{"id":"https://openalex.org/W2951731136","doi":"https://doi.org/10.1093/bioinformatics/bty130","title":"GOLabeler: improving sequence-based large-scale protein function prediction by learning to rank","display_name":"GOLabeler: improving sequence-based large-scale protein function prediction by learning to rank","publication_year":2018,"publication_date":"2018-03-06","ids":{"openalex":"https://openalex.org/W2951731136","doi":"https://doi.org/10.1093/bioinformatics/bty130","mag":"2951731136","pmid":"https://pubmed.ncbi.nlm.nih.gov/29522145"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/bty130","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bty130","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/34/14/2465/25138245/bty130.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/34/14/2465/25138245/bty130.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015677036","display_name":"Ronghui You","orcid":"https://orcid.org/0000-0002-7608-4867"},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ronghui You","raw_affiliation_strings":["Center for Computational System Biology, ISTBI, Fudan University, Shanghai, China","School of Computer Science and Shanghai Key Lab of Intelligent Information Processing"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Computational System Biology, ISTBI, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067"]},{"raw_affiliation_string":"School of Computer Science and Shanghai Key Lab of Intelligent Information Processing","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100410554","display_name":"Zihan Zhang","orcid":"https://orcid.org/0000-0002-8099-5081"},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zihan Zhang","raw_affiliation_strings":["Center for Computational System Biology, ISTBI, Fudan University, Shanghai, China","School of Computer Science and Shanghai Key Lab of Intelligent Information Processing"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Computational System Biology, ISTBI, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067"]},{"raw_affiliation_string":"School of Computer Science and Shanghai Key Lab of Intelligent Information Processing","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014672057","display_name":"Yi Xiong","orcid":"https://orcid.org/0000-0003-2910-6725"},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi Xiong","raw_affiliation_strings":["Department of Bioinformatics and Biostatistics, Shanghai Jiaotong University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics and Biostatistics, Shanghai Jiaotong University, Shanghai, China","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022255550","display_name":"Fengzhu Sun","orcid":"https://orcid.org/0000-0002-8552-043X"},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Fengzhu Sun","raw_affiliation_strings":["Center for Computational System Biology, ISTBI, Fudan University, Shanghai, China","Molecular and Computational Biology Program, Department of Biological Sciences, University of Southern California, Los Angeles, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Computational System Biology, ISTBI, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067"]},{"raw_affiliation_string":"Molecular and Computational Biology Program, Department of Biological Sciences, University of Southern California, Los Angeles, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059001924","display_name":"Hiroshi Mamitsuka","orcid":"https://orcid.org/0000-0002-6607-5617"},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]},{"id":"https://openalex.org/I4399598384","display_name":"Kyoto University Institute for Chemical Research","ror":"https://ror.org/0349bbg69","country_code":null,"type":"facility","lineage":["https://openalex.org/I22299242","https://openalex.org/I4399598384"]},{"id":"https://openalex.org/I9927081","display_name":"Aalto University","ror":"https://ror.org/020hwjq30","country_code":"FI","type":"education","lineage":["https://openalex.org/I9927081"]}],"countries":["FI","JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Mamitsuka","raw_affiliation_strings":["Bioinformatics Center, Institute for Chemical Research, Kyoto University, Uji, Kyoto Prefecture, Japan","Department of Computer Science, Aalto University, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics Center, Institute for Chemical Research, Kyoto University, Uji, Kyoto Prefecture, Japan","institution_ids":["https://openalex.org/I22299242","https://openalex.org/I4399598384"]},{"raw_affiliation_string":"Department of Computer Science, Aalto University, Helsinki, Finland","institution_ids":["https://openalex.org/I9927081"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045866167","display_name":"Shanfeng Zhu","orcid":"https://orcid.org/0000-0002-6067-5312"},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Shanfeng Zhu","raw_affiliation_strings":["Center for Computational System Biology, ISTBI, Fudan University, Shanghai, China","School of Computer Science and Shanghai Key Lab of Intelligent Information Processing"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Computational System Biology, ISTBI, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067"]},{"raw_affiliation_string":"School of Computer Science and Shanghai Key Lab of Intelligent Information Processing","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5045866167"],"corresponding_institution_ids":["https://openalex.org/I24943067"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":6.4959,"has_fulltext":false,"cited_by_count":209,"citation_normalized_percentile":{"value":0.9767104,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"34","issue":"14","first_page":"2465","last_page":"2473"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.5224000215530396,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.5224000215530396,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.3278999924659729,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11710","display_name":"Biomedical Text Mining and Ontologies","score":0.08020000159740448,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rank","display_name":"Rank (graph theory)","score":0.6647400856018066},{"id":"https://openalex.org/keywords/sequence","display_name":"Sequence (biology)","score":0.6492882966995239},{"id":"https://openalex.org/keywords/scale","display_name":"Scale (ratio)","score":0.6092476844787598},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6067542433738708},{"id":"https://openalex.org/keywords/function","display_name":"Function (biology)","score":0.5405207872390747},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3791027069091797},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.36449918150901794},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.3552011251449585},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.18240362405776978},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.1589733064174652},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.08269360661506653},{"id":"https://openalex.org/keywords/geography","display_name":"Geography","score":0.06605800986289978},{"id":"https://openalex.org/keywords/cartography","display_name":"Cartography","score":0.05531623959541321},{"id":"https://openalex.org/keywords/combinatorics","display_name":"Combinatorics","score":0.04975292086601257}],"concepts":[{"id":"https://openalex.org/C164226766","wikidata":"https://www.wikidata.org/wiki/Q7293202","display_name":"Rank (graph theory)","level":2,"score":0.6647400856018066},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.6492882966995239},{"id":"https://openalex.org/C2778755073","wikidata":"https://www.wikidata.org/wiki/Q10858537","display_name":"Scale (ratio)","level":2,"score":0.6092476844787598},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6067542433738708},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.5405207872390747},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3791027069091797},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.36449918150901794},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3552011251449585},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.18240362405776978},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1589733064174652},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08269360661506653},{"id":"https://openalex.org/C205649164","wikidata":"https://www.wikidata.org/wiki/Q1071","display_name":"Geography","level":0,"score":0.06605800986289978},{"id":"https://openalex.org/C58640448","wikidata":"https://www.wikidata.org/wiki/Q42515","display_name":"Cartography","level":1,"score":0.05531623959541321},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.04975292086601257}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072416","descriptor_name":"Protein Structural Elements","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072416","descriptor_name":"Protein Structural Elements","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072416","descriptor_name":"Protein Structural Elements","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D056890","descriptor_name":"Eukaryota","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D056890","descriptor_name":"Eukaryota","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D056890","descriptor_name":"Eukaryota","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D058977","descriptor_name":"Molecular Sequence Annotation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058977","descriptor_name":"Molecular Sequence Annotation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058977","descriptor_name":"Molecular Sequence Annotation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063990","descriptor_name":"Gene Ontology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063990","descriptor_name":"Gene Ontology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063990","descriptor_name":"Gene Ontology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/bioinformatics/bty130","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bty130","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/34/14/2465/25138245/bty130.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:29522145","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29522145","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/bty130","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bty130","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/34/14/2465/25138245/bty130.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1767995656","display_name":"\u5927\u89c4\u6a21\u751f\u7269\u533b\u5b66\u6587\u732e\u533b\u5b66\u4e3b\u9898\u8bcd\u7684\u9ad8\u7cbe\u5ea6\u81ea\u52a8\u6807\u6ce8\u7814\u7a76","funder_award_id":"61572139","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5997710061","display_name":"Estimating the factor structure in multiple matrices","funder_award_id":"16H02868","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G8237087745","display_name":null,"funder_award_id":"31601074","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320320907","display_name":"Japan Science and Technology Corporation","ror":"https://ror.org/00097mb19"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"},{"id":"https://openalex.org/F4320338113","display_name":"Accelerated Innovation Research Initiative Turning Top Science and Ideas into High-Impact Values","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W1144107824","https://openalex.org/W1872414266","https://openalex.org/W1998490996","https://openalex.org/W2050163349","https://openalex.org/W2068916031","https://openalex.org/W2085277871","https://openalex.org/W2098432760","https://openalex.org/W2100383158","https://openalex.org/W2101626488","https://openalex.org/W2102814386","https://openalex.org/W2103017472","https://openalex.org/W2108984616","https://openalex.org/W2114315281","https://openalex.org/W2117486996","https://openalex.org/W2129448726","https://openalex.org/W2139294595","https://openalex.org/W2141879010","https://openalex.org/W2142955026","https://openalex.org/W2151946481","https://openalex.org/W2152689720","https://openalex.org/W2153544371","https://openalex.org/W2158714788","https://openalex.org/W2161955763","https://openalex.org/W2164461702","https://openalex.org/W2227395312","https://openalex.org/W2252523470","https://openalex.org/W2419892062","https://openalex.org/W2428528690","https://openalex.org/W2472351724","https://openalex.org/W2509894479","https://openalex.org/W2535702297","https://openalex.org/W2536286076","https://openalex.org/W2739999456","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2112835755","https://openalex.org/W4291951920","https://openalex.org/W2349674371","https://openalex.org/W2097495471","https://openalex.org/W1696545756","https://openalex.org/W2952827811","https://openalex.org/W2056202066","https://openalex.org/W2963262648","https://openalex.org/W4301867002","https://openalex.org/W2056790378"],"abstract_inverted_index":{"Motivation:":[0],"Gene":[1],"Ontology":[2],"(GO)":[3],"has":[4],"been":[5],"widely":[6],"used":[7],"to":[8,51,108,122,139,199],"annotate":[9],"functions":[10],"of":[11,21,35,40,58,62,74,135,197,204,231],"proteins":[12,24,64,109],"and":[13,116,153,163,188,190,221,242],"understand":[14],"their":[15],"biological":[16],"roles.":[17],"Currently":[18],"only":[19,66,81,142],"<1%":[20],">70":[22],"million":[23],"in":[25,89,159,194],"UniProtKB":[26],"have":[27,65,104],"experimental":[28],"GO":[29,59,179],"annotations,":[30],"implying":[31],"the":[32,72,80,114,195],"strong":[33],"necessity":[34],"automated":[36],"function":[37],"prediction":[38],"(AFP)":[39],"proteins,":[41,102],"where":[42],"AFP":[43,76,90,239],"is":[44,120,138],"a":[45,55,124,157,160,202],"hard":[46],"multilabel":[47,210],"classification":[48],"problem":[49,118],"due":[50],"one":[52],"protein":[53],"with":[54,110],"diverse":[56],"number":[57],"terms.":[60],"Most":[61],"these":[63],"sequences":[67,78],"as":[68],"input":[69],"information,":[70],"indicating":[71],"importance":[73],"sequence-based":[75],"(SAFP:":[77],"are":[79,87,249],"input).":[82],"Furthermore,":[83],"homology-based":[84],"SAFP":[85],"tools":[86],"competitive":[88],"competitions,":[91],"while":[92],"they":[93],"do":[94],"not":[95,141],"necessarily":[96],"work":[97],"well":[98],"for":[99,126,129,209],"so-called":[100],"difficult":[101,130],"which":[103,169],"<60%":[105],"sequence":[106,151,182],"identity":[107],"annotations":[111],"already.":[112],"Thus,":[113],"vital":[115],"challenging":[117],"now":[119],"how":[121],"develop":[123],"method":[125,137],"SAFP,":[127],"particularly":[128],"proteins.":[131],"Methods:":[132],"The":[133,213],"key":[134],"this":[136],"extract":[140],"homology":[143],"information":[144],"but":[145],"also":[146],"diverse,":[147],"deep-rooted":[148],"information/evidence":[149],"from":[150,175],"inputs":[152],"integrate":[154],"them":[155],"into":[156],"predictor":[158],"both":[161],"effective":[162],"efficient":[164],"manner.":[165],"We":[166],"propose":[167],"GOLabeler,":[168,232],"integrates":[170],"five":[171],"component":[172],"classifiers,":[173],"trained":[174],"different":[176],"features,":[177],"including":[178,233],"term":[180],"frequency,":[181],"alignment,":[183],"amino":[184],"acid":[185],"trigram,":[186],"domains":[187],"motifs,":[189],"biophysical":[191],"properties,":[192],"etc.,":[193],"framework":[196],"learning":[198],"rank":[200],"(LTR),":[201],"paradigm":[203],"machine":[205],"learning,":[206],"especially":[207],"powerful":[208],"classification.":[211],"Results:":[212],"empirical":[214],"results":[215],"obtained":[216],"by":[217,223],"examining":[218],"GOLabeler":[219],"extensively":[220],"thoroughly":[222],"using":[224],"large-scale":[225],"datasets":[226],"revealed":[227],"numerous":[228],"favorable":[229],"aspects":[230],"significant":[234],"performance":[235],"advantage":[236],"over":[237],"state-of-the-art":[238],"methods.":[240],"Availability":[241],"implementation:":[243],"http://datamining-iip.fudan.edu.cn/golabeler.":[244],"Supplementary":[245,247],"information:":[246],"data":[248],"available":[250],"at":[251],"Bioinformatics":[252],"online.":[253]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":38},{"year":2024,"cited_by_count":29},{"year":2023,"cited_by_count":34},{"year":2022,"cited_by_count":28},{"year":2021,"cited_by_count":22},{"year":2020,"cited_by_count":23},{"year":2019,"cited_by_count":21},{"year":2018,"cited_by_count":6}],"updated_date":"2026-07-14T08:27:34.040176","created_date":"2025-10-10T00:00:00"}