://openalex.org/W2554068199","https://openalex.org/W2580821343","https://openalex.org/W2581605534","https://openalex.org/W2595840341","https://openalex.org/W2727475156","https://openalex.org/W2748885884","https://openalex.org/W2757504960","https://openalex.org/W3023757607","https://openalex.org/W3047398590","https://openalex.org/W3169372665","https://openalex.org/W4290305201","https://openalex.org/W4387760836","https://openalex.org/W6638847521"],"related_works":["https://openalex.org/W2965546495","https://openalex.org/W2153315159","https://openalex.org/W3103844505","https://openalex.org/W4205463238","https://openalex.org/W259157601","https://openalex.org/W2761785940","https://openalex.org/W2110523656","https://openalex.org/W1482209366","https://openalex.org/W2521627374","https://openalex.org/W2981954115"],"abstract_inverted_index":{"Motivation:":[0],"Most":[1],"modern":[2],"intensive":[3],"care":[4],"units":[5],"record":[6],"the":[7,30,73,99,108,122,170,190,217,253,260],"physiological":[8,111,128],"and":[9,113,124,135,146,153,176,209,238,246,252],"vital":[10,203],"signs":[11],"of":[12,33,68,75,101,110,119,127,138,163,172,192,200,216,219],"patients.":[13],"These":[14],"data":[15,269],"can":[16,233],"be":[17],"used":[18],"to":[19,97,228,235,258],"extract":[20],"signatures,":[21],"commonly":[22],"known":[23],"as":[24],"biomarkers,":[25],"that":[26,62,115,130,157,213,232,255],"help":[27],"physicians":[28],"understand":[29],"biological":[31,38],"complexity":[32],"many":[34],"syndromes.":[35],"However,":[36],"most":[37,64,87],"biomarkers":[39,112],"suffer":[40],"from":[41],"either":[42],"poor":[43],"predictive":[44,65,79],"performance":[45,80],"or":[46],"weak":[47],"explanatory":[48],"power.":[49],"Recent":[50],"developments":[51],"in":[52,66,198,243],"time":[53,151],"series":[54,152],"classification":[55],"focus":[56],"on":[57,94],"discovering":[58,196],"shapelets,":[59],"i.e.":[60,224],"subsequences":[61],"are":[63,131,158,214,256,270],"terms":[67],"class":[69],"membership.":[70],"Shapelets":[71],"have":[72],"advantage":[74],"combining":[76],"a":[77,144,164,201,220],"high":[78],"with":[81,185],"an":[82,225,229],"interpretable":[83],"component-their":[84],"shape.":[85],"Currently,":[86],"shapelet":[88,165,183],"discovery":[89,123],"methods":[90],"do":[91],"not":[92,241],"rely":[93],"statistical":[95],"tests":[96],"verify":[98],"significance":[100,162],"individual":[102],"shapelets.":[103],"Therefore,":[104],"identifying":[105,154],"associations":[106],"between":[107],"shapelets":[109],"patients":[114],"exhibit":[116],"certain":[117],"phenotypes":[118],"interest":[120],"enables":[121],"subsequent":[125],"ranking":[126],"signatures":[129],"interpretable,":[132],"statistically":[133,159],"validated":[134],"accurate":[136],"predictors":[137],"clinical":[139],"endpoints.":[140],"Results:":[141],"We":[142,188,248],"present":[143],"novel":[145],"scalable":[147],"method":[148,194,251],"for":[149],"scanning":[150],"discriminative":[155],"patterns":[156,197],"significant.":[160],"The":[161],"is":[166],"evaluated":[167],"while":[168],"considering":[169],"problem":[171],"multiple":[173],"hypothesis":[174],"testing":[175],"mitigating":[177],"it":[178],"by":[179,195],"efficiently":[180],"pruning":[181],"untestable":[182],"candidates":[184],"Tarone's":[186],"method.":[187],"demonstrate":[189],"utility":[191],"our":[193,250],"three":[199],"patient's":[202],"signs:":[204],"heart":[205],"rate,":[206],"respiratory":[207],"rate":[208],"systolic":[210],"blood":[211],"pressure":[212],"indicators":[215],"severity":[218],"future":[221],"sepsis":[222],"event,":[223],"inflammatory":[226],"response":[227],"infective":[230],"agent":[231],"lead":[234],"organ":[236],"failure":[237],"death,":[239],"if":[240],"treated":[242],"time.":[244],"Availability":[245],"implementation:":[247],"make":[249],"scripts":[254],"required":[257],"reproduce":[259],"experiments":[261],"publicly":[262],"available":[263,271],"at":[264,272],"https://github.com/BorgwardtLab/S3M.":[265],"Supplementary":[266,268],"information:":[267],"Bioinformatics":[273],"online.":[274]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}