{"id":"https://openalex.org/W2691730529","doi":"https://doi.org/10.1093/bioinformatics/btx552","title":"Three-dimensional cardiovascular imaging-genetics: a mass univariate framework","display_name":"Three-dimensional cardiovascular imaging-genetics: a mass univariate framework","publication_year":2017,"publication_date":"2017-09-01","ids":{"openalex":"https://openalex.org/W2691730529","doi":"https://doi.org/10.1093/bioinformatics/btx552","mag":"2691730529","pmid":"https://pubmed.ncbi.nlm.nih.gov/28968671"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btx552","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btx552","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/34/1/97/49043452/bioinformatics_34_1_97.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["arxiv","crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/34/1/97/49043452/bioinformatics_34_1_97.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016254297","display_name":"Carlo Biffi","orcid":"https://orcid.org/0000-0002-4913-7441"},"institutions":[{"id":"https://openalex.org/I2801748203","display_name":"Hammersmith Hospital","ror":"https://ror.org/05jg8yp15","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I153355300","https://openalex.org/I2801748203"]},{"id":"https://openalex.org/I4210161592","display_name":"MRC London Institute of Medical Sciences","ror":"https://ror.org/05p1n6x86","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210161592","https://openalex.org/I47508984"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Carlo Biffi","raw_affiliation_strings":["Cardiovascular Magnetic Resonance Imaging and Genetics, MRC London Institute of Medical Sciences, Imperial College London, Hammersmith Hospital Campus, London, UK","Department of Computing, Imperial College London, South Kensington Campus, London, UK"],"raw_orcid":"https://orcid.org/0000-0002-4913-7441","affiliations":[{"raw_affiliation_string":"Cardiovascular Magnetic Resonance Imaging and Genetics, MRC London Institute of Medical Sciences, Imperial College London, Hammersmith Hospital Campus, London, UK","institution_ids":["https://openalex.org/I2801748203","https://openalex.org/I4210161592","https://openalex.org/I47508984"]},{"raw_affiliation_string":"Department of Computing, Imperial College London, South Kensington Campus, London, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071762687","display_name":"Antonio de Marvao","orcid":"https://orcid.org/0000-0001-9095-5887"},"institutions":[{"id":"https://openalex.org/I2801748203","display_name":"Hammersmith Hospital","ror":"https://ror.org/05jg8yp15","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I153355300","https://openalex.org/I2801748203"]},{"id":"https://openalex.org/I4210161592","display_name":"MRC London Institute of Medical Sciences","ror":"https://ror.org/05p1n6x86","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210161592","https://openalex.org/I47508984"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Antonio de Marvao","raw_affiliation_strings":["Cardiovascular Magnetic Resonance Imaging and Genetics, MRC London Institute of Medical Sciences, Imperial College London, Hammersmith Hospital Campus, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Magnetic Resonance Imaging and Genetics, MRC London Institute of Medical Sciences, Imperial College London, Hammersmith Hospital Campus, London, UK","institution_ids":["https://openalex.org/I2801748203","https://openalex.org/I4210161592","https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108821492","display_name":"Mark Attard","orcid":null},"institutions":[{"id":"https://openalex.org/I2801748203","display_name":"Hammersmith Hospital","ror":"https://ror.org/05jg8yp15","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I153355300","https://openalex.org/I2801748203"]},{"id":"https://openalex.org/I4210161592","display_name":"MRC London Institute of Medical Sciences","ror":"https://ror.org/05p1n6x86","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210161592","https://openalex.org/I47508984"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mark I Attard","raw_affiliation_strings":["Cardiovascular Magnetic Resonance Imaging and Genetics, MRC London Institute of Medical Sciences, Imperial College London, Hammersmith Hospital Campus, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Magnetic Resonance Imaging and Genetics, MRC London Institute of Medical Sciences, Imperial College London, Hammersmith Hospital Campus, London, UK","institution_ids":["https://openalex.org/I2801748203","https://openalex.org/I4210161592","https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089066482","display_name":"Timothy J. W. Dawes","orcid":"https://orcid.org/0000-0001-7871-524X"},"institutions":[{"id":"https://openalex.org/I2801748203","display_name":"Hammersmith Hospital","ror":"https://ror.org/05jg8yp15","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I153355300","https://openalex.org/I2801748203"]},{"id":"https://openalex.org/I4210161592","display_name":"MRC London Institute of Medical Sciences","ror":"https://ror.org/05p1n6x86","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210161592","https://openalex.org/I47508984"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Timothy J W Dawes","raw_affiliation_strings":["Cardiovascular Magnetic Resonance Imaging and Genetics, MRC London Institute of Medical Sciences, Imperial College London, Hammersmith Hospital Campus, London, UK","Quantitative Physiology and Genetics, National Heart and Lung Institute, Imperial College London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Magnetic Resonance Imaging and Genetics, MRC London Institute of Medical Sciences, Imperial College London, Hammersmith Hospital Campus, London, UK","institution_ids":["https://openalex.org/I2801748203","https://openalex.org/I4210161592","https://openalex.org/I47508984"]},{"raw_affiliation_string":"Quantitative Physiology and Genetics, National Heart and Lung Institute, Imperial College London, London, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080840846","display_name":"Nicola Whiffin","orcid":"https://orcid.org/0000-0003-1554-6594"},"institutions":[{"id":"https://openalex.org/I2801748203","display_name":"Hammersmith Hospital","ror":"https://ror.org/05jg8yp15","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I153355300","https://openalex.org/I2801748203"]},{"id":"https://openalex.org/I4210111309","display_name":"NIHR Royal Brompton Cardiovascular Biomedical Research Unit","ror":"https://ror.org/01y4kmz24","country_code":"GB","type":"government","lineage":["https://openalex.org/I2800036501","https://openalex.org/I34931013","https://openalex.org/I4210111309"]},{"id":"https://openalex.org/I4210161592","display_name":"MRC London Institute of Medical Sciences","ror":"https://ror.org/05p1n6x86","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210161592","https://openalex.org/I47508984"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Nicola Whiffin","raw_affiliation_strings":["Cardiovascular Magnetic Resonance Imaging and Genetics, MRC London Institute of Medical Sciences, Imperial College London, Hammersmith Hospital Campus, London, UK","NIHR Cardiovascular Biomedical Research Unit, Royal Brompton and Harefield NHS Trust, London, UK","Quantitative Physiology and Genetics, National Heart and Lung Institute, Imperial College London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Magnetic Resonance Imaging and Genetics, MRC London Institute of Medical Sciences, Imperial College London, Hammersmith Hospital Campus, London, UK","institution_ids":["https://openalex.org/I2801748203","https://openalex.org/I4210161592","https://openalex.org/I47508984"]},{"raw_affiliation_string":"NIHR Cardiovascular Biomedical Research Unit, Royal Brompton and Harefield NHS Trust, London, UK","institution_ids":["https://openalex.org/I4210111309"]},{"raw_affiliation_string":"Quantitative Physiology and Genetics, National Heart and Lung Institute, Imperial College London, London, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059823739","display_name":"Wenjia Bai","orcid":"https://orcid.org/0000-0003-2943-7698"},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Wenjia Bai","raw_affiliation_strings":["Department of Computing, Imperial College London, South Kensington Campus, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computing, Imperial College London, South Kensington Campus, London, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018244514","display_name":"Wenzhe Shi","orcid":"https://orcid.org/0000-0002-9750-6379"},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Wenzhe Shi","raw_affiliation_strings":["Department of Computing, Imperial College London, South Kensington Campus, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computing, Imperial College London, South Kensington Campus, London, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030202355","display_name":"Catherine Francis","orcid":"https://orcid.org/0000-0002-4370-9461"},"institutions":[{"id":"https://openalex.org/I4210111309","display_name":"NIHR Royal Brompton Cardiovascular Biomedical Research Unit","ror":"https://ror.org/01y4kmz24","country_code":"GB","type":"government","lineage":["https://openalex.org/I2800036501","https://openalex.org/I34931013","https://openalex.org/I4210111309"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Catherine Francis","raw_affiliation_strings":["NIHR Cardiovascular Biomedical Research Unit, Royal Brompton and Harefield NHS Trust, London, UK","Quantitative Physiology and Genetics, National Heart and Lung Institute, Imperial College London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NIHR Cardiovascular Biomedical Research Unit, Royal Brompton and Harefield NHS Trust, London, UK","institution_ids":["https://openalex.org/I4210111309"]},{"raw_affiliation_string":"Quantitative Physiology and Genetics, National Heart and Lung Institute, Imperial College London, London, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021290397","display_name":"Hannah V. Meyer","orcid":"https://orcid.org/0000-0003-4564-0899"},"institutions":[{"id":"https://openalex.org/I1303153112","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1303153112","https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I87048295","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I87048295"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Hannah Meyer","raw_affiliation_strings":["European Molecular Biology Laboratory (EMBL), European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"European Molecular Biology Laboratory (EMBL), European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, UK","institution_ids":["https://openalex.org/I1303153112","https://openalex.org/I87048295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034314016","display_name":"Rachel Buchan","orcid":"https://orcid.org/0000-0003-2490-9289"},"institutions":[{"id":"https://openalex.org/I4210111309","display_name":"NIHR Royal Brompton Cardiovascular Biomedical Research Unit","ror":"https://ror.org/01y4kmz24","country_code":"GB","type":"government","lineage":["https://openalex.org/I2800036501","https://openalex.org/I34931013","https://openalex.org/I4210111309"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Rachel Buchan","raw_affiliation_strings":["NIHR Cardiovascular Biomedical Research Unit, Royal Brompton and Harefield NHS Trust, London, UK","Quantitative Physiology and Genetics, National Heart and Lung Institute, Imperial College London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NIHR Cardiovascular Biomedical Research Unit, Royal Brompton and Harefield NHS Trust, London, UK","institution_ids":["https://openalex.org/I4210111309"]},{"raw_affiliation_string":"Quantitative Physiology and Genetics, National Heart and Lung Institute, Imperial College London, London, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071216592","display_name":"Stuart A. Cook","orcid":"https://orcid.org/0000-0001-6628-194X"},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I2801748203","display_name":"Hammersmith Hospital","ror":"https://ror.org/05jg8yp15","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I153355300","https://openalex.org/I2801748203"]},{"id":"https://openalex.org/I4210111309","display_name":"NIHR Royal Brompton Cardiovascular Biomedical Research Unit","ror":"https://ror.org/01y4kmz24","country_code":"GB","type":"government","lineage":["https://openalex.org/I2800036501","https://openalex.org/I34931013","https://openalex.org/I4210111309"]},{"id":"https://openalex.org/I4210147238","display_name":"National Heart Centre Singapore","ror":"https://ror.org/04f8k9513","country_code":"SG","type":"healthcare","lineage":["https://openalex.org/I4210147238"]},{"id":"https://openalex.org/I4210161592","display_name":"MRC London Institute of Medical Sciences","ror":"https://ror.org/05p1n6x86","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210161592","https://openalex.org/I47508984"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB","SG"],"is_corresponding":false,"raw_author_name":"Stuart A Cook","raw_affiliation_strings":["Cardiovascular Magnetic Resonance Imaging and Genetics, MRC London Institute of Medical Sciences, Imperial College London, Hammersmith Hospital Campus, London, UK","Department of Cardiology, National Heart Centre Singapore, Singapore","NIHR Cardiovascular Biomedical Research Unit, Royal Brompton and Harefield NHS Trust, London, UK","Programme in Cardiovascular and Metabolic Disorders, Duke National University Singapore, Singapore","Quantitative Physiology and Genetics, National Heart and Lung Institute, Imperial College London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Magnetic Resonance Imaging and Genetics, MRC London Institute of Medical Sciences, Imperial College London, Hammersmith Hospital Campus, London, UK","institution_ids":["https://openalex.org/I2801748203","https://openalex.org/I4210161592","https://openalex.org/I47508984"]},{"raw_affiliation_string":"Department of Cardiology, National Heart Centre Singapore, Singapore","institution_ids":["https://openalex.org/I4210147238"]},{"raw_affiliation_string":"NIHR Cardiovascular Biomedical Research Unit, Royal Brompton and Harefield NHS Trust, London, UK","institution_ids":["https://openalex.org/I4210111309"]},{"raw_affiliation_string":"Programme in Cardiovascular and Metabolic Disorders, Duke National University Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]},{"raw_affiliation_string":"Quantitative Physiology and Genetics, National Heart and Lung Institute, Imperial College London, London, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006461848","display_name":"Daniel Rueckert","orcid":"https://orcid.org/0000-0002-5683-5889"},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Daniel Rueckert","raw_affiliation_strings":["Department of Computing, Imperial College London, South Kensington Campus, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computing, Imperial College London, South Kensington Campus, London, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068696789","display_name":"Declan P. O\u2019Regan","orcid":"https://orcid.org/0000-0002-0691-0270"},"institutions":[{"id":"https://openalex.org/I2801748203","display_name":"Hammersmith Hospital","ror":"https://ror.org/05jg8yp15","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I153355300","https://openalex.org/I2801748203"]},{"id":"https://openalex.org/I4210161592","display_name":"MRC London Institute of Medical Sciences","ror":"https://ror.org/05p1n6x86","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210161592","https://openalex.org/I47508984"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Declan P O\u2019Regan","raw_affiliation_strings":["Cardiovascular Magnetic Resonance Imaging and Genetics, MRC London Institute of Medical Sciences, Imperial College London, Hammersmith Hospital Campus, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Magnetic Resonance Imaging and Genetics, MRC London Institute of Medical Sciences, Imperial College London, Hammersmith Hospital Campus, London, UK","institution_ids":["https://openalex.org/I2801748203","https://openalex.org/I4210161592","https://openalex.org/I47508984"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5068696789"],"corresponding_institution_ids":["https://openalex.org/I2801748203","https://openalex.org/I4210161592","https://openalex.org/I47508984"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":{"value":2090,"currency":"EUR","value_usd":2254},"fwci":1.4188,"has_fulltext":true,"cited_by_count":46,"citation_normalized_percentile":{"value":0.81178233,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"34","issue":"1","first_page":"97","last_page":"103"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.219200000166893,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.219200000166893,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.20419999957084656,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.09099999815225601,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/univariate","display_name":"Univariate","score":0.7006598114967346},{"id":"https://openalex.org/keywords/magnetic-resonance-imaging","display_name":"Magnetic resonance imaging","score":0.4609411954879761},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.44313913583755493},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4113510251045227},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3544917702674866},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.3249284625053406},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.31943851709365845},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.30053743720054626},{"id":"https://openalex.org/keywords/multivariate-statistics","display_name":"Multivariate statistics","score":0.260567307472229},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.23279830813407898},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.12517330050468445}],"concepts":[{"id":"https://openalex.org/C199163554","wikidata":"https://www.wikidata.org/wiki/Q1681619","display_name":"Univariate","level":3,"score":0.7006598114967346},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.4609411954879761},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.44313913583755493},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4113510251045227},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3544917702674866},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.3249284625053406},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.31943851709365845},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30053743720054626},{"id":"https://openalex.org/C161584116","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate statistics","level":2,"score":0.260567307472229},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.23279830813407898},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.12517330050468445},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017379","descriptor_name":"Hypertrophy, Left Ventricular","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D017379","descriptor_name":"Hypertrophy, Left Ventricular","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D017379","descriptor_name":"Hypertrophy, Left Ventricular","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D017379","descriptor_name":"Hypertrophy, Left Ventricular","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D017379","descriptor_name":"Hypertrophy, Left Ventricular","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D017379","descriptor_name":"Hypertrophy, Left Ventricular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017379","descriptor_name":"Hypertrophy, Left Ventricular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017379","descriptor_name":"Hypertrophy, Left Ventricular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017379","descriptor_name":"Hypertrophy, Left Ventricular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017379","descriptor_name":"Hypertrophy, Left Ventricular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D021621","descriptor_name":"Imaging, Three-Dimensional","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D021621","descriptor_name":"Imaging, Three-Dimensional","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D021621","descriptor_name":"Imaging, Three-Dimensional","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D021621","descriptor_name":"Imaging, Three-Dimensional","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D021621","descriptor_name":"Imaging, Three-Dimensional","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D056726","descriptor_name":"Genetic Association Studies","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D056726","descriptor_name":"Genetic Association Studies","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D056726","descriptor_name":"Genetic Association Studies","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D056726","descriptor_name":"Genetic Association Studies","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D056726","descriptor_name":"Genetic Association Studies","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1093/bioinformatics/btx552","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btx552","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/34/1/97/49043452/bioinformatics_34_1_97.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:28968671","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28968671","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:arXiv.org:1706.07355","is_oa":true,"landing_page_url":"http://arxiv.org/abs/1706.07355","pdf_url":"https://arxiv.org/pdf/1706.07355","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":"2331-8422","issn":["2331-8422"],"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5870605","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5870605","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"Text"},{"id":"pmh:oai:repository.cshl.edu:37741","is_oa":false,"landing_page_url":"https://repository.cshl.edu/id/eprint/37741/","pdf_url":null,"source":{"id":"https://openalex.org/S4306402288","display_name":"Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Paper"},{"id":"pmh:oai:scholarbank.nus.edu.sg:10635/150627","is_oa":false,"landing_page_url":"http://scholarbank.nus.edu.sg/handle/10635/150627","pdf_url":null,"source":{"id":"https://openalex.org/S7407052290","display_name":"National University of Singapore","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scopus","raw_type":"Article"},{"id":"pmh:oai:spiral.imperial.ac.uk:10044/1/50589","is_oa":true,"landing_page_url":"http://hdl.handle.net/10044/1/50589","pdf_url":null,"source":{"id":"https://openalex.org/S4306401396","display_name":"Spiral (Imperial College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I47508984","host_organization_name":"Imperial College London","host_organization_lineage":["https://openalex.org/I47508984"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"},{"id":"pmh:oai:spiral.imperial.ac.uk:10044/1/51613","is_oa":true,"landing_page_url":"http://hdl.handle.net/10044/1/51613","pdf_url":null,"source":{"id":"https://openalex.org/S4306401396","display_name":"Spiral (Imperial College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I47508984","host_organization_name":"Imperial College London","host_organization_lineage":["https://openalex.org/I47508984"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btx552","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btx552","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/34/1/97/49043452/bioinformatics_34_1_97.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1386472411","display_name":"Genetic determinants of aortic morphology and function","funder_award_id":"FS/15/81/31817","funder_id":"https://openalex.org/F4320319992","funder_display_name":"British Heart Foundation"},{"id":"https://openalex.org/G2112047048","display_name":null,"funder_award_id":"PG/12/27/29489, NH/17/1/32725, SP/10/10/28431 and RE/13/4/30184","funder_id":"https://openalex.org/F4320319992","funder_display_name":"British Heart Foundation"},{"id":"https://openalex.org/G2161252477","display_name":"Next generation sequencing of inherited cardiac conditions","funder_award_id":"SP/10/10/28431","funder_id":"https://openalex.org/F4320319992","funder_display_name":"British Heart Foundation"},{"id":"https://openalex.org/G2608652111","display_name":null,"funder_award_id":"RE/13/4/30184","funder_id":"https://openalex.org/F4320320283","funder_display_name":"Imperial College London"},{"id":"https://openalex.org/G3398902372","display_name":null,"funder_award_id":"/12/27/29489","funder_id":"https://openalex.org/F4320319992","funder_display_name":"British Heart Foundation"},{"id":"https://openalex.org/G3566914561","display_name":"Translational Medicine and Therapeutics Programme at Imperial College London: 'The genetic determinants of right ventricular dysfunction'.","funder_award_id":"100211","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G3755794838","display_name":null,"funder_award_id":"SP/10/10/28431 and RE/13/4/30184","funder_id":"https://openalex.org/F4320319992","funder_display_name":"British Heart Foundation"},{"id":"https://openalex.org/G4356162509","display_name":"Translational Medicine and Therapeutics Programme at Imperial College London: 'The genetic determinants of right ventricular dysfunction'.","funder_award_id":"100211/Z/12/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G4450932479","display_name":null,"funder_award_id":"SGL015\\1006","funder_id":"https://openalex.org/F4320320241","funder_display_name":"Academy of Medical Sciences"},{"id":"https://openalex.org/G6541509879","display_name":"Using machine learning to predict clinical outcomes in heart failure","funder_award_id":"NH/17/1/32725","funder_id":"https://openalex.org/F4320319992","funder_display_name":"British Heart Foundation"},{"id":"https://openalex.org/G6550315070","display_name":"Research Excellence (renewal)","funder_award_id":"RE/13/4/30184","funder_id":"https://openalex.org/F4320319992","funder_display_name":"British Heart Foundation"},{"id":"https://openalex.org/G7253079222","display_name":"Effect of rare variants in endonuclease G and phospholamban on left ventricular function assessed with 3D cardiac MRI","funder_award_id":"PG/12/27/29489","funder_id":"https://openalex.org/F4320319992","funder_display_name":"British Heart Foundation"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320319992","display_name":"British Heart Foundation","ror":"https://ror.org/02wdwnk04"},{"id":"https://openalex.org/F4320320241","display_name":"Academy of Medical Sciences","ror":"https://ror.org/00c489v88"},{"id":"https://openalex.org/F4320320283","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10"},{"id":"https://openalex.org/F4320320284","display_name":"Imperial College Healthcare NHS Trust","ror":"https://ror.org/056ffv270"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2691730529.pdf","grobid_xml":"https://content.openalex.org/works/W2691730529.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W399819550","https://openalex.org/W1500072073","https://openalex.org/W1528119265","https://openalex.org/W1596515083","https://openalex.org/W1608875353","https://openalex.org/W1872336954","https://openalex.org/W1977611243","https://openalex.org/W1978116054","https://openalex.org/W1980361506","https://openalex.org/W1987736934","https://openalex.org/W1992436001","https://openalex.org/W1996282906","https://openalex.org/W2022137702","https://openalex.org/W2025389038","https://openalex.org/W2027662587","https://openalex.org/W2031334359","https://openalex.org/W2046557060","https://openalex.org/W2046847841","https://openalex.org/W2052357007","https://openalex.org/W2052597048","https://openalex.org/W2056495535","https://openalex.org/W2069899827","https://openalex.org/W2083255899","https://openalex.org/W2096491260","https://openalex.org/W2098128167","https://openalex.org/W2109907633","https://openalex.org/W2110065044","https://openalex.org/W2116948892","https://openalex.org/W2126388596","https://openalex.org/W2126693856","https://openalex.org/W2129655528","https://openalex.org/W2131288011","https://openalex.org/W2166349250","https://openalex.org/W2175293826","https://openalex.org/W2555626725","https://openalex.org/W2556701428","https://openalex.org/W2604500500","https://openalex.org/W2620296437","https://openalex.org/W2765984649","https://openalex.org/W3157407122","https://openalex.org/W3184801616"],"related_works":["https://openalex.org/W1828158523","https://openalex.org/W2047547195","https://openalex.org/W204175656","https://openalex.org/W2911841387","https://openalex.org/W2803255289","https://openalex.org/W1512294453","https://openalex.org/W1993992974","https://openalex.org/W2550734047","https://openalex.org/W2176526134","https://openalex.org/W2341571017"],"abstract_inverted_index":{"Motivation:":[0],"Left":[1],"ventricular":[2],"(LV)":[3],"hypertrophy":[4],"is":[5],"a":[6,64,78,89,102,134],"strong":[7],"predictor":[8],"of":[9,25,42,68,91,116,148,158],"cardiovascular":[10],"outcomes,":[11],"but":[12,31],"its":[13],"genetic":[14,159],"regulation":[15],"remains":[16],"largely":[17],"unexplained.":[18],"Conventional":[19],"phenotyping":[20],"relies":[21],"on":[22,122],"manual":[23],"calculation":[24],"LV":[26],"mass":[27],"and":[28,88,126,164,174],"wall":[29,86],"thickness,":[30],"advanced":[32],"cardiac":[33,51,141],"image":[34],"analysis":[35],"presents":[36],"an":[37,183],"opportunity":[38],"for":[39,82,140],"high-throughput":[40],"mapping":[41],"genotype-phenotype":[43,142],"associations":[44,143],"in":[45,58,96,137,182,196],"three":[46],"dimensions":[47],"(3D).":[48],"Results:":[49],"High-resolution":[50],"magnetic":[52],"resonance":[53],"images":[54],"were":[55,106],"automatically":[56,167],"segmented":[57],"1124":[59],"healthy":[60],"volunteers":[61],"to":[62,76,113,169],"create":[63],"3D":[65,79],"shape":[66],"model":[67],"the":[69,83,97,149,156,162,192],"heart.":[70],"Mass":[71],"univariate":[72],"regression":[73],"was":[74],"used":[75,195],"plot":[77],"effect-size":[80],"map":[81],"association":[84],"between":[85],"thickness":[87],"set":[90],"predictors":[92],"at":[93,188,207],"each":[94],"vertex":[95],"mesh.":[98],"The":[99,176],"vertices":[100],"where":[101],"significant":[103],"effect":[104],"exists":[105],"determined":[107],"by":[108],"applying":[109],"threshold-free":[110],"cluster":[111],"enhancement":[112],"boost":[114],"areas":[115],"signal":[117],"with":[118,191],"spatial":[119],"contiguity.":[120],"Experiments":[121],"simulated":[123],"phenotypic":[124],"signals":[125],"SNP":[127],"replication":[128],"show":[129],"that":[130],"this":[131,197],"approach":[132,178],"offers":[133],"substantial":[135],"gain":[136],"statistical":[138],"power":[139],"while":[144],"providing":[145],"good":[146],"control":[147],"false":[150],"discovery":[151],"rate.":[152],"This":[153],"framework":[154],"models":[155],"effects":[157],"variation":[160],"throughout":[161],"heart":[163],"can":[165],"be":[166],"applied":[168],"large":[170],"population":[171],"cohorts.":[172],"Availability":[173],"implementation:":[175],"proposed":[177],"has":[179],"been":[180],"coded":[181],"R":[184],"package":[185],"freely":[186],"available":[187,206],"https://doi.org/10.5281/zenodo.834610":[189],"together":[190],"clinical":[193],"data":[194,204],"work.":[198],"Contact:":[199],"declan.oregan@imperial.ac.uk.":[200],"Supplementary":[201,203],"information:":[202],"are":[205],"Bioinformatics":[208],"online.":[209]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":3}],"updated_date":"2026-08-11T07:18:39.950985","created_date":"2025-10-10T00:00:00"}