{"id":"https://openalex.org/W2108363029","doi":"https://doi.org/10.1093/bioinformatics/btv243","title":"Refined elasticity sampling for Monte Carlo-based identification of stabilizing network patterns","display_name":"Refined elasticity sampling for Monte Carlo-based identification of stabilizing network patterns","publication_year":2015,"publication_date":"2015-06-10","ids":{"openalex":"https://openalex.org/W2108363029","doi":"https://doi.org/10.1093/bioinformatics/btv243","mag":"2108363029","pmid":"https://pubmed.ncbi.nlm.nih.gov/26072485"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btv243","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btv243","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/31/12/i214/17101689/btv243.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/31/12/i214/17101689/btv243.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026181240","display_name":"Dorothee Childs","orcid":"https://orcid.org/0000-0002-2432-4128"},"institutions":[{"id":"https://openalex.org/I176453806","display_name":"University of Potsdam","ror":"https://ror.org/03bnmw459","country_code":"DE","type":"education","lineage":["https://openalex.org/I176453806"]},{"id":"https://openalex.org/I193619901","display_name":"Constructor University","ror":"https://ror.org/02yrs2n53","country_code":"DE","type":"education","lineage":["https://openalex.org/I193619901"]},{"id":"https://openalex.org/I4210138560","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/03mstc592","country_code":"DE","type":"government","lineage":["https://openalex.org/I4210138560"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Dorothee Childs","raw_affiliation_strings":["1 Genome Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany, 2Bioinformatics Group, University of Potsdam and Max-Planck Institute for Molecular Plant Physiology, Potsdam, Germany and 3Computational Systems Biology Group, School of Engineering and Science, Jacobs University Bremen, Bremen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Genome Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany, 2Bioinformatics Group, University of Potsdam and Max-Planck Institute for Molecular Plant Physiology, Potsdam, Germany and 3Computational Systems Biology Group, School of Engineering and Science, Jacobs University Bremen, Bremen, Germany","institution_ids":["https://openalex.org/I176453806","https://openalex.org/I193619901","https://openalex.org/I4210138560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043536357","display_name":"Sergio Grimbs","orcid":"https://orcid.org/0000-0001-5891-2342"},"institutions":[{"id":"https://openalex.org/I176453806","display_name":"University of Potsdam","ror":"https://ror.org/03bnmw459","country_code":"DE","type":"education","lineage":["https://openalex.org/I176453806"]},{"id":"https://openalex.org/I193619901","display_name":"Constructor University","ror":"https://ror.org/02yrs2n53","country_code":"DE","type":"education","lineage":["https://openalex.org/I193619901"]},{"id":"https://openalex.org/I4210138560","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/03mstc592","country_code":"DE","type":"government","lineage":["https://openalex.org/I4210138560"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sergio Grimbs","raw_affiliation_strings":["1 Genome Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany, 2Bioinformatics Group, University of Potsdam and Max-Planck Institute for Molecular Plant Physiology, Potsdam, Germany and 3Computational Systems Biology Group, School of Engineering and Science, Jacobs University Bremen, Bremen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Genome Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany, 2Bioinformatics Group, University of Potsdam and Max-Planck Institute for Molecular Plant Physiology, Potsdam, Germany and 3Computational Systems Biology Group, School of Engineering and Science, Jacobs University Bremen, Bremen, Germany","institution_ids":["https://openalex.org/I176453806","https://openalex.org/I193619901","https://openalex.org/I4210138560"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034181383","display_name":"Joachim Selbig","orcid":null},"institutions":[{"id":"https://openalex.org/I176453806","display_name":"University of Potsdam","ror":"https://ror.org/03bnmw459","country_code":"DE","type":"education","lineage":["https://openalex.org/I176453806"]},{"id":"https://openalex.org/I193619901","display_name":"Constructor University","ror":"https://ror.org/02yrs2n53","country_code":"DE","type":"education","lineage":["https://openalex.org/I193619901"]},{"id":"https://openalex.org/I4210138560","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/03mstc592","country_code":"DE","type":"government","lineage":["https://openalex.org/I4210138560"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Joachim Selbig","raw_affiliation_strings":["1 Genome Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany, 2Bioinformatics Group, University of Potsdam and Max-Planck Institute for Molecular Plant Physiology, Potsdam, Germany and 3Computational Systems Biology Group, School of Engineering and Science, Jacobs University Bremen, Bremen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Genome Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany, 2Bioinformatics Group, University of Potsdam and Max-Planck Institute for Molecular Plant Physiology, Potsdam, Germany and 3Computational Systems Biology Group, School of Engineering and Science, Jacobs University Bremen, Bremen, Germany","institution_ids":["https://openalex.org/I176453806","https://openalex.org/I193619901","https://openalex.org/I4210138560"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5026181240"],"corresponding_institution_ids":["https://openalex.org/I176453806","https://openalex.org/I193619901","https://openalex.org/I4210138560"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":{"value":3618,"currency":"USD","value_usd":3618},"fwci":0.2956,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.61455335,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":96},"biblio":{"volume":"31","issue":"12","first_page":"i214","last_page":"i220"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.26170000433921814,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.26170000433921814,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.1485999971628189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10791","display_name":"Advanced Control Systems Optimization","score":0.04769999906420708,"subfield":{"id":"https://openalex.org/subfields/2207","display_name":"Control and Systems Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/monte-carlo-method","display_name":"Monte Carlo method","score":0.6859498620033264},{"id":"https://openalex.org/keywords/jacobian-matrix-and-determinant","display_name":"Jacobian matrix and determinant","score":0.6800551414489746},{"id":"https://openalex.org/keywords/elasticity","display_name":"Elasticity (physics)","score":0.6111809611320496},{"id":"https://openalex.org/keywords/perturbation","display_name":"Perturbation (astronomy)","score":0.5798282027244568},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4432459771633148},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.3734535574913025},{"id":"https://openalex.org/keywords/mathematical-optimization","display_name":"Mathematical optimization","score":0.3342294692993164},{"id":"https://openalex.org/keywords/applied-mathematics","display_name":"Applied mathematics","score":0.32693004608154297},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.21612799167633057},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.1368860900402069},{"id":"https://openalex.org/keywords/thermodynamics","display_name":"Thermodynamics","score":0.08946293592453003}],"concepts":[{"id":"https://openalex.org/C19499675","wikidata":"https://www.wikidata.org/wiki/Q232207","display_name":"Monte Carlo method","level":2,"score":0.6859498620033264},{"id":"https://openalex.org/C200331156","wikidata":"https://www.wikidata.org/wiki/Q506041","display_name":"Jacobian matrix and determinant","level":2,"score":0.6800551414489746},{"id":"https://openalex.org/C121854251","wikidata":"https://www.wikidata.org/wiki/Q62932","display_name":"Elasticity (physics)","level":2,"score":0.6111809611320496},{"id":"https://openalex.org/C177918212","wikidata":"https://www.wikidata.org/wiki/Q803623","display_name":"Perturbation (astronomy)","level":2,"score":0.5798282027244568},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4432459771633148},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.3734535574913025},{"id":"https://openalex.org/C126255220","wikidata":"https://www.wikidata.org/wiki/Q141495","display_name":"Mathematical optimization","level":1,"score":0.3342294692993164},{"id":"https://openalex.org/C28826006","wikidata":"https://www.wikidata.org/wiki/Q33521","display_name":"Applied mathematics","level":1,"score":0.32693004608154297},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.21612799167633057},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.1368860900402069},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.08946293592453003},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002952","descriptor_name":"Citric Acid Cycle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002952","descriptor_name":"Citric Acid Cycle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002952","descriptor_name":"Citric Acid Cycle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009010","descriptor_name":"Monte Carlo Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009010","descriptor_name":"Monte Carlo Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009010","descriptor_name":"Monte Carlo Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1093/bioinformatics/btv243","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btv243","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/31/12/i214/17101689/btv243.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:26072485","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26072485","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:kobv.de-opus4-uni-potsdam:38824","is_oa":false,"landing_page_url":"https://publishup.uni-potsdam.de/frontdoor/index/index/docId/38824","pdf_url":null,"source":{"id":"https://openalex.org/S4306400594","display_name":"publish.UP (University of Potsdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I176453806","host_organization_name":"University of Potsdam","host_organization_lineage":["https://openalex.org/I176453806"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:open-archive.highwire.org:bioinfo:31/12/i214","is_oa":false,"landing_page_url":"http://bioinformatics.oxfordjournals.org/cgi/content/short/31/12/i214","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"},{"id":"pmh:oai:pubmedcentral.nih.gov:4765856","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4765856","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"Text"},{"id":"pmh:oai:pure.mpg.de:item_2166515","is_oa":false,"landing_page_url":"http://hdl.handle.net/11858/00-001M-0000-0027-A665-9","pdf_url":null,"source":{"id":"https://openalex.org/S4306400654","display_name":"MPG.PuRe (Max Planck Society)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btv243","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btv243","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/31/12/i214/17101689/btv243.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320317967","display_name":"International Max Planck Research School for Environmental, Cellular and Molecular Microbiology","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W129383413","https://openalex.org/W1484198052","https://openalex.org/W1504385853","https://openalex.org/W1561767438","https://openalex.org/W1966174134","https://openalex.org/W1967500610","https://openalex.org/W1987300639","https://openalex.org/W1997972137","https://openalex.org/W2000933774","https://openalex.org/W2015743230","https://openalex.org/W2029918421","https://openalex.org/W2037702045","https://openalex.org/W2065096279","https://openalex.org/W2071198763","https://openalex.org/W2078136197","https://openalex.org/W2082102376","https://openalex.org/W2094305273","https://openalex.org/W2108469278","https://openalex.org/W2115343689","https://openalex.org/W2126738076","https://openalex.org/W2131509316","https://openalex.org/W2132950414","https://openalex.org/W2160566673","https://openalex.org/W2161227644","https://openalex.org/W2162297633","https://openalex.org/W2567359348","https://openalex.org/W3105799469","https://openalex.org/W4244785210","https://openalex.org/W4399577370","https://openalex.org/W6605243846","https://openalex.org/W6731817975"],"related_works":["https://openalex.org/W2007405763","https://openalex.org/W3136087161","https://openalex.org/W2145980196","https://openalex.org/W2018238589","https://openalex.org/W1486373823","https://openalex.org/W1984283682","https://openalex.org/W2235865024","https://openalex.org/W1965257389","https://openalex.org/W3145558417","https://openalex.org/W2883743867"],"abstract_inverted_index":{"MOTIVATION:":[0],"Structural":[1],"kinetic":[2,108,138,146],"modelling":[3],"(SKM)":[4],"is":[5,155],"a":[6,11,29,54,65,121,152],"framework":[7],"to":[8,89,96,172,206],"analyse":[9],"whether":[10],"metabolic":[12],"steady":[13,43,51,56,175],"state":[14,44],"remains":[15],"stable":[16],"under":[17],"perturbation,":[18],"without":[19],"requiring":[20],"detailed":[21],"knowledge":[22],"about":[23],"individual":[24],"rate":[25],"equations.":[26],"It":[27],"provides":[28],"representation":[30],"of":[31,68,110,123,132,177,194],"the":[32,40,47,50,76,97,107,111,130,164,168,178,183,195,211,220],"system's":[33],"Jacobian":[34,78],"matrix":[35],"that":[36,93,129,157,200,210],"depends":[37],"solely":[38],"on":[39],"network":[41,91],"structure,":[42],"measurements,":[45],"and":[46,74,182,209],"elasticities":[48,73,202],"at":[49],"state.":[52],"For":[53],"measured":[55],"state,":[57],"stability":[58,189,208],"criteria":[59],"can":[60,83],"be":[61,84],"derived":[62],"by":[63,105],"generating":[64],"large":[66],"number":[67],"SKMs":[69,134],"with":[70],"randomly":[71],"sampled":[72,133],"evaluating":[75,163],"resulting":[77],"matrices.":[79],"The":[80,192],"elasticity":[81,112,197],"space":[82],"analysed":[85],"statistically":[86],"in":[87,219],"order":[88],"detect":[90],"positions":[92],"contribute":[94],"significantly":[95],"perturbation":[98],"response.":[99],"Here,":[100],"we":[101,127],"extend":[102],"this":[103,150],"approach":[104],"examining":[106],"feasibility":[109],"combinations":[113],"created":[114],"during":[115],"Monte":[116],"Carlo":[117],"sampling.":[118],"RESULTS:":[119],"Using":[120],"set":[122],"small":[124,165],"example":[125,166],"systems,":[126],"show":[128],"majority":[131],"would":[135],"yield":[136],"negative":[137],"parameters":[139],"if":[140],"they":[141],"were":[142],"translated":[143],"back":[144],"into":[145],"models.":[147,161],"To":[148],"overcome":[149],"problem,":[151],"simple":[153],"criterion":[154],"formulated":[156],"mitigates":[158],"such":[159],"infeasible":[160],"After":[162],"pathways,":[167],"methodology":[169],"was":[170],"used":[171],"study":[173],"two":[174],"states":[176],"neuronal":[179],"TCA":[180],"cycle":[181],"intrinsic":[184],"mechanisms":[185],"responsible":[186],"for":[187,214],"their":[188],"or":[190],"instability.":[191],"findings":[193],"statistical":[196],"analysis":[198],"confirm":[199],"several":[201],"are":[203,217],"jointly":[204],"coordinated":[205],"control":[207],"main":[212],"source":[213],"potential":[215],"instabilities":[216],"mutations":[218],"enzyme":[221],"alpha-ketoglutarate":[222],"dehydrogenase.":[223]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2017,"cited_by_count":2}],"updated_date":"2026-06-18T08:10:14.011955","created_date":"2025-10-10T00:00:00"}
