{"id":"https://openalex.org/W2776132197","doi":"https://doi.org/10.1093/bioinformatics/btx834","title":"polyPK: an R package for pharmacokinetic analysis of multi-component drugs using a metabolomics approach","display_name":"polyPK: an R package for pharmacokinetic analysis of multi-component drugs using a metabolomics approach","publication_year":2017,"publication_date":"2017-12-22","ids":{"openalex":"https://openalex.org/W2776132197","doi":"https://doi.org/10.1093/bioinformatics/btx834","mag":"2776132197","pmid":"https://pubmed.ncbi.nlm.nih.gov/29293946"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btx834","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btx834","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/34/10/1792/25118152/btx834.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/34/10/1792/25118152/btx834.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008364904","display_name":"Mengci Li","orcid":"https://orcid.org/0000-0002-8181-2232"},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210144482","display_name":"Shanghai Sixth People's Hospital","ror":"https://ror.org/049zrh188","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210144482"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mengci Li","raw_affiliation_strings":["Center for Translational Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China","School of Biomedical Engineering and Med-X Research Institute, Shanghai Jiao Tong University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Translational Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China","institution_ids":["https://openalex.org/I4210144482","https://openalex.org/I183067930"]},{"raw_affiliation_string":"School of Biomedical Engineering and Med-X Research Institute, Shanghai Jiao Tong University, Shanghai, China","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101654323","display_name":"Shouli Wang","orcid":"https://orcid.org/0000-0002-6582-0726"},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210144482","display_name":"Shanghai Sixth People's Hospital","ror":"https://ror.org/049zrh188","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210144482"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shouli Wang","raw_affiliation_strings":["Center for Translational Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Translational Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China","institution_ids":["https://openalex.org/I4210144482","https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051833306","display_name":"Guoxiang Xie","orcid":"https://orcid.org/0000-0002-0951-4150"},"institutions":[{"id":"https://openalex.org/I117965899","display_name":"University of Hawai\u02bbi at M\u0101noa","ror":"https://ror.org/01wspgy28","country_code":"US","type":"education","lineage":["https://openalex.org/I117965899"]},{"id":"https://openalex.org/I1331384533","display_name":"University of Hawaii System","ror":"https://ror.org/03tzaeb71","country_code":"US","type":"education","lineage":["https://openalex.org/I1331384533"]},{"id":"https://openalex.org/I4210093646","display_name":"Cancer Center of Hawaii","ror":"https://ror.org/0065jhh26","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210093646"]},{"id":"https://openalex.org/I4390039246","display_name":"University of Hawaii Cancer Center","ror":"https://ror.org/00kt3nk56","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I4390039246"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guoxiang Xie","raw_affiliation_strings":["University of Hawaii Cancer Center, Honolulu, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Hawaii Cancer Center, Honolulu, USA","institution_ids":["https://openalex.org/I4210093646","https://openalex.org/I117965899","https://openalex.org/I1331384533","https://openalex.org/I4390039246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100667074","display_name":"Xiaohui Ma","orcid":"https://orcid.org/0000-0001-5358-8790"},"institutions":[{"id":"https://openalex.org/I4210127436","display_name":"Tasly Holding Group (China)","ror":"https://ror.org/034kb7s93","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210127436"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaohui Ma","raw_affiliation_strings":["State Key Laboratory of Core Technology in Innovative Chinese Medicine, Pharmacology and Toxicology Research Centre, Tasly Academy, Tasly Holding Group Co., Ltd, Tianjin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Core Technology in Innovative Chinese Medicine, Pharmacology and Toxicology Research Centre, Tasly Academy, Tasly Holding Group Co., Ltd, Tianjin, China","institution_ids":["https://openalex.org/I4210127436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101987223","display_name":"Tianlu Chen","orcid":"https://orcid.org/0000-0003-1798-5435"},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210144482","display_name":"Shanghai Sixth People's Hospital","ror":"https://ror.org/049zrh188","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210144482"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Tianlu Chen","raw_affiliation_strings":["Center for Translational Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Translational Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China","institution_ids":["https://openalex.org/I4210144482","https://openalex.org/I183067930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100404644","display_name":"Wei Jia","orcid":"https://orcid.org/0000-0002-3739-8994"},"institutions":[{"id":"https://openalex.org/I117965899","display_name":"University of Hawai\u02bbi at M\u0101noa","ror":"https://ror.org/01wspgy28","country_code":"US","type":"education","lineage":["https://openalex.org/I117965899"]},{"id":"https://openalex.org/I1331384533","display_name":"University of Hawaii System","ror":"https://ror.org/03tzaeb71","country_code":"US","type":"education","lineage":["https://openalex.org/I1331384533"]},{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210093646","display_name":"Cancer Center of Hawaii","ror":"https://ror.org/0065jhh26","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210093646"]},{"id":"https://openalex.org/I4210144482","display_name":"Shanghai Sixth People's Hospital","ror":"https://ror.org/049zrh188","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210144482"]},{"id":"https://openalex.org/I4390039246","display_name":"University of Hawaii Cancer Center","ror":"https://ror.org/00kt3nk56","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I4390039246"]}],"countries":["CN","US"],"is_corresponding":true,"raw_author_name":"Wei Jia","raw_affiliation_strings":["Center for Translational Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China","University of Hawaii Cancer Center, Honolulu, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Translational Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China","institution_ids":["https://openalex.org/I4210144482","https://openalex.org/I183067930"]},{"raw_affiliation_string":"University of Hawaii Cancer Center, Honolulu, USA","institution_ids":["https://openalex.org/I4210093646","https://openalex.org/I117965899","https://openalex.org/I1331384533","https://openalex.org/I4390039246"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5100404644","https://openalex.org/A5101987223"],"corresponding_institution_ids":["https://openalex.org/I117965899","https://openalex.org/I1331384533","https://openalex.org/I183067930","https://openalex.org/I4210093646","https://openalex.org/I4210144482","https://openalex.org/I4390039246"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":0.6729,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.70076161,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"34","issue":"10","first_page":"1792","last_page":"1794"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.5468999743461609,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.5468999743461609,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11709","display_name":"Traditional Chinese Medicine Analysis","score":0.3619999885559082,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11889","display_name":"Ginseng Biological Effects and Applications","score":0.010099999606609344,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/r-package","display_name":"R package","score":0.6261281967163086},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6078525185585022},{"id":"https://openalex.org/keywords/bottleneck","display_name":"Bottleneck","score":0.5712572336196899},{"id":"https://openalex.org/keywords/pipeline","display_name":"Pipeline (software)","score":0.48913151025772095},{"id":"https://openalex.org/keywords/component","display_name":"Component (thermodynamics)","score":0.46699443459510803},{"id":"https://openalex.org/keywords/principal-component-analysis","display_name":"Principal component analysis","score":0.45241639018058777},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.40355193614959717},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3687124252319336},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.1909266710281372},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.15711989998817444}],"concepts":[{"id":"https://openalex.org/C2984074130","wikidata":"https://www.wikidata.org/wiki/Q73539779","display_name":"R package","level":2,"score":0.6261281967163086},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6078525185585022},{"id":"https://openalex.org/C2780513914","wikidata":"https://www.wikidata.org/wiki/Q18210350","display_name":"Bottleneck","level":2,"score":0.5712572336196899},{"id":"https://openalex.org/C43521106","wikidata":"https://www.wikidata.org/wiki/Q2165493","display_name":"Pipeline (software)","level":2,"score":0.48913151025772095},{"id":"https://openalex.org/C168167062","wikidata":"https://www.wikidata.org/wiki/Q1117970","display_name":"Component (thermodynamics)","level":2,"score":0.46699443459510803},{"id":"https://openalex.org/C27438332","wikidata":"https://www.wikidata.org/wiki/Q2873","display_name":"Principal component analysis","level":2,"score":0.45241639018058777},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.40355193614959717},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3687124252319336},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.1909266710281372},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15711989998817444},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0},{"id":"https://openalex.org/C459310","wikidata":"https://www.wikidata.org/wiki/Q117801","display_name":"Computational science","level":1,"score":0.0},{"id":"https://openalex.org/C149635348","wikidata":"https://www.wikidata.org/wiki/Q193040","display_name":"Embedded system","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D010599","descriptor_name":"Pharmacokinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010599","descriptor_name":"Pharmacokinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010599","descriptor_name":"Pharmacokinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bioinformatics/btx834","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btx834","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/34/10/1792/25118152/btx834.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:29293946","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29293946","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:8861262","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8861262","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btx834","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btx834","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/34/10/1792/25118152/btx834.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G4595617625","display_name":"\u57fa\u4e8e\u201c\u534a\u805a\u7126\u201d\u4ee3\u8c22\u7ec4\u5b66\u7b56\u7565\u7684\u4e3b\u8981\u6d88\u5316\u7cfb\u7edf\u80bf\u7624\u5171\u6709\u548c\u7279\u6709\u4ee3\u8c22\u6a21\u5f0f\u7814\u7a76","funder_award_id":"31501079","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5207231112","display_name":null,"funder_award_id":"31500954","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2776132197.pdf","grobid_xml":"https://content.openalex.org/works/W2776132197.grobid-xml"},"referenced_works_count":5,"referenced_works":["https://openalex.org/W1975517602","https://openalex.org/W2028805211","https://openalex.org/W2029784301","https://openalex.org/W2724292747","https://openalex.org/W6740153790"],"related_works":["https://openalex.org/W1657880117","https://openalex.org/W2595172197","https://openalex.org/W2127970246","https://openalex.org/W2084856301","https://openalex.org/W1001352512","https://openalex.org/W4382618745","https://openalex.org/W2885125400","https://openalex.org/W1989889224","https://openalex.org/W2748922771","https://openalex.org/W1987128138"],"abstract_inverted_index":{"Summary:":[0],"Pharmacokinetics":[1],"(PK)":[2],"is":[3,65,165],"a":[4,29,83,142],"long-standing":[5],"bottleneck":[6],"for":[7,118],"botanical":[8],"drug":[9,39],"and":[10,19,41,55,71,89,103,124,136,150,161],"traditional":[11,84,126],"medicine":[12,86],"research.":[13],"By":[14],"using":[15],"an":[16,97],"integrated":[17],"phytochemical":[18],"metabolomics":[20],"approach":[21],"coupled":[22],"with":[23],"multivariate":[24,130],"statistical":[25,131],"analysis,":[26,132],"we":[27,95],"propose":[28],"new":[30],"strategy,":[31],"Poly-PK,":[32],"to":[33],"simultaneously":[34],"monitor":[35],"the":[36,48,51,60,77,101,107,154,169],"performance":[37],"of":[38,50,67,80,106,111,145,157],"constituents":[40],"endogenous":[42],"metabolites,":[43],"taking":[44],"into":[45],"account":[46],"both":[47],"diversity":[49],"drug's":[52],"chemical":[53],"composition":[54],"its":[56],"complex":[57],"effects":[58],"on":[59],"mammalian":[61],"metabolic":[62,155],"pathways.":[63],"Poly-PK":[64,112],"independent":[66],"specific":[68],"measurement":[69],"platforms":[70],"has":[72],"been":[73],"successfully":[74],"applied":[75],"in":[76,152],"PK":[78,127],"studies":[79],"Puerh":[81],"tea,":[82],"Chinese":[85],"Huangqi":[87],"decoction":[88],"many":[90],"other":[91],"multi-component":[92,158],"drugs.":[93,159],"Here,":[94],"introduce":[96],"R":[98,170],"package,":[99],"polyPK,":[100],"first":[102],"only":[104],"automation":[105],"data":[108,119,181],"analysis":[109],"pipeline":[110],"strategy.":[113],"polyPK":[114,163],"provides":[115],"10":[116],"functions":[117],"pre-processing,":[120],"differential":[121],"compound":[122],"identification":[123],"grouping,":[125],"parameters":[128],"calculation,":[129],"correlations,":[133],"cluster":[134],"analyses":[135],"resulting":[137],"visualization.":[138],"It":[139],"may":[140],"serve":[141],"wide":[143],"range":[144],"users,":[146],"including":[147],"pharmacologists,":[148],"biologists":[149],"doctors,":[151],"understanding":[153],"fate":[156],"Availability":[160],"implementation:":[162],"package":[164],"freely":[166],"available":[167,183],"from":[168],"archive":[171],"CRAN":[172],"(https://CRAN.R-project.org/package=polyPK).":[173],"Contact:":[174],"wjia@cc.hawaii.edu":[175],"or":[176],"chentianlu@sjtu.edu.cn.":[177],"Supplementary":[178,180],"information:":[179],"are":[182],"at":[184],"Bioinformatics":[185],"online.":[186]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1}],"updated_date":"2026-06-06T09:05:17.133730","created_date":"2025-10-10T00:00:00"}