{"id":"https://openalex.org/W2791484882","doi":"https://doi.org/10.1093/bioinformatics/bty115","title":"A new method for the high-precision assessment of tumor changes in response to treatment","display_name":"A new method for the high-precision assessment of tumor changes in response to treatment","publication_year":2018,"publication_date":"2018-03-12","ids":{"openalex":"https://openalex.org/W2791484882","doi":"https://doi.org/10.1093/bioinformatics/bty115","mag":"2791484882","pmid":"https://pubmed.ncbi.nlm.nih.gov/29547950"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/bty115","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bty115","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/34/15/2625/25230734/bty115.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/34/15/2625/25230734/bty115.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075666274","display_name":"P. Tar","orcid":null},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"P D Tar","raw_affiliation_strings":["Division of Informatics, Imaging and Data Science, Manchester Pharmacy School, Manchester, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Informatics, Imaging and Data Science, Manchester Pharmacy School, Manchester, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110020977","display_name":"N. A. Thacker","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N A Thacker","raw_affiliation_strings":["Division of Informatics, Imaging and Data Science, Manchester Pharmacy School, Manchester, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Informatics, Imaging and Data Science, Manchester Pharmacy School, Manchester, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020149711","display_name":"Muhammad Babur","orcid":"https://orcid.org/0000-0002-5437-2497"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Babur","raw_affiliation_strings":["Division of Pharmacy and Optometry, Manchester Pharmacy School, Manchester, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pharmacy and Optometry, Manchester Pharmacy School, Manchester, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111968808","display_name":"Y. Watson","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Watson","raw_affiliation_strings":["Division of Informatics, Imaging and Data Science, Manchester Pharmacy School, Manchester, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Informatics, Imaging and Data Science, Manchester Pharmacy School, Manchester, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022090297","display_name":"Sen-ching S. Cheung","orcid":"https://orcid.org/0000-0002-9207-5514"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Cheung","raw_affiliation_strings":["Division of Informatics, Imaging and Data Science, Manchester Pharmacy School, Manchester, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Informatics, Imaging and Data Science, Manchester Pharmacy School, Manchester, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046653012","display_name":"Robert Little","orcid":"https://orcid.org/0000-0003-1870-3241"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R A Little","raw_affiliation_strings":["Division of Informatics, Imaging and Data Science, Manchester Pharmacy School, Manchester, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Informatics, Imaging and Data Science, Manchester Pharmacy School, Manchester, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050749739","display_name":"Roben G. Gieling","orcid":"https://orcid.org/0000-0003-3452-637X"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R G Gieling","raw_affiliation_strings":["Division of Pharmacy and Optometry, Manchester Pharmacy School, Manchester, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pharmacy and Optometry, Manchester Pharmacy School, Manchester, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031947326","display_name":"Kaye J. Williams","orcid":"https://orcid.org/0000-0001-7708-3770"},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"K J Williams","raw_affiliation_strings":["Division of Cancer Sciences, University of Manchester","Division of Pharmacy and Optometry, Manchester Pharmacy School, Manchester, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cancer Sciences, University of Manchester","institution_ids":["https://openalex.org/I28407311"]},{"raw_affiliation_string":"Division of Pharmacy and Optometry, Manchester Pharmacy School, Manchester, UK","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091801564","display_name":"James P.B. O\u2019Connor","orcid":"https://orcid.org/0000-0002-4044-8497"},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]},{"id":"https://openalex.org/I4210131968","display_name":"The Christie Hospital","ror":"https://ror.org/03nd63441","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210131968","https://openalex.org/I4210133995"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J P B O\u2019Connor","raw_affiliation_strings":["Department of Radiology, The Christie Hospital NHS Trust, Manchester, UK","Division of Cancer Sciences, University of Manchester"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, The Christie Hospital NHS Trust, Manchester, UK","institution_ids":["https://openalex.org/I4210131968"]},{"raw_affiliation_string":"Division of Cancer Sciences, University of Manchester","institution_ids":["https://openalex.org/I28407311"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5075666274"],"corresponding_institution_ids":[],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":{"value":2518,"currency":"EUR","value_usd":2715},"fwci":0.359,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.61972221,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"34","issue":"15","first_page":"2625","last_page":"2633"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11885","display_name":"MRI in cancer diagnosis","score":0.8427000045776367,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11885","display_name":"MRI in cancer diagnosis","score":0.8427000045776367,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.05220000073313713,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.03680000081658363,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sample-size-determination","display_name":"Sample size determination","score":0.5681095123291016},{"id":"https://openalex.org/keywords/outlier","display_name":"Outlier","score":0.5021274089813232},{"id":"https://openalex.org/keywords/contrast","display_name":"Contrast (vision)","score":0.4599202871322632},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.4481375813484192},{"id":"https://openalex.org/keywords/false-positive-paradox","display_name":"False positive paradox","score":0.441297709941864},{"id":"https://openalex.org/keywords/oncology","display_name":"Oncology","score":0.3583868145942688},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.3501349091529846},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.3382227122783661},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3210376501083374},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.2975738048553467},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.12288373708724976}],"concepts":[{"id":"https://openalex.org/C129848803","wikidata":"https://www.wikidata.org/wiki/Q2564360","display_name":"Sample size determination","level":2,"score":0.5681095123291016},{"id":"https://openalex.org/C79337645","wikidata":"https://www.wikidata.org/wiki/Q779824","display_name":"Outlier","level":2,"score":0.5021274089813232},{"id":"https://openalex.org/C2776502983","wikidata":"https://www.wikidata.org/wiki/Q690182","display_name":"Contrast (vision)","level":2,"score":0.4599202871322632},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4481375813484192},{"id":"https://openalex.org/C64869954","wikidata":"https://www.wikidata.org/wiki/Q1859747","display_name":"False positive paradox","level":2,"score":0.441297709941864},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3583868145942688},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.3501349091529846},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3382227122783661},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3210376501083374},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.2975738048553467},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.12288373708724976}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018401","descriptor_name":"Sample Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018401","descriptor_name":"Sample Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018401","descriptor_name":"Sample Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018401","descriptor_name":"Sample Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018401","descriptor_name":"Sample Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D045325","descriptor_name":"HCT116 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045325","descriptor_name":"HCT116 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045325","descriptor_name":"HCT116 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045325","descriptor_name":"HCT116 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045325","descriptor_name":"HCT116 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1093/bioinformatics/bty115","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bty115","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/34/15/2625/25230734/bty115.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:29547950","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29547950","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:pure.atira.dk:openaire/60d958a2-7f23-4512-aa2c-10c8ddee04a6","is_oa":true,"landing_page_url":"https://research.manchester.ac.uk/en/publications/60d958a2-7f23-4512-aa2c-10c8ddee04a6","pdf_url":null,"source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tar, P, Thacker, N, Babur, M, Watson, Y, Cheung, S, Little, R, Gieling, R, Williams, K & O'Connor, J 2018, 'A new method for the high-precision assessment of tumor changes in response to treatment', Bioinformatics, vol. 34, no. 15, pp. 2625-2633. https://doi.org/10.1093/bioinformatics/bty115","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:nrl.northumbria.ac.uk:34859","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":{"id":"https://openalex.org/S4306401884","display_name":"Northumbria Research Link (Northumbria University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I32394136","host_organization_name":"Northumbria University","host_organization_lineage":["https://openalex.org/I32394136"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:europepmc.org:5027449","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6061877","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/bty115","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bty115","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/34/15/2625/25230734/bty115.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.49000000953674316,"display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G2106699394","display_name":null,"funder_award_id":"C8742/A18097","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G3760566539","display_name":null,"funder_award_id":"RPG-2014-019","funder_id":"https://openalex.org/F4320319993","funder_display_name":"Leverhulme Trust"},{"id":"https://openalex.org/G4991097456","display_name":null,"funder_award_id":"C19221/A22746","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G6288703092","display_name":null,"funder_award_id":"22746","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G6650042716","display_name":null,"funder_award_id":"15267","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G8284940888","display_name":null,"funder_award_id":"C8742/A18097","funder_id":"https://openalex.org/F4320320291","funder_display_name":"University of Manchester"}],"funders":[{"id":"https://openalex.org/F4320319985","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67"},{"id":"https://openalex.org/F4320319993","display_name":"Leverhulme Trust","ror":"https://ror.org/012mzw131"},{"id":"https://openalex.org/F4320320291","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W2791484882.pdf"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W1676308325","https://openalex.org/W1943756471","https://openalex.org/W1974910032","https://openalex.org/W1983749425","https://openalex.org/W1987370132","https://openalex.org/W2000196730","https://openalex.org/W2001679453","https://openalex.org/W2005563858","https://openalex.org/W2021262032","https://openalex.org/W2049633694","https://openalex.org/W2056390240","https://openalex.org/W2087750317","https://openalex.org/W2099741732","https://openalex.org/W2102624911","https://openalex.org/W2103243046","https://openalex.org/W2115785123","https://openalex.org/W2116172872","https://openalex.org/W2142266080","https://openalex.org/W2150575159","https://openalex.org/W2162615654","https://openalex.org/W2169644362","https://openalex.org/W2183716640","https://openalex.org/W2528829099","https://openalex.org/W2566498094","https://openalex.org/W2604468722","https://openalex.org/W2607497028","https://openalex.org/W2763327666","https://openalex.org/W3010898908","https://openalex.org/W4238280656","https://openalex.org/W4298032220","https://openalex.org/W6686285042","https://openalex.org/W6745196859","https://openalex.org/W6822120570"],"related_works":["https://openalex.org/W1557094818","https://openalex.org/W2183246718","https://openalex.org/W2099261052","https://openalex.org/W3209204065","https://openalex.org/W3006513224","https://openalex.org/W2046456988","https://openalex.org/W2105707930","https://openalex.org/W1755711892","https://openalex.org/W3012357814","https://openalex.org/W1997267813"],"abstract_inverted_index":{"Motivation:":[0],"Imaging":[1],"demonstrates":[2],"that":[3,18],"preclinical":[4],"and":[5,24,80,100,200,217,236,251],"human":[6],"tumors":[7,37],"are":[8,184,266],"heterogeneous,":[9],"i.e.":[10],"a":[11,124,158,168,188],"single":[12],"tumor":[13],"can":[14,38,55],"exhibit":[15],"multiple":[16],"regions":[17],"behave":[19],"differently":[20],"during":[21,207],"both":[22],"development":[23,57],"also":[25],"in":[26,34,49,64,82,94,105,160,242],"response":[27],"to":[28,46,62,70,76,120,140,157,166,220],"treatment.":[29],"The":[30,112,149],"large":[31],"variations":[32],"observed":[33],"control":[35,235],"group,":[36],"obscure":[39],"detection":[40],"of":[41,52,58,109,115,162,204,215,229],"significant":[42,147,152,182],"therapeutic":[43,71],"effects":[44],"due":[45,61,69],"the":[47,143,176,202,212,230],"ambiguity":[48],"attributing":[50],"causes":[51],"change.":[53],"This":[54],"hinder":[56],"effective":[59],"therapies":[60],"limitations":[63],"experimental":[65],"design":[66],"rather":[67],"than":[68],"failure.":[72],"An":[73],"improved":[74],"method":[75],"model":[77],"biological":[78],"variation":[79],"heterogeneity":[81],"imaging":[83],"signals":[84],"is":[85,118,258],"described.":[86],"Specifically,":[87],"linear":[88],"Poisson":[89],"modeling":[90],"(LPM)":[91],"evaluates":[92],"changes":[93,117,183],"apparent":[95,130],"diffusion":[96,131],"co-efficient":[97,132],"between":[98],"baseline":[99],"72":[101],"h":[102],"after":[103],"radiotherapy,":[104],"two":[106],"xenograft":[107,225],"models":[108],"colorectal":[110],"cancer.":[111],"statistical":[113],"significance":[114],"measured":[116],"compared":[119,174],"those":[121],"attainable":[122],"using":[123,191],"conventional":[125,177],"t-test":[126],"analysis":[127,228],"on":[128],"basic":[129],"distribution":[133],"parameters.":[134],"Results:":[135],"When":[136],"LPMs":[137,144],"were":[138,151],"applied":[139],"treated":[141,231],"tumors,":[142,155],"detected":[145,186],"highly":[146,181],"changes.":[148],"analyses":[150],"for":[153,223],"all":[154],"equating":[156],"gain":[159],"power":[161],"4-fold":[163],"(i.e.":[164],"equivalent":[165],"having":[167],"sample":[169,248],"size":[170],"16":[171],"times":[172],"larger),":[173],"with":[175],"approach.":[178],"In":[179],"contrast,":[180],"only":[185],"at":[187,245,268],"cohort":[189],"level":[190],"t-tests,":[192],"restricting":[193],"their":[194],"potential":[195,238],"use":[196],"within":[197],"personalized":[198],"medicine":[199],"increasing":[201],"number":[203],"animals":[205],"required":[206],"testing.":[208],"Furthermore,":[209],"LPM":[210,243],"enabled":[211],"relative":[213],"volumes":[214],"responding":[216],"non-responding":[218],"tissue":[219],"be":[221],"estimated":[222],"each":[224],"model.":[226],"Leave-one-out":[227],"xenografts":[232],"provided":[233],"quality":[234],"identified":[237],"outliers,":[239],"raising":[240],"confidence":[241],"data":[244,265],"clinically":[246],"relevant":[247],"sizes.":[249],"Availability":[250],"implementation:":[252],"TINA":[253],"Vision":[254],"open":[255],"source":[256],"software":[257],"available":[259,267],"from":[260],"www.tina-vision.net.":[261],"Supplementary":[262,264],"information:":[263],"Bioinformatics":[269],"online.":[270]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":2}],"updated_date":"2026-07-02T09:51:11.867554","created_date":"2025-10-10T00:00:00"}