{"id":"https://openalex.org/W2532527181","doi":"https://doi.org/10.1093/bioinformatics/btw662","title":"Cancer driver gene discovery through an integrative genomics approach in a non-parametric Bayesian framework","display_name":"Cancer driver gene discovery through an integrative genomics approach in a non-parametric Bayesian framework","publication_year":2016,"publication_date":"2016-10-17","ids":{"openalex":"https://openalex.org/W2532527181","doi":"https://doi.org/10.1093/bioinformatics/btw662","mag":"2532527181","pmid":"https://pubmed.ncbi.nlm.nih.gov/27797769"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btw662","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btw662","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/33/4/483/25417023/btw662.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/33/4/483/25417023/btw662.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079410677","display_name":"Yang Hai","orcid":"https://orcid.org/0000-0002-9420-0614"},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]},{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I4210106595","display_name":"Sidney Kimmel Cancer Center","ror":"https://ror.org/010h6g454","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210106595"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Hai Yang","raw_affiliation_strings":["Department of Medical Oncology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA","Department of Molecular Physiology & Biophysics, Vanderbilt University, Nashville, TN, USA","Vanderbilt Genetics Institute, Nashville, TN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I4210106595","https://openalex.org/I149251103"]},{"raw_affiliation_string":"Department of Molecular Physiology & Biophysics, Vanderbilt University, Nashville, TN, USA","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Vanderbilt Genetics Institute, Nashville, TN, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052729067","display_name":"Qiang Wei","orcid":"https://orcid.org/0000-0001-9926-1646"},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qiang Wei","raw_affiliation_strings":["Department of Molecular Physiology & Biophysics, Vanderbilt University, Nashville, TN, USA","Vanderbilt Genetics Institute, Nashville, TN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Physiology & Biophysics, Vanderbilt University, Nashville, TN, USA","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Vanderbilt Genetics Institute, Nashville, TN, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102720820","display_name":"Xue Zhong","orcid":"https://orcid.org/0000-0002-7482-8471"},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xue Zhong","raw_affiliation_strings":["Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA","Vanderbilt Genetics Institute, Nashville, TN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA","institution_ids":["https://openalex.org/I901861585"]},{"raw_affiliation_string":"Vanderbilt Genetics Institute, Nashville, TN, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088600970","display_name":"Hushan Yang","orcid":"https://orcid.org/0000-0001-9920-1731"},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]},{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I4210106595","display_name":"Sidney Kimmel Cancer Center","ror":"https://ror.org/010h6g454","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210106595"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hushan Yang","raw_affiliation_strings":["Department of Medical Oncology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA","Department of Molecular Physiology & Biophysics, Vanderbilt University, Nashville, TN, USA","Vanderbilt Genetics Institute, Nashville, TN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I4210106595","https://openalex.org/I149251103"]},{"raw_affiliation_string":"Department of Molecular Physiology & Biophysics, Vanderbilt University, Nashville, TN, USA","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Vanderbilt Genetics Institute, Nashville, TN, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028708641","display_name":"Bingshan Li","orcid":"https://orcid.org/0000-0003-2129-168X"},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Bingshan Li","raw_affiliation_strings":["Department of Molecular Physiology & Biophysics, Vanderbilt University, Nashville, TN, USA","Vanderbilt Genetics Institute, Nashville, TN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Physiology & Biophysics, Vanderbilt University, Nashville, TN, USA","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Vanderbilt Genetics Institute, Nashville, TN, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5028708641","https://openalex.org/A5079410677"],"corresponding_institution_ids":["https://openalex.org/I149251103","https://openalex.org/I200719446","https://openalex.org/I4210106595"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":2.6116,"has_fulltext":false,"cited_by_count":33,"citation_normalized_percentile":{"value":0.90009438,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"33","issue":"4","first_page":"483","last_page":"490"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.2320999950170517,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.2320999950170517,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.22190000116825104,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.18539999425411224,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5788957476615906},{"id":"https://openalex.org/keywords/genomics","display_name":"Genomics","score":0.5742791295051575},{"id":"https://openalex.org/keywords/leverage","display_name":"Leverage (statistics)","score":0.47185492515563965},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.4649933874607086},{"id":"https://openalex.org/keywords/bayesian-probability","display_name":"Bayesian probability","score":0.42821401357650757},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4265310764312744},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.4249250888824463},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3659312129020691},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.36211472749710083},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.2662946879863739},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.13625317811965942},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.09612351655960083}],"concepts":[{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5788957476615906},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.5742791295051575},{"id":"https://openalex.org/C153083717","wikidata":"https://www.wikidata.org/wiki/Q6535263","display_name":"Leverage (statistics)","level":2,"score":0.47185492515563965},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4649933874607086},{"id":"https://openalex.org/C107673813","wikidata":"https://www.wikidata.org/wiki/Q812534","display_name":"Bayesian probability","level":2,"score":0.42821401357650757},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4265310764312744},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.4249250888824463},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3659312129020691},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.36211472749710083},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2662946879863739},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.13625317811965942},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.09612351655960083}],"mesh":[{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D052138","descriptor_name":"Genes, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D052138","descriptor_name":"Genes, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D052138","descriptor_name":"Genes, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1093/bioinformatics/btw662","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btw662","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/33/4/483/25417023/btw662.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:27797769","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27797769","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:europepmc.org:5032469","is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6075201","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btw662","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btw662","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/33/4/483/25417023/btw662.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5}],"awards":[{"id":"https://openalex.org/G4833657548","display_name":null,"funder_award_id":"R01HG00680","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5025373473","display_name":null,"funder_award_id":"R21 CA159047","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6212011661","display_name":null,"funder_award_id":"R03 CA162201","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W1937853139","https://openalex.org/W1965440903","https://openalex.org/W1967137553","https://openalex.org/W1967687583","https://openalex.org/W1968667083","https://openalex.org/W1971875278","https://openalex.org/W1975428912","https://openalex.org/W1980548655","https://openalex.org/W1990292945","https://openalex.org/W1999390452","https://openalex.org/W2002404925","https://openalex.org/W2007490905","https://openalex.org/W2009720434","https://openalex.org/W2016661249","https://openalex.org/W2022495797","https://openalex.org/W2023461603","https://openalex.org/W2029532166","https://openalex.org/W2036124215","https://openalex.org/W2038156301","https://openalex.org/W2044433401","https://openalex.org/W2044702943","https://openalex.org/W2059069581","https://openalex.org/W2059300459","https://openalex.org/W2069429561","https://openalex.org/W2069739265","https://openalex.org/W2081606773","https://openalex.org/W2094129019","https://openalex.org/W2095202886","https://openalex.org/W2096283457","https://openalex.org/W2102140136","https://openalex.org/W2110065044","https://openalex.org/W2111476798","https://openalex.org/W2112947018","https://openalex.org/W2114031931","https://openalex.org/W2122769974","https://openalex.org/W2125118217","https://openalex.org/W2127498532","https://openalex.org/W2129946644","https://openalex.org/W2135881334","https://openalex.org/W2138014988","https://openalex.org/W2151794156","https://openalex.org/W2153032620","https://openalex.org/W2153056550","https://openalex.org/W2157852151","https://openalex.org/W2159482845","https://openalex.org/W2167064353","https://openalex.org/W2168303063","https://openalex.org/W2169126554","https://openalex.org/W2172085063","https://openalex.org/W2560367415","https://openalex.org/W2770983033","https://openalex.org/W4285719527","https://openalex.org/W4294216483","https://openalex.org/W6642070592","https://openalex.org/W6667932521"],"related_works":["https://openalex.org/W2086525401","https://openalex.org/W2079327011","https://openalex.org/W2787993192","https://openalex.org/W2006735166","https://openalex.org/W2053325634","https://openalex.org/W193851735","https://openalex.org/W3178279768","https://openalex.org/W2158269427","https://openalex.org/W2275805942","https://openalex.org/W4381280689"],"abstract_inverted_index":{"Motivation:":[0],"Comprehensive":[1],"catalogue":[2,27],"of":[3,24,59,119,136,188,237],"genes":[4,38,67,109,138,159,183,203],"that":[5,36,127,160,204,219],"drive":[6],"tumor":[7],"initiation":[8],"and":[9,19,83,94,122,132,155,184,232,242],"progression":[10],"in":[11,45,57,88,110,153,181],"cancer":[12,151,212,230,238],"is":[13,28,128,249],"key":[14],"to":[15,52,63,106,130,149],"advancing":[16],"diagnostics,":[17],"therapeutics":[18],"treatment.":[20],"Given":[21],"the":[22,26,60,116,124,134,147,234],"complexity":[23],"cancer,":[25],"far":[29],"from":[30,194],"complete":[31],"yet.":[32],"Increasing":[33],"evidence":[34],"shows":[35],"driver":[37,66,108,137,158,202],"exhibit":[39],"consistent":[40],"aberration":[41],"patterns":[42],"across":[43,209],"multiple-omics":[44],"tumors.":[46],"In":[47],"this":[48],"study,":[49],"we":[50,73,198],"aim":[51],"leverage":[53],"complementary":[54],"information":[55],"encoded":[56],"each":[58],"omics":[61],"data":[62,223,262],"identify":[64,107,229],"novel":[65,182],"through":[68,140],"an":[69,111],"integrative":[70],"framework.":[71],"Specifically,":[72],"integrated":[74],"mutations,":[75],"gene":[76,120],"expression,":[77],"DNA":[78,81],"copy":[79],"numbers,":[80],"methylation":[82],"protein":[84],"abundance,":[85],"all":[86],"available":[87,251,264],"The":[89,214,244],"Cancer":[90],"Genome":[91],"Atlas":[92],"(TCGA)":[93],"developed":[95],"iDriver,":[96],"a":[97],"non-parametric":[98],"Bayesian":[99],"framework":[100],"based":[101],"on":[102],"multivariate":[103,225],"statistical":[104],"modeling":[105],"unsupervised":[112],"fashion.":[113],"iDriver":[114],"captures":[115],"inherent":[117],"clusters":[118],"aberrations":[121],"constructs":[123],"background":[125],"distribution":[126],"used":[129],"assess":[131],"calibrate":[133],"confidence":[135],"identified":[139,156,199],"multi-dimensional":[141],"genomic":[142,222],"data.":[143],"Results:":[144],"We":[145,177],"applied":[146],"method":[148],"4":[150,211],"types":[152],"TCGA":[154],"candidate":[157,201],"are":[161,178,263],"highly":[162],"enriched":[163],"with":[164,224],"known":[165,208],"drivers.":[166],"(e.g.:":[167],"P":[168],"<":[169],"3.40":[170],"\u00d7":[171],"10":[172],"-36":[173],"for":[174],"breast":[175],"cancer).":[176],"particularly":[179],"interested":[180],"observed":[185],"multiple":[186,195],"lines":[187],"supporting":[189],"evidence.":[190],"Using":[191],"systematic":[192],"evaluation":[193],"independent":[196],"aspects,":[197],"45":[200],"were":[205],"not":[206],"previously":[207],"these":[210],"types.":[213],"finding":[215],"has":[216],"important":[217],"implications":[218],"integrating":[220],"additional":[221],"statistics":[226],"can":[227],"help":[228],"drivers":[231],"guide":[233],"next":[235],"stage":[236],"genomics":[239],"research.":[240],"Availability":[241],"Implementation:":[243],"C":[245],"++":[246],"source":[247],"code":[248],"freely":[250],"at":[252,265],"https://medschool.vanderbilt.edu/cgg/":[253],".":[254],"Contacts:":[255],"hai.yang@vanderbilt.edu":[256],"or":[257],"bingshan.li@Vanderbilt.Edu.":[258],"Supplementary":[259,261],"information:":[260],"Bioinformatics":[266],"online.":[267]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":7}],"updated_date":"2026-06-24T13:16:06.693445","created_date":"2025-10-10T00:00:00"}