{"id":"https://openalex.org/W2103073877","doi":"https://doi.org/10.1093/bioinformatics/btv215","title":"Addressing false discoveries in network inference","display_name":"Addressing false discoveries in network inference","publication_year":2015,"publication_date":"2015-04-24","ids":{"openalex":"https://openalex.org/W2103073877","doi":"https://doi.org/10.1093/bioinformatics/btv215","mag":"2103073877","pmid":"https://pubmed.ncbi.nlm.nih.gov/25910697"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btv215","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btv215","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/31/17/2836/49034862/bioinformatics_31_17_2836.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/31/17/2836/49034862/bioinformatics_31_17_2836.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021877095","display_name":"Tobias Petri","orcid":null},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Tobias Petri","raw_affiliation_strings":["1 Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Institut f\u00fcr Informatik, Munich, Germany and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Institut f\u00fcr Informatik, Munich, Germany and","institution_ids":["https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022826552","display_name":"Stefan Altmann","orcid":"https://orcid.org/0000-0002-7605-6794"},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Stefan Altmann","raw_affiliation_strings":["1 Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Institut f\u00fcr Informatik, Munich, Germany and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Institut f\u00fcr Informatik, Munich, Germany and","institution_ids":["https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021558653","display_name":"Ludwig Geistlinger","orcid":"https://orcid.org/0000-0002-2495-5464"},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ludwig Geistlinger","raw_affiliation_strings":["1 Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Institut f\u00fcr Informatik, Munich, Germany and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Institut f\u00fcr Informatik, Munich, Germany and","institution_ids":["https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068859428","display_name":"Ralf Zimmer","orcid":"https://orcid.org/0000-0003-1439-2327"},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ralf Zimmer","raw_affiliation_strings":["1 Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Institut f\u00fcr Informatik, Munich, Germany and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Institut f\u00fcr Informatik, Munich, Germany and","institution_ids":["https://openalex.org/I8204097"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027062146","display_name":"Robert K\u00fcffner","orcid":null},"institutions":[{"id":"https://openalex.org/I3018134672","display_name":"Helmholtz Zentrum M\u00fcnchen","ror":"https://ror.org/00cfam450","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672"]},{"id":"https://openalex.org/I4210100097","display_name":"Institute of Bioinformatics and Systems Biology","ror":"https://ror.org/0127fwn18","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672","https://openalex.org/I4210100097"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Robert K\u00fcffner","raw_affiliation_strings":["1 Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Institut f\u00fcr Informatik, Munich, Germany and","2 Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum M\u00fcnchen, German Research Center for Environmental Health, Neuherberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Institut f\u00fcr Informatik, Munich, Germany and","institution_ids":["https://openalex.org/I8204097"]},{"raw_affiliation_string":"2 Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum M\u00fcnchen, German Research Center for Environmental Health, Neuherberg, Germany","institution_ids":["https://openalex.org/I4210100097","https://openalex.org/I3018134672"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5027062146"],"corresponding_institution_ids":["https://openalex.org/I3018134672","https://openalex.org/I4210100097","https://openalex.org/I8204097"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":1.2046,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.78840721,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"31","issue":"17","first_page":"2836","last_page":"2843"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.7293999791145325,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.7293999791145325,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.20600000023841858,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.04360000044107437,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inference","display_name":"Inference","score":0.8120267987251282},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7206907272338867},{"id":"https://openalex.org/keywords/spurious-relationship","display_name":"Spurious relationship","score":0.69073086977005},{"id":"https://openalex.org/keywords/executable","display_name":"Executable","score":0.6697672009468079},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.5124650597572327},{"id":"https://openalex.org/keywords/a-priori-and-a-posteriori","display_name":"A priori and a posteriori","score":0.4816352427005768},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.46857523918151855},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.462923526763916},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.46119260787963867},{"id":"https://openalex.org/keywords/exploit","display_name":"Exploit","score":0.4387807250022888},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.33613523840904236},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.20440596342086792},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.12734243273735046}],"concepts":[{"id":"https://openalex.org/C2776214188","wikidata":"https://www.wikidata.org/wiki/Q408386","display_name":"Inference","level":2,"score":0.8120267987251282},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7206907272338867},{"id":"https://openalex.org/C97256817","wikidata":"https://www.wikidata.org/wiki/Q1462316","display_name":"Spurious relationship","level":2,"score":0.69073086977005},{"id":"https://openalex.org/C160145156","wikidata":"https://www.wikidata.org/wiki/Q778586","display_name":"Executable","level":2,"score":0.6697672009468079},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.5124650597572327},{"id":"https://openalex.org/C75553542","wikidata":"https://www.wikidata.org/wiki/Q178161","display_name":"A priori and a posteriori","level":2,"score":0.4816352427005768},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.46857523918151855},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.462923526763916},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.46119260787963867},{"id":"https://openalex.org/C165696696","wikidata":"https://www.wikidata.org/wiki/Q11287","display_name":"Exploit","level":2,"score":0.4387807250022888},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.33613523840904236},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20440596342086792},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12734243273735046},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0},{"id":"https://openalex.org/C38652104","wikidata":"https://www.wikidata.org/wiki/Q3510521","display_name":"Computer security","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005189","descriptor_name":"False Positive Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005189","descriptor_name":"False Positive Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005189","descriptor_name":"False Positive Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015966","descriptor_name":"Gene Expression Regulation, Fungal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015966","descriptor_name":"Gene Expression Regulation, Fungal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015966","descriptor_name":"Gene Expression Regulation, Fungal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1093/bioinformatics/btv215","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btv215","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/31/17/2836/49034862/bioinformatics_31_17_2836.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:25910697","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25910697","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:open-archive.highwire.org:bioinfo:31/17/2836","is_oa":false,"landing_page_url":"http://bioinformatics.oxfordjournals.org/cgi/content/short/31/17/2836","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"},{"id":"pmh:oai:opus-zb.helmholtz-muenchen.de:46790","is_oa":false,"landing_page_url":"https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=46790","pdf_url":null,"source":{"id":"https://openalex.org/S4377196115","display_name":"Site cant be reached","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics 31, 2836-2843 (2015)","raw_type":"article"},{"id":"pmh:oai:push-zb.helmholtz-munich.de:46790","is_oa":false,"landing_page_url":"https://push-zb.helmholtz-munich.de/frontdoor.php?source_opus=46790","pdf_url":null,"source":{"id":"https://openalex.org/S7407055352","display_name":"PuSH - Publication Server of Helmholtz Zentrum M\u00fcnchen","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics 31, 2836-2843 (2015)","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btv215","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btv215","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/31/17/2836/49034862/bioinformatics_31_17_2836.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Partnerships for the goals","id":"https://metadata.un.org/sdg/17","score":0.41999998688697815}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W1236321187","https://openalex.org/W1536819918","https://openalex.org/W1597335013","https://openalex.org/W1644724366","https://openalex.org/W1977547738","https://openalex.org/W1988100928","https://openalex.org/W1993735334","https://openalex.org/W2001554877","https://openalex.org/W2019012779","https://openalex.org/W2021340905","https://openalex.org/W2029583014","https://openalex.org/W2037544231","https://openalex.org/W2043977568","https://openalex.org/W2044525257","https://openalex.org/W2061163312","https://openalex.org/W2077941487","https://openalex.org/W2081468394","https://openalex.org/W2081875512","https://openalex.org/W2084833542","https://openalex.org/W2087390320","https://openalex.org/W2094678200","https://openalex.org/W2104239076","https://openalex.org/W2105129830","https://openalex.org/W2106945333","https://openalex.org/W2109384743","https://openalex.org/W2110503722","https://openalex.org/W2114937915","https://openalex.org/W2116008456","https://openalex.org/W2124327251","https://openalex.org/W2138973161","https://openalex.org/W2139947030","https://openalex.org/W2143891888","https://openalex.org/W2144927010","https://openalex.org/W2146546288","https://openalex.org/W2152360905","https://openalex.org/W2152941516","https://openalex.org/W2158107150","https://openalex.org/W2158261276","https://openalex.org/W2160095931","https://openalex.org/W2163296115","https://openalex.org/W2167190345","https://openalex.org/W2169251996","https://openalex.org/W2229749168","https://openalex.org/W2905472553","https://openalex.org/W2951779057","https://openalex.org/W3099289621","https://openalex.org/W3122657004","https://openalex.org/W4210901545"],"related_works":["https://openalex.org/W3113091479","https://openalex.org/W2162899405","https://openalex.org/W941090075","https://openalex.org/W17155033","https://openalex.org/W2044987316","https://openalex.org/W3134374554","https://openalex.org/W2237480245","https://openalex.org/W2075065631","https://openalex.org/W2519167559","https://openalex.org/W4311248832"],"abstract_inverted_index":{"MOTIVATION:":[0],"Experimentally":[1],"determined":[2],"gene":[3],"regulatory":[4,20,163],"networks":[5,164,206],"can":[6],"be":[7,195],"enriched":[8],"by":[9,25,39],"computational":[10],"inference":[11,139,159,193],"from":[12,99],"high-throughput":[13],"expression":[14,55],"profiles.":[15,56],"However,":[16],"the":[17,41,80,121,135,148,158,189],"prediction":[18,81],"of":[19,46,70,82,86,137,152,160,188,191],"interactions":[21,88],"is":[22,106],"severely":[23],"impaired":[24],"indirect":[26],"and":[27,79,102,125,156,205],"spurious":[28],"effects,":[29],"particularly":[30],"for":[31,89],"eukaryotes.":[32,166],"Recently,":[33],"published":[34],"methods":[35,61,140],"report":[36],"improved":[37],"predictions":[38],"exploiting":[40,62],"a":[42,47,113,127,171],"priori":[43],"known":[44,63,93,143],"targets":[45,64],"regulator":[48],"(its":[49],"local":[50],"topology)":[51],"in":[52,165],"addition":[53],"to":[54,75,108],"RESULTS:":[57],"We":[58,111,180],"find":[59],"that":[60,119,141,183],"show":[65],"an":[66,83],"unexpectedly":[67],"high":[68],"rate":[69,124],"false":[71,122],"discoveries.":[72],"This":[73],"leads":[74],"inflated":[76],"performance":[77,129],"estimates":[78],"excessive":[84],"number":[85],"new":[87],"regulators":[90,153],"with":[91,173],"many":[92],"targets.":[94,144],"These":[95],"issues":[96],"are":[97,207,219],"hidden":[98],"common":[100],"evaluation":[101],"cross-validation":[103],"setups,":[104],"which":[105],"due":[107],"Simpson's":[109],"paradox.":[110],"suggest":[112],"confidence":[114],"score":[115],"recalibration":[116],"method":[117],"(CoRe)":[118],"reduces":[120],"discovery":[123],"enables":[126],"reliable":[128],"estimation.":[130],"CONCLUSIONS:":[131],"CoRe":[132],"considerably":[133],"improves":[134],"results":[136],"network":[138,172,192],"exploit":[142],"Predictions":[145],"then":[146],"display":[147],"biological":[149],"process":[150],"specificity":[151],"more":[154,174],"correctly":[155],"enable":[157],"accurate":[161],"genome-wide":[162],"For":[167],"yeast,":[168],"we":[169],"propose":[170],"than":[175],"22":[176],"000":[177],"confident":[178],"interactions.":[179],"point":[181],"out":[182],"machine":[184],"learning":[185],"approaches":[186],"outside":[187],"area":[190],"may":[194],"affected":[196],"as":[197],"well.":[198],"AVAILABILITY":[199],"AND":[200],"IMPLEMENTATION:":[201],"Results,":[202],"executable":[203],"code":[204],"available":[208,220],"via":[209],"our":[210],"website":[211],"http://www.bio.ifi.lmu.de/forschung/CoRe.":[212],"CONTACT:":[213],"robert.kueffner@helmholtz-muenchen.de":[214],"SUPPLEMENTARY":[215],"INFORMATION:":[216],"Supplementary":[217],"data":[218],"at":[221],"Bioinformatics":[222],"online.":[223]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}