{"id":"https://openalex.org/W2625162235","doi":"https://doi.org/10.1093/bioinformatics/btx374","title":"Sparse redundancy analysis of high-dimensional genetic and genomic data","display_name":"Sparse redundancy analysis of high-dimensional genetic and genomic data","publication_year":2017,"publication_date":"2017-06-07","ids":{"openalex":"https://openalex.org/W2625162235","doi":"https://doi.org/10.1093/bioinformatics/btx374","mag":"2625162235","pmid":"https://pubmed.ncbi.nlm.nih.gov/28605402"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btx374","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btx374","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/33/20/3228/25165718/btx374.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/33/20/3228/25165718/btx374.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090373934","display_name":"Attila Csala","orcid":"https://orcid.org/0000-0003-4969-5555"},"institutions":[{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Attila Csala","raw_affiliation_strings":["Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, Amsterdam, AZ, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, Amsterdam, AZ, The Netherlands","institution_ids":["https://openalex.org/I2802928900"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108528676","display_name":"Frans Voorbraak","orcid":null},"institutions":[{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Frans P J M Voorbraak","raw_affiliation_strings":["Department of Medical Informatics, Academic Medical Center, Amsterdam, AZ, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Informatics, Academic Medical Center, Amsterdam, AZ, The Netherlands","institution_ids":["https://openalex.org/I2802928900"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051056050","display_name":"Aeilko H. Zwinderman","orcid":"https://orcid.org/0000-0003-0361-3139"},"institutions":[{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Aeilko H Zwinderman","raw_affiliation_strings":["Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, Amsterdam, AZ, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, Amsterdam, AZ, The Netherlands","institution_ids":["https://openalex.org/I2802928900"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001976256","display_name":"Michel H. Hof","orcid":"https://orcid.org/0000-0003-2049-4338"},"institutions":[{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Michel H Hof","raw_affiliation_strings":["Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, Amsterdam, AZ, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, Amsterdam, AZ, The Netherlands","institution_ids":["https://openalex.org/I2802928900"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5090373934"],"corresponding_institution_ids":["https://openalex.org/I2802928900"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":1.0091,"has_fulltext":true,"cited_by_count":31,"citation_normalized_percentile":{"value":0.75351335,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"33","issue":"20","first_page":"3228","last_page":"3234"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.38909998536109924,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.38909998536109924,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.210099995136261,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.13369999825954437,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5836576223373413},{"id":"https://openalex.org/keywords/redundancy","display_name":"Redundancy (engineering)","score":0.5724132657051086},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4521234333515167},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.3512237071990967},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3067466616630554}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5836576223373413},{"id":"https://openalex.org/C152124472","wikidata":"https://www.wikidata.org/wiki/Q1204361","display_name":"Redundancy (engineering)","level":2,"score":0.5724132657051086},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4521234333515167},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3512237071990967},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3067466616630554},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008382","descriptor_name":"Marfan Syndrome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008382","descriptor_name":"Marfan Syndrome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008382","descriptor_name":"Marfan Syndrome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/bioinformatics/btx374","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btx374","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/33/20/3228/25165718/btx374.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:28605402","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28605402","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:pure.amsterdamumc.nl:publications/e6115058-b190-452f-b86f-60e932508ecc","is_oa":true,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/e6115058-b190-452f-b86f-60e932508ecc","pdf_url":"https://pure.amsterdamumc.nl/ws/files/158991353/Sparse-redundancy-analysis-of-high-dimensional-genetic-and-genomic-data.pdf","source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Csala, A, Voorbraak, F P J M, Zwinderman, A H & Hof, M H 2017, 'Sparse redundancy analysis of high-dimensional genetic and genomic data', Bioinformatics (Oxford, England), vol. 33, no. 20, pp. 3228-3234. https://doi.org/10.1093/bioinformatics/btx374","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:amcpub:oai:pure.amc.nl:publications/19e2b7f8-ed25-42a2-bc5f-f2afdfd3e987","is_oa":false,"landing_page_url":"https://pure.amc.nl/en/publications/sparse-redundancy-analysis-of-highdimensional-genetic-and-genomic-data(19e2b7f8-ed25-42a2-bc5f-f2afdfd3e987).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics (Oxford, England), 33(20), 3228 - 3234. Oxford University Press","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btx374","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btx374","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/33/20/3228/25165718/btx374.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2625162235.pdf","grobid_xml":"https://content.openalex.org/works/W2625162235.grobid-xml"},"referenced_works_count":18,"referenced_works":["https://openalex.org/W1970105865","https://openalex.org/W2008929650","https://openalex.org/W2012691952","https://openalex.org/W2013188317","https://openalex.org/W2036010272","https://openalex.org/W2055214702","https://openalex.org/W2068431404","https://openalex.org/W2085792040","https://openalex.org/W2102919818","https://openalex.org/W2122825543","https://openalex.org/W2124634097","https://openalex.org/W2127552572","https://openalex.org/W2128040385","https://openalex.org/W2129182769","https://openalex.org/W2134469465","https://openalex.org/W2134642866","https://openalex.org/W2165015714","https://openalex.org/W2165507622"],"related_works":["https://openalex.org/W2748952813","https://openalex.org/W2082860237","https://openalex.org/W2119695867","https://openalex.org/W2130076355","https://openalex.org/W1990804418","https://openalex.org/W1993764875","https://openalex.org/W2046158694","https://openalex.org/W2788277189","https://openalex.org/W2013243191","https://openalex.org/W1971568933"],"abstract_inverted_index":{"MOTIVATION:":[0],"Recent":[1],"technological":[2],"developments":[3],"have":[4,79],"enabled":[5],"the":[6,50,53,59,90,127,150,197,202,208,237],"possibility":[7],"of":[8,52,63,82,116,121,130,193,199,204,210,223,241],"genetic":[9,47,55,61],"and":[10,26,39,49,93,207,215],"genomic":[11],"integrated":[12],"data":[13,132,183,253],"analysis":[14,105,177,203,209],"approaches,":[15],"where":[16],"multiple":[17],"omics":[18,131,182,242],"datasets":[19],"from":[20],"various":[21],"biological":[22],"levels":[23],"are":[24,254],"combined":[25],"used":[27],"to":[28,37,88,100,111,157,167,195,234],"describe":[29],"(disease)":[30],"phenotypic":[31,42,64],"variations.":[32],"The":[33,134],"main":[34],"goal":[35],"is":[36,66,107,142,232],"explain":[38],"ultimately":[40],"predict":[41],"variations":[43,65],"by":[44],"understanding":[45,58],"their":[46],"basis":[48],"interaction":[51],"associated":[54],"factors.":[56],"Therefore,":[57],"underlying":[60],"mechanisms":[62],"an":[67,108,163],"ever":[68],"increasing":[69],"research":[70],"interest":[71],"in":[72,149,162,220],"biomedical":[73],"sciences.":[74],"In":[75],"many":[76],"situations,":[77],"we":[78,155],"a":[80,94,153,169,221],"set":[81,95,222],"variables":[83,92,148],"that":[84,96,230],"can":[85,97],"be":[86,89,98,101],"considered":[87,99],"outcome":[91],"explanatory":[102],"variables.":[103],"Redundancy":[104],"(RDA)":[106],"analytic":[109],"method":[110],"deal":[112,124,235],"with":[113,126,189,226,236],"this":[114],"type":[115],"directionality.":[117],"Unfortunately,":[118],"current":[119],"implementations":[120],"RDA":[122,165],"cannot":[123],"optimally":[125],"high":[128,180,239],"dimensionality":[129,240],"(p\u226bn).":[133],"existing":[135],"theoretical":[136],"framework,":[137],"based":[138],"on":[139],"Ridge":[140],"penalization,":[141],"suboptimal,":[143],"since":[144],"it":[145],"includes":[146],"all":[147],"analysis.":[151,184],"As":[152],"solution,":[154],"propose":[156],"use":[158],"Elastic":[159],"Net":[160],"penalization":[161],"iterative":[164],"framework":[166],"obtain":[168],"sparse":[170,175],"solution.":[171],"RESULTS:":[172],"We":[173,185],"proposed":[174],"redundancy":[176],"(sRDA)":[178],"for":[179],"dimensional":[181],"conducted":[186],"simulation":[187],"studies":[188],"our":[190],"software":[191],"implementation":[192],"sRDA":[194,231],"assess":[196],"reliability":[198],"sRDA.":[200],"Both":[201],"simulated":[205],"data,":[206],"485":[211],"512":[212],"methylation":[213],"markers":[214],"18,424":[216],"gene-expression":[217],"values":[218],"measured":[219],"55":[224],"patients":[225],"Marfan":[227],"syndrome":[228],"show":[229],"able":[233],"usual":[238],"data.":[243],"AVAILABILITY":[244],"AND":[245],"IMPLEMENTATION:":[246],"http://uva.csala.me/rda.":[247],"CONTACT:":[248],"a.csala@amc.uva.nl.":[249],"SUPPLEMENTARY":[250],"INFORMATION:":[251],"Supplementary":[252],"available":[255],"at":[256],"Bioinformatics":[257],"online.":[258]},"counts_by_year":[{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}