{"id":"https://openalex.org/W2173780949","doi":"https://doi.org/10.1093/bioinformatics/btv253","title":"Dynamic changes of RNA-sequencing expression for precision medicine: N-of-1-pathways Mahalanobis distance within pathways of single subjects predicts breast cancer survival","display_name":"Dynamic changes of RNA-sequencing expression for precision medicine: N-of-1-pathways Mahalanobis distance within pathways of single subjects predicts breast cancer survival","publication_year":2015,"publication_date":"2015-06-10","ids":{"openalex":"https://openalex.org/W2173780949","doi":"https://doi.org/10.1093/bioinformatics/btv253","mag":"2173780949","pmid":"https://pubmed.ncbi.nlm.nih.gov/26072495"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btv253","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btv253","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/31/12/i293/49013977/bioinformatics_31_12_i293.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/31/12/i293/49013977/bioinformatics_31_12_i293.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071638480","display_name":"A. Grant Schissler","orcid":"https://orcid.org/0000-0002-5101-3958"},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Grant Schissler","raw_affiliation_strings":["1 University of Arizona Center for Biomedical Informatics and Biostatistics (CB2), Tucson, AZ, USA, 2Graduate Interdisciplinary Program in Statistics, 3Department of Medicine and 4BIO5 Institute, University of Arizona, Tucson, AZ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 University of Arizona Center for Biomedical Informatics and Biostatistics (CB2), Tucson, AZ, USA, 2Graduate Interdisciplinary Program in Statistics, 3Department of Medicine and 4BIO5 Institute, University of Arizona, Tucson, AZ, USA","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071438373","display_name":"Vincent Gardeux","orcid":"https://orcid.org/0000-0001-8954-2161"},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vincent Gardeux","raw_affiliation_strings":["1 University of Arizona Center for Biomedical Informatics and Biostatistics (CB2), Tucson, AZ, USA, 2Graduate Interdisciplinary Program in Statistics, 3Department of Medicine and 4BIO5 Institute, University of Arizona, Tucson, AZ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 University of Arizona Center for Biomedical Informatics and Biostatistics (CB2), Tucson, AZ, USA, 2Graduate Interdisciplinary Program in Statistics, 3Department of Medicine and 4BIO5 Institute, University of Arizona, Tucson, AZ, USA","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108099314","display_name":"Qike Li","orcid":null},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qike Li","raw_affiliation_strings":["1 University of Arizona Center for Biomedical Informatics and Biostatistics (CB2), Tucson, AZ, USA, 2Graduate Interdisciplinary Program in Statistics, 3Department of Medicine and 4BIO5 Institute, University of Arizona, Tucson, AZ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 University of Arizona Center for Biomedical Informatics and Biostatistics (CB2), Tucson, AZ, USA, 2Graduate Interdisciplinary Program in Statistics, 3Department of Medicine and 4BIO5 Institute, University of Arizona, Tucson, AZ, USA","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070645277","display_name":"Ikbel Achour","orcid":"https://orcid.org/0000-0001-6103-4069"},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ikbel Achour","raw_affiliation_strings":["1 University of Arizona Center for Biomedical Informatics and Biostatistics (CB2), Tucson, AZ, USA, 2Graduate Interdisciplinary Program in Statistics, 3Department of Medicine and 4BIO5 Institute, University of Arizona, Tucson, AZ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 University of Arizona Center for Biomedical Informatics and Biostatistics (CB2), Tucson, AZ, USA, 2Graduate Interdisciplinary Program in Statistics, 3Department of Medicine and 4BIO5 Institute, University of Arizona, Tucson, AZ, USA","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066737474","display_name":"Haiquan Li","orcid":"https://orcid.org/0000-0002-8049-0278"},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Haiquan Li","raw_affiliation_strings":["1 University of Arizona Center for Biomedical Informatics and Biostatistics (CB2), Tucson, AZ, USA, 2Graduate Interdisciplinary Program in Statistics, 3Department of Medicine and 4BIO5 Institute, University of Arizona, Tucson, AZ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 University of Arizona Center for Biomedical Informatics and Biostatistics (CB2), Tucson, AZ, USA, 2Graduate Interdisciplinary Program in Statistics, 3Department of Medicine and 4BIO5 Institute, University of Arizona, Tucson, AZ, USA","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039107676","display_name":"Walter W. Piegorsch","orcid":"https://orcid.org/0000-0003-2725-5604"},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Walter W. Piegorsch","raw_affiliation_strings":["1 University of Arizona Center for Biomedical Informatics and Biostatistics (CB2), Tucson, AZ, USA, 2Graduate Interdisciplinary Program in Statistics, 3Department of Medicine and 4BIO5 Institute, University of Arizona, Tucson, AZ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 University of Arizona Center for Biomedical Informatics and Biostatistics (CB2), Tucson, AZ, USA, 2Graduate Interdisciplinary Program in Statistics, 3Department of Medicine and 4BIO5 Institute, University of Arizona, Tucson, AZ, USA","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074706648","display_name":"Yves A. Lussier","orcid":"https://orcid.org/0000-0001-9854-1005"},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yves A. Lussier","raw_affiliation_strings":["1 University of Arizona Center for Biomedical Informatics and Biostatistics (CB2), Tucson, AZ, USA, 2Graduate Interdisciplinary Program in Statistics, 3Department of Medicine and 4BIO5 Institute, University of Arizona, Tucson, AZ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 University of Arizona Center for Biomedical Informatics and Biostatistics (CB2), Tucson, AZ, USA, 2Graduate Interdisciplinary Program in Statistics, 3Department of Medicine and 4BIO5 Institute, University of Arizona, Tucson, AZ, USA","institution_ids":["https://openalex.org/I138006243"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5039107676","https://openalex.org/A5074706648"],"corresponding_institution_ids":["https://openalex.org/I138006243"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":{"value":3618,"currency":"USD","value_usd":3618},"fwci":2.5125,"has_fulltext":true,"cited_by_count":34,"citation_normalized_percentile":{"value":0.89802565,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"31","issue":"12","first_page":"i293","last_page":"i302"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.4848000109195709,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.4848000109195709,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.21299999952316284,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.0575999990105629,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mahalanobis-distance","display_name":"Mahalanobis distance","score":0.6644633412361145},{"id":"https://openalex.org/keywords/interpretability","display_name":"Interpretability","score":0.6108910441398621},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5732281804084778},{"id":"https://openalex.org/keywords/biological-pathway","display_name":"Biological pathway","score":0.4649461805820465},{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.4527303874492645},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4464232921600342},{"id":"https://openalex.org/keywords/precision-medicine","display_name":"Precision medicine","score":0.44050124287605286},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.42829596996307373},{"id":"https://openalex.org/keywords/transcriptome","display_name":"Transcriptome","score":0.4205835461616516},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3817920684814453},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3247929513454437},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.3210480809211731},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.29401522874832153},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.20966243743896484},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.1729174256324768}],"concepts":[{"id":"https://openalex.org/C1921717","wikidata":"https://www.wikidata.org/wiki/Q1334846","display_name":"Mahalanobis distance","level":2,"score":0.6644633412361145},{"id":"https://openalex.org/C2781067378","wikidata":"https://www.wikidata.org/wiki/Q17027399","display_name":"Interpretability","level":2,"score":0.6108910441398621},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5732281804084778},{"id":"https://openalex.org/C9927688","wikidata":"https://www.wikidata.org/wiki/Q4915012","display_name":"Biological pathway","level":4,"score":0.4649461805820465},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.4527303874492645},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4464232921600342},{"id":"https://openalex.org/C163763905","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision medicine","level":2,"score":0.44050124287605286},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.42829596996307373},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.4205835461616516},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3817920684814453},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3247929513454437},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3210480809211731},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.29401522874832153},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.20966243743896484},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.1729174256324768}],"mesh":[{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D053208","descriptor_name":"Kaplan-Meier Estimate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053208","descriptor_name":"Kaplan-Meier Estimate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053208","descriptor_name":"Kaplan-Meier Estimate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1093/bioinformatics/btv253","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btv253","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/31/12/i293/49013977/bioinformatics_31_12_i293.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:26072495","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26072495","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:open-archive.highwire.org:bioinfo:31/12/i293","is_oa":false,"landing_page_url":"http://bioinformatics.oxfordjournals.org/cgi/content/short/31/12/i293","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"},{"id":"pmh:oai:pubmedcentral.nih.gov:4765863","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4765863","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"Text"},{"id":"pmh:oai:repository.arizona.edu:10150/603628","is_oa":false,"landing_page_url":"http://hdl.handle.net/10150/603628","pdf_url":null,"source":{"id":"https://openalex.org/S4306400271","display_name":"UA Campus Repository (The University of Arizona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I138006243","host_organization_name":"University of Arizona","host_organization_lineage":["https://openalex.org/I138006243"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btv253","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btv253","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/31/12/i293/49013977/bioinformatics_31_12_i293.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6399999856948853,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320310160","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2173780949.pdf"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W143101809","https://openalex.org/W1233208954","https://openalex.org/W1236321187","https://openalex.org/W1540089290","https://openalex.org/W1540596182","https://openalex.org/W1570448133","https://openalex.org/W1587026990","https://openalex.org/W1884291487","https://openalex.org/W1990190154","https://openalex.org/W1999574084","https://openalex.org/W2008422283","https://openalex.org/W2062584010","https://openalex.org/W2063841568","https://openalex.org/W2103017472","https://openalex.org/W2106578604","https://openalex.org/W2109034705","https://openalex.org/W2116634113","https://openalex.org/W2124097252","https://openalex.org/W2127372456","https://openalex.org/W2130410032","https://openalex.org/W2134736660","https://openalex.org/W2145029433","https://openalex.org/W2145435933","https://openalex.org/W2160697532","https://openalex.org/W2165909549","https://openalex.org/W2169896388","https://openalex.org/W2478431269","https://openalex.org/W2582743722","https://openalex.org/W3099514962","https://openalex.org/W4230096730","https://openalex.org/W4249430878","https://openalex.org/W6632267817","https://openalex.org/W6679841778","https://openalex.org/W7073761954"],"related_works":["https://openalex.org/W2905433371","https://openalex.org/W4390569940","https://openalex.org/W2888392564","https://openalex.org/W4361193272","https://openalex.org/W4310278675","https://openalex.org/W4388422664","https://openalex.org/W2806259446","https://openalex.org/W2963326959","https://openalex.org/W2066632517","https://openalex.org/W1986892844"],"abstract_inverted_index":{"MOTIVATION:":[0],"The":[1,15,166],"conventional":[2],"approach":[3,41,88,162],"to":[4,17,42,75,97,200,225],"personalized":[5],"medicine":[6,19],"relies":[7],"on":[8],"molecular":[9,22],"data":[10,23,46],"analytics":[11,24],"across":[12],"multiple":[13],"patients.":[14],"path":[16],"precision":[18,164],"lies":[20],"with":[21,89,125],"that":[25,53,104,131,196],"can":[26],"discover":[27],"interpretable":[28],"single-subject":[29,43],"signals":[30],"(N-of-1).":[31],"We":[32,48,102],"developed":[33],"a":[34,39,51,60,76,123,160],"global":[35],"framework,":[36],"N-of-1-pathways,":[37],"for":[38,191,223],"mechanistic-anchored":[40],"gene":[44,77],"expression":[45,78],"analysis.":[47],"previously":[49],"employed":[50],"metric":[52],"could":[54],"prioritize":[55],"the":[56,73,90,169,172,183,189,198,202,238],"statistical":[57,93],"significance":[58,174],"of":[59,92,142,175,205,241],"deregulated":[61,113,177],"pathway":[62],"in":[63,69,227],"single":[64,242],"subjects,":[65],"however,":[66],"it":[67,219],"lacked":[68],"quantitative":[70],"interpretability":[71,204],"(e.g.":[72,244],"equivalent":[74],"fold-change).":[79],"RESULTS:":[80],"In":[81,217],"this":[82,105],"study,":[83],"we":[84,129],"extend":[85],"our":[86],"previous":[87],"application":[91],"Mahalanobis":[94],"distance":[95],"(MD)":[96],"quantify":[98],"personal":[99,176,206],"pathway-level":[100],"deregulation.":[101],"demonstrate":[103],"approach,":[106],"N-of-1-pathways":[107,157],"Paired":[108],"Samples":[109],"MD":[110,158],"(N-OF-1-PATHWAYS-MD),":[111],"detects":[112],"pathways":[114,178,187],"(empirical":[115],"simulations),":[116],"while":[117],"not":[118,232],"inflating":[119],"false-positive":[120],"rate":[121],"using":[122],"study":[124],"biological":[126,173],"replicates.":[127],"Finally,":[128],"establish":[130],"N-OF-1-PATHWAYS-MD":[132],"scores":[133],"are,":[134],"biologically":[135],"significant,":[136],"clinically":[137,193],"relevant":[138],"and":[139,171,215,235],"are":[140],"predictive":[141],"breast":[143],"cancer":[144],"survival":[145],"(P":[146],"<":[147],"0.05,":[148],"n":[149],"=":[150],"80":[151],"invasive":[152],"carcinoma;":[153],"TCGA":[154],"RNA-sequences).":[155],"CONCLUSION:":[156],"provides":[159],"practical":[161],"towards":[163],"medicine.":[165],"method":[167],"generates":[168],"magnitude":[170],"results":[179],"derived":[180],"solely":[181],"from":[182,209],"patient's":[184],"transcriptome.":[185],"These":[186],"offer":[188],"opportunities":[190],"deriving":[192],"actionable":[194],"decisions":[195],"have":[197],"potential":[199],"complement":[201],"clinical":[203],"polymorphisms":[207,214],"obtained":[208],"DNA":[210,229],"acquired":[211],"or":[212],"inherited":[213],"mutations.":[216],"addition,":[218],"offers":[220],"an":[221],"opportunity":[222],"applicability":[224],"diseases":[226],"which":[228],"changes":[230],"may":[231],"be":[233],"relevant,":[234],"thus":[236],"expand":[237],"'interpretable":[239],"'omics'":[240],"subjects":[243],"personalome).":[245],"AVAILABILITY":[246],"AND":[247],"IMPLEMENTATION:":[248],"http://www.lussierlab.net/publications/N-of-1-pathways.":[249]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":3}],"updated_date":"2026-05-22T06:13:13.366637","created_date":"2025-10-10T00:00:00"}
