{"id":"https://openalex.org/W2511281583","doi":"https://doi.org/10.1093/bioinformatics/btv602","title":"LoFtool: a gene intolerance score based on loss-of-function variants in 60 706 individuals","display_name":"LoFtool: a gene intolerance score based on loss-of-function variants in 60 706 individuals","publication_year":2016,"publication_date":"2016-08-23","ids":{"openalex":"https://openalex.org/W2511281583","doi":"https://doi.org/10.1093/bioinformatics/btv602","mag":"2511281583","pmid":"https://pubmed.ncbi.nlm.nih.gov/27563026"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btv602","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btv602","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/33/4/471/25146562/btv602.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/33/4/471/25146562/btv602.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012035615","display_name":"Jo\u00e3o Fadista","orcid":"https://orcid.org/0000-0003-2539-634X"},"institutions":[{"id":"https://openalex.org/I101527212","display_name":"Statens Serum Institut","ror":"https://ror.org/0417ye583","country_code":"DK","type":"facility","lineage":["https://openalex.org/I101527212"]},{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["DK","SE"],"is_corresponding":true,"raw_author_name":"Jo\u00e3o Fadista","raw_affiliation_strings":["Department of Clinical Sciences, Lund University Diabetes Centre, Lund University, Sweden","Department of Epidemiology Research, Statens Serum Institut, Copenhagen S, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Sciences, Lund University Diabetes Centre, Lund University, Sweden","institution_ids":["https://openalex.org/I187531555"]},{"raw_affiliation_string":"Department of Epidemiology Research, Statens Serum Institut, Copenhagen S, Denmark","institution_ids":["https://openalex.org/I101527212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074609315","display_name":"Nikolay Oskolkov","orcid":"https://orcid.org/0000-0001-5326-8893"},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Nikolay Oskolkov","raw_affiliation_strings":["Department of Clinical Sciences, Lund University Diabetes Centre, Lund University, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Sciences, Lund University Diabetes Centre, Lund University, Sweden","institution_ids":["https://openalex.org/I187531555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033111679","display_name":"Ola Hansson","orcid":"https://orcid.org/0000-0002-7394-7639"},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Ola Hansson","raw_affiliation_strings":["Department of Clinical Sciences, Lund University Diabetes Centre, Lund University, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Sciences, Lund University Diabetes Centre, Lund University, Sweden","institution_ids":["https://openalex.org/I187531555"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074771810","display_name":"Leif Groop","orcid":"https://orcid.org/0000-0002-0187-3263"},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]},{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]}],"countries":["FI","SE"],"is_corresponding":false,"raw_author_name":"Leif Groop","raw_affiliation_strings":["Department of Clinical Sciences, Lund University Diabetes Centre, Lund University, Sweden","Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Sciences, Lund University Diabetes Centre, Lund University, Sweden","institution_ids":["https://openalex.org/I187531555"]},{"raw_affiliation_string":"Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I4210133586","https://openalex.org/I133731052"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5012035615"],"corresponding_institution_ids":["https://openalex.org/I101527212","https://openalex.org/I187531555"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":5.786,"has_fulltext":true,"cited_by_count":135,"citation_normalized_percentile":{"value":0.96005551,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"33","issue":"4","first_page":"471","last_page":"474"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11642","display_name":"Genomics and Rare Diseases","score":0.8123000264167786,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11642","display_name":"Genomics and Rare Diseases","score":0.8123000264167786,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10949","display_name":"Genetic Neurodegenerative Diseases","score":0.03099999949336052,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12331","display_name":"Hereditary Neurological Disorders","score":0.02710000053048134,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/haploinsufficiency","display_name":"Haploinsufficiency","score":0.7304139733314514},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.6950482130050659},{"id":"https://openalex.org/keywords/loss-function","display_name":"Loss function","score":0.6692330837249756},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.6559733152389526},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.562213122844696},{"id":"https://openalex.org/keywords/mutation","display_name":"Mutation","score":0.4590105414390564},{"id":"https://openalex.org/keywords/function","display_name":"Function (biology)","score":0.4543333649635315},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.39451712369918823},{"id":"https://openalex.org/keywords/phenotype","display_name":"Phenotype","score":0.21692022681236267}],"concepts":[{"id":"https://openalex.org/C68838962","wikidata":"https://www.wikidata.org/wiki/Q852654","display_name":"Haploinsufficiency","level":4,"score":0.7304139733314514},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6950482130050659},{"id":"https://openalex.org/C105951970","wikidata":"https://www.wikidata.org/wiki/Q1036748","display_name":"Loss function","level":4,"score":0.6692330837249756},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6559733152389526},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.562213122844696},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.4590105414390564},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.4543333649635315},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.39451712369918823},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.21692022681236267}],"mesh":[{"descriptor_ui":"D000073658","descriptor_name":"Loss of Function Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000073658","descriptor_name":"Loss of Function Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000073658","descriptor_name":"Loss of Function Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D030342","descriptor_name":"Genetic Diseases, Inborn","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D030342","descriptor_name":"Genetic Diseases, Inborn","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D030342","descriptor_name":"Genetic Diseases, Inborn","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bioinformatics/btv602","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btv602","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/33/4/471/25146562/btv602.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:27563026","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27563026","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:lup.lub.lu.se:7d3207be-0efd-4339-bd31-33c871c79a67","is_oa":false,"landing_page_url":"https://lup.lub.lu.se/record/7d3207be-0efd-4339-bd31-33c871c79a67","pdf_url":null,"source":{"id":"https://openalex.org/S4306400536","display_name":"Lund University Publications (Lund University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I187531555","host_organization_name":"Lund University","host_organization_lineage":["https://openalex.org/I187531555"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 1367-4803","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btv602","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btv602","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/33/4/471/25146562/btv602.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1005589922","display_name":null,"funder_award_id":"NNF16OC0021480","funder_id":"https://openalex.org/F4320325957","funder_display_name":"Novo Nordisk Fonden"},{"id":"https://openalex.org/G1014786138","display_name":null,"funder_award_id":"269045","funder_id":"https://openalex.org/F4320333065","funder_display_name":"Seventh Framework Programme"},{"id":"https://openalex.org/G1816994784","display_name":null,"funder_award_id":"FP7/2007-2013","funder_id":"https://openalex.org/F4320333065","funder_display_name":"Seventh Framework Programme"},{"id":"https://openalex.org/G209546920","display_name":null,"funder_award_id":"FP7/2007","funder_id":"https://openalex.org/F4320333065","funder_display_name":"Seventh Framework Programme"},{"id":"https://openalex.org/G3321368313","display_name":null,"funder_award_id":"269045","funder_id":"https://openalex.org/F4320338335","funder_display_name":"H2020 European Research Council"},{"id":"https://openalex.org/G3829048491","display_name":null,"funder_award_id":"FP7/2007-2013","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G5593277320","display_name":null,"funder_award_id":"2007-2013","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G5699539586","display_name":null,"funder_award_id":"115006","funder_id":"https://openalex.org/F4320326631","funder_display_name":"Innovative Medicines Initiative"},{"id":"https://openalex.org/G5702163051","display_name":null,"funder_award_id":"FP7/2007","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G7195248210","display_name":null,"funder_award_id":"FP7/2007-2013","funder_id":"https://openalex.org/F4320326631","funder_display_name":"Innovative Medicines Initiative"},{"id":"https://openalex.org/G7364720146","display_name":null,"funder_award_id":"FP7/2007-2013","funder_id":"https://openalex.org/F4320314178","funder_display_name":"European Federation of Pharmaceutical Industries and Associations"},{"id":"https://openalex.org/G7485613527","display_name":null,"funder_award_id":"2007-2013","funder_id":"https://openalex.org/F4320333065","funder_display_name":"Seventh Framework Programme"},{"id":"https://openalex.org/G8745101887","display_name":"SUrrogate markers for vascular Micro- and Macrovascular hard endpoints for Innovative diabetes Tools","funder_award_id":"115006","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320314178","display_name":"European Federation of Pharmaceutical Industries and Associations","ror":"https://ror.org/00g1x4v36"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320325957","display_name":"Novo Nordisk Fonden","ror":"https://ror.org/04txyc737"},{"id":"https://openalex.org/F4320326631","display_name":"Innovative Medicines Initiative","ror":"https://ror.org/019af4n30"},{"id":"https://openalex.org/F4320333065","display_name":"Seventh Framework Programme","ror":null},{"id":"https://openalex.org/F4320338335","display_name":"H2020 European Research Council","ror":"https://ror.org/0472cxd90"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2511281583.pdf","grobid_xml":"https://content.openalex.org/works/W2511281583.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W1533942137","https://openalex.org/W1563940013","https://openalex.org/W1749057191","https://openalex.org/W1964426200","https://openalex.org/W1984068087","https://openalex.org/W1987754412","https://openalex.org/W1990984319","https://openalex.org/W2023962370","https://openalex.org/W2024663595","https://openalex.org/W2032755318","https://openalex.org/W2050212230","https://openalex.org/W2058536769","https://openalex.org/W2063655230","https://openalex.org/W2070412833","https://openalex.org/W2086072858","https://openalex.org/W2100407705","https://openalex.org/W2101735289","https://openalex.org/W2104276565","https://openalex.org/W2104570606","https://openalex.org/W2106578986","https://openalex.org/W2117239785","https://openalex.org/W2119412782","https://openalex.org/W2136941319","https://openalex.org/W2138014988","https://openalex.org/W2138956466","https://openalex.org/W2143238378","https://openalex.org/W2143887298","https://openalex.org/W2154866190","https://openalex.org/W2172139908","https://openalex.org/W2558692177","https://openalex.org/W6633589378","https://openalex.org/W6663175288"],"related_works":["https://openalex.org/W2804323293","https://openalex.org/W4234813344","https://openalex.org/W4321099955","https://openalex.org/W2079712075","https://openalex.org/W4256529473","https://openalex.org/W4231038228","https://openalex.org/W2733092557","https://openalex.org/W2031015263","https://openalex.org/W4244639227","https://openalex.org/W2366111644"],"abstract_inverted_index":{"Motivation:":[0],"Depletion":[1],"of":[2,10,38,52,72,109,130],"loss-of-function":[3],"(LoF)":[4],"mutations":[5,25,93],"may":[6,125],"provide":[7],"a":[8,116],"rank":[9],"genic":[11],"functional":[12],"intolerance":[13,119,136],"and":[14,31,45,49,137,141],"consequently":[15],"susceptibility":[16],"to":[17,106],"disease.":[18],"Results:":[19],"Here":[20],"we":[21,103],"have":[22],"studied":[23],"LoF":[24,75,135],"in":[26,43,70,77,99,127,149],"60":[27],"706":[28],"unrelated":[29],"individuals":[30],"show":[32],"that":[33],"the":[34,73,150],"most":[35],"intolerant":[36],"quartile":[37],"ranked":[39],"genes":[40,76,129],"is":[41],"enriched":[42],"rare":[44],"early":[46],"onset":[47],"diseases":[48],"explains":[50],"87%":[51],"de":[53,90],"novo":[54,91],"haploinsufficient":[55,92],"OMIM":[56],"mutations,":[57],"17%":[58],"more":[59],"than":[60],"any":[61],"other":[62],"gene":[63,118,145],"scoring":[64],"tool.":[65],"We":[66],"detected":[67],"particular":[68],"enrichment":[69],"expression":[71],"depleted":[74],"brain":[78],"(odds":[79],"ratio":[80],"=":[81,85],"1.5;":[82],"P":[83],"-value":[84],"4.2e-07).":[86],"By":[87],"searching":[88],"for":[89],"putatively":[94],"associated":[95],"with":[96],"neurodevelopmental":[97],"disorders":[98],"four":[100],"recent":[101],"studies,":[102],"were":[104],"able":[105],"explain":[107],"81%":[108],"them.":[110],"Taken":[111],"together,":[112],"this":[113],"study":[114],"provides":[115],"novel":[117],"ranking":[120,128],"system,":[121],"called":[122],"LoFtool,":[123],"which":[124],"help":[126],"interest":[131],"based":[132],"on":[133],"their":[134],"tissue":[138],"expression.":[139],"Availability":[140],"implementation:":[142],"The":[143],"LoFtool":[144],"scores":[146],"are":[147,160],"available":[148,161],"Supplementary":[151,156,158],"data":[152,159],".":[153],"Contact:":[154],"joaofadista@gmail.com.":[155],"information:":[157],"at":[162],"Bioinformatics":[163],"online.":[164]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":17},{"year":2023,"cited_by_count":30},{"year":2022,"cited_by_count":20},{"year":2021,"cited_by_count":25},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":4}],"updated_date":"2026-07-13T07:31:44.756512","created_date":"2025-10-10T00:00:00"}
