{"id":"https://openalex.org/W2569195183","doi":"https://doi.org/10.1093/bioinformatics/btw703","title":"Robust parameter estimation for dynamical systems from outlier-corrupted data","display_name":"Robust parameter estimation for dynamical systems from outlier-corrupted data","publication_year":2016,"publication_date":"2016-11-04","ids":{"openalex":"https://openalex.org/W2569195183","doi":"https://doi.org/10.1093/bioinformatics/btw703","mag":"2569195183","pmid":"https://pubmed.ncbi.nlm.nih.gov/28062444"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btw703","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btw703","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/33/5/718/25148530/btw703.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/33/5/718/25148530/btw703.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029512906","display_name":"Corinna Maier","orcid":"https://orcid.org/0000-0003-0115-2500"},"institutions":[{"id":"https://openalex.org/I3018134672","display_name":"Helmholtz Zentrum M\u00fcnchen","ror":"https://ror.org/00cfam450","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Corinna Maier","raw_affiliation_strings":["Helmholtz Zentrum M\u00fcnchen \u2013 German Research Center for Environmental Health, Institute of Computational Biology, Neuherberg, Germany","Technische Universit\u00e4t M\u00fcnchen, Center for Mathematics, Chair of Mathematical Modeling of Biological Systems, Garching, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Helmholtz Zentrum M\u00fcnchen \u2013 German Research Center for Environmental Health, Institute of Computational Biology, Neuherberg, Germany","institution_ids":["https://openalex.org/I3018134672"]},{"raw_affiliation_string":"Technische Universit\u00e4t M\u00fcnchen, Center for Mathematics, Chair of Mathematical Modeling of Biological Systems, Garching, Germany","institution_ids":["https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048802653","display_name":"Carolin Loos","orcid":"https://orcid.org/0000-0003-3680-0627"},"institutions":[{"id":"https://openalex.org/I3018134672","display_name":"Helmholtz Zentrum M\u00fcnchen","ror":"https://ror.org/00cfam450","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Carolin Loos","raw_affiliation_strings":["Helmholtz Zentrum M\u00fcnchen \u2013 German Research Center for Environmental Health, Institute of Computational Biology, Neuherberg, Germany","Technische Universit\u00e4t M\u00fcnchen, Center for Mathematics, Chair of Mathematical Modeling of Biological Systems, Garching, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Helmholtz Zentrum M\u00fcnchen \u2013 German Research Center for Environmental Health, Institute of Computational Biology, Neuherberg, Germany","institution_ids":["https://openalex.org/I3018134672"]},{"raw_affiliation_string":"Technische Universit\u00e4t M\u00fcnchen, Center for Mathematics, Chair of Mathematical Modeling of Biological Systems, Garching, Germany","institution_ids":["https://openalex.org/I62916508"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063254041","display_name":"Jan Hasenauer","orcid":"https://orcid.org/0000-0002-4935-3312"},"institutions":[{"id":"https://openalex.org/I3018134672","display_name":"Helmholtz Zentrum M\u00fcnchen","ror":"https://ror.org/00cfam450","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Jan Hasenauer","raw_affiliation_strings":["Helmholtz Zentrum M\u00fcnchen \u2013 German Research Center for Environmental Health, Institute of Computational Biology, Neuherberg, Germany","Technische Universit\u00e4t M\u00fcnchen, Center for Mathematics, Chair of Mathematical Modeling of Biological Systems, Garching, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Helmholtz Zentrum M\u00fcnchen \u2013 German Research Center for Environmental Health, Institute of Computational Biology, Neuherberg, Germany","institution_ids":["https://openalex.org/I3018134672"]},{"raw_affiliation_string":"Technische Universit\u00e4t M\u00fcnchen, Center for Mathematics, Chair of Mathematical Modeling of Biological Systems, Garching, Germany","institution_ids":["https://openalex.org/I62916508"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5063254041"],"corresponding_institution_ids":["https://openalex.org/I3018134672","https://openalex.org/I62916508"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":3.2462,"has_fulltext":true,"cited_by_count":47,"citation_normalized_percentile":{"value":0.92381232,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"33","issue":"5","first_page":"718","last_page":"725"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.5277000069618225,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.5277000069618225,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.041600000113248825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.04050000011920929,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/outlier","display_name":"Outlier","score":0.8089503049850464},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6602466106414795},{"id":"https://openalex.org/keywords/estimation","display_name":"Estimation","score":0.5577373504638672},{"id":"https://openalex.org/keywords/anomaly-detection","display_name":"Anomaly detection","score":0.5228902697563171},{"id":"https://openalex.org/keywords/estimation-theory","display_name":"Estimation theory","score":0.47219976782798767},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.43548744916915894},{"id":"https://openalex.org/keywords/robust-statistics","display_name":"Robust statistics","score":0.43430525064468384},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.38016414642333984},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.35109269618988037}],"concepts":[{"id":"https://openalex.org/C79337645","wikidata":"https://www.wikidata.org/wiki/Q779824","display_name":"Outlier","level":2,"score":0.8089503049850464},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6602466106414795},{"id":"https://openalex.org/C96250715","wikidata":"https://www.wikidata.org/wiki/Q965330","display_name":"Estimation","level":2,"score":0.5577373504638672},{"id":"https://openalex.org/C739882","wikidata":"https://www.wikidata.org/wiki/Q3560506","display_name":"Anomaly detection","level":2,"score":0.5228902697563171},{"id":"https://openalex.org/C167928553","wikidata":"https://www.wikidata.org/wiki/Q1376021","display_name":"Estimation theory","level":2,"score":0.47219976782798767},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.43548744916915894},{"id":"https://openalex.org/C67226441","wikidata":"https://www.wikidata.org/wiki/Q1665389","display_name":"Robust statistics","level":3,"score":0.43430525064468384},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.38016414642333984},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.35109269618988037},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C187736073","wikidata":"https://www.wikidata.org/wiki/Q2920921","display_name":"Management","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016013","descriptor_name":"Likelihood Functions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016013","descriptor_name":"Likelihood Functions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016013","descriptor_name":"Likelihood Functions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/bioinformatics/btw703","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btw703","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/33/5/718/25148530/btw703.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:28062444","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28062444","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:push-zb.helmholtz-munich.de:49864","is_oa":false,"landing_page_url":"https://push-zb.helmholtz-munich.de/frontdoor.php?source_opus=49864","pdf_url":null,"source":{"id":"https://openalex.org/S7407055352","display_name":"PuSH - Publication Server of Helmholtz Zentrum M\u00fcnchen","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics 33, 1-8 (2017)","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:opus-zb.helmholtz-muenchen.de:49864","is_oa":false,"landing_page_url":"https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=49864","pdf_url":null,"source":{"id":"https://openalex.org/S4377196115","display_name":"Site cant be reached","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics 33, 1-8 (2017)","raw_type":null}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btw703","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btw703","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/33/5/718/25148530/btw703.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Peace, Justice and strong institutions","score":0.8199999928474426,"id":"https://metadata.un.org/sdg/16"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2569195183.pdf","grobid_xml":"https://content.openalex.org/works/W2569195183.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W122923078","https://openalex.org/W1512208174","https://openalex.org/W1538795295","https://openalex.org/W1585339076","https://openalex.org/W1856341315","https://openalex.org/W1978486653","https://openalex.org/W2002830978","https://openalex.org/W2010016312","https://openalex.org/W2019841176","https://openalex.org/W2023479660","https://openalex.org/W2034661498","https://openalex.org/W2046033161","https://openalex.org/W2046854548","https://openalex.org/W2049058890","https://openalex.org/W2064189889","https://openalex.org/W2064817422","https://openalex.org/W2091808868","https://openalex.org/W2091826868","https://openalex.org/W2102434872","https://openalex.org/W2108723074","https://openalex.org/W2118522007","https://openalex.org/W2129281431","https://openalex.org/W2131043603","https://openalex.org/W2131230954","https://openalex.org/W2133257834","https://openalex.org/W2137130182","https://openalex.org/W2137971377","https://openalex.org/W2143894094","https://openalex.org/W2168175751","https://openalex.org/W2168648059","https://openalex.org/W2179709018","https://openalex.org/W2265281604","https://openalex.org/W2316766276","https://openalex.org/W2338990760","https://openalex.org/W2796837256","https://openalex.org/W2966207845","https://openalex.org/W3102649939","https://openalex.org/W4206165574","https://openalex.org/W4211128380","https://openalex.org/W4238726034","https://openalex.org/W4239954780","https://openalex.org/W6808577644"],"related_works":["https://openalex.org/W2499612753","https://openalex.org/W3111802945","https://openalex.org/W2946096271","https://openalex.org/W2295423552","https://openalex.org/W2046343964","https://openalex.org/W3107369729","https://openalex.org/W4379515847","https://openalex.org/W2216963642","https://openalex.org/W2283061017","https://openalex.org/W3121734683"],"abstract_inverted_index":{"Motivation:":[0],"Dynamics":[1],"of":[2,31,63,78,115,129,166,175],"cellular":[3],"processes":[4],"are":[5,18,53,194],"often":[6,33],"studied":[7],"using":[8,117,160,179],"mechanistic":[9],"mathematical":[10],"models.":[11],"These":[12,37],"models":[13,82],"possess":[14],"unknown":[15],"parameters":[16,77],"which":[17,55],"generally":[19],"estimated":[20],"from":[21,83],"experimental":[22,137],"data":[23,128,138],"assuming":[24],"normally":[25],"distributed":[26],"measurement":[27],"noise.":[28],"Outlier":[29],"corruption":[30],"datasets":[32],"cannot":[34],"be":[35],"avoided.":[36],"outliers":[38],"may":[39],"distort":[40],"the":[41,61,76,89,97,99,101,104,147,164,176,180],"parameter":[42,50,58,167],"estimates,":[43],"resulting":[44],"in":[45,60],"incorrect":[46],"model":[47],"predictions.":[48],"Robust":[49],"estimation":[51],"methods":[52,73,148],"required":[54],"provide":[56],"reliable":[57],"estimates":[59],"presence":[62],"outliers.":[64,155],"Results:":[65],"In":[66],"this":[67,123],"manuscript,":[68],"we":[69,95,125],"propose":[70],"and":[71,103,112,151,170],"evaluate":[72],"for":[74,139],"estimating":[75],"ordinary":[79],"differential":[80],"equation":[81],"outlier-corrupted":[84],"data.":[85],"As":[86],"alternatives":[87],"to":[88],"normal":[90],"distribution":[91,120,181],"as":[92,133,135],"noise":[93],"distribution,":[94],"consider":[96,126],"Laplace,":[98],"Huber,":[100],"Cauchy":[102],"Student's":[105],"t":[106],"distribution.":[107],"We":[108,143],"assess":[109],"accuracy,":[110],"robustness":[111,165],"computational":[113],"efficiency":[114],"estimators":[116],"these":[118],"different":[119],"assumptions.":[121],"To":[122],"end,":[124],"artificial":[127],"a":[130],"conversion":[131],"process,":[132],"well":[134,146],"published":[136],"Epo-induced":[140],"JAK/STAT":[141],"signaling.":[142],"study":[144],"how":[145],"can":[149],"compensate":[150],"discover":[152],"artificially":[153],"introduced":[154],"Our":[156],"evaluation":[157],"reveals":[158],"that":[159],"alternative":[161],"distributions":[162],"improves":[163],"estimates.":[168],"Availability":[169],"Implementation:":[171],"The":[172],"MATLAB":[173],"implementation":[174],"likelihood":[177],"functions":[178],"assumptions":[182],"is":[183],"available":[184,195],"at":[185,196],"Bioinformatics":[186,197],"online.":[187,198],"Contact:":[188],"jan.hasenauer@helmholtz-muenchen.de.":[189],"Supplementary":[190,192],"information:":[191],"material":[193]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":1}],"updated_date":"2026-07-02T09:51:11.867554","created_date":"2025-10-10T00:00:00"}
