{"id":"https://openalex.org/W2579434750","doi":"https://doi.org/10.1093/bioinformatics/btw770","title":"LRSSL: predict and interpret drug\u2013disease associations based on data integration using sparse subspace learning","display_name":"LRSSL: predict and interpret drug\u2013disease associations based on data integration using sparse subspace learning","publication_year":2016,"publication_date":"2016-12-02","ids":{"openalex":"https://openalex.org/W2579434750","doi":"https://doi.org/10.1093/bioinformatics/btw770","mag":"2579434750","pmid":"https://pubmed.ncbi.nlm.nih.gov/28096083"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btw770","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btw770","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/33/8/1187/25150439/btw770.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/33/8/1187/25150439/btw770.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020544678","display_name":"Xujun Liang","orcid":"https://orcid.org/0000-0003-1698-5193"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xujun Liang","raw_affiliation_strings":["Key Laboratory of Cancer Proteomics of Chinese Ministry of Health, XiangYa Hospital, Central South University, ChangSha, HuNan, People\u2019s Republic of China","Key Laboratory of Cancer Proteomics of Chinese Ministry of Health, XiangYa Hospital, Central South University, ChangSha, HuNan, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Cancer Proteomics of Chinese Ministry of Health, XiangYa Hospital, Central South University, ChangSha, HuNan, People\u2019s Republic of China","institution_ids":["https://openalex.org/I139660479"]},{"raw_affiliation_string":"Key Laboratory of Cancer Proteomics of Chinese Ministry of Health, XiangYa Hospital, Central South University, ChangSha, HuNan, People's Republic of China","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100426136","display_name":"Pengfei Zhang","orcid":"https://orcid.org/0000-0003-3470-085X"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Pengfei Zhang","raw_affiliation_strings":["Key Laboratory of Cancer Proteomics of Chinese Ministry of Health, XiangYa Hospital, Central South University, ChangSha, HuNan, People\u2019s Republic of China","Key Laboratory of Cancer Proteomics of Chinese Ministry of Health, XiangYa Hospital, Central South University, ChangSha, HuNan, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Cancer Proteomics of Chinese Ministry of Health, XiangYa Hospital, Central South University, ChangSha, HuNan, People\u2019s Republic of China","institution_ids":["https://openalex.org/I139660479"]},{"raw_affiliation_string":"Key Laboratory of Cancer Proteomics of Chinese Ministry of Health, XiangYa Hospital, Central South University, ChangSha, HuNan, People's Republic of China","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002413682","display_name":"Yan L\u00fc","orcid":"https://orcid.org/0000-0003-3468-2241"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lu Yan","raw_affiliation_strings":["Key Laboratory of Cancer Proteomics of Chinese Ministry of Health, XiangYa Hospital, Central South University, ChangSha, HuNan, People\u2019s Republic of China","Key Laboratory of Cancer Proteomics of Chinese Ministry of Health, XiangYa Hospital, Central South University, ChangSha, HuNan, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Cancer Proteomics of Chinese Ministry of Health, XiangYa Hospital, Central South University, ChangSha, HuNan, People\u2019s Republic of China","institution_ids":["https://openalex.org/I139660479"]},{"raw_affiliation_string":"Key Laboratory of Cancer Proteomics of Chinese Ministry of Health, XiangYa Hospital, Central South University, ChangSha, HuNan, People's Republic of China","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004429108","display_name":"Ying Fu","orcid":"https://orcid.org/0000-0002-8196-6493"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying Fu","raw_affiliation_strings":["Key Laboratory of Cancer Proteomics of Chinese Ministry of Health, XiangYa Hospital, Central South University, ChangSha, HuNan, People\u2019s Republic of China","Key Laboratory of Cancer Proteomics of Chinese Ministry of Health, XiangYa Hospital, Central South University, ChangSha, HuNan, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Cancer Proteomics of Chinese Ministry of Health, XiangYa Hospital, Central South University, ChangSha, HuNan, People\u2019s Republic of China","institution_ids":["https://openalex.org/I139660479"]},{"raw_affiliation_string":"Key Laboratory of Cancer Proteomics of Chinese Ministry of Health, XiangYa Hospital, Central South University, ChangSha, HuNan, People's Republic of China","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051038241","display_name":"Peng Fang","orcid":"https://orcid.org/0000-0002-1256-2241"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fang Peng","raw_affiliation_strings":["Key Laboratory of Cancer Proteomics of Chinese Ministry of Health, XiangYa Hospital, Central South University, ChangSha, HuNan, People\u2019s Republic of China","Key Laboratory of Cancer Proteomics of Chinese Ministry of Health, XiangYa Hospital, Central South University, ChangSha, HuNan, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Cancer Proteomics of Chinese Ministry of Health, XiangYa Hospital, Central South University, ChangSha, HuNan, People\u2019s Republic of China","institution_ids":["https://openalex.org/I139660479"]},{"raw_affiliation_string":"Key Laboratory of Cancer Proteomics of Chinese Ministry of Health, XiangYa Hospital, Central South University, ChangSha, HuNan, People's Republic of China","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054904663","display_name":"Lingzhi Qu","orcid":"https://orcid.org/0000-0002-8212-6605"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lingzhi Qu","raw_affiliation_strings":["Key Laboratory of Cancer Proteomics of Chinese Ministry of Health, XiangYa Hospital, Central South University, ChangSha, HuNan, People\u2019s Republic of China","Key Laboratory of Cancer Proteomics of Chinese Ministry of Health, XiangYa Hospital, Central South University, ChangSha, HuNan, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Cancer Proteomics of Chinese Ministry of Health, XiangYa Hospital, Central South University, ChangSha, HuNan, People\u2019s Republic of China","institution_ids":["https://openalex.org/I139660479"]},{"raw_affiliation_string":"Key Laboratory of Cancer Proteomics of Chinese Ministry of Health, XiangYa Hospital, Central South University, ChangSha, HuNan, People's Republic of China","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064893799","display_name":"Meiying Shao","orcid":"https://orcid.org/0000-0002-3384-9508"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Meiying Shao","raw_affiliation_strings":["Key Laboratory of Cancer Proteomics of Chinese Ministry of Health, XiangYa Hospital, Central South University, ChangSha, HuNan, People\u2019s Republic of China","Key Laboratory of Cancer Proteomics of Chinese Ministry of Health, XiangYa Hospital, Central South University, ChangSha, HuNan, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Cancer Proteomics of Chinese Ministry of Health, XiangYa Hospital, Central South University, ChangSha, HuNan, People\u2019s Republic of China","institution_ids":["https://openalex.org/I139660479"]},{"raw_affiliation_string":"Key Laboratory of Cancer Proteomics of Chinese Ministry of Health, XiangYa Hospital, Central South University, ChangSha, HuNan, People's Republic of China","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002430973","display_name":"Yongheng Chen","orcid":"https://orcid.org/0000-0001-8139-6892"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yongheng Chen","raw_affiliation_strings":["Key Laboratory of Cancer Proteomics of Chinese Ministry of Health, XiangYa Hospital, Central South University, ChangSha, HuNan, People\u2019s Republic of China","Key Laboratory of Cancer Proteomics of Chinese Ministry of Health, XiangYa Hospital, Central South University, ChangSha, HuNan, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Cancer Proteomics of Chinese Ministry of Health, XiangYa Hospital, Central South University, ChangSha, HuNan, People\u2019s Republic of China","institution_ids":["https://openalex.org/I139660479"]},{"raw_affiliation_string":"Key Laboratory of Cancer Proteomics of Chinese Ministry of Health, XiangYa Hospital, Central South University, ChangSha, HuNan, People's Republic of China","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020457809","display_name":"Zhuchu Chen","orcid":null},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhuchu Chen","raw_affiliation_strings":["Key Laboratory of Cancer Proteomics of Chinese Ministry of Health, XiangYa Hospital, Central South University, ChangSha, HuNan, People\u2019s Republic of China","Key Laboratory of Cancer Proteomics of Chinese Ministry of Health, XiangYa Hospital, Central South University, ChangSha, HuNan, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Cancer Proteomics of Chinese Ministry of Health, XiangYa Hospital, Central South University, ChangSha, HuNan, People\u2019s Republic of China","institution_ids":["https://openalex.org/I139660479"]},{"raw_affiliation_string":"Key Laboratory of Cancer Proteomics of Chinese Ministry of Health, XiangYa Hospital, Central South University, ChangSha, HuNan, People's Republic of China","institution_ids":["https://openalex.org/I139660479"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5020457809"],"corresponding_institution_ids":["https://openalex.org/I139660479"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":10.7586,"has_fulltext":false,"cited_by_count":173,"citation_normalized_percentile":{"value":0.98447366,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"33","issue":"8","first_page":"1187","last_page":"1196"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9858999848365784,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9858999848365784,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11943","display_name":"Pharmacovigilance and Adverse Drug Reactions","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/subspace-topology","display_name":"Subspace topology","score":0.6552183628082275},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6041594743728638},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.457006573677063},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.45269328355789185},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4426802694797516},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.17291131615638733},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.11804959177970886}],"concepts":[{"id":"https://openalex.org/C32834561","wikidata":"https://www.wikidata.org/wiki/Q660730","display_name":"Subspace topology","level":2,"score":0.6552183628082275},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6041594743728638},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.457006573677063},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.45269328355789185},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4426802694797516},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17291131615638733},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.11804959177970886}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003093","descriptor_name":"Colitis, Ulcerative","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003093","descriptor_name":"Colitis, Ulcerative","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003093","descriptor_name":"Colitis, Ulcerative","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D004194","descriptor_name":"Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004194","descriptor_name":"Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004194","descriptor_name":"Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013223","descriptor_name":"Statistics as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013223","descriptor_name":"Statistics as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013223","descriptor_name":"Statistics as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/bioinformatics/btw770","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btw770","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/33/8/1187/25150439/btw770.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:28096083","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28096083","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btw770","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btw770","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/33/8/1187/25150439/btw770.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.4399999976158142}],"awards":[{"id":"https://openalex.org/G2560003566","display_name":null,"funder_award_id":"81372516","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4505555509","display_name":null,"funder_award_id":"2016JJ5013","funder_id":"https://openalex.org/F4320322866","funder_display_name":"Natural Science Foundation of Hainan Province"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322866","display_name":"Natural Science Foundation of Hainan Province","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W1158669065","https://openalex.org/W1188421738","https://openalex.org/W1983248350","https://openalex.org/W1987527242","https://openalex.org/W1992442866","https://openalex.org/W1994658365","https://openalex.org/W1998898494","https://openalex.org/W2002069556","https://openalex.org/W2005314755","https://openalex.org/W2019707847","https://openalex.org/W2020132970","https://openalex.org/W2028471633","https://openalex.org/W2030590901","https://openalex.org/W2031669877","https://openalex.org/W2035977761","https://openalex.org/W2041729187","https://openalex.org/W2050078980","https://openalex.org/W2106729876","https://openalex.org/W2110325612","https://openalex.org/W2113072832","https://openalex.org/W2127553917","https://openalex.org/W2137632714","https://openalex.org/W2141222510","https://openalex.org/W2145578524","https://openalex.org/W2158576941","https://openalex.org/W2159675211","https://openalex.org/W2164461702","https://openalex.org/W2165685007","https://openalex.org/W2166550586","https://openalex.org/W2168103112","https://openalex.org/W2352802179","https://openalex.org/W2772934464","https://openalex.org/W4211208250"],"related_works":["https://openalex.org/W2961085424","https://openalex.org/W4306674287","https://openalex.org/W3046775127","https://openalex.org/W4394896187","https://openalex.org/W3170094116","https://openalex.org/W4386462264","https://openalex.org/W3107602296","https://openalex.org/W4364306694","https://openalex.org/W4312192474","https://openalex.org/W4283697347"],"abstract_inverted_index":{"Motivation:":[0],":":[1,56],"Exploring":[2],"the":[3,40,103,120,149,159],"potential":[4],"curative":[5],"effects":[6,117],"of":[7,21,24,33,68,158],"drugs":[8,71],"is":[9,77],"crucial":[10],"for":[11,65,110],"effective":[12],"drug":[13,88,91,115,135,142,151],"development.":[14],"Previous":[15],"studies":[16,146],"have":[17,137],"indicated":[18],"that":[19,102,148],"integration":[20],"multiple":[22,141],"types":[23],"information":[25,94],"could":[26,122,153],"be":[27,123,154],"conducive":[28],"to":[29,37,156],"discovering":[30],"novel":[31,63],"indications":[32],"drugs.":[34,74],"However,":[35],"how":[36],"efficiently":[38],"identify":[39],"mechanism":[41],"behind":[42],"drug-disease":[43,112],"associations":[44],"while":[45],"integrating":[46],"data":[47,171],"from":[48,140],"different":[49],"sources":[50],"remains":[51],"a":[52,62],"challenging":[53],"problem.":[54],"Results:":[55],"In":[57],"this":[58],"research,":[59],"we":[60],"present":[61],"method":[64,76,105,121],"indication":[66],"prediction":[67],"both":[69],"new":[70],"and":[72,95,163],"approved":[73],"This":[75],"based":[78],"on":[79],"Laplacian":[80],"regularized":[81],"sparse":[82],"subspace":[83],"learning":[84],"(LRSSL),":[85],"which":[86],"integrates":[87],"chemical":[89],"information,":[90],"target":[92,96],"domain":[93],"annotation":[97],"information.":[98],"Experimental":[99],"results":[100],"show":[101],"proposed":[104],"outperforms":[106],"several":[107],"recent":[108],"approaches":[109],"predicting":[111],"associations.":[113],"Some":[114],"therapeutic":[116],"predicted":[118,160],"by":[119,125],"validated":[124],"database":[126],"records":[127],"or":[128],"literatures.":[129],"Moreover,":[130],"with":[131],"L1-norm":[132],"constraint,":[133],"important":[134],"features":[136,152],"been":[138],"extracted":[139,150],"feature":[143],"profiles.":[144],"Case":[145],"suggest":[147],"beneficial":[155],"interpretation":[157],"results.":[161],"Availability":[162],"Implementation:":[164],"https://github.com/LiangXujun/LRSSL.":[165],"Contact:":[166],"proteomics@csu.edu.cn.":[167],"Supplementary":[168,170],"information:":[169],"are":[172],"available":[173],"at":[174],"Bioinformatics":[175],"online.":[176]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":33},{"year":2024,"cited_by_count":24},{"year":2023,"cited_by_count":20},{"year":2022,"cited_by_count":20},{"year":2021,"cited_by_count":21},{"year":2020,"cited_by_count":15},{"year":2019,"cited_by_count":21},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":3}],"updated_date":"2026-07-15T18:14:33.161393","created_date":"2025-10-10T00:00:00"}