{"id":"https://openalex.org/W2339613031","doi":"https://doi.org/10.1093/bioinformatics/btw202","title":"Beta-Poisson model for single-cell RNA-seq data analyses","display_name":"Beta-Poisson model for single-cell RNA-seq data analyses","publication_year":2016,"publication_date":"2016-04-19","ids":{"openalex":"https://openalex.org/W2339613031","doi":"https://doi.org/10.1093/bioinformatics/btw202","mag":"2339613031","pmid":"https://pubmed.ncbi.nlm.nih.gov/27153638"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btw202","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btw202","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/32/14/2128/19568119/btw202.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/32/14/2128/19568119/btw202.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046377219","display_name":"Trung Nghia Vu","orcid":"https://orcid.org/0000-0001-7945-5750"},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Trung Nghia Vu","raw_affiliation_strings":["1 Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 17177 Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 17177 Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088148164","display_name":"Quin F. Wills","orcid":null},"institutions":[{"id":"https://openalex.org/I1336263701","display_name":"Centre for Human Genetics","ror":"https://ror.org/01rjnta51","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1336263701","https://openalex.org/I40120149"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4210110594","display_name":"MRC Weatherall Institute of Molecular Medicine","ror":"https://ror.org/01q496a73","country_code":"GB","type":"facility","lineage":["https://openalex.org/I40120149","https://openalex.org/I4210087105","https://openalex.org/I4210110594","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Quin F. Wills","raw_affiliation_strings":["2 Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK","3 Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2 Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK","institution_ids":["https://openalex.org/I1336263701","https://openalex.org/I40120149"]},{"raw_affiliation_string":"3 Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK","institution_ids":["https://openalex.org/I4210110594","https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085014608","display_name":"Krishna R. Kalari","orcid":"https://orcid.org/0000-0001-8944-8378"},"institutions":[{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Krishna R. Kalari","raw_affiliation_strings":["4 Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4 Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA","institution_ids":["https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109335158","display_name":"Nifang Niu","orcid":null},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"funder","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I2802423016","display_name":"WinnMed","ror":"https://ror.org/02s47w807","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2802423016"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nifang Niu","raw_affiliation_strings":["5 Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN 55905, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5 Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN 55905, USA","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I2802423016"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069578729","display_name":"Liewei Wang","orcid":"https://orcid.org/0000-0003-3818-8531"},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"funder","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I2802423016","display_name":"WinnMed","ror":"https://ror.org/02s47w807","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2802423016"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Liewei Wang","raw_affiliation_strings":["5 Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN 55905, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5 Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN 55905, USA","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I2802423016"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046937219","display_name":"Mattias Rantalainen","orcid":"https://orcid.org/0000-0002-7740-2986"},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Mattias Rantalainen","raw_affiliation_strings":["1 Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 17177 Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 17177 Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012606625","display_name":"Yudi Pawitan","orcid":"https://orcid.org/0000-0003-0324-7052"},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Yudi Pawitan","raw_affiliation_strings":["1 Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 17177 Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 17177 Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5012606625","https://openalex.org/A5046937219"],"corresponding_institution_ids":["https://openalex.org/I28166907"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":9.75,"has_fulltext":true,"cited_by_count":186,"citation_normalized_percentile":{"value":0.9846943,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"32","issue":"14","first_page":"2128","last_page":"2135"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9894999861717224,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9894999861717224,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13410","display_name":"Immune responses and vaccinations","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/poisson-distribution","display_name":"Poisson distribution","score":0.7109458446502686},{"id":"https://openalex.org/keywords/rna","display_name":"RNA","score":0.5628899335861206},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5214004516601562},{"id":"https://openalex.org/keywords/bimodality","display_name":"Bimodality","score":0.5156297087669373},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.49648863077163696},{"id":"https://openalex.org/keywords/negative-binomial-distribution","display_name":"Negative binomial distribution","score":0.41822415590286255},{"id":"https://openalex.org/keywords/rna-seq","display_name":"RNA-Seq","score":0.4174523651599884},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.3917376697063446},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3628900647163391},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.360740602016449},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.3238786458969116},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.2753066420555115},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.1953611671924591},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.15712395310401917},{"id":"https://openalex.org/keywords/transcriptome","display_name":"Transcriptome","score":0.13736432790756226},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.09291988611221313}],"concepts":[{"id":"https://openalex.org/C100906024","wikidata":"https://www.wikidata.org/wiki/Q205692","display_name":"Poisson distribution","level":2,"score":0.7109458446502686},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.5628899335861206},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5214004516601562},{"id":"https://openalex.org/C2779287300","wikidata":"https://www.wikidata.org/wiki/Q4913752","display_name":"Bimodality","level":3,"score":0.5156297087669373},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.49648863077163696},{"id":"https://openalex.org/C199335787","wikidata":"https://www.wikidata.org/wiki/Q743364","display_name":"Negative binomial distribution","level":3,"score":0.41822415590286255},{"id":"https://openalex.org/C107397762","wikidata":"https://www.wikidata.org/wiki/Q2542347","display_name":"RNA-Seq","level":5,"score":0.4174523651599884},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3917376697063446},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3628900647163391},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.360740602016449},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.3238786458969116},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.2753066420555115},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.1953611671924591},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15712395310401917},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.13736432790756226},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.09291988611221313},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C98444146","wikidata":"https://www.wikidata.org/wiki/Q318","display_name":"Galaxy","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1093/bioinformatics/btw202","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btw202","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/32/14/2128/19568119/btw202.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:27153638","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27153638","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:open-archive.highwire.org:bioinfo:32/14/2128","is_oa":false,"landing_page_url":"http://bioinformatics.oxfordjournals.org/cgi/content/short/32/14/2128","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"},{"id":"pmh:oai:pubmedcentral.nih.gov:13048230","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13048230/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btw202","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btw202","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/32/14/2128/19568119/btw202.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G4088506818","display_name":null,"funder_award_id":"U19 GM061388","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320313607","display_name":"Swedish Cancer Foundation","ror":null},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2339613031.pdf","grobid_xml":"https://content.openalex.org/works/W2339613031.grobid-xml"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W1490229695","https://openalex.org/W1967327758","https://openalex.org/W1989277387","https://openalex.org/W2021880506","https://openalex.org/W2037685552","https://openalex.org/W2065128082","https://openalex.org/W2071396361","https://openalex.org/W2072478189","https://openalex.org/W2081728154","https://openalex.org/W2096705138","https://openalex.org/W2100118577","https://openalex.org/W2110768394","https://openalex.org/W2114104545","https://openalex.org/W2122364231","https://openalex.org/W2128909276","https://openalex.org/W2130116522","https://openalex.org/W2134526812","https://openalex.org/W2137526110","https://openalex.org/W2138375970","https://openalex.org/W2141458291","https://openalex.org/W2171501288","https://openalex.org/W2190545194","https://openalex.org/W2314485382","https://openalex.org/W4237335579","https://openalex.org/W6675207208"],"related_works":["https://openalex.org/W2995051414","https://openalex.org/W2047907216","https://openalex.org/W2129537379","https://openalex.org/W1553793542","https://openalex.org/W2036731318","https://openalex.org/W1991230619","https://openalex.org/W4311363496","https://openalex.org/W4319841362","https://openalex.org/W4232372158","https://openalex.org/W13072069"],"abstract_inverted_index":{"MOTIVATION:":[0],"Single-cell":[1],"RNA-sequencing":[2,52,166],"technology":[3],"allows":[4],"detection":[5],"of":[6,16,36,72,114,133,141,149,196],"gene":[7,75],"expression":[8,76,94,147,194],"at":[9,205,217],"the":[10,17,23,42,70,73,81,84,115,121,124,131,134,142],"single-cell":[11,74,108,179,197],"level.":[12],"One":[13],"typical":[14],"feature":[15],"data":[18,199,214],"is":[19,100,128,200],"a":[20,34,63,159],"bimodality":[21,71],"in":[22,50,89,138,145,164],"cellular":[24],"distribution":[25],"even":[26],"for":[27,178,189],"highly":[28],"expressed":[29],"genes,":[30],"primarily":[31],"caused":[32],"by":[33,120],"proportion":[35],"non-expressing":[37],"cells.":[38],"The":[39,96,103],"standard":[40,135],"and":[41,151,168,171,192],"over-dispersed":[43],"gamma-Poisson":[44,136],"models":[45],"that":[46,67,112],"are":[47,53,117,215],"commonly":[48],"used":[49,163],"bulk-cell":[51,165],"not":[54],"able":[55],"to":[56,91],"capture":[57,69],"this":[58],"property.":[59],"RESULTS:":[60],"We":[61,78],"introduce":[62],"beta-Poisson":[64,122],"mixture":[65],"model":[66,82,87,137,190],"can":[68],"distribution.":[77],"further":[79],"integrate":[80],"into":[83],"generalized":[85],"linear":[86],"framework":[88],"order":[90],"perform":[92],"differential":[93,146,193],"analyses.":[95],"whole":[97],"analytical":[98],"procedure":[99],"called":[101],"BPSC.":[102],"results":[104],"from":[105,126],"several":[106],"real":[107,152],"RNA-seq":[109,180,198],"datasets":[110],"indicate":[111],"\u223c90%":[113],"transcripts":[116],"well":[118,156],"characterized":[119],"model;":[123],"model-fit":[125],"BPSC":[127,154,188],"better":[129],"than":[130],"fit":[132],">":[139],"80%":[140],"transcripts.":[143],"Moreover,":[144],"analyses":[148,195],"simulated":[150],"datasets,":[153],"performs":[155],"against":[157,169],"edgeR,":[158],"conventional":[160],"method":[161],"widely":[162],"data,":[167],"scde":[170],"MAST,":[172],"two":[173],"recent":[174],"methods":[175],"specifically":[176],"designed":[177],"data.":[181],"AVAILABILITY":[182],"AND":[183],"IMPLEMENTATION:":[184],"An":[185],"R":[186],"package":[187],"fitting":[191],"available":[201,216],"under":[202],"GPL-3":[203],"license":[204],"https://github.com/nghiavtr/BPSC":[206],"CONTACT:":[207],"yudi.pawitan@ki.se":[208],"or":[209],"mattias.rantalainen@ki.se":[210],"SUPPLEMENTARY":[211],"INFORMATION:":[212],"Supplementary":[213],"Bioinformatics":[218],"online.":[219]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":18},{"year":2023,"cited_by_count":26},{"year":2022,"cited_by_count":27},{"year":2021,"cited_by_count":29},{"year":2020,"cited_by_count":14},{"year":2019,"cited_by_count":14},{"year":2018,"cited_by_count":18},{"year":2017,"cited_by_count":19},{"year":2016,"cited_by_count":5}],"updated_date":"2026-06-27T08:28:00.272161","created_date":"2025-10-10T00:00:00"}