{"id":"https://openalex.org/W2749837661","doi":"https://doi.org/10.1093/bioinformatics/btx534","title":"FIRE: functional inference of genetic variants that regulate gene expression","display_name":"FIRE: functional inference of genetic variants that regulate gene expression","publication_year":2017,"publication_date":"2017-08-23","ids":{"openalex":"https://openalex.org/W2749837661","doi":"https://doi.org/10.1093/bioinformatics/btx534","mag":"2749837661","pmid":"https://pubmed.ncbi.nlm.nih.gov/28961785"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btx534","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btx534","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/33/24/3895/25168492/btx534.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/33/24/3895/25168492/btx534.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063118302","display_name":"Nilah M. Ioannidis","orcid":"https://orcid.org/0000-0001-9628-8229"},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Nilah M Ioannidis","raw_affiliation_strings":["Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA","Department of Health Research & Policy, Stanford University School of Medicine, Stanford, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Health Research & Policy, Stanford University School of Medicine, Stanford, CA, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115592056","display_name":"Joe R. Davis","orcid":null},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joe R Davis","raw_affiliation_strings":["Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019744329","display_name":"Marianne K. DeGorter","orcid":"https://orcid.org/0000-0001-7592-752X"},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marianne K DeGorter","raw_affiliation_strings":["Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA","Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006476798","display_name":"Nicholas B. Larson","orcid":"https://orcid.org/0000-0002-3468-4215"},"institutions":[{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicholas B Larson","raw_affiliation_strings":["Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088358437","display_name":"Shannon K. McDonnell","orcid":"https://orcid.org/0000-0001-6201-369X"},"institutions":[{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shannon K McDonnell","raw_affiliation_strings":["Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086141666","display_name":"Amy J. French","orcid":null},"institutions":[{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amy J French","raw_affiliation_strings":["Department of Laboratory Medicine & Pathology, Mayo Clinic, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine & Pathology, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I4210125099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063708781","display_name":"Alexis Battle","orcid":"https://orcid.org/0000-0002-5287-627X"},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexis J Battle","raw_affiliation_strings":["Department of Computer Science, Johns Hopkins University, Baltimore, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, Johns Hopkins University, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045744709","display_name":"Trevor Hastie","orcid":"https://orcid.org/0000-0002-0164-3142"},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Trevor J Hastie","raw_affiliation_strings":["Department of Biomedical Data Science, Stanford University School of Medicine, Stanford, CA, USA","Department of Statistics, Stanford University, Stanford, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Data Science, Stanford University School of Medicine, Stanford, CA, USA","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Statistics, Stanford University, Stanford, CA, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090473173","display_name":"Stephen N. Thibodeau","orcid":"https://orcid.org/0000-0003-0078-8558"},"institutions":[{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen N Thibodeau","raw_affiliation_strings":["Department of Laboratory Medicine & Pathology, Mayo Clinic, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine & Pathology, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I4210125099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025409424","display_name":"Stephen B. Montgomery","orcid":"https://orcid.org/0000-0002-5200-3903"},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen B Montgomery","raw_affiliation_strings":["Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA","Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025246130","display_name":"Carlos D. Bustamante","orcid":"https://orcid.org/0000-0002-4187-7920"},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carlos D Bustamante","raw_affiliation_strings":["Department of Biomedical Data Science, Stanford University School of Medicine, Stanford, CA, USA","Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Data Science, Stanford University School of Medicine, Stanford, CA, USA","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004680860","display_name":"Weiva Sieh","orcid":"https://orcid.org/0000-0003-0085-1190"},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Weiva Sieh","raw_affiliation_strings":["Department of Genetics & Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA","Department of Health Research & Policy, Stanford University School of Medicine, Stanford, CA, USA","Department of Population Health Science & Policy, Icahn School of Medicine at Mount Sinai, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics & Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Department of Health Research & Policy, Stanford University School of Medicine, Stanford, CA, USA","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Population Health Science & Policy, Icahn School of Medicine at Mount Sinai, New York, NY, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037849512","display_name":"Alice S. Whittemore","orcid":"https://orcid.org/0000-0003-1985-9926"},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alice S Whittemore","raw_affiliation_strings":["Department of Biomedical Data Science, Stanford University School of Medicine, Stanford, CA, USA","Department of Health Research & Policy, Stanford University School of Medicine, Stanford, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Data Science, Stanford University School of Medicine, Stanford, CA, USA","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Health Research & Policy, Stanford University School of Medicine, Stanford, CA, USA","institution_ids":["https://openalex.org/I97018004"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":13,"corresponding_author_ids":["https://openalex.org/A5063118302"],"corresponding_institution_ids":["https://openalex.org/I97018004"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":2.6226,"has_fulltext":false,"cited_by_count":47,"citation_normalized_percentile":{"value":0.90022952,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"33","issue":"24","first_page":"3895","last_page":"3901"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.54830002784729,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.54830002784729,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11642","display_name":"Genomics and Rare Diseases","score":0.4185999929904938,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.007600000128149986,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/expression-quantitative-trait-loci","display_name":"Expression quantitative trait loci","score":0.7737663984298706},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6129850149154663},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.56820148229599},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.5524720549583435},{"id":"https://openalex.org/keywords/inference","display_name":"Inference","score":0.5346673130989075},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.45722830295562744},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.4419524073600769},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.2890608012676239},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphism","display_name":"Single-nucleotide polymorphism","score":0.23927384614944458},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.16686859726905823},{"id":"https://openalex.org/keywords/genotype","display_name":"Genotype","score":0.10493046045303345}],"concepts":[{"id":"https://openalex.org/C168393362","wikidata":"https://www.wikidata.org/wiki/Q5421706","display_name":"Expression quantitative trait loci","level":5,"score":0.7737663984298706},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6129850149154663},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.56820148229599},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.5524720549583435},{"id":"https://openalex.org/C2776214188","wikidata":"https://www.wikidata.org/wiki/Q408386","display_name":"Inference","level":2,"score":0.5346673130989075},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.45722830295562744},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4419524073600769},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2890608012676239},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.23927384614944458},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.16686859726905823},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.10493046045303345}],"mesh":[{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/bioinformatics/btx534","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btx534","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/33/24/3895/25168492/btx534.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:28961785","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28961785","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:escholarship.org:ark:/13030/qt1p51s9fm","is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/1p51s9fm","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Computer applications in the biosciences : CABIOS, vol 33, iss 24","raw_type":"article"},{"id":"pmh:oai:europepmc.org:5261142","is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5860093","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btx534","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btx534","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/33/24/3895/25168492/btx534.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5600000023841858,"display_name":"Reduced inequalities","id":"https://metadata.un.org/sdg/10"},{"score":0.4699999988079071,"display_name":"Peace, Justice and strong institutions","id":"https://metadata.un.org/sdg/16"}],"awards":[{"id":"https://openalex.org/G1648696114","display_name":null,"funder_award_id":"R01HG008150","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G1696487843","display_name":null,"funder_award_id":"U01CA089600","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G1826961927","display_name":null,"funder_award_id":"U01 CA089600","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3853692652","display_name":null,"funder_award_id":"F32HG008330","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4002850085","display_name":null,"funder_award_id":"U01HG007436","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4873419780","display_name":null,"funder_award_id":"R01 HG008150","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G5171270215","display_name":null,"funder_award_id":"U01 HG007436","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G5409424429","display_name":null,"funder_award_id":"R01CA151254","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6681046907","display_name":null,"funder_award_id":"R01 CA094069","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7690514483","display_name":null,"funder_award_id":"T32 HG000044","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G8176942851","display_name":null,"funder_award_id":"F32 HG008330","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G8866690509","display_name":null,"funder_award_id":"R01 CA151254","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320333064","display_name":"Center for Computational, Evolutionary and Human Genomics, Stanford University","ror":null},{"id":"https://openalex.org/F4320337348","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W273955616","https://openalex.org/W1533942137","https://openalex.org/W1554944419","https://openalex.org/W1980740976","https://openalex.org/W2006617902","https://openalex.org/W2011582941","https://openalex.org/W2018189081","https://openalex.org/W2019983262","https://openalex.org/W2024818793","https://openalex.org/W2025943989","https://openalex.org/W2032311106","https://openalex.org/W2033202128","https://openalex.org/W2045791858","https://openalex.org/W2059145105","https://openalex.org/W2063739210","https://openalex.org/W2067673709","https://openalex.org/W2085459418","https://openalex.org/W2092334563","https://openalex.org/W2116868464","https://openalex.org/W2117396697","https://openalex.org/W2117446594","https://openalex.org/W2135993011","https://openalex.org/W2144961623","https://openalex.org/W2148105023","https://openalex.org/W2160995259","https://openalex.org/W2166783472","https://openalex.org/W2169243280","https://openalex.org/W2198606573","https://openalex.org/W2212528563","https://openalex.org/W2225726427","https://openalex.org/W2257370818","https://openalex.org/W2415245143","https://openalex.org/W2521967673","https://openalex.org/W2535426958","https://openalex.org/W2555614465","https://openalex.org/W2559028527","https://openalex.org/W2582743722","https://openalex.org/W2595351638","https://openalex.org/W2597215890","https://openalex.org/W2787894218","https://openalex.org/W2911964244","https://openalex.org/W3104729244","https://openalex.org/W6610017368"],"related_works":["https://openalex.org/W2164780420","https://openalex.org/W2995716764","https://openalex.org/W2161056048","https://openalex.org/W2587589680","https://openalex.org/W2995369528","https://openalex.org/W2901416251","https://openalex.org/W2110614590","https://openalex.org/W2889598755","https://openalex.org/W2987420353","https://openalex.org/W1491897707"],"abstract_inverted_index":{"MOTIVATION:":[0],"Interpreting":[1],"genetic":[2],"variation":[3],"in":[4,60,105,129,187],"noncoding":[5,22,79],"regions":[6],"of":[7,34,54,56,70,72,92,97,114,144,154,163,170,176],"the":[8,32,89,130,138],"genome":[9,16],"is":[10,30],"an":[11,161],"important":[12],"challenge":[13],"for":[14,184,191],"personal":[15],"analysis.":[17],"One":[18],"mechanism":[19],"by":[20],"which":[21],"single":[23],"nucleotide":[24],"variants":[25,55],"(SNVs)":[26],"influence":[27],"downstream":[28],"phenotypes":[29],"through":[31],"regulation":[33],"gene":[35,49],"expression.":[36],"Methods":[37],"to":[38,47,76,87,102],"predict":[39],"whether":[40],"or":[41],"not":[42],"individual":[43],"SNVs":[44,82,104,125,128,149,159,172,186],"are":[45,167,189,201],"likely":[46],"regulate":[48,88],"expression":[50,90],"would":[51],"aid":[52],"interpretation":[53],"unknown":[57],"significance":[58],"identified":[59],"whole-genome":[61],"sequencing":[62],"studies.":[63],"RESULTS:":[64],"We":[65],"developed":[66],"FIRE":[67,95,121,165,182],"(Functional":[68],"Inference":[69],"Regulators":[71],"Expression),":[73],"a":[74,112,134,174],"tool":[75],"score":[77],"both":[78],"and":[80,146],"coding":[81],"based":[83],"on":[84],"their":[85],"potential":[86],"levels":[91],"nearby":[93],"genes.":[94],"consists":[96],"23":[98],"random":[99],"forests":[100],"trained":[101],"recognize":[103],"cis-expression":[106],"quantitative":[107],"trait":[108],"loci":[109],"(cis-eQTLs)":[110],"using":[111],"set":[113,132],"92":[115],"genomic":[116],"annotations":[117],"as":[118],"predictive":[119,169],"features.":[120],"scores":[122,166,183],"discriminate":[123,147],"cis-eQTL":[124,148,171],"from":[126,157],"non-eQTL":[127,158],"training":[131],"with":[133,160],"cross-validated":[135],"area":[136],"under":[137],"receiver":[139],"operating":[140],"characteristic":[141],"curve":[142],"(AUC)":[143],"0.807,":[145],"shared":[150],"across":[151,173],"six":[152],"populations":[153],"different":[155],"ancestry":[156],"AUC":[162],"0.939.":[164],"also":[168],"variety":[175],"tissue":[177],"types.":[178],"AVAILABILITY":[179],"AND":[180],"IMPLEMENTATION:":[181],"genome-wide":[185],"hg19/GRCh37":[188],"available":[190,202],"download":[192],"at":[193,203],"https://sites.google.com/site/fireregulatoryvariation/.":[194],"CONTACT:":[195],"nilah@stanford.edu.":[196],"SUPPLEMENTARY":[197],"INFORMATION:":[198],"Supplementary":[199],"data":[200],"Bioinformatics":[204],"online.":[205]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":14},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":3}],"updated_date":"2026-06-24T13:16:06.693445","created_date":"2025-10-10T00:00:00"}