{"id":"https://openalex.org/W2737058756","doi":"https://doi.org/10.1093/bioinformatics/btx467","title":"Detect differentially methylated regions using non-homogeneous hidden Markov model for methylation array data","display_name":"Detect differentially methylated regions using non-homogeneous hidden Markov model for methylation array data","publication_year":2017,"publication_date":"2017-07-18","ids":{"openalex":"https://openalex.org/W2737058756","doi":"https://doi.org/10.1093/bioinformatics/btx467","mag":"2737058756","pmid":"https://pubmed.ncbi.nlm.nih.gov/29036320"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btx467","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btx467","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/33/23/3701/25168136/btx467.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/33/23/3701/25168136/btx467.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014711914","display_name":"Linghao Shen","orcid":"https://orcid.org/0000-0003-2358-5243"},"institutions":[{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"CN","type":"education","lineage":["https://openalex.org/I177725633"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Linghao Shen","raw_affiliation_strings":["Department of Information Engineering, The Chinese University of Hong Kong, Hong Kong"],"affiliations":[{"raw_affiliation_string":"Department of Information Engineering, The Chinese University of Hong Kong, Hong Kong","institution_ids":["https://openalex.org/I177725633"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058745924","display_name":"Jun Zhu","orcid":"https://orcid.org/0000-0003-0834-8178"},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jun Zhu","raw_affiliation_strings":["Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York University, New York, NY, USA"],"affiliations":[{"raw_affiliation_string":"Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York University, New York, NY, USA","institution_ids":["https://openalex.org/I98704320","https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100386630","display_name":"Shuo Li","orcid":"https://orcid.org/0000-0002-5184-3230"},"institutions":[{"id":"https://openalex.org/I150229711","display_name":"University of Electronic Science and Technology of China","ror":"https://ror.org/04qr3zq92","country_code":"CN","type":"education","lineage":["https://openalex.org/I150229711"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuo-Yen Robert Li","raw_affiliation_strings":["University of Electronic Science and Technology of China, Sichuan, China"],"affiliations":[{"raw_affiliation_string":"University of Electronic Science and Technology of China, Sichuan, China","institution_ids":["https://openalex.org/I150229711"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060018541","display_name":"Xiaodan Fan","orcid":"https://orcid.org/0000-0002-2744-9030"},"institutions":[{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"CN","type":"education","lineage":["https://openalex.org/I177725633"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiaodan Fan","raw_affiliation_strings":["Department of Statistics, The Chinese University of Hong Kong, Hong Kong"],"affiliations":[{"raw_affiliation_string":"Department of Statistics, The Chinese University of Hong Kong, Hong Kong","institution_ids":["https://openalex.org/I177725633"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5060018541"],"corresponding_institution_ids":["https://openalex.org/I177725633"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":0.6298,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.67064976,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"33","issue":"23","first_page":"3701","last_page":"3708"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9962999820709229,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9962999820709229,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11269","display_name":"Algorithms and Data Compression","score":0.9692999720573425,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/methylation","display_name":"Methylation","score":0.6920400857925415},{"id":"https://openalex.org/keywords/homogeneous","display_name":"Homogeneous","score":0.5901214480400085},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5793836712837219},{"id":"https://openalex.org/keywords/markov-model","display_name":"Markov model","score":0.5514748692512512},{"id":"https://openalex.org/keywords/hidden-markov-model","display_name":"Hidden Markov model","score":0.5168019533157349},{"id":"https://openalex.org/keywords/markov-chain","display_name":"Markov chain","score":0.4899853765964508},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.40062227845191956},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.257223904132843},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.24486222863197327},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.19614878296852112},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.12980768084526062},{"id":"https://openalex.org/keywords/statistical-physics","display_name":"Statistical physics","score":0.11608010530471802},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.08257541060447693},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.07466906309127808}],"concepts":[{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.6920400857925415},{"id":"https://openalex.org/C66882249","wikidata":"https://www.wikidata.org/wiki/Q169336","display_name":"Homogeneous","level":2,"score":0.5901214480400085},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5793836712837219},{"id":"https://openalex.org/C163836022","wikidata":"https://www.wikidata.org/wiki/Q6771326","display_name":"Markov model","level":3,"score":0.5514748692512512},{"id":"https://openalex.org/C23224414","wikidata":"https://www.wikidata.org/wiki/Q176769","display_name":"Hidden Markov model","level":2,"score":0.5168019533157349},{"id":"https://openalex.org/C98763669","wikidata":"https://www.wikidata.org/wiki/Q176645","display_name":"Markov chain","level":2,"score":0.4899853765964508},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.40062227845191956},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.257223904132843},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24486222863197327},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.19614878296852112},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.12980768084526062},{"id":"https://openalex.org/C121864883","wikidata":"https://www.wikidata.org/wiki/Q677916","display_name":"Statistical physics","level":1,"score":0.11608010530471802},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.08257541060447693},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07466906309127808}],"mesh":[{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1093/bioinformatics/btx467","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btx467","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/33/23/3701/25168136/btx467.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:29036320","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29036320","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:europepmc.org:5355441","is_oa":false,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6355111","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6355111","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6355111","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btx467","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btx467","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/33/23/3701/25168136/btx467.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Peace, Justice and strong institutions","id":"https://metadata.un.org/sdg/16","score":0.550000011920929}],"awards":[{"id":"https://openalex.org/G5584233542","display_name":null,"funder_award_id":"CUHK4053135","funder_id":"https://openalex.org/F4320322942","funder_display_name":"Chinese University of Hong Kong"},{"id":"https://openalex.org/G8457838874","display_name":null,"funder_award_id":"CUHK3132753","funder_id":"https://openalex.org/F4320322942","funder_display_name":"Chinese University of Hong Kong"}],"funders":[{"id":"https://openalex.org/F4320322942","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2737058756.pdf","grobid_xml":"https://content.openalex.org/works/W2737058756.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W61024959","https://openalex.org/W1607675287","https://openalex.org/W1678624296","https://openalex.org/W1878239255","https://openalex.org/W1917637636","https://openalex.org/W1964278453","https://openalex.org/W1970225064","https://openalex.org/W1972914767","https://openalex.org/W1975528145","https://openalex.org/W1992223383","https://openalex.org/W2029033394","https://openalex.org/W2033243734","https://openalex.org/W2041621429","https://openalex.org/W2045515441","https://openalex.org/W2045656233","https://openalex.org/W2056040742","https://openalex.org/W2056927568","https://openalex.org/W2059704197","https://openalex.org/W2068523052","https://openalex.org/W2074628531","https://openalex.org/W2081098333","https://openalex.org/W2097324844","https://openalex.org/W2098855821","https://openalex.org/W2101870168","https://openalex.org/W2102868331","https://openalex.org/W2105893097","https://openalex.org/W2105992849","https://openalex.org/W2107776519","https://openalex.org/W2114970231","https://openalex.org/W2115919763","https://openalex.org/W2120391355","https://openalex.org/W2123929789","https://openalex.org/W2130752875","https://openalex.org/W2148405421","https://openalex.org/W2150987201","https://openalex.org/W2154935569","https://openalex.org/W2162813066","https://openalex.org/W2163592640","https://openalex.org/W2254593627","https://openalex.org/W2264799017","https://openalex.org/W2388497630","https://openalex.org/W2467449522","https://openalex.org/W2530091399","https://openalex.org/W2563727277","https://openalex.org/W2569123556","https://openalex.org/W2580601263","https://openalex.org/W4232037809","https://openalex.org/W4232383088","https://openalex.org/W6637328457","https://openalex.org/W6711281043"],"related_works":["https://openalex.org/W1510894296","https://openalex.org/W2134386692","https://openalex.org/W2082284720","https://openalex.org/W2084326697","https://openalex.org/W2194396582","https://openalex.org/W2027903142","https://openalex.org/W2116722627","https://openalex.org/W2354322608","https://openalex.org/W2379938888","https://openalex.org/W2804608325"],"abstract_inverted_index":{"Supplementary":[0],"data":[1],"are":[2],"available":[3],"at":[4],"Bioinformatics":[5],"online.":[6]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}