{"id":"https://openalex.org/W1870389819","doi":"https://doi.org/10.1093/bioinformatics/btv568","title":"MT-HESS: an efficient Bayesian approach for simultaneous association detection in OMICS datasets, with application to eQTL mapping in multiple tissues","display_name":"MT-HESS: an efficient Bayesian approach for simultaneous association detection in OMICS datasets, with application to eQTL mapping in multiple tissues","publication_year":2015,"publication_date":"2015-10-26","ids":{"openalex":"https://openalex.org/W1870389819","doi":"https://doi.org/10.1093/bioinformatics/btv568","mag":"1870389819","pmid":"https://pubmed.ncbi.nlm.nih.gov/26504141"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btv568","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btv568","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/32/4/523/49017546/bioinformatics_32_4_523.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/32/4/523/49017546/bioinformatics_32_4_523.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074789240","display_name":"Alex Lewin","orcid":"https://orcid.org/0000-0003-0081-7582"},"institutions":[{"id":"https://openalex.org/I59433898","display_name":"Brunel University of London","ror":"https://ror.org/00dn4t376","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I59433898"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alex Lewin","raw_affiliation_strings":["1 Department of Mathematics, Brunel University London,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Mathematics, Brunel University London,","institution_ids":["https://openalex.org/I59433898"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Habib Saadi","orcid":null},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Habib Saadi","raw_affiliation_strings":["2 Department of Epidemiology and Biostatistics, Imperial College London, London,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2 Department of Epidemiology and Biostatistics, Imperial College London, London,","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030188473","display_name":"James E. Peters","orcid":"https://orcid.org/0000-0002-9415-3440"},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I4210134973","display_name":"MRC Biostatistics Unit","ror":"https://ror.org/046vje122","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I4210087105","https://openalex.org/I4210134973","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"James E. Peters","raw_affiliation_strings":["3 Cambridge Institute for Medical Research, University of Cambridge, Cambridge,","4 MRC Biostatistics Unit, Cambridge Institute of Public Health, Cambridge,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3 Cambridge Institute for Medical Research, University of Cambridge, Cambridge,","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"4 MRC Biostatistics Unit, Cambridge Institute of Public Health, Cambridge,","institution_ids":["https://openalex.org/I4210134973"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024786499","display_name":"Aida Moreno\u2010Moral","orcid":"https://orcid.org/0000-0002-8155-3146"},"institutions":[{"id":"https://openalex.org/I4210109636","display_name":"NIHR Imperial Biomedical Research Centre","ror":"https://ror.org/01kmhx639","country_code":"GB","type":"facility","lineage":["https://openalex.org/I34931013","https://openalex.org/I4210109636"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Aida Moreno-Moral","raw_affiliation_strings":["5 MRC Clinical Sciences Centre, Imperial College London, London, UK,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5 MRC Clinical Sciences Centre, Imperial College London, London, UK,","institution_ids":["https://openalex.org/I4210109636","https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100666789","display_name":"James Lee","orcid":"https://orcid.org/0000-0001-5711-9385"},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"James C. Lee","raw_affiliation_strings":["3 Cambridge Institute for Medical Research, University of Cambridge, Cambridge,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3 Cambridge Institute for Medical Research, University of Cambridge, Cambridge,","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001067070","display_name":"Kenneth G. C. Smith","orcid":"https://orcid.org/0000-0003-3829-4326"},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Kenneth G. C. Smith","raw_affiliation_strings":["3 Cambridge Institute for Medical Research, University of Cambridge, Cambridge,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3 Cambridge Institute for Medical Research, University of Cambridge, Cambridge,","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070290329","display_name":"Enrico Petretto","orcid":"https://orcid.org/0000-0003-2163-5921"},"institutions":[{"id":"https://openalex.org/I4210109636","display_name":"NIHR Imperial Biomedical Research Centre","ror":"https://ror.org/01kmhx639","country_code":"GB","type":"facility","lineage":["https://openalex.org/I34931013","https://openalex.org/I4210109636"]},{"id":"https://openalex.org/I4210126319","display_name":"Duke-NUS Medical School","ror":"https://ror.org/02j1m6098","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596","https://openalex.org/I170897317","https://openalex.org/I4210126319"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB","SG"],"is_corresponding":false,"raw_author_name":"Enrico Petretto","raw_affiliation_strings":["5 MRC Clinical Sciences Centre, Imperial College London, London, UK,","6 Duke-NUS Graduate Medical School, Singapore, Singapore,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5 MRC Clinical Sciences Centre, Imperial College London, London, UK,","institution_ids":["https://openalex.org/I4210109636","https://openalex.org/I47508984"]},{"raw_affiliation_string":"6 Duke-NUS Graduate Medical School, Singapore, Singapore,","institution_ids":["https://openalex.org/I4210126319"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016094222","display_name":"Leonardo Bottolo","orcid":"https://orcid.org/0000-0002-6381-2327"},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Leonardo Bottolo","raw_affiliation_strings":["7 Department of Mathematics, Imperial College London, London, UK and","8 Department of Medical Genetics, University of Cambridge"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"7 Department of Mathematics, Imperial College London, London, UK and","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"8 Department of Medical Genetics, University of Cambridge","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086827100","display_name":"Sylvia Richardson","orcid":"https://orcid.org/0000-0003-1998-492X"},"institutions":[{"id":"https://openalex.org/I4210134973","display_name":"MRC Biostatistics Unit","ror":"https://ror.org/046vje122","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I4210087105","https://openalex.org/I4210134973","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Sylvia Richardson","raw_affiliation_strings":["4 MRC Biostatistics Unit, Cambridge Institute of Public Health, Cambridge,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4 MRC Biostatistics Unit, Cambridge Institute of Public Health, Cambridge,","institution_ids":["https://openalex.org/I4210134973"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5016094222","https://openalex.org/A5086827100"],"corresponding_institution_ids":["https://openalex.org/I241749","https://openalex.org/I4210134973","https://openalex.org/I47508984"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":{"value":3618,"currency":"USD","value_usd":3618},"fwci":2.38,"has_fulltext":true,"cited_by_count":40,"citation_normalized_percentile":{"value":0.88972534,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"32","issue":"4","first_page":"523","last_page":"532"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9721999764442444,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9721999764442444,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.008100000210106373,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/expression-quantitative-trait-loci","display_name":"Expression quantitative trait loci","score":0.7792844176292419},{"id":"https://openalex.org/keywords/bayesian-probability","display_name":"Bayesian probability","score":0.6013866662979126},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5220296382904053},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4837932288646698},{"id":"https://openalex.org/keywords/genetic-association","display_name":"Genetic association","score":0.47418174147605896},{"id":"https://openalex.org/keywords/bayesian-hierarchical-modeling","display_name":"Bayesian hierarchical modeling","score":0.4506903886795044},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphism","display_name":"Single-nucleotide polymorphism","score":0.44883227348327637},{"id":"https://openalex.org/keywords/genome-wide-association-study","display_name":"Genome-wide association study","score":0.44565606117248535},{"id":"https://openalex.org/keywords/leverage","display_name":"Leverage (statistics)","score":0.4368930160999298},{"id":"https://openalex.org/keywords/statistical-power","display_name":"Statistical power","score":0.43359124660491943},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.4299893379211426},{"id":"https://openalex.org/keywords/multiple-comparisons-problem","display_name":"Multiple comparisons problem","score":0.42992857098579407},{"id":"https://openalex.org/keywords/multivariate-statistics","display_name":"Multivariate statistics","score":0.4163784980773926},{"id":"https://openalex.org/keywords/bayes-theorem","display_name":"Bayes' theorem","score":0.41588103771209717},{"id":"https://openalex.org/keywords/regression","display_name":"Regression","score":0.4130100607872009},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3463730812072754},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.3295174837112427},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.2475963830947876},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.19956165552139282},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.15363669395446777},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.15090882778167725},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.12374210357666016}],"concepts":[{"id":"https://openalex.org/C168393362","wikidata":"https://www.wikidata.org/wiki/Q5421706","display_name":"Expression quantitative trait loci","level":5,"score":0.7792844176292419},{"id":"https://openalex.org/C107673813","wikidata":"https://www.wikidata.org/wiki/Q812534","display_name":"Bayesian probability","level":2,"score":0.6013866662979126},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5220296382904053},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4837932288646698},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.47418174147605896},{"id":"https://openalex.org/C191413810","wikidata":"https://www.wikidata.org/wiki/Q17100952","display_name":"Bayesian hierarchical modeling","level":4,"score":0.4506903886795044},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.44883227348327637},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.44565606117248535},{"id":"https://openalex.org/C153083717","wikidata":"https://www.wikidata.org/wiki/Q6535263","display_name":"Leverage (statistics)","level":2,"score":0.4368930160999298},{"id":"https://openalex.org/C96608239","wikidata":"https://www.wikidata.org/wiki/Q1199823","display_name":"Statistical power","level":2,"score":0.43359124660491943},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.4299893379211426},{"id":"https://openalex.org/C183905921","wikidata":"https://www.wikidata.org/wiki/Q1038757","display_name":"Multiple comparisons problem","level":2,"score":0.42992857098579407},{"id":"https://openalex.org/C161584116","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate statistics","level":2,"score":0.4163784980773926},{"id":"https://openalex.org/C207201462","wikidata":"https://www.wikidata.org/wiki/Q182505","display_name":"Bayes' theorem","level":3,"score":0.41588103771209717},{"id":"https://openalex.org/C83546350","wikidata":"https://www.wikidata.org/wiki/Q1139051","display_name":"Regression","level":2,"score":0.4130100607872009},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3463730812072754},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3295174837112427},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.2475963830947876},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.19956165552139282},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.15363669395446777},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15090882778167725},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.12374210357666016},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011381","descriptor_name":"Programming Languages","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011381","descriptor_name":"Programming Languages","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011381","descriptor_name":"Programming Languages","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011381","descriptor_name":"Programming Languages","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015212","descriptor_name":"Inflammatory Bowel Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015212","descriptor_name":"Inflammatory Bowel Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015212","descriptor_name":"Inflammatory Bowel Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015212","descriptor_name":"Inflammatory Bowel Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":9,"locations":[{"id":"doi:10.1093/bioinformatics/btv568","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btv568","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/32/4/523/49017546/bioinformatics_32_4_523.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:26504141","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26504141","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:researchonline.lshtm.ac.uk:4649141","is_oa":false,"landing_page_url":"https://researchonline.lshtm.ac.uk/view/creators/emsualew.html>;","pdf_url":null,"source":{"id":"https://openalex.org/S4306402527","display_name":"LSHTM Research Online (London School of Hygiene and Tropical Medicine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210089966","host_organization_name":"London School of Hygiene & Tropical Medicine","host_organization_lineage":["https://openalex.org/I4210089966"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:www.repository.cam.ac.uk:1810/279502","is_oa":true,"landing_page_url":"https://www.repository.cam.ac.uk/handle/1810/279502","pdf_url":"https://www.repository.cam.ac.uk/handle/1810/279502","source":{"id":"https://openalex.org/S4306401777","display_name":"Apollo (University of Cambridge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I241749","host_organization_name":"University of Cambridge","host_organization_lineage":["https://openalex.org/I241749"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:bura.brunel.ac.uk:2438/12716","is_oa":false,"landing_page_url":"http://bura.brunel.ac.uk/handle/2438/12716","pdf_url":null,"source":{"id":"https://openalex.org/S4306401473","display_name":"Brunel University Research Archive (BURA) (Brunel University London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I59433898","host_organization_name":"Brunel University of London","host_organization_lineage":["https://openalex.org/I59433898"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:open-archive.highwire.org:bioinfo:32/4/523","is_oa":false,"landing_page_url":"http://bioinformatics.oxfordjournals.org/cgi/content/short/32/4/523","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"},{"id":"pmh:oai:pubmedcentral.nih.gov:4743623","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4743623","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"Text"},{"id":"pmh:oai:spiral.imperial.ac.uk:10044/1/41065","is_oa":true,"landing_page_url":"http://hdl.handle.net/10044/1/41065","pdf_url":null,"source":{"id":"https://openalex.org/S4306401396","display_name":"Spiral (Imperial College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I47508984","host_organization_name":"Imperial College London","host_organization_lineage":["https://openalex.org/I47508984"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"532","raw_type":"Journal Article"},{"id":"doi:10.17863/cam.26876","is_oa":true,"landing_page_url":"https://doi.org/10.17863/cam.26876","pdf_url":null,"source":{"id":"https://openalex.org/S7407050737","display_name":"Apollo","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btv568","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btv568","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/32/4/523/49017546/bioinformatics_32_4_523.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.46000000834465027,"id":"https://metadata.un.org/sdg/17","display_name":"Partnerships for the goals"}],"awards":[{"id":"https://openalex.org/G174719709","display_name":"Small Items of Research Equipment at Imperial College London","funder_award_id":"EP/K030760/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G176017220","display_name":null,"funder_award_id":"EP/K030760/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G286410827","display_name":null,"funder_award_id":"EP/K030760","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G3078340812","display_name":"Integrated network analysis of the regulation of left ventricular hypertrophy and microvascular remodelling","funder_award_id":"FS/11/25/28740","funder_id":"https://openalex.org/F4320319992","funder_display_name":"British Heart Foundation"},{"id":"https://openalex.org/G3858069403","display_name":null,"funder_award_id":"083650/Z/07/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G4869868672","display_name":"Cellular Medicine at the Cambridge Institute for Medical Research.","funder_award_id":"100140","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G5030582063","display_name":null,"funder_award_id":"MR/M013138/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G5787068823","display_name":null,"funder_award_id":"G1002319","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G7368943397","display_name":null,"funder_award_id":"100140/Z/12/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320319992","display_name":"British Heart Foundation","ror":"https://ror.org/02wdwnk04"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"},{"id":"https://openalex.org/F4320336709","display_name":"NIHR Cambridge Biomedical Research Centre","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1870389819.pdf","grobid_xml":"https://content.openalex.org/works/W1870389819.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W109386094","https://openalex.org/W1816176398","https://openalex.org/W1978236554","https://openalex.org/W1986911601","https://openalex.org/W1997494129","https://openalex.org/W2009178411","https://openalex.org/W2020389170","https://openalex.org/W2025897051","https://openalex.org/W2029459061","https://openalex.org/W2035451872","https://openalex.org/W2044849026","https://openalex.org/W2048868021","https://openalex.org/W2069728797","https://openalex.org/W2078370799","https://openalex.org/W2100697281","https://openalex.org/W2101280135","https://openalex.org/W2105349784","https://openalex.org/W2108530422","https://openalex.org/W2112793962","https://openalex.org/W2116265489","https://openalex.org/W2130854041","https://openalex.org/W2133045519","https://openalex.org/W2135199713","https://openalex.org/W2143736326","https://openalex.org/W2152438005","https://openalex.org/W2156948997","https://openalex.org/W2159347337","https://openalex.org/W2160624840","https://openalex.org/W2166903146","https://openalex.org/W2171863224","https://openalex.org/W2185425968","https://openalex.org/W2197585008","https://openalex.org/W2259938310","https://openalex.org/W2481795843","https://openalex.org/W2519244818","https://openalex.org/W2963680191","https://openalex.org/W6604525207","https://openalex.org/W6722100533","https://openalex.org/W7056616908"],"related_works":["https://openalex.org/W2949247377","https://openalex.org/W2766106220","https://openalex.org/W2067135330","https://openalex.org/W4385388142","https://openalex.org/W2113330311","https://openalex.org/W154531455","https://openalex.org/W2620592310","https://openalex.org/W4388293756","https://openalex.org/W22819304","https://openalex.org/W1570450443"],"abstract_inverted_index":{"MOTIVATION:":[0],"Analysing":[1],"the":[2,34,45,87,143,164,170],"joint":[3],"association":[4,88,119],"between":[5,89,121,145],"a":[6,14,73,81,90,127,140,152],"large":[7,91],"set":[8,92],"of":[9,47,93,136,142,166,172,186],"responses":[10,124],"and":[11,97,123,125,200,223],"predictors":[12],"is":[13],"fundamental":[15],"statistical":[16],"task":[17],"in":[18,103,179],"integrative":[19],"genomics,":[20],"exemplified":[21],"by":[22,197],"numerous":[23],"expression":[24,46],"Quantitative":[25],"Trait":[26],"Loci":[27],"(eQTL)":[28],"studies.":[29],"Of":[30],"particular":[31,74],"interest":[32],"are":[33,57,70,212,228],"so-called":[35],"':":[36,38,116,118],"hotspots":[37,192],",":[39],"important":[40],"genetic":[41],"variants":[42],"that":[43,85,193],"regulate":[44],"many":[48,98],"genes.":[49],"Recently,":[50],"attention":[51],"has":[52],"focussed":[53],"on":[54],"whether":[55,68],"eQTLs":[56],"common":[58],"to":[59,72,155],"several":[60,210],"tissues,":[61,105],"cell-types":[62],"or,":[63],"more":[64],"generally,":[65],"conditions":[66],"or":[67,107],"they":[69],"specific":[71],"condition.":[75],"RESULTS:":[76],"We":[77,168],"have":[78],"implemented":[79],"MT-HESS,":[80],"Bayesian":[82,110],"hierarchical":[83,153],"model":[84,130,141],"analyses":[86],"predictors,":[94],"e.g.":[95,100],"SNPs,":[96,137],"responses,":[99],"gene":[101],"expression,":[102],"multiple":[104],"cells":[106],"conditions.":[108],"Our":[109,184],"sparse":[111],"regression":[112],"algorithm":[113],"goes":[114],"beyond":[115],"one-at-a-time":[117],"tests":[120],"SNPs":[122],"uses":[126],"fully":[128],"multivariate":[129],"search":[131],"across":[132,159],"all":[133],"linear":[134],"combinations":[135],"coupled":[138],"with":[139],"correlation":[144],"condition/tissue-specific":[146],"responses.":[147],"In":[148],"addition,":[149],"we":[150],"use":[151],"structure":[154],"leverage":[156],"shared":[157],"information":[158],"different":[160],"genes,":[161],"thus":[162],"improving":[163],"detection":[165],"hotspots.":[167],"show":[169],"increase":[171],"power":[173,205],"resulting":[174],"from":[175],"our":[176],"new":[177,191],"approach":[178],"an":[180],"extensive":[181],"simulation":[182],"study.":[183],"analysis":[185],"two":[187],"case":[188],"studies":[189],"highlights":[190],"would":[194],"remain":[195],"undetected":[196],"standard":[198],"approaches":[199],"shows":[201],"how":[202],"greater":[203],"prediction":[204],"can":[206],"be":[207],"achieved":[208],"when":[209],"tissues":[211],"jointly":[213],"considered.":[214],"AVAILABILITY":[215],"AND":[216],"IMPLEMENTATION:":[217],"C[Formula:":[218],"see":[219],"text]":[220],"source":[221],"code":[222],"documentation":[224],"including":[225],"compilation":[226],"instructions":[227],"available":[229],"under":[230],"GNU":[231],"licence":[232],"at":[233],"http://www.mrc-bsu.cam.ac.uk/software/.":[234]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3}],"updated_date":"2026-06-18T08:10:14.011955","created_date":"2025-10-10T00:00:00"}