{"id":"https://openalex.org/W2660983679","doi":"https://doi.org/10.1093/bioinformatics/btx418","title":"HybridSim-VS: a web server for large-scale ligand-based virtual screening using hybrid similarity recognition techniques","display_name":"HybridSim-VS: a web server for large-scale ligand-based virtual screening using hybrid similarity recognition techniques","publication_year":2017,"publication_date":"2017-06-22","ids":{"openalex":"https://openalex.org/W2660983679","doi":"https://doi.org/10.1093/bioinformatics/btx418","mag":"2660983679","pmid":"https://pubmed.ncbi.nlm.nih.gov/29036579"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btx418","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btx418","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/33/21/3480/25166040/btx418.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/33/21/3480/25166040/btx418.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061196811","display_name":"Jinling Shang","orcid":null},"institutions":[{"id":"https://openalex.org/I90610280","display_name":"South China University of Technology","ror":"https://ror.org/0530pts50","country_code":"CN","type":"education","lineage":["https://openalex.org/I90610280"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinling Shang","raw_affiliation_strings":["School of Bioscience and Bioengineering, South China University of Technology, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Bioscience and Bioengineering, South China University of Technology, Guangzhou, China","institution_ids":["https://openalex.org/I90610280"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101755730","display_name":"Xi Dai","orcid":"https://orcid.org/0000-0002-8964-793X"},"institutions":[{"id":"https://openalex.org/I90610280","display_name":"South China University of Technology","ror":"https://ror.org/0530pts50","country_code":"CN","type":"education","lineage":["https://openalex.org/I90610280"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xi Dai","raw_affiliation_strings":["School of Bioscience and Bioengineering, South China University of Technology, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Bioscience and Bioengineering, South China University of Technology, Guangzhou, China","institution_ids":["https://openalex.org/I90610280"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058921003","display_name":"Yecheng Li","orcid":"https://orcid.org/0000-0002-8759-538X"},"institutions":[{"id":"https://openalex.org/I90610280","display_name":"South China University of Technology","ror":"https://ror.org/0530pts50","country_code":"CN","type":"education","lineage":["https://openalex.org/I90610280"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yecheng Li","raw_affiliation_strings":["School of Bioscience and Bioengineering, South China University of Technology, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Bioscience and Bioengineering, South China University of Technology, Guangzhou, China","institution_ids":["https://openalex.org/I90610280"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074138353","display_name":"Marco Pistolozzi","orcid":"https://orcid.org/0000-0001-7957-2025"},"institutions":[{"id":"https://openalex.org/I90610280","display_name":"South China University of Technology","ror":"https://ror.org/0530pts50","country_code":"CN","type":"education","lineage":["https://openalex.org/I90610280"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Marco Pistolozzi","raw_affiliation_strings":["School of Bioscience and Bioengineering, South China University of Technology, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Bioscience and Bioengineering, South China University of Technology, Guangzhou, China","institution_ids":["https://openalex.org/I90610280"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100398640","display_name":"Ling Wang","orcid":"https://orcid.org/0000-0001-5116-7749"},"institutions":[{"id":"https://openalex.org/I90610280","display_name":"South China University of Technology","ror":"https://ror.org/0530pts50","country_code":"CN","type":"education","lineage":["https://openalex.org/I90610280"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ling Wang","raw_affiliation_strings":["School of Bioscience and Bioengineering, South China University of Technology, Guangzhou, China"],"raw_orcid":"https://orcid.org/0000-0001-5116-7749","affiliations":[{"raw_affiliation_string":"School of Bioscience and Bioengineering, South China University of Technology, Guangzhou, China","institution_ids":["https://openalex.org/I90610280"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5100398640"],"corresponding_institution_ids":["https://openalex.org/I90610280"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":3.3482,"has_fulltext":true,"cited_by_count":30,"citation_normalized_percentile":{"value":0.93218616,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"33","issue":"21","first_page":"3480","last_page":"3481"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9915000200271606,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9915000200271606,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fingerprint","display_name":"Fingerprint (computing)","score":0.7866253852844238},{"id":"https://openalex.org/keywords/similarity","display_name":"Similarity (geometry)","score":0.7749828100204468},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7264339327812195},{"id":"https://openalex.org/keywords/virtual-screening","display_name":"Virtual screening","score":0.6458740830421448},{"id":"https://openalex.org/keywords/directory","display_name":"Directory","score":0.5282177925109863},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.46672478318214417},{"id":"https://openalex.org/keywords/scale","display_name":"Scale (ratio)","score":0.4561861753463745},{"id":"https://openalex.org/keywords/nearest-neighbor-search","display_name":"Nearest neighbor search","score":0.4385181963443756},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.43792372941970825},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.433444619178772},{"id":"https://openalex.org/keywords/binary-number","display_name":"Binary number","score":0.42532479763031006},{"id":"https://openalex.org/keywords/similitude","display_name":"Similitude","score":0.4242754876613617},{"id":"https://openalex.org/keywords/information-retrieval","display_name":"Information retrieval","score":0.36206161975860596},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"Drug discovery","score":0.2598678469657898},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.25133606791496277},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.11597079038619995},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.11429643630981445},{"id":"https://openalex.org/keywords/image","display_name":"Image (mathematics)","score":0.07264658808708191}],"concepts":[{"id":"https://openalex.org/C2777826928","wikidata":"https://www.wikidata.org/wiki/Q3745713","display_name":"Fingerprint (computing)","level":2,"score":0.7866253852844238},{"id":"https://openalex.org/C103278499","wikidata":"https://www.wikidata.org/wiki/Q254465","display_name":"Similarity (geometry)","level":3,"score":0.7749828100204468},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7264339327812195},{"id":"https://openalex.org/C103697762","wikidata":"https://www.wikidata.org/wiki/Q4112105","display_name":"Virtual screening","level":3,"score":0.6458740830421448},{"id":"https://openalex.org/C2777683733","wikidata":"https://www.wikidata.org/wiki/Q201456","display_name":"Directory","level":2,"score":0.5282177925109863},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.46672478318214417},{"id":"https://openalex.org/C2778755073","wikidata":"https://www.wikidata.org/wiki/Q10858537","display_name":"Scale (ratio)","level":2,"score":0.4561861753463745},{"id":"https://openalex.org/C116738811","wikidata":"https://www.wikidata.org/wiki/Q608751","display_name":"Nearest neighbor search","level":2,"score":0.4385181963443756},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.43792372941970825},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.433444619178772},{"id":"https://openalex.org/C48372109","wikidata":"https://www.wikidata.org/wiki/Q3913","display_name":"Binary number","level":2,"score":0.42532479763031006},{"id":"https://openalex.org/C143271835","wikidata":"https://www.wikidata.org/wiki/Q254515","display_name":"Similitude","level":2,"score":0.4242754876613617},{"id":"https://openalex.org/C23123220","wikidata":"https://www.wikidata.org/wiki/Q816826","display_name":"Information retrieval","level":1,"score":0.36206161975860596},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.2598678469657898},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.25133606791496277},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11597079038619995},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.11429643630981445},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.07264658808708191},{"id":"https://openalex.org/C94375191","wikidata":"https://www.wikidata.org/wiki/Q11205","display_name":"Arithmetic","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008968","descriptor_name":"Molecular Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008968","descriptor_name":"Molecular Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008968","descriptor_name":"Molecular Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/bioinformatics/btx418","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btx418","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/33/21/3480/25166040/btx418.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:29036579","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29036579","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btx418","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btx418","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/33/21/3480/25166040/btx418.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.46000000834465027,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G398675709","display_name":null,"funder_award_id":"81502984","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4902922151","display_name":null,"funder_award_id":"2016A030310421","funder_id":"https://openalex.org/F4320321921","funder_display_name":"Natural Science Foundation of Guangdong Province"},{"id":"https://openalex.org/G7929130408","display_name":null,"funder_award_id":"No. 81502984","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321921","display_name":"Natural Science Foundation of Guangdong Province","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2660983679.pdf","grobid_xml":"https://content.openalex.org/works/W2660983679.grobid-xml"},"referenced_works_count":9,"referenced_works":["https://openalex.org/W1968319881","https://openalex.org/W1969340429","https://openalex.org/W1993452491","https://openalex.org/W2013422579","https://openalex.org/W2038361288","https://openalex.org/W2049988693","https://openalex.org/W2096729078","https://openalex.org/W2125033229","https://openalex.org/W2169678694"],"related_works":["https://openalex.org/W1992095612","https://openalex.org/W2389470892","https://openalex.org/W2949836374","https://openalex.org/W2116898701","https://openalex.org/W1571610579","https://openalex.org/W1994440731","https://openalex.org/W2056162765","https://openalex.org/W1498782543","https://openalex.org/W2660983679","https://openalex.org/W2007239199"],"abstract_inverted_index":{"SUMMARY:":[0],"Molecular-similarity":[1],"searches":[2],"based":[3],"on":[4,33,101],"two-dimensional":[5],"(2D)":[6],"fingerprint":[7,64,140],"and":[8,65,91,97,104,141,160,168,174],"three-dimensional":[9],"(3D)":[10],"shape":[11,67,143],"represent":[12],"two":[13],"widely":[14],"used":[15],"ligand-based":[16],"virtual":[17],"screening":[18],"(VS)":[19],"methods":[20,96],"in":[21,70,112,130,176],"computer-aided":[22],"drug":[23,71],"design.":[24],"2D":[25,63,89,139],"fingerprint-based":[26],"VS":[27,40,132,170],"utilizes":[28],"the":[29,88,113,127,147,152,177],"binary":[30],"fragment":[31],"information":[32,45],"a":[34,50,76],"known":[35],"ligand,":[36],"whereas":[37],"3D":[38,51,66,92,142],"shape-based":[39,93],"takes":[41],"advantage":[42],"of":[43,115],"geometric":[44],"for":[46,106],"predefined":[47],"features":[48],"from":[49],"conformation.":[52],"Given":[53],"their":[54],"different":[55],"advantages,":[56],"it":[57],"would":[58],"be":[59],"desirable":[60],"to":[61,82,165,172],"hybridize":[62],"molecular-similarity":[68,79],"approaches":[69],"discovery.":[72],"Here,":[73],"we":[74],"presented":[75],"general":[77],"hybrid":[78],"protocol,":[80],"referred":[81],"as":[83,134],"HybridSim,":[84],"obtained":[85],"by":[86],"combining":[87],"fingerprint-":[90],"similarity":[94],"search":[95],"evaluated":[98],"its":[99],"performance":[100,129],"595,036":[102],"actives":[103],"decoys":[105],"40":[107,131],"pharmaceutically":[108],"relevant":[109],"targets":[110],"available":[111,187,197],"Directory":[114],"Useful":[116],"Decoys":[117],"Enhanced":[118],"(DUD-E).":[119],"Our":[120],"results":[121],"showed":[122],"that":[123],"HybridSim":[124,154],"significantly":[125],"improved":[126],"overall":[128],"projects":[133],"compared":[135],"with":[136,157],"using":[137,151],"only":[138],"methods.":[144],"Furthermore,":[145],"HybridSim-VS,":[146],"first":[148],"online":[149],"platform":[150],"proposed":[153],"method":[155],"coupled":[156],"17,839,945":[158],"screenable":[159],"purchasable":[161],"compounds,":[162],"was":[163],"developed":[164],"provide":[166],"large-scale":[167],"proficient":[169],"capabilities":[171],"experts":[173],"nonexperts":[175],"field.":[178],"AVAILABILITY":[179],"AND":[180],"IMPLEMENTATION:":[181],"HybridSim-VS":[182],"web":[183],"server":[184],"is":[185],"freely":[186],"at":[188,198],"http://www.rcidm.org/HybridSim-VS/.":[189],"CONTACT:":[190],"lingwang@scut.edu.cn.":[191],"SUPPLEMENTARY":[192],"INFORMATION:":[193],"Supplementary":[194],"data":[195],"are":[196],"Bioinformatics":[199],"online.":[200]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":6}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}