{"id":"https://openalex.org/W2134617070","doi":"https://doi.org/10.1093/bioinformatics/btv474","title":"DSviaDRM: an R package for estimating disease similarity via dysfunctional regulation mechanism","display_name":"DSviaDRM: an R package for estimating disease similarity via dysfunctional regulation mechanism","publication_year":2015,"publication_date":"2015-08-13","ids":{"openalex":"https://openalex.org/W2134617070","doi":"https://doi.org/10.1093/bioinformatics/btv474","mag":"2134617070","pmid":"https://pubmed.ncbi.nlm.nih.gov/26275896"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btv474","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btv474","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/31/23/3870/49036123/bioinformatics_31_23_3870.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/31/23/3870/49036123/bioinformatics_31_23_3870.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019029226","display_name":"Jing Yang","orcid":"https://orcid.org/0000-0003-3670-2971"},"institutions":[{"id":"https://openalex.org/I143593769","display_name":"East China University of Science and Technology","ror":"https://ror.org/01vyrm377","country_code":"CN","type":"education","lineage":["https://openalex.org/I143593769"]},{"id":"https://openalex.org/I4210162648","display_name":"Shanghai Center For Bioinformation Technology","ror":"https://ror.org/04nyf1f54","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210162648"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Yang","raw_affiliation_strings":["1 School of Biotechnology, East China University of Science and Technology, Shanghai 200237, People\u2019s Republic of China,","2 System biology group, Shanghai Center for Bioinformation Technology, Shanghai 201203, People\u2019s Republic of China,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 School of Biotechnology, East China University of Science and Technology, Shanghai 200237, People\u2019s Republic of China,","institution_ids":["https://openalex.org/I143593769"]},{"raw_affiliation_string":"2 System biology group, Shanghai Center for Bioinformation Technology, Shanghai 201203, People\u2019s Republic of China,","institution_ids":["https://openalex.org/I4210162648"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012906479","display_name":"Su-Juan Wu","orcid":null},"institutions":[{"id":"https://openalex.org/I143593769","display_name":"East China University of Science and Technology","ror":"https://ror.org/01vyrm377","country_code":"CN","type":"education","lineage":["https://openalex.org/I143593769"]},{"id":"https://openalex.org/I4210162648","display_name":"Shanghai Center For Bioinformation Technology","ror":"https://ror.org/04nyf1f54","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210162648"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Su-Juan Wu","raw_affiliation_strings":["1 School of Biotechnology, East China University of Science and Technology, Shanghai 200237, People\u2019s Republic of China,","2 System biology group, Shanghai Center for Bioinformation Technology, Shanghai 201203, People\u2019s Republic of China,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 School of Biotechnology, East China University of Science and Technology, Shanghai 200237, People\u2019s Republic of China,","institution_ids":["https://openalex.org/I143593769"]},{"raw_affiliation_string":"2 System biology group, Shanghai Center for Bioinformation Technology, Shanghai 201203, People\u2019s Republic of China,","institution_ids":["https://openalex.org/I4210162648"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008280608","display_name":"Yixue Li","orcid":"https://orcid.org/0000-0002-1198-7176"},"institutions":[{"id":"https://openalex.org/I143593769","display_name":"East China University of Science and Technology","ror":"https://ror.org/01vyrm377","country_code":"CN","type":"education","lineage":["https://openalex.org/I143593769"]},{"id":"https://openalex.org/I4210146919","display_name":"Shanghai Industrial Technology Institute","ror":"https://ror.org/03j1pdd39","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210146919"]},{"id":"https://openalex.org/I4210162648","display_name":"Shanghai Center For Bioinformation Technology","ror":"https://ror.org/04nyf1f54","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210162648"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yi-Xue Li","raw_affiliation_strings":["1 School of Biotechnology, East China University of Science and Technology, Shanghai 200237, People\u2019s Republic of China,","2 System biology group, Shanghai Center for Bioinformation Technology, Shanghai 201203, People\u2019s Republic of China,","3 Shanghai Industrial Technology Institute, Shanghai 201203, People\u2019s Republic of China and","4 Shanghai Engineering Research Center of Pharmaceutical Translation, Shanghai 201203, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 School of Biotechnology, East China University of Science and Technology, Shanghai 200237, People\u2019s Republic of China,","institution_ids":["https://openalex.org/I143593769"]},{"raw_affiliation_string":"2 System biology group, Shanghai Center for Bioinformation Technology, Shanghai 201203, People\u2019s Republic of China,","institution_ids":["https://openalex.org/I4210162648"]},{"raw_affiliation_string":"3 Shanghai Industrial Technology Institute, Shanghai 201203, People\u2019s Republic of China and","institution_ids":["https://openalex.org/I4210146919"]},{"raw_affiliation_string":"4 Shanghai Engineering Research Center of Pharmaceutical Translation, Shanghai 201203, People\u2019s Republic of China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100724921","display_name":"Yuanyuan Li","orcid":"https://orcid.org/0000-0002-0320-5664"},"institutions":[{"id":"https://openalex.org/I143593769","display_name":"East China University of Science and Technology","ror":"https://ror.org/01vyrm377","country_code":"CN","type":"education","lineage":["https://openalex.org/I143593769"]},{"id":"https://openalex.org/I4210146919","display_name":"Shanghai Industrial Technology Institute","ror":"https://ror.org/03j1pdd39","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210146919"]},{"id":"https://openalex.org/I4210162648","display_name":"Shanghai Center For Bioinformation Technology","ror":"https://ror.org/04nyf1f54","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210162648"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yuan-Yuan Li","raw_affiliation_strings":["1 School of Biotechnology, East China University of Science and Technology, Shanghai 200237, People\u2019s Republic of China,","2 System biology group, Shanghai Center for Bioinformation Technology, Shanghai 201203, People\u2019s Republic of China,","3 Shanghai Industrial Technology Institute, Shanghai 201203, People\u2019s Republic of China and","4 Shanghai Engineering Research Center of Pharmaceutical Translation, Shanghai 201203, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 School of Biotechnology, East China University of Science and Technology, Shanghai 200237, People\u2019s Republic of China,","institution_ids":["https://openalex.org/I143593769"]},{"raw_affiliation_string":"2 System biology group, Shanghai Center for Bioinformation Technology, Shanghai 201203, People\u2019s Republic of China,","institution_ids":["https://openalex.org/I4210162648"]},{"raw_affiliation_string":"3 Shanghai Industrial Technology Institute, Shanghai 201203, People\u2019s Republic of China and","institution_ids":["https://openalex.org/I4210146919"]},{"raw_affiliation_string":"4 Shanghai Engineering Research Center of Pharmaceutical Translation, Shanghai 201203, People\u2019s Republic of China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5008280608","https://openalex.org/A5100724921"],"corresponding_institution_ids":["https://openalex.org/I143593769","https://openalex.org/I4210146919","https://openalex.org/I4210162648"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":{"value":3618,"currency":"USD","value_usd":3618},"fwci":0.2956,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.61611193,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"31","issue":"23","first_page":"3870","last_page":"3872"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.4814999997615814,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.4814999997615814,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.23440000414848328,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.08709999918937683,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dysfunctional-family","display_name":"Dysfunctional family","score":0.6785792708396912},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6067924499511719},{"id":"https://openalex.org/keywords/mechanism","display_name":"Mechanism (biology)","score":0.5780995488166809},{"id":"https://openalex.org/keywords/similarity","display_name":"Similarity (geometry)","score":0.5578504800796509},{"id":"https://openalex.org/keywords/r-package","display_name":"R package","score":0.5436058640480042},{"id":"https://openalex.org/keywords/public-domain","display_name":"Public domain","score":0.5029391646385193},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.41927266120910645},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.38309213519096375},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.2096930742263794},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.20774191617965698},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.16710048913955688},{"id":"https://openalex.org/keywords/programming-language","display_name":"Programming language","score":0.08786189556121826}],"concepts":[{"id":"https://openalex.org/C27502469","wikidata":"https://www.wikidata.org/wiki/Q906343","display_name":"Dysfunctional family","level":2,"score":0.6785792708396912},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6067924499511719},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.5780995488166809},{"id":"https://openalex.org/C103278499","wikidata":"https://www.wikidata.org/wiki/Q254465","display_name":"Similarity (geometry)","level":3,"score":0.5578504800796509},{"id":"https://openalex.org/C2984074130","wikidata":"https://www.wikidata.org/wiki/Q73539779","display_name":"R package","level":2,"score":0.5436058640480042},{"id":"https://openalex.org/C512654426","wikidata":"https://www.wikidata.org/wiki/Q19652","display_name":"Public domain","level":2,"score":0.5029391646385193},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.41927266120910645},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.38309213519096375},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.2096930742263794},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20774191617965698},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16710048913955688},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.08786189556121826},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C27206212","wikidata":"https://www.wikidata.org/wiki/Q34178","display_name":"Theology","level":1,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D004194","descriptor_name":"Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004194","descriptor_name":"Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004194","descriptor_name":"Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1093/bioinformatics/btv474","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btv474","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/31/23/3870/49036123/bioinformatics_31_23_3870.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:26275896","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26275896","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:open-archive.highwire.org:bioinfo:31/23/3870","is_oa":false,"landing_page_url":"http://bioinformatics.oxfordjournals.org/cgi/content/short/31/23/3870","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btv474","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btv474","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/31/23/3870/49036123/bioinformatics_31_23_3870.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W1965055200","https://openalex.org/W1966267765","https://openalex.org/W1977878983","https://openalex.org/W1984789788","https://openalex.org/W2061016350","https://openalex.org/W2083045667","https://openalex.org/W2124001239","https://openalex.org/W2132964144","https://openalex.org/W2136410628","https://openalex.org/W2138842039","https://openalex.org/W2148499186","https://openalex.org/W2150862213","https://openalex.org/W2172024938"],"related_works":["https://openalex.org/W2509948331","https://openalex.org/W4247167749","https://openalex.org/W4235404868","https://openalex.org/W4248285285","https://openalex.org/W3174759616","https://openalex.org/W1874010598","https://openalex.org/W2034829954","https://openalex.org/W2783369496","https://openalex.org/W2519461700","https://openalex.org/W2093232221"],"abstract_inverted_index":{"UNLABELLED:":[0],"Elucidation":[1],"of":[2,26,34,60,68],"human":[3],"disease":[4,12,29,102],"similarities":[5],"has":[6],"provided":[7],"new":[8],"insights":[9],"into":[10],"etiology,":[11],"classification":[13],"and":[14,98,104,128],"drug":[15],"repositioning.":[16],"Since":[17],"dysfunctional":[18,35],"regulation":[19,36,108],"would":[20],"be":[21,40],"manifested":[22],"as":[23,120],"the":[24,58,66],"decoupling":[25],"expression":[27],"correlation,":[28],"similarity":[30],"(DS)":[31],"in":[32,52,70],"terms":[33],"mechanism":[37],"(DRM)":[38],"could":[39],"estimated":[41],"by":[42,111],"using":[43],"a":[44,53,125],"differential":[45,107],"coexpression":[46],"based":[47,85],"approach,":[48],"which":[49],"is":[50,118],"described":[51],"companion":[54],"paper.":[55],"Due":[56],"to":[57,79],"lack":[59],"tools":[61],"for":[62,100],"estimating":[63],"DS":[64,82],"from":[65],"viewpoint":[67],"DRM":[69,84],"public":[71],"domain,":[72],"we":[73],"implemented":[74],"an":[75,121],"R":[76,122],"package":[77],"'DSviaDRM'":[78],"identify":[80],"significant":[81],"via":[83],"on":[86],"transcriptomic":[87],"data.":[88],"DSviaDRM":[89,117],"contains":[90],"five":[91],"easy-to-use":[92],"functions,":[93],"DCEA,":[94],"DCpathway,":[95],"DS,":[96],"comDCGL":[97],"comDCGLplot,":[99],"identifying":[101],"relationships":[103],"showing":[105],"common":[106],"information":[109],"shared":[110],"similar":[112],"diseases.":[113],"AVAILABILITY":[114],"AND":[115],"IMPLEMENTATION:":[116],"available":[119,142],"package,":[123],"with":[124],"user's":[126],"guide":[127],"source":[129],"code,":[130],"at":[131,143],"http://cran.r-project.org/web/packages/DSviaDRM/index.html.":[132],"CONTACT:":[133],"yyli@scbit.org":[134],"or":[135],"yxli@scbit.org.":[136],"SUPPLEMENTARY":[137],"INFORMATION:":[138],"Supplementary":[139],"data":[140],"are":[141],"Bioinformatics":[144],"online.":[145]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":2}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}