{"id":"https://openalex.org/W2595956553","doi":"https://doi.org/10.1093/bioinformatics/btx145","title":"SeqArray\u2014a storage-efficient high-performance data format for WGS variant calls","display_name":"SeqArray\u2014a storage-efficient high-performance data format for WGS variant calls","publication_year":2017,"publication_date":"2017-03-15","ids":{"openalex":"https://openalex.org/W2595956553","doi":"https://doi.org/10.1093/bioinformatics/btx145","mag":"2595956553","pmid":"https://pubmed.ncbi.nlm.nih.gov/28334390"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btx145","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btx145","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/33/15/2251/25157677/btx145.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/33/15/2251/25157677/btx145.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005837780","display_name":"Xiuwen Zheng","orcid":"https://orcid.org/0000-0002-1390-0708"},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Xiuwen Zheng","raw_affiliation_strings":["Department of Biostatistics, University of Washington, Seattle, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081885552","display_name":"Stephanie M. Gogarten","orcid":"https://orcid.org/0000-0002-7231-9745"},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephanie M Gogarten","raw_affiliation_strings":["Department of Biostatistics, University of Washington, Seattle, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075334756","display_name":"Michael C. Lawrence","orcid":"https://orcid.org/0000-0003-1999-0801"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Lawrence","raw_affiliation_strings":["Bioinformatics and Computational Biology, Genentech, Inc, South San Francisco, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics and Computational Biology, Genentech, Inc, South San Francisco, CA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090121504","display_name":"Adrienne M. Stilp","orcid":"https://orcid.org/0000-0002-3910-0776"},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adrienne Stilp","raw_affiliation_strings":["Department of Biostatistics, University of Washington, Seattle, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036980922","display_name":"Matthew P. Conomos","orcid":"https://orcid.org/0000-0001-9744-0851"},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew P Conomos","raw_affiliation_strings":["Department of Biostatistics, University of Washington, Seattle, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013703682","display_name":"Bruce S. Weir","orcid":"https://orcid.org/0000-0002-4883-1247"},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bruce S Weir","raw_affiliation_strings":["Department of Biostatistics, University of Washington, Seattle, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047463043","display_name":"Cathy C. Laurie","orcid":"https://orcid.org/0000-0003-2572-4040"},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cathy Laurie","raw_affiliation_strings":["Department of Biostatistics, University of Washington, Seattle, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085922041","display_name":"David Levine","orcid":"https://orcid.org/0000-0002-9292-570X"},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Levine","raw_affiliation_strings":["Department of Biostatistics, University of Washington, Seattle, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5005837780"],"corresponding_institution_ids":["https://openalex.org/I201448701"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":5.2705,"has_fulltext":false,"cited_by_count":201,"citation_normalized_percentile":{"value":0.96703988,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"33","issue":"15","first_page":"2251","last_page":"2257"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.788100004196167,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.788100004196167,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11642","display_name":"Genomics and Rare Diseases","score":0.17000000178813934,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.010400000028312206,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7039282321929932},{"id":"https://openalex.org/keywords/database","display_name":"Database","score":0.3761729598045349},{"id":"https://openalex.org/keywords/operating-system","display_name":"Operating system","score":0.345842570066452}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7039282321929932},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.3761729598045349},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.345842570066452}],"mesh":[{"descriptor_ui":"D000073336","descriptor_name":"Whole Genome Sequencing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D000073336","descriptor_name":"Whole Genome Sequencing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D000073336","descriptor_name":"Whole Genome Sequencing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D000073336","descriptor_name":"Whole Genome Sequencing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D000073336","descriptor_name":"Whole Genome Sequencing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D044962","descriptor_name":"Data Compression","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D044962","descriptor_name":"Data Compression","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D044962","descriptor_name":"Data Compression","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D044962","descriptor_name":"Data Compression","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D044962","descriptor_name":"Data Compression","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/bioinformatics/btx145","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btx145","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/33/15/2251/25157677/btx145.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:28334390","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28334390","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:europepmc.org:5020441","is_oa":false,"landing_page_url":"http://europepmc.org/pmc/articles/PMC5860110","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5860110","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5860110","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btx145","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btx145","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/33/15/2251/25157677/btx145.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G5747877973","display_name":null,"funder_award_id":"R01 GM075091","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6106082789","display_name":null,"funder_award_id":"P01 GM099568","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7190411563","display_name":null,"funder_award_id":"GM099568","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320310094","display_name":"University of Washington","ror":"https://ror.org/00cvxb145"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W783262033","https://openalex.org/W1997476591","https://openalex.org/W2014988121","https://openalex.org/W2019794729","https://openalex.org/W2033151532","https://openalex.org/W2060427373","https://openalex.org/W2097076008","https://openalex.org/W2097103181","https://openalex.org/W2099085143","https://openalex.org/W2102213696","https://openalex.org/W2108169091","https://openalex.org/W2118526609","https://openalex.org/W2131478115","https://openalex.org/W2136939537","https://openalex.org/W2144504271","https://openalex.org/W2147477044","https://openalex.org/W2149992227","https://openalex.org/W2150131459","https://openalex.org/W2159325249","https://openalex.org/W2160697532","https://openalex.org/W2161633633","https://openalex.org/W2171777347","https://openalex.org/W2179226428","https://openalex.org/W2200727588","https://openalex.org/W2231185426","https://openalex.org/W2280860630","https://openalex.org/W2284253967","https://openalex.org/W2396849069","https://openalex.org/W2574839832","https://openalex.org/W2885727518","https://openalex.org/W4231311503","https://openalex.org/W6643894950","https://openalex.org/W6813131194"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W2390279801","https://openalex.org/W4391913857","https://openalex.org/W2358668433","https://openalex.org/W4396701345","https://openalex.org/W2376932109","https://openalex.org/W2001405890","https://openalex.org/W4396696052"],"abstract_inverted_index":{"MOTIVATION:":[0],"Whole-genome":[1],"sequencing":[2],"(WGS)":[3],"data":[4,15,19,52,64,94,107,213],"are":[5,49,111,134,214],"being":[6],"generated":[7],"at":[8,216],"an":[9,77],"unprecedented":[10],"rate.":[11],"Analysis":[12],"of":[13,26,200],"WGS":[14,62,201],"requires":[16],"a":[17,34,60,192],"flexible":[18],"format":[20,31,37,65],"to":[21,39,136],"store":[22,40],"the":[23,68,82,131,142,150,154,157,187],"different":[24],"types":[25],"DNA":[27],"variation.":[28],"Variant":[29],"call":[30],"(VCF)":[32],"is":[33,54,160],"general":[35],"text-based":[36],"developed":[38],"variant":[41,63,74,202],"genotypes":[42,129],"and":[43,51,93,123,170,173],"their":[44],"annotations.":[45],"However,":[46],"VCF":[47,169],"files":[48],"large":[50],"retrieval":[53],"relatively":[55],"slow.":[56],"Here":[57],"we":[58],"introduce":[59],"new":[61],"implemented":[66],"in":[67,76,130,156,182],"R/Bioconductor":[69,185],"package":[70,133,159,189],"'SeqArray'":[71],"for":[72,198],"storing":[73],"calls":[75],"array-oriented":[78],"manner":[79],"which":[80],"provides":[81,190],"same":[83],"capabilities":[84],"as":[85],"VCF,":[86],"but":[87],"with":[88,141,168,184],"multiple":[89],"high":[90],"compression":[91],"options":[92],"access":[95],"using":[96,102,146],"high-performance":[97,195],"parallel":[98],"computing.":[99],"RESULTS:":[100],"Benchmarks":[101],"1000":[103],"Genomes":[104],"Phase":[105],"3":[106],"show":[108],"file":[109],"sizes":[110],"14.0":[112],"Gb":[113,116,121,125],"(VCF),":[114],"12.3":[115],"(BCF,":[117],"binary":[118],"VCF),":[119],"3.5":[120],"(BGT)":[122],"2.6":[124],"(SeqArray)":[126],"respectively.":[127],"Reading":[128],"SeqArray":[132,158,188],"two":[135],"three":[137],"times":[138,163,176],"faster":[139,164,177],"compared":[140],"htslib":[143],"C":[144],"library":[145],"BCF":[147,171],"files.":[148],"For":[149],"allele":[151],"frequency":[152],"calculation,":[153],"implementation":[155],"over":[161,174],"5":[162],"than":[165,178],"PLINK":[166],"v1.9":[167],"files,":[172],"16":[175],"vcftools.":[179],"When":[180],"used":[181],"conjunction":[183],"packages,":[186],"users":[191],"flexible,":[193],"feature-rich,":[194],"programming":[196],"environment":[197],"analysis":[199],"data.":[203],"AVAILABILITY":[204],"AND":[205],"IMPLEMENTATION:":[206],"http://www.bioconductor.org/packages/SeqArray.":[207],"CONTACT:":[208],"zhengx@u.washington.edu.":[209],"SUPPLEMENTARY":[210],"INFORMATION:":[211],"Supplementary":[212],"available":[215],"Bioinformatics":[217],"online.":[218]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":23},{"year":2024,"cited_by_count":34},{"year":2023,"cited_by_count":21},{"year":2022,"cited_by_count":39},{"year":2021,"cited_by_count":24},{"year":2020,"cited_by_count":19},{"year":2019,"cited_by_count":19},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":4}],"updated_date":"2026-07-15T18:14:33.161393","created_date":"2025-10-10T00:00:00"}