{"id":"https://openalex.org/W1664117961","doi":"https://doi.org/10.1093/bioinformatics/btv542","title":"CD30 cell graphs of Hodgkin lymphoma are not scale-free\u2014an image analysis approach","display_name":"CD30 cell graphs of Hodgkin lymphoma are not scale-free\u2014an image analysis approach","publication_year":2015,"publication_date":"2015-09-11","ids":{"openalex":"https://openalex.org/W1664117961","doi":"https://doi.org/10.1093/bioinformatics/btv542","mag":"1664117961","pmid":"https://pubmed.ncbi.nlm.nih.gov/26363177"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btv542","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btv542","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/32/1/122/49016593/bioinformatics_32_1_122.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/32/1/122/49016593/bioinformatics_32_1_122.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043065288","display_name":"Hendrik Sch\u00e4fer","orcid":null},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]},{"id":"https://openalex.org/I4210155092","display_name":"Czech Academy of Sciences, Institute of Computer Science","ror":"https://ror.org/0496n6574","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210155092"]}],"countries":["CZ","DE"],"is_corresponding":false,"raw_author_name":"Hendrik Sch\u00e4fer","raw_affiliation_strings":["1 Department of Molecular Bioinformatics, Institute of Computer Science, Cluster of Excellence Macromolecular Complexes, Johann Wolfgang Goethe-University Frankfurt am Main, Robert-Mayer-Str. 11-15, 60325 Frankfurt am Main and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Molecular Bioinformatics, Institute of Computer Science, Cluster of Excellence Macromolecular Complexes, Johann Wolfgang Goethe-University Frankfurt am Main, Robert-Mayer-Str. 11-15, 60325 Frankfurt am Main and","institution_ids":["https://openalex.org/I114090438","https://openalex.org/I4210155092"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113949256","display_name":"Tim Sch\u00e4fer","orcid":null},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]},{"id":"https://openalex.org/I4210155092","display_name":"Czech Academy of Sciences, Institute of Computer Science","ror":"https://ror.org/0496n6574","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210155092"]}],"countries":["CZ","DE"],"is_corresponding":false,"raw_author_name":"Tim Sch\u00e4fer","raw_affiliation_strings":["1 Department of Molecular Bioinformatics, Institute of Computer Science, Cluster of Excellence Macromolecular Complexes, Johann Wolfgang Goethe-University Frankfurt am Main, Robert-Mayer-Str. 11-15, 60325 Frankfurt am Main and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Molecular Bioinformatics, Institute of Computer Science, Cluster of Excellence Macromolecular Complexes, Johann Wolfgang Goethe-University Frankfurt am Main, Robert-Mayer-Str. 11-15, 60325 Frankfurt am Main and","institution_ids":["https://openalex.org/I114090438","https://openalex.org/I4210155092"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101628744","display_name":"J\u00f6rg Ackermann","orcid":"https://orcid.org/0000-0002-9942-0958"},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]},{"id":"https://openalex.org/I4210155092","display_name":"Czech Academy of Sciences, Institute of Computer Science","ror":"https://ror.org/0496n6574","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210155092"]}],"countries":["CZ","DE"],"is_corresponding":false,"raw_author_name":"J\u00f6rg Ackermann","raw_affiliation_strings":["1 Department of Molecular Bioinformatics, Institute of Computer Science, Cluster of Excellence Macromolecular Complexes, Johann Wolfgang Goethe-University Frankfurt am Main, Robert-Mayer-Str. 11-15, 60325 Frankfurt am Main and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Molecular Bioinformatics, Institute of Computer Science, Cluster of Excellence Macromolecular Complexes, Johann Wolfgang Goethe-University Frankfurt am Main, Robert-Mayer-Str. 11-15, 60325 Frankfurt am Main and","institution_ids":["https://openalex.org/I114090438","https://openalex.org/I4210155092"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014550028","display_name":"Norbert Dichter","orcid":null},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]},{"id":"https://openalex.org/I4210155092","display_name":"Czech Academy of Sciences, Institute of Computer Science","ror":"https://ror.org/0496n6574","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210155092"]}],"countries":["CZ","DE"],"is_corresponding":false,"raw_author_name":"Norbert Dichter","raw_affiliation_strings":["1 Department of Molecular Bioinformatics, Institute of Computer Science, Cluster of Excellence Macromolecular Complexes, Johann Wolfgang Goethe-University Frankfurt am Main, Robert-Mayer-Str. 11-15, 60325 Frankfurt am Main and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Molecular Bioinformatics, Institute of Computer Science, Cluster of Excellence Macromolecular Complexes, Johann Wolfgang Goethe-University Frankfurt am Main, Robert-Mayer-Str. 11-15, 60325 Frankfurt am Main and","institution_ids":["https://openalex.org/I114090438","https://openalex.org/I4210155092"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113813524","display_name":"Claudia D\u00f6ring","orcid":null},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]},{"id":"https://openalex.org/I4210132578","display_name":"University Hospital Frankfurt","ror":"https://ror.org/03f6n9m15","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210132578"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Claudia D\u00f6ring","raw_affiliation_strings":["2 Dr. Senckenbergisches Institut f\u00fcr Pathologie, Universit\u00e4tsklinikum Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2 Dr. Senckenbergisches Institut f\u00fcr Pathologie, Universit\u00e4tsklinikum Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany","institution_ids":["https://openalex.org/I114090438","https://openalex.org/I4210132578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061378179","display_name":"Sylvia Hartmann","orcid":"https://orcid.org/0000-0003-3424-1091"},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]},{"id":"https://openalex.org/I4210132578","display_name":"University Hospital Frankfurt","ror":"https://ror.org/03f6n9m15","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210132578"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sylvia Hartmann","raw_affiliation_strings":["2 Dr. Senckenbergisches Institut f\u00fcr Pathologie, Universit\u00e4tsklinikum Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2 Dr. Senckenbergisches Institut f\u00fcr Pathologie, Universit\u00e4tsklinikum Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany","institution_ids":["https://openalex.org/I114090438","https://openalex.org/I4210132578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108083069","display_name":"Martin\u2010Leo Hansmann","orcid":null},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]},{"id":"https://openalex.org/I4210132578","display_name":"University Hospital Frankfurt","ror":"https://ror.org/03f6n9m15","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210132578"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Martin-Leo Hansmann","raw_affiliation_strings":["2 Dr. Senckenbergisches Institut f\u00fcr Pathologie, Universit\u00e4tsklinikum Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2 Dr. Senckenbergisches Institut f\u00fcr Pathologie, Universit\u00e4tsklinikum Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany","institution_ids":["https://openalex.org/I114090438","https://openalex.org/I4210132578"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015346451","display_name":"Ina Koch","orcid":"https://orcid.org/0000-0002-3621-003X"},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]},{"id":"https://openalex.org/I4210155092","display_name":"Czech Academy of Sciences, Institute of Computer Science","ror":"https://ror.org/0496n6574","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210155092"]}],"countries":["CZ","DE"],"is_corresponding":true,"raw_author_name":"Ina Koch","raw_affiliation_strings":["1 Department of Molecular Bioinformatics, Institute of Computer Science, Cluster of Excellence Macromolecular Complexes, Johann Wolfgang Goethe-University Frankfurt am Main, Robert-Mayer-Str. 11-15, 60325 Frankfurt am Main and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Molecular Bioinformatics, Institute of Computer Science, Cluster of Excellence Macromolecular Complexes, Johann Wolfgang Goethe-University Frankfurt am Main, Robert-Mayer-Str. 11-15, 60325 Frankfurt am Main and","institution_ids":["https://openalex.org/I114090438","https://openalex.org/I4210155092"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5015346451"],"corresponding_institution_ids":["https://openalex.org/I114090438","https://openalex.org/I4210155092"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":2.1078,"has_fulltext":true,"cited_by_count":20,"citation_normalized_percentile":{"value":0.90284149,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"32","issue":"1","first_page":"122","last_page":"129"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.5893999934196472,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.5893999934196472,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.0763000026345253,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10052","display_name":"Medical Image Segmentation Techniques","score":0.0737999975681305,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vertex","display_name":"Vertex (graph theory)","score":0.512148380279541},{"id":"https://openalex.org/keywords/color-coding","display_name":"Color-coding","score":0.5040292143821716},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4887115955352783},{"id":"https://openalex.org/keywords/cd30","display_name":"CD30","score":0.472752183675766},{"id":"https://openalex.org/keywords/lymph-node","display_name":"Lymph node","score":0.4626188576221466},{"id":"https://openalex.org/keywords/lymphoma","display_name":"Lymphoma","score":0.44344085454940796},{"id":"https://openalex.org/keywords/graph","display_name":"Graph","score":0.39315930008888245},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.36057040095329285},{"id":"https://openalex.org/keywords/combinatorics","display_name":"Combinatorics","score":0.32093021273612976},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.3181917071342468},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.2316756546497345},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.18921729922294617},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.1678178310394287}],"concepts":[{"id":"https://openalex.org/C80899671","wikidata":"https://www.wikidata.org/wiki/Q1304193","display_name":"Vertex (graph theory)","level":3,"score":0.512148380279541},{"id":"https://openalex.org/C104597421","wikidata":"https://www.wikidata.org/wiki/Q5148529","display_name":"Color-coding","level":2,"score":0.5040292143821716},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4887115955352783},{"id":"https://openalex.org/C70905583","wikidata":"https://www.wikidata.org/wiki/Q3648608","display_name":"CD30","level":3,"score":0.472752183675766},{"id":"https://openalex.org/C2780849966","wikidata":"https://www.wikidata.org/wiki/Q170758","display_name":"Lymph node","level":2,"score":0.4626188576221466},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.44344085454940796},{"id":"https://openalex.org/C132525143","wikidata":"https://www.wikidata.org/wiki/Q141488","display_name":"Graph","level":2,"score":0.39315930008888245},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.36057040095329285},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.32093021273612976},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.3181917071342468},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.2316756546497345},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.18921729922294617},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1678178310394287}],"mesh":[{"descriptor_ui":"D002449","descriptor_name":"Cell Aggregation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002449","descriptor_name":"Cell Aggregation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002449","descriptor_name":"Cell Aggregation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002452","descriptor_name":"Cell Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002452","descriptor_name":"Cell Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002452","descriptor_name":"Cell Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006689","descriptor_name":"Hodgkin Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006689","descriptor_name":"Hodgkin Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006689","descriptor_name":"Hodgkin Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006689","descriptor_name":"Hodgkin Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006689","descriptor_name":"Hodgkin Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006689","descriptor_name":"Hodgkin Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017730","descriptor_name":"Ki-1 Antigen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017730","descriptor_name":"Ki-1 Antigen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017730","descriptor_name":"Ki-1 Antigen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/bioinformatics/btv542","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btv542","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/32/1/122/49016593/bioinformatics_32_1_122.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:26363177","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26363177","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btv542","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btv542","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/32/1/122/49016593/bioinformatics_32_1_122.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320324430","display_name":"Friedrich Naumann Stiftung","ror":"https://ror.org/04qy50a03"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1664117961.pdf","grobid_xml":"https://content.openalex.org/works/W1664117961.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W1490441963","https://openalex.org/W1501069996","https://openalex.org/W1523069120","https://openalex.org/W1549012094","https://openalex.org/W1554739819","https://openalex.org/W1605230984","https://openalex.org/W1900291629","https://openalex.org/W1965824265","https://openalex.org/W1971196949","https://openalex.org/W1974781388","https://openalex.org/W1979614424","https://openalex.org/W1982390426","https://openalex.org/W1983874109","https://openalex.org/W1990433019","https://openalex.org/W1992814851","https://openalex.org/W1994292275","https://openalex.org/W1994401253","https://openalex.org/W2006632549","https://openalex.org/W2008263861","https://openalex.org/W2008620264","https://openalex.org/W2014676949","https://openalex.org/W2024984678","https://openalex.org/W2031147505","https://openalex.org/W2037586865","https://openalex.org/W2051132263","https://openalex.org/W2063572899","https://openalex.org/W2064557552","https://openalex.org/W2069898971","https://openalex.org/W2073554231","https://openalex.org/W2074829227","https://openalex.org/W2075762450","https://openalex.org/W2083929635","https://openalex.org/W2112090702","https://openalex.org/W2124637492","https://openalex.org/W2126563020","https://openalex.org/W2132031490","https://openalex.org/W2144885342","https://openalex.org/W2154536753","https://openalex.org/W2154813452","https://openalex.org/W2161634498","https://openalex.org/W2613177285","https://openalex.org/W3103786587","https://openalex.org/W4229921563","https://openalex.org/W4252401126","https://openalex.org/W4312512934","https://openalex.org/W6656854094"],"related_works":["https://openalex.org/W4383369002","https://openalex.org/W4206462147","https://openalex.org/W2981634038","https://openalex.org/W2126854625","https://openalex.org/W4376226532","https://openalex.org/W2981453158","https://openalex.org/W2105446032","https://openalex.org/W1968571833","https://openalex.org/W2399211474","https://openalex.org/W2353137601"],"abstract_inverted_index":{"MOTIVATION:":[0],"Hodgkin":[1],"lymphoma":[2],"(HL)":[3],"is":[4,41,201,267],"a":[5,172,185,198],"type":[6],"of":[7,37,47,61,68,101,115,124,134,156,164,192,209,229,244],"B-cell":[8],"lymphoma.":[9],"To":[10],"diagnose":[11],"the":[12,34,44,59,66,72,76,99,113,116,142,160,193,205,222,245],"subtypes,":[13],"biopsies":[14],"are":[15,21,216,277],"taken":[16],"and":[17,75,85,104,131,137,153,168,226,232,250],"immunostained.":[18],"The":[19,240,260],"slides":[20],"scanned":[22],"to":[23,127,171,203],"produce":[24],"high-resolution":[25],"digital":[26,102],"whole":[27],"slide":[28],"images":[29],"(WSI).":[30],"Pathologists":[31],"manually":[32],"inspect":[33],"spatial":[35,139],"distribution":[36,140,200],"cells,":[38],"but":[39],"little":[40],"known":[42],"on":[43,112],"statistical":[45],"properties":[46,53],"cell":[48,88,166,176,211,265],"distributions":[49,163,208,243],"in":[50,71,94,141],"WSIs.":[51],"Such":[52],"would":[54],"give":[55],"valuable":[56],"information":[57],"for":[58,224,264],"construction":[60],"theoretical":[62],"models":[63],"that":[64,197,214],"describe":[65],"invasion":[67],"malignant":[69],"cells":[70,93,136],"lymph":[73,143],"node":[74,144],"intercellular":[77],"interactions.":[78],"RESULTS:":[79],"In":[80],"this":[81],"work,":[82],"we":[83,220],"define":[84,108],"discuss":[86],"HL":[87,95,135,234,247,253],"graphs.":[89],"We":[90,107,119,158,195],"identify":[91],"CD30(+)":[92],"WSIs,":[96],"bringing":[97],"together":[98],"fields":[100],"imaging":[103],"network":[105],"analysis.":[106],"special":[109],"graphs":[110,167,177,223],"based":[111],"positions":[114],"immunostained":[117],"cells.":[118,194],"present":[120],"an":[121],"automatic":[122],"analysis":[123],"complete":[125],"WSIs":[126],"determine":[128],"significant":[129],"morphological":[130],"immunohistochemical":[132],"features":[133],"their":[138],"tissue":[145],"under":[146],"three":[147],"different":[148,236],"medical":[149],"conditions:":[150],"lymphadenitis":[151],"(LA)":[152],"two":[154,227,246],"types":[155],"HL.":[157,230],"analyze":[159],"vertex":[161,180,206,237,241],"degree":[162,207,238,242],"CD30":[165,175,210],"compare":[169,221],"them":[170],"null":[173],"model.":[174],"show":[178],"higher":[179],"degrees":[181],"than":[182],"expected":[183],"by":[184],"random":[186],"unit":[187],"disk":[188],"graph,":[189],"suggesting":[190],"clustering":[191],"found":[196],"gamma":[199],"suitable":[202],"model":[204],"graphs,":[212],"meaning":[213],"they":[215],"not":[217],"scale-free.":[218],"Moreover,":[219],"LA":[225,231],"subtypes":[228,248],"classical":[233],"showed":[235],"distributions.":[239],"NScHL":[249],"mixed":[251],"cellularity":[252],"(MXcHL)":[254],"were":[255],"similar.":[256],"AVAILABILITY":[257],"AND":[258],"IMPLEMENTATION:":[259],"CellProfiler":[261],"pipeline":[262],"used":[263],"detection":[266],"available":[268,278],"at":[269,279],"https://sourceforge.net/projects/cellgraphs/.":[270],"CONTACT:":[271],"ina.koch@bioinformatik.uni-frankfurt.de":[272],"SUPPLEMENTARY":[273],"INFORMATION:":[274],"Supplementary":[275],"data":[276],"Bioinformatics":[280],"online.":[281]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1}],"updated_date":"2026-07-22T07:51:19.307946","created_date":"2025-10-10T00:00:00"}
