{"id":"https://openalex.org/W2235818404","doi":"https://doi.org/10.1093/bioinformatics/btv535","title":"Group and sparse group partial least square approaches applied in genomics context","display_name":"Group and sparse group partial least square approaches applied in genomics context","publication_year":2015,"publication_date":"2015-09-10","ids":{"openalex":"https://openalex.org/W2235818404","doi":"https://doi.org/10.1093/bioinformatics/btv535","mag":"2235818404","pmid":"https://pubmed.ncbi.nlm.nih.gov/26358727"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btv535","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btv535","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/32/1/35/49016265/bioinformatics_32_1_35.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/32/1/35/49016265/bioinformatics_32_1_35.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040962966","display_name":"Beno\u00eet Liquet","orcid":"https://orcid.org/0000-0002-8136-2294"},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]},{"id":"https://openalex.org/I4210123005","display_name":"ARC Centre of Excellence for Mathematical and Statistical Frontiers","ror":"https://ror.org/02vcqg248","country_code":"AU","type":"facility","lineage":["https://openalex.org/I1337719021","https://openalex.org/I165779595","https://openalex.org/I2801453606","https://openalex.org/I4210123005","https://openalex.org/I4210132349"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Beno\u00eet Liquet","raw_affiliation_strings":["1 School of Mathematics and Physics, The University of Queensland, Brisbane 4066, Australia,","2 ARC Centre of Excellence for Mathematical and Statistical Frontiers, QUT, Brisbane, Australia,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 School of Mathematics and Physics, The University of Queensland, Brisbane 4066, Australia,","institution_ids":["https://openalex.org/I165143802"]},{"raw_affiliation_string":"2 ARC Centre of Excellence for Mathematical and Statistical Frontiers, QUT, Brisbane, Australia,","institution_ids":["https://openalex.org/I4210123005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021848861","display_name":"Pierre Lafaye de Micheaux","orcid":"https://orcid.org/0000-0002-0247-5136"},"institutions":[{"id":"https://openalex.org/I4210094214","display_name":"\u00c9cole Nationale de la Statistique et de l'Analyse de l'Information","ror":"https://ror.org/00k206f19","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210094214","https://openalex.org/I4210108488"]},{"id":"https://openalex.org/I4210137396","display_name":"Centre de Recherche en \u00c9conomie et Statistique","ror":"https://ror.org/0449khs19","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I142476485","https://openalex.org/I4210108488","https://openalex.org/I4210108488","https://openalex.org/I4210137396","https://openalex.org/I4210145102","https://openalex.org/I4210145102","https://openalex.org/I4210150854","https://openalex.org/I84009706"]},{"id":"https://openalex.org/I84009706","display_name":"ENSAE Paris","ror":"https://ror.org/01fz7mn40","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210108488","https://openalex.org/I4210145102","https://openalex.org/I84009706"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Pierre Lafaye de Micheaux","raw_affiliation_strings":["3 CREST, ENSAI, Campus de Ker-Lann, Rue Blaise Pascal, BP 37203, 35172 Bruz cedex, France,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3 CREST, ENSAI, Campus de Ker-Lann, Rue Blaise Pascal, BP 37203, 35172 Bruz cedex, France,","institution_ids":["https://openalex.org/I84009706","https://openalex.org/I4210137396","https://openalex.org/I4210094214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068107043","display_name":"Boris P. Hejblum","orcid":"https://orcid.org/0000-0003-0646-452X"},"institutions":[{"id":"https://openalex.org/I1326498283","display_name":"Institut national de recherche en sciences et technologies du num\u00e9rique","ror":"https://ror.org/02kvxyf05","country_code":"FR","type":"government","lineage":["https://openalex.org/I1326498283"]},{"id":"https://openalex.org/I15057530","display_name":"Universit\u00e9 de Bordeaux","ror":"https://ror.org/057qpr032","country_code":"FR","type":"education","lineage":["https://openalex.org/I15057530"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210106115","display_name":"Bordeaux Population Health","ror":"https://ror.org/00xzzba89","country_code":"FR","type":"facility","lineage":["https://openalex.org/I15057530","https://openalex.org/I154526488","https://openalex.org/I4210106115"]},{"id":"https://openalex.org/I4210119150","display_name":"Institut de Recherche Vaccinale","ror":"https://ror.org/02f9r3321","country_code":"FR","type":"facility","lineage":["https://openalex.org/I197681013","https://openalex.org/I4210116296","https://openalex.org/I4210119150"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Boris P. Hejblum","raw_affiliation_strings":["4 Inria, SISTM, Talence and","5 Inserm, U897, Bordeaux,","6 Bordeaux University, Bordeaux and","7 Vaccine Research Institute, Creteil, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4 Inria, SISTM, Talence and","institution_ids":["https://openalex.org/I1326498283"]},{"raw_affiliation_string":"5 Inserm, U897, Bordeaux,","institution_ids":["https://openalex.org/I4210106115","https://openalex.org/I154526488"]},{"raw_affiliation_string":"6 Bordeaux University, Bordeaux and","institution_ids":["https://openalex.org/I15057530"]},{"raw_affiliation_string":"7 Vaccine Research Institute, Creteil, France","institution_ids":["https://openalex.org/I4210119150"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022077216","display_name":"Rodolphe Thi\u00e9baut","orcid":"https://orcid.org/0000-0002-5235-3962"},"institutions":[{"id":"https://openalex.org/I1326498283","display_name":"Institut national de recherche en sciences et technologies du num\u00e9rique","ror":"https://ror.org/02kvxyf05","country_code":"FR","type":"government","lineage":["https://openalex.org/I1326498283"]},{"id":"https://openalex.org/I15057530","display_name":"Universit\u00e9 de Bordeaux","ror":"https://ror.org/057qpr032","country_code":"FR","type":"education","lineage":["https://openalex.org/I15057530"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210106115","display_name":"Bordeaux Population Health","ror":"https://ror.org/00xzzba89","country_code":"FR","type":"facility","lineage":["https://openalex.org/I15057530","https://openalex.org/I154526488","https://openalex.org/I4210106115"]},{"id":"https://openalex.org/I4210119150","display_name":"Institut de Recherche Vaccinale","ror":"https://ror.org/02f9r3321","country_code":"FR","type":"facility","lineage":["https://openalex.org/I197681013","https://openalex.org/I4210116296","https://openalex.org/I4210119150"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Rodolphe Thi\u00e9baut","raw_affiliation_strings":["4 Inria, SISTM, Talence and","5 Inserm, U897, Bordeaux,","6 Bordeaux University, Bordeaux and","7 Vaccine Research Institute, Creteil, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4 Inria, SISTM, Talence and","institution_ids":["https://openalex.org/I1326498283"]},{"raw_affiliation_string":"5 Inserm, U897, Bordeaux,","institution_ids":["https://openalex.org/I4210106115","https://openalex.org/I154526488"]},{"raw_affiliation_string":"6 Bordeaux University, Bordeaux and","institution_ids":["https://openalex.org/I15057530"]},{"raw_affiliation_string":"7 Vaccine Research Institute, Creteil, France","institution_ids":["https://openalex.org/I4210119150"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5040962966"],"corresponding_institution_ids":["https://openalex.org/I165143802","https://openalex.org/I4210123005"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":3.464,"has_fulltext":false,"cited_by_count":57,"citation_normalized_percentile":{"value":0.93291874,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"32","issue":"1","first_page":"35","last_page":"42"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.45730000734329224,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.45730000734329224,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12867","display_name":"Advanced Biosensing Techniques and Applications","score":0.2718999981880188,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10136","display_name":"Statistical Methods and Inference","score":0.05429999902844429,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/context","display_name":"Context (archaeology)","score":0.7087175846099854},{"id":"https://openalex.org/keywords/multivariate-statistics","display_name":"Multivariate statistics","score":0.6727626323699951},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.539519190788269},{"id":"https://openalex.org/keywords/relevance","display_name":"Relevance (law)","score":0.5232071876525879},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.49318045377731323},{"id":"https://openalex.org/keywords/genomics","display_name":"Genomics","score":0.47251662611961365},{"id":"https://openalex.org/keywords/snp","display_name":"SNP","score":0.45874840021133423},{"id":"https://openalex.org/keywords/multivariate-analysis","display_name":"Multivariate analysis","score":0.4424929916858673},{"id":"https://openalex.org/keywords/omics","display_name":"Omics","score":0.44164174795150757},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.3334923982620239},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2991349697113037},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.29787909984588623},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.27919912338256836},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.16870522499084473},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.11878129839897156},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.10570064187049866},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphism","display_name":"Single-nucleotide polymorphism","score":0.0920669436454773},{"id":"https://openalex.org/keywords/genotype","display_name":"Genotype","score":0.08799111843109131}],"concepts":[{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.7087175846099854},{"id":"https://openalex.org/C161584116","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate statistics","level":2,"score":0.6727626323699951},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.539519190788269},{"id":"https://openalex.org/C158154518","wikidata":"https://www.wikidata.org/wiki/Q7310970","display_name":"Relevance (law)","level":2,"score":0.5232071876525879},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.49318045377731323},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.47251662611961365},{"id":"https://openalex.org/C139275648","wikidata":"https://www.wikidata.org/wiki/Q17134011","display_name":"SNP","level":5,"score":0.45874840021133423},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.4424929916858673},{"id":"https://openalex.org/C157585117","wikidata":"https://www.wikidata.org/wiki/Q158666","display_name":"Omics","level":2,"score":0.44164174795150757},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3334923982620239},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2991349697113037},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.29787909984588623},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.27919912338256836},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16870522499084473},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.11878129839897156},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10570064187049866},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.0920669436454773},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.08799111843109131},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016018","descriptor_name":"Least-Squares Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016018","descriptor_name":"Least-Squares Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016018","descriptor_name":"Least-Squares Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016915","descriptor_name":"AIDS Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016915","descriptor_name":"AIDS Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016915","descriptor_name":"AIDS Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018401","descriptor_name":"Sample Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018401","descriptor_name":"Sample Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018401","descriptor_name":"Sample Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bioinformatics/btv535","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btv535","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/32/1/35/49016265/bioinformatics_32_1_35.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:26358727","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26358727","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:HAL:hal-01288891v1","is_oa":false,"landing_page_url":"https://inria.hal.science/hal-01288891","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics, 2016, 32 (1), pp.35-42. ⟨10.1093/bioinformatics/btv535⟩","raw_type":"Journal articles"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btv535","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btv535","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/32/1/35/49016265/bioinformatics_32_1_35.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6399999856948853,"display_name":"Good health and well-being"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320334593","display_name":"Natural Sciences and Engineering Research Council of Canada","ror":"https://ror.org/01h531d29"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W2235818404.pdf"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W3644042","https://openalex.org/W1560240297","https://openalex.org/W1880834807","https://openalex.org/W1901229639","https://openalex.org/W1942060679","https://openalex.org/W1967827763","https://openalex.org/W1968206427","https://openalex.org/W1969435618","https://openalex.org/W1970554427","https://openalex.org/W1984311170","https://openalex.org/W1987371344","https://openalex.org/W1990552935","https://openalex.org/W1992549770","https://openalex.org/W1993528080","https://openalex.org/W2022960516","https://openalex.org/W2030854293","https://openalex.org/W2036010272","https://openalex.org/W2044809283","https://openalex.org/W2050077513","https://openalex.org/W2061070863","https://openalex.org/W2077964948","https://openalex.org/W2079210771","https://openalex.org/W2082253757","https://openalex.org/W2095705347","https://openalex.org/W2097057782","https://openalex.org/W2097360283","https://openalex.org/W2098290597","https://openalex.org/W2104111843","https://openalex.org/W2105351532","https://openalex.org/W2106398669","https://openalex.org/W2122825543","https://openalex.org/W2126017970","https://openalex.org/W2130410032","https://openalex.org/W2133199783","https://openalex.org/W2136186510","https://openalex.org/W2138019504","https://openalex.org/W2143784594","https://openalex.org/W2147932348","https://openalex.org/W2150742808","https://openalex.org/W2150932450","https://openalex.org/W2160222246","https://openalex.org/W2164583936","https://openalex.org/W2166999091","https://openalex.org/W2169281074","https://openalex.org/W2170917242","https://openalex.org/W2252150807","https://openalex.org/W2323665732","https://openalex.org/W2562162676","https://openalex.org/W4252602300","https://openalex.org/W4294541781"],"related_works":["https://openalex.org/W2406638334","https://openalex.org/W40745829","https://openalex.org/W4318262572","https://openalex.org/W1978357124","https://openalex.org/W1578824628","https://openalex.org/W2032728545","https://openalex.org/W1570805059","https://openalex.org/W4250754046","https://openalex.org/W4243682621","https://openalex.org/W2036849593"],"abstract_inverted_index":{"MOTIVATION:":[0],"The":[1,192],"association":[2],"between":[3,70,117,130,179],"two":[4,44,99,118],"blocks":[5],"of":[6,27,38,43,80,92,121,145,156],"'omics'":[7],"data":[8,123,212],"brings":[9],"challenging":[10],"issues":[11],"in":[12,153,196],"computational":[13],"biology":[14],"due":[15,66],"to":[16,67,113,175,186],"their":[17],"size":[18],"and":[19,89,106,126,134,147,182],"complexity.":[20],"Here,":[21],"we":[22],"focus":[23],"on":[24,204],"a":[25,197],"class":[26],"multivariate":[28,135],"statistical":[29],"methods":[30,54,161],"called":[31,102,201],"partial":[32],"least":[33],"square":[34],"(PLS).":[35],"Sparse":[36],"version":[37],"PLS":[39,94,100,104],"(sPLS)":[40],"operates":[41],"integration":[42],"datasets":[45],"while":[46],"simultaneously":[47],"selecting":[48],"the":[49,60,68,77,87,90,93,115,142,151,154,177,183,187,205],"contributing":[50],"variables.":[51],"However,":[52],"these":[53,160],"do":[55],"not":[56],"take":[57],"into":[58],"account":[59],"important":[61],"structural":[62],"or":[63,129],"group":[64,103],"effects":[65],"relationship":[69,116,178],"markers":[71,81],"among":[72],"biological":[73],"pathways.":[74],"Hence,":[75],"considering":[76],"predefined":[78],"groups":[79],"(e.g.":[82,124,137],"genesets),":[83],"this":[84],"could":[85],"improve":[86],"relevance":[88],"efficacy":[91],"approach.":[95],"RESULTS:":[96],"We":[97,140],"propose":[98],"extensions":[101],"(gPLS)":[105],"sparse":[107],"gPLS":[108,146],"(sgPLS).":[109],"Our":[110,170],"algorithm":[111],"enables":[112],"study":[114],"different":[119],"types":[120],"omics":[122,132],"SNP":[125],"gene":[127,180],"expression)":[128],"an":[131,165],"dataset":[133],"phenotypes":[136],"cytokine":[138],"secretion).":[139],"demonstrate":[141],"good":[143],"performance":[144],"sgPLS":[148,202],"compared":[149,163],"with":[150],"sPLS":[152],"context":[155],"grouped":[157],"data.":[158],"Then,":[159],"are":[162,213],"through":[164],"HIV":[166],"therapeutic":[167],"vaccine":[168],"trial.":[169],"approaches":[171],"provide":[172],"parsimonious":[173],"models":[174],"reveal":[176],"abundance":[181],"immunological":[184],"response":[185],"vaccine.":[188],"AVAILABILITY":[189],"AND":[190],"IMPLEMENTATION:":[191],"approach":[193],"is":[194],"implemented":[195],"comprehensive":[198],"R":[199],"package":[200],"available":[203,214],"CRAN.":[206],"CONTACT:":[207],"b.liquet@uq.edu.au":[208],"SUPPLEMENTARY":[209],"INFORMATION:":[210],"Supplementary":[211],"at":[215],"Bioinformatics":[216],"online.":[217]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":3}],"updated_date":"2026-06-19T15:47:20.252518","created_date":"2025-10-10T00:00:00"}