{"id":"https://openalex.org/W2790385355","doi":"https://doi.org/10.1093/bioinformatics/bty013","title":"Computational drug repositioning using low-rank matrix approximation and randomized algorithms","display_name":"Computational drug repositioning using low-rank matrix approximation and randomized algorithms","publication_year":2018,"publication_date":"2018-01-19","ids":{"openalex":"https://openalex.org/W2790385355","doi":"https://doi.org/10.1093/bioinformatics/bty013","mag":"2790385355","pmid":"https://pubmed.ncbi.nlm.nih.gov/29365057"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/bty013","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bty013","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/34/11/1904/25121588/bty013.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/34/11/1904/25121588/bty013.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012174743","display_name":"Huimin Luo","orcid":"https://orcid.org/0000-0002-5066-5372"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I173899330","display_name":"Henan University","ror":"https://ror.org/003xyzq10","country_code":"CN","type":"education","lineage":["https://openalex.org/I173899330"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huimin Luo","raw_affiliation_strings":["School of Computer and Information Engineering, Henan University, KaiFeng, China","School of Information Science and Engineering, Central South University, ChangSha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computer and Information Engineering, Henan University, KaiFeng, China","institution_ids":["https://openalex.org/I173899330"]},{"raw_affiliation_string":"School of Information Science and Engineering, Central South University, ChangSha, China","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100719013","display_name":"Min Li","orcid":"https://orcid.org/0000-0002-0188-1394"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Min Li","raw_affiliation_strings":["School of Information Science and Engineering, Central South University, ChangSha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Information Science and Engineering, Central South University, ChangSha, China","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101842704","display_name":"Shaokai Wang","orcid":"https://orcid.org/0000-0001-8177-067X"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shaokai Wang","raw_affiliation_strings":["School of Information Science and Engineering, Central South University, ChangSha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Information Science and Engineering, Central South University, ChangSha, China","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100414582","display_name":"Quan Liu","orcid":"https://orcid.org/0000-0003-2472-7485"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Quan Liu","raw_affiliation_strings":["School of Information Science and Engineering, Central South University, ChangSha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Information Science and Engineering, Central South University, ChangSha, China","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079316675","display_name":"Yaohang Li","orcid":"https://orcid.org/0000-0003-0178-1876"},"institutions":[{"id":"https://openalex.org/I81365321","display_name":"Old Dominion University","ror":"https://ror.org/04zjtrb98","country_code":"US","type":"education","lineage":["https://openalex.org/I81365321"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yaohang Li","raw_affiliation_strings":["Department of Computer Science, Old Dominion University, Norfolk, VA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, Old Dominion University, Norfolk, VA, USA","institution_ids":["https://openalex.org/I81365321"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100438360","display_name":"Jianxin Wang","orcid":"https://orcid.org/0000-0003-1516-0480"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jianxin Wang","raw_affiliation_strings":["School of Information Science and Engineering, Central South University, ChangSha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Information Science and Engineering, Central South University, ChangSha, China","institution_ids":["https://openalex.org/I139660479"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5079316675","https://openalex.org/A5100438360"],"corresponding_institution_ids":["https://openalex.org/I139660479","https://openalex.org/I81365321"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":24.7238,"has_fulltext":false,"cited_by_count":269,"citation_normalized_percentile":{"value":0.99709788,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":100},"biblio":{"volume":"34","issue":"11","first_page":"1904","last_page":"1912"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9607999920845032,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9607999920845032,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.01600000075995922,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.004800000227987766,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug-repositioning","display_name":"Drug repositioning","score":0.707307755947113},{"id":"https://openalex.org/keywords/matrix-completion","display_name":"Matrix completion","score":0.6709681749343872},{"id":"https://openalex.org/keywords/adjacency-matrix","display_name":"Adjacency matrix","score":0.6458176374435425},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.6370446681976318},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.585468053817749},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.5087710022926331},{"id":"https://openalex.org/keywords/rank","display_name":"Rank (graph theory)","score":0.4565526843070984},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"Drug discovery","score":0.4436291456222534},{"id":"https://openalex.org/keywords/matrix","display_name":"Matrix (chemical analysis)","score":0.4417656660079956},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.4409739673137665},{"id":"https://openalex.org/keywords/thresholding","display_name":"Thresholding","score":0.4302520751953125},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3924505412578583},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.3698754906654358},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.33704477548599243},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.2762565314769745},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.23789134621620178},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.2363358438014984},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.2179151177406311},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.10813310742378235},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.09664693474769592}],"concepts":[{"id":"https://openalex.org/C103637391","wikidata":"https://www.wikidata.org/wiki/Q5308921","display_name":"Drug repositioning","level":3,"score":0.707307755947113},{"id":"https://openalex.org/C2778459887","wikidata":"https://www.wikidata.org/wiki/Q6787865","display_name":"Matrix completion","level":3,"score":0.6709681749343872},{"id":"https://openalex.org/C180356752","wikidata":"https://www.wikidata.org/wiki/Q727035","display_name":"Adjacency matrix","level":3,"score":0.6458176374435425},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.6370446681976318},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.585468053817749},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5087710022926331},{"id":"https://openalex.org/C164226766","wikidata":"https://www.wikidata.org/wiki/Q7293202","display_name":"Rank (graph theory)","level":2,"score":0.4565526843070984},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.4436291456222534},{"id":"https://openalex.org/C106487976","wikidata":"https://www.wikidata.org/wiki/Q685816","display_name":"Matrix (chemical analysis)","level":2,"score":0.4417656660079956},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.4409739673137665},{"id":"https://openalex.org/C191178318","wikidata":"https://www.wikidata.org/wiki/Q2256906","display_name":"Thresholding","level":3,"score":0.4302520751953125},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3924505412578583},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3698754906654358},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.33704477548599243},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.2762565314769745},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23789134621620178},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.2363358438014984},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2179151177406311},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.10813310742378235},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09664693474769592},{"id":"https://openalex.org/C132525143","wikidata":"https://www.wikidata.org/wiki/Q141488","display_name":"Graph","level":2,"score":0.0},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.0},{"id":"https://openalex.org/C163716315","wikidata":"https://www.wikidata.org/wiki/Q901177","display_name":"Gaussian","level":2,"score":0.0},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bioinformatics/bty013","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bty013","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/34/11/1904/25121588/bty013.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:29365057","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29365057","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:digitalcommons.odu.edu:computerscience_fac_pubs-1367","is_oa":false,"landing_page_url":"https://digitalcommons.odu.edu/computerscience_fac_pubs/362","pdf_url":null,"source":{"id":"https://openalex.org/S4377196314","display_name":"ODU Digital Commons (Old Dominion University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I81365321","host_organization_name":"Old Dominion University","host_organization_lineage":["https://openalex.org/I81365321"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Computer Science Faculty Publications","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/bty013","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bty013","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/34/11/1904/25121588/bty013.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1341588548","display_name":null,"funder_award_id":"No. 61728211","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2727026650","display_name":null,"funder_award_id":"61420106009, No. 61622213, No. 61732009, No. 61728211","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2802940568","display_name":null,"funder_award_id":"No. 61622213","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3327866426","display_name":"CAREER: Novel Sampling Approaches for Protein Modeling Applications","funder_award_id":"1066471","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G358564744","display_name":null,"funder_award_id":"61420106009","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5562823499","display_name":null,"funder_award_id":"No. 61732009","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W1530703867","https://openalex.org/W1975147762","https://openalex.org/W1996287810","https://openalex.org/W1998898494","https://openalex.org/W2020274161","https://openalex.org/W2028781966","https://openalex.org/W2031954078","https://openalex.org/W2046885214","https://openalex.org/W2070741095","https://openalex.org/W2088632292","https://openalex.org/W2093313266","https://openalex.org/W2100582962","https://openalex.org/W2100929382","https://openalex.org/W2103972604","https://openalex.org/W2113072832","https://openalex.org/W2119220491","https://openalex.org/W2119412782","https://openalex.org/W2123688186","https://openalex.org/W2124001239","https://openalex.org/W2131848047","https://openalex.org/W2148797284","https://openalex.org/W2151357092","https://openalex.org/W2154654747","https://openalex.org/W2170146596","https://openalex.org/W2173044177","https://openalex.org/W2183717576","https://openalex.org/W2344978273","https://openalex.org/W2346950316","https://openalex.org/W2424876691","https://openalex.org/W2611328865","https://openalex.org/W2797302609","https://openalex.org/W3016074254","https://openalex.org/W4248234957","https://openalex.org/W6686420396"],"related_works":["https://openalex.org/W3044296243","https://openalex.org/W4220885170","https://openalex.org/W2989777174","https://openalex.org/W4205715258","https://openalex.org/W4285506882","https://openalex.org/W2561827752","https://openalex.org/W2108753466","https://openalex.org/W2299074827","https://openalex.org/W2054519467","https://openalex.org/W3159848998"],"abstract_inverted_index":{"Motivation:":[0],"Computational":[1],"drug":[2,17,36,40,128,136,179],"repositioning":[3,37,41,129],"is":[4,65,86,168],"an":[5,30],"important":[6],"and":[7,25,80,143,148,162,187,249],"efficient":[8],"approach":[9],"towards":[10],"identifying":[11],"novel":[12,52,135],"treatments":[13,53],"for":[14,33,210,235],"diseases":[15],"in":[16,100],"discovery.":[18],"The":[19,39,59,165,214],"emergence":[20],"of":[21,146,244],"large-scale,":[22],"heterogeneous":[23,154,166],"biological":[24],"biomedical":[26],"datasets":[27],"has":[28],"provided":[29],"unprecedented":[31],"opportunity":[32],"developing":[34],"computational":[35],"methods.":[38],"problem":[42],"can":[43,118],"be":[44,119],"modeled":[45],"as":[46],"a":[47,106,127,153,171,194],"recommendation":[48,63,130],"system":[49,64,131],"that":[50,69,219],"recommends":[51],"based":[54],"on":[55],"known":[56,183],"drug-disease":[57,75,102,112,155,163,173,184,189,204,212],"associations.":[58],"formulation":[60],"under":[61],"this":[62,89,123],"matrix":[66,85,92,103,108,206],"completion,":[67],"assuming":[68],"the":[70,82,91,97,101,203,222,227,241,245],"hidden":[71],"factors":[72],"contributing":[73],"to":[74,133,201],"associations":[76,113],"are":[77,260],"highly":[78],"correlated":[79],"thus":[81],"corresponding":[83],"data":[84,141,259],"low-rank.":[87],"Under":[88],"assumption,":[90],"completion":[93],"algorithm":[94,200],"fills":[95],"out":[96],"unknown":[98,188,211],"entries":[99,177],"by":[104,138,158,170],"constructing":[105],"low-rank":[107],"approximation,":[109],"where":[110],"new":[111],"having":[114],"not":[115],"been":[116],"validated":[117,144],"screened.":[120],"Results:":[121],"In":[122,231],"work,":[124],"we":[125,151,192],"propose":[126],"(DRRS)":[132],"predict":[134],"indications":[137],"integrating":[139,159],"related":[140],"sources":[142],"information":[145],"drugs":[147,238],"diseases.":[149],"Firstly,":[150],"construct":[152],"interaction":[156,185],"network":[157,167],"drug-drug,":[160],"disease-disease":[161],"networks.":[164],"represented":[169],"large":[172],"adjacency":[174,205],"matrix,":[175],"whose":[176],"include":[178],"pairs,":[180,182],"disease":[181],"pairs":[186],"pairs.":[190,213],"Then,":[191],"adopt":[193],"fast":[195],"Singular":[196],"Value":[197],"Thresholding":[198],"(SVT)":[199],"complete":[202],"with":[207,226],"predicted":[208],"scores":[209],"comprehensive":[215],"experimental":[216],"results":[217],"show":[218],"DRRS":[220],"improves":[221],"prediction":[223],"accuracy":[224],"compared":[225],"other":[228],"state-of-the-art":[229],"approaches.":[230],"addition,":[232],"case":[233],"studies":[234],"several":[236],"selected":[237],"further":[239],"demonstrate":[240],"practical":[242],"usefulness":[243],"proposed":[246],"method.":[247],"Availability":[248],"implementation:":[250],"http://bioinformatics.csu.edu.cn/resources/softs/DrugRepositioning/DRRS/index.html.":[251],"Contact:":[252],"yaohang@cs.odu.edu":[253],"or":[254],"jxwang@mail.csu.edu.cn.":[255],"Supplementary":[256,258],"information:":[257],"available":[261],"at":[262],"Bioinformatics":[263],"online.":[264]},"counts_by_year":[{"year":2026,"cited_by_count":12},{"year":2025,"cited_by_count":30},{"year":2024,"cited_by_count":32},{"year":2023,"cited_by_count":37},{"year":2022,"cited_by_count":37},{"year":2021,"cited_by_count":40},{"year":2020,"cited_by_count":33},{"year":2019,"cited_by_count":37},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":1}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}
