{"id":"https://openalex.org/W2204029753","doi":"https://doi.org/10.1093/bioinformatics/btw029","title":"FastLSU: a more practical approach for the Benjamini\u2013Hochberg FDR controlling procedure for huge-scale testing problems","display_name":"FastLSU: a more practical approach for the Benjamini\u2013Hochberg FDR controlling procedure for huge-scale testing problems","publication_year":2016,"publication_date":"2016-01-30","ids":{"openalex":"https://openalex.org/W2204029753","doi":"https://doi.org/10.1093/bioinformatics/btw029","mag":"2204029753","pmid":"https://pubmed.ncbi.nlm.nih.gov/26826716"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btw029","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btw029","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070991337","display_name":"Vered Madar","orcid":"https://orcid.org/0000-0003-2743-6851"},"institutions":[{"id":"https://openalex.org/I1343558604","display_name":"Statistical and Applied Mathematical Sciences Institute","ror":"https://ror.org/01shctp43","country_code":"US","type":"facility","lineage":["https://openalex.org/I1311060795","https://openalex.org/I1343558604"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vered Madar","raw_affiliation_strings":["1Statistical and Applied Mathematical Sciences Institute, Research Triangle Park, NC 27709, USA and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Statistical and Applied Mathematical Sciences Institute, Research Triangle Park, NC 27709, USA and","institution_ids":["https://openalex.org/I1343558604"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061407169","display_name":"Sandra Batista","orcid":"https://orcid.org/0000-0003-4605-9836"},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sandra Batista","raw_affiliation_strings":["2Department of Computer Science, Princeton University, Princeton, NJ 08540, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Computer Science, Princeton University, Princeton, NJ 08540, USA","institution_ids":["https://openalex.org/I20089843"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5061407169"],"corresponding_institution_ids":["https://openalex.org/I20089843"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":3.6206,"has_fulltext":false,"cited_by_count":52,"citation_normalized_percentile":{"value":0.92903639,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"32","issue":"11","first_page":"1716","last_page":"1723"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.5480999946594238,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.5480999946594238,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10743","display_name":"Software Testing and Debugging Techniques","score":0.15919999778270721,"subfield":{"id":"https://openalex.org/subfields/1712","display_name":"Software"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.055399999022483826,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/false-discovery-rate","display_name":"False discovery rate","score":0.7883539795875549},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7348260879516602},{"id":"https://openalex.org/keywords/multiple-comparisons-problem","display_name":"Multiple comparisons problem","score":0.6489284038543701},{"id":"https://openalex.org/keywords/scale","display_name":"Scale (ratio)","score":0.6322331428527832},{"id":"https://openalex.org/keywords/set","display_name":"Set (abstract data type)","score":0.5161003470420837},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.48458635807037354},{"id":"https://openalex.org/keywords/code","display_name":"Code (set theory)","score":0.4526112973690033},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.3888986110687256},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.18475115299224854},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.1522344946861267}],"concepts":[{"id":"https://openalex.org/C193244246","wikidata":"https://www.wikidata.org/wiki/Q5432696","display_name":"False discovery rate","level":3,"score":0.7883539795875549},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7348260879516602},{"id":"https://openalex.org/C183905921","wikidata":"https://www.wikidata.org/wiki/Q1038757","display_name":"Multiple comparisons problem","level":2,"score":0.6489284038543701},{"id":"https://openalex.org/C2778755073","wikidata":"https://www.wikidata.org/wiki/Q10858537","display_name":"Scale (ratio)","level":2,"score":0.6322331428527832},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.5161003470420837},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.48458635807037354},{"id":"https://openalex.org/C2776760102","wikidata":"https://www.wikidata.org/wiki/Q5139990","display_name":"Code (set theory)","level":3,"score":0.4526112973690033},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3888986110687256},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.18475115299224854},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.1522344946861267},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1093/bioinformatics/btw029","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btw029","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:26826716","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26826716","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:open-archive.highwire.org:bioinfo:32/11/1716","is_oa":false,"landing_page_url":"http://bioinformatics.oxfordjournals.org/cgi/content/short/32/11/1716","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Decent work and economic growth","score":0.46000000834465027,"id":"https://metadata.un.org/sdg/8"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320337380","display_name":"Division of Mathematical Sciences","ror":"https://ror.org/051fftw81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1596515083","https://openalex.org/W1824047490","https://openalex.org/W2002234191","https://openalex.org/W2016113637","https://openalex.org/W2054714441","https://openalex.org/W2058846847","https://openalex.org/W2070685632","https://openalex.org/W2073622765","https://openalex.org/W2085126855","https://openalex.org/W2103225674","https://openalex.org/W2105239414","https://openalex.org/W2105381419","https://openalex.org/W2110065044","https://openalex.org/W2110496823","https://openalex.org/W2112087830","https://openalex.org/W2146355875","https://openalex.org/W2148791309","https://openalex.org/W2152816554","https://openalex.org/W3098652185","https://openalex.org/W4231390238"],"related_works":["https://openalex.org/W2467227750","https://openalex.org/W4293336298","https://openalex.org/W4300887971","https://openalex.org/W2178204436","https://openalex.org/W2143079975","https://openalex.org/W2032708737","https://openalex.org/W2026085942","https://openalex.org/W2333750400","https://openalex.org/W2076024021","https://openalex.org/W2766832551"],"abstract_inverted_index":{"MOTIVATION:":[0],"We":[1],"address":[2],"a":[3,30,43],"common":[4],"problem":[5],"in":[6,146],"large-scale":[7],"data":[8,155],"analysis,":[9],"and":[10,59,67],"especially":[11],"the":[12,16,35,38,51,89,98,102,106,113,134,147],"field":[13],"of":[14,24,37,57,109,136],"genetics,":[15],"huge-scale":[17,77],"testing":[18,78],"problem,":[19],"where":[20],"millions":[21],"to":[22,33,96],"billions":[23],"hypotheses":[25],"are":[26,91,121,156],"tested":[27],"together":[28],"creating":[29],"computational":[31],"challenge":[32],"control":[34],"inflation":[36],"false":[39,115],"discovery":[40,116],"rate.":[41],"As":[42],"solution":[44],"we":[45],"propose":[46],"an":[47],"alternative":[48],"algorithm":[49,63,95],"for":[50],"famous":[52],"Linear":[53],"Step":[54],"Up":[55],"procedure":[56,104],"Benjamini":[58],"Hochberg.":[60],"RESULTS:":[61],"Our":[62],"requires":[64],"linear":[65],"time":[66],"does":[68],"not":[69],"require":[70],"any":[71],"P-value":[72],"ordering.":[73],"It":[74],"permits":[75],"separating":[76],"problems":[79],"arbitrarily":[80,122,132],"into":[81],"computationally":[82],"feasible":[83],"sets":[84],"or":[85],"chunks":[86,90],"Results":[87],"from":[88],"combined":[92],"by":[93,133],"our":[94],"produce":[97],"same":[99],"results":[100],"as":[101],"controlling":[103,112],"on":[105],"entire":[107],"set":[108],"tests,":[110],"thus":[111],"global":[114],"rate":[117],"even":[118],"when":[119],"P-values":[120],"divided.":[123],"The":[124],"practical":[125],"memory":[126],"usage":[127],"may":[128],"also":[129],"be":[130],"determined":[131],"size":[135],"available":[137,157],"memory.":[138],"AVAILABILITY":[139],"AND":[140],"IMPLEMENTATION:":[141],"R":[142],"code":[143],"is":[144],"provided":[145],"supplementary":[148],"material.":[149],"CONTACT:":[150],"sbatista@cs.princeton.edu":[151],"SUPPLEMENTARY":[152],"INFORMATION:":[153],"Supplementary":[154],"at":[158],"Bioinformatics":[159],"online.":[160]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1}],"updated_date":"2026-08-15T07:11:24.734988","created_date":"2025-10-10T00:00:00"}