{"id":"https://openalex.org/W2104406447","doi":"https://doi.org/10.1093/bioinformatics/btv196","title":"GeneTIER: prioritization of candidate disease genes using tissue-specific gene expression profiles","display_name":"GeneTIER: prioritization of candidate disease genes using tissue-specific gene expression profiles","publication_year":2015,"publication_date":"2015-04-09","ids":{"openalex":"https://openalex.org/W2104406447","doi":"https://doi.org/10.1093/bioinformatics/btv196","mag":"2104406447","pmid":"https://pubmed.ncbi.nlm.nih.gov/25861967"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btv196","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btv196","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/31/16/2728/17084856/btv196.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/31/16/2728/17084856/btv196.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028372846","display_name":"Agne Antanaviciute","orcid":"https://orcid.org/0000-0002-9019-2215"},"institutions":[{"id":"https://openalex.org/I130828816","display_name":"University of Leeds","ror":"https://ror.org/024mrxd33","country_code":"GB","type":"education","lineage":["https://openalex.org/I130828816"]},{"id":"https://openalex.org/I2801331674","display_name":"St James's University Hospital","ror":"https://ror.org/013s89d74","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799390153","https://openalex.org/I2801331674"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Agne Antanaviciute","raw_affiliation_strings":["1 Section of Genetics, Institute of Biomedical and Clinical Sciences, School of Medicine, University of Leeds, St James\u2019s University Hospital and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Section of Genetics, Institute of Biomedical and Clinical Sciences, School of Medicine, University of Leeds, St James\u2019s University Hospital and","institution_ids":["https://openalex.org/I2801331674","https://openalex.org/I130828816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110237316","display_name":"Catherine Daly","orcid":null},"institutions":[{"id":"https://openalex.org/I130828816","display_name":"University of Leeds","ror":"https://ror.org/024mrxd33","country_code":"GB","type":"education","lineage":["https://openalex.org/I130828816"]},{"id":"https://openalex.org/I2801331674","display_name":"St James's University Hospital","ror":"https://ror.org/013s89d74","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799390153","https://openalex.org/I2801331674"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Catherine Daly","raw_affiliation_strings":["1 Section of Genetics, Institute of Biomedical and Clinical Sciences, School of Medicine, University of Leeds, St James\u2019s University Hospital and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Section of Genetics, Institute of Biomedical and Clinical Sciences, School of Medicine, University of Leeds, St James\u2019s University Hospital and","institution_ids":["https://openalex.org/I2801331674","https://openalex.org/I130828816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034703299","display_name":"Laura A. Crinnion","orcid":"https://orcid.org/0000-0003-4805-5353"},"institutions":[{"id":"https://openalex.org/I2801331674","display_name":"St James's University Hospital","ror":"https://ror.org/013s89d74","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799390153","https://openalex.org/I2801331674"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Laura A. Crinnion","raw_affiliation_strings":["2 Yorkshire Regional Genetics Service, St James\u2019s University Hospital, Leeds, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2 Yorkshire Regional Genetics Service, St James\u2019s University Hospital, Leeds, UK","institution_ids":["https://openalex.org/I2801331674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112079404","display_name":"Alexander F. Markham","orcid":null},"institutions":[{"id":"https://openalex.org/I130828816","display_name":"University of Leeds","ror":"https://ror.org/024mrxd33","country_code":"GB","type":"education","lineage":["https://openalex.org/I130828816"]},{"id":"https://openalex.org/I2801331674","display_name":"St James's University Hospital","ror":"https://ror.org/013s89d74","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799390153","https://openalex.org/I2801331674"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alexander F. Markham","raw_affiliation_strings":["1 Section of Genetics, Institute of Biomedical and Clinical Sciences, School of Medicine, University of Leeds, St James\u2019s University Hospital and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Section of Genetics, Institute of Biomedical and Clinical Sciences, School of Medicine, University of Leeds, St James\u2019s University Hospital and","institution_ids":["https://openalex.org/I2801331674","https://openalex.org/I130828816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013302197","display_name":"Christopher M. Watson","orcid":"https://orcid.org/0000-0003-2371-1844"},"institutions":[{"id":"https://openalex.org/I2801331674","display_name":"St James's University Hospital","ror":"https://ror.org/013s89d74","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799390153","https://openalex.org/I2801331674"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Christopher M. Watson","raw_affiliation_strings":["2 Yorkshire Regional Genetics Service, St James\u2019s University Hospital, Leeds, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2 Yorkshire Regional Genetics Service, St James\u2019s University Hospital, Leeds, UK","institution_ids":["https://openalex.org/I2801331674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008230485","display_name":"David T. Bonthron","orcid":"https://orcid.org/0000-0001-8132-8179"},"institutions":[{"id":"https://openalex.org/I130828816","display_name":"University of Leeds","ror":"https://ror.org/024mrxd33","country_code":"GB","type":"education","lineage":["https://openalex.org/I130828816"]},{"id":"https://openalex.org/I2801331674","display_name":"St James's University Hospital","ror":"https://ror.org/013s89d74","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799390153","https://openalex.org/I2801331674"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"David T. Bonthron","raw_affiliation_strings":["1 Section of Genetics, Institute of Biomedical and Clinical Sciences, School of Medicine, University of Leeds, St James\u2019s University Hospital and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Section of Genetics, Institute of Biomedical and Clinical Sciences, School of Medicine, University of Leeds, St James\u2019s University Hospital and","institution_ids":["https://openalex.org/I2801331674","https://openalex.org/I130828816"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086164504","display_name":"Ian Carr","orcid":"https://orcid.org/0000-0001-9544-1068"},"institutions":[{"id":"https://openalex.org/I130828816","display_name":"University of Leeds","ror":"https://ror.org/024mrxd33","country_code":"GB","type":"education","lineage":["https://openalex.org/I130828816"]},{"id":"https://openalex.org/I2801331674","display_name":"St James's University Hospital","ror":"https://ror.org/013s89d74","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799390153","https://openalex.org/I2801331674"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ian M. Carr","raw_affiliation_strings":["1 Section of Genetics, Institute of Biomedical and Clinical Sciences, School of Medicine, University of Leeds, St James\u2019s University Hospital and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Section of Genetics, Institute of Biomedical and Clinical Sciences, School of Medicine, University of Leeds, St James\u2019s University Hospital and","institution_ids":["https://openalex.org/I2801331674","https://openalex.org/I130828816"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5028372846"],"corresponding_institution_ids":["https://openalex.org/I130828816","https://openalex.org/I2801331674"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":{"value":3618,"currency":"USD","value_usd":3618},"fwci":2.4098,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":{"value":0.89074475,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"31","issue":"16","first_page":"2728","last_page":"2735"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.7402999997138977,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.7402999997138977,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.11460000276565552,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.0494999997317791,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/candidate-gene","display_name":"Candidate gene","score":0.7705806493759155},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.5858084559440613},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5834949612617493},{"id":"https://openalex.org/keywords/prioritization","display_name":"Prioritization","score":0.5509862899780273},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4590410888195038},{"id":"https://openalex.org/keywords/inference","display_name":"Inference","score":0.4330076575279236},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.40012475848197937},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.39061158895492554},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.35393309593200684},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3390633761882782},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.13118517398834229}],"concepts":[{"id":"https://openalex.org/C69991583","wikidata":"https://www.wikidata.org/wiki/Q1423575","display_name":"Candidate gene","level":3,"score":0.7705806493759155},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5858084559440613},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5834949612617493},{"id":"https://openalex.org/C2777615720","wikidata":"https://www.wikidata.org/wiki/Q11888847","display_name":"Prioritization","level":2,"score":0.5509862899780273},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4590410888195038},{"id":"https://openalex.org/C2776214188","wikidata":"https://www.wikidata.org/wiki/Q408386","display_name":"Inference","level":2,"score":0.4330076575279236},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40012475848197937},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.39061158895492554},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.35393309593200684},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3390633761882782},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.13118517398834229},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C539667460","wikidata":"https://www.wikidata.org/wiki/Q2414942","display_name":"Management science","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004194","descriptor_name":"Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004194","descriptor_name":"Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004194","descriptor_name":"Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056726","descriptor_name":"Genetic Association Studies","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D056726","descriptor_name":"Genetic Association Studies","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D056726","descriptor_name":"Genetic Association Studies","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1093/bioinformatics/btv196","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btv196","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/31/16/2728/17084856/btv196.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:25861967","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25861967","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:eprints.whiterose.ac.uk:88507","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":{"id":"https://openalex.org/S4306400854","display_name":"White Rose Research Online (University of Leeds, The University of Sheffield, University of York)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2800616092","host_organization_name":"White Rose University Consortium","host_organization_lineage":["https://openalex.org/I2800616092"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:open-archive.highwire.org:bioinfo:31/16/2728","is_oa":false,"landing_page_url":"http://bioinformatics.oxfordjournals.org/cgi/content/short/31/16/2728","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"},{"id":"pmh:oai:pubmedcentral.nih.gov:4528628","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4528628","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btv196","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btv196","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/31/16/2728/17084856/btv196.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G276470579","display_name":null,"funder_award_id":"MR/L01629X/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"}],"funders":[{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W2104406447.pdf"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W1981215030","https://openalex.org/W1989996002","https://openalex.org/W2032755318","https://openalex.org/W2040712196","https://openalex.org/W2051944123","https://openalex.org/W2054108659","https://openalex.org/W2058320302","https://openalex.org/W2088853613","https://openalex.org/W2096410350","https://openalex.org/W2098731159","https://openalex.org/W2107580398","https://openalex.org/W2108871359","https://openalex.org/W2119418518","https://openalex.org/W2121723702","https://openalex.org/W2123724865","https://openalex.org/W2124649657","https://openalex.org/W2132352688","https://openalex.org/W2136101247","https://openalex.org/W2136514583","https://openalex.org/W2139685618","https://openalex.org/W2141009231","https://openalex.org/W2144606631","https://openalex.org/W2152602212","https://openalex.org/W2154981570","https://openalex.org/W2157079123","https://openalex.org/W2160198684","https://openalex.org/W2162361752","https://openalex.org/W2168546553","https://openalex.org/W2170282111","https://openalex.org/W2170866859","https://openalex.org/W2915667579","https://openalex.org/W4210767115","https://openalex.org/W4234674830","https://openalex.org/W4237381349","https://openalex.org/W6645668516","https://openalex.org/W6679992805"],"related_works":["https://openalex.org/W2506292322","https://openalex.org/W4283209547","https://openalex.org/W4367627632","https://openalex.org/W2184980933","https://openalex.org/W653452717","https://openalex.org/W4206918580","https://openalex.org/W2554445088","https://openalex.org/W4280529353","https://openalex.org/W2062935816","https://openalex.org/W2065112873"],"abstract_inverted_index":{"MOTIVATION:":[0],"In":[1],"attempts":[2],"to":[3,26,65,81,93,96,112],"determine":[4],"the":[5,35,91,98,105,158,161,198],"genetic":[6,47],"causes":[7],"of":[8,19,32,45,53,104,177],"human":[9],"disease,":[10],"researchers":[11],"are":[12,69,208],"often":[13,40],"faced":[14],"with":[15,146],"a":[16,27,42,61,79,102,110,126],"large":[17],"number":[18,44],"candidate":[20,56,131,141,179],"genes.":[21],"Linkage":[22],"studies":[23],"can":[24],"point":[25],"genomic":[28],"region":[29],"containing":[30],"hundreds":[31],"genes,":[33],"while":[34],"high-throughput":[36],"sequencing":[37],"approach":[38,174],"will":[39],"identify":[41],"great":[43],"non-synonymous":[46],"variants.":[48],"Since":[49],"systematic":[50],"experimental":[51,147],"verification":[52],"each":[54,88],"such":[55,114],"gene":[57,74,89,132,143,151,180],"is":[58,63,175],"not":[59],"feasible,":[60],"method":[62],"needed":[64],"decide":[66],"which":[67],"genes":[68],"worth":[70],"investigating":[71],"further.":[72],"Computational":[73],"prioritization":[75,144,181],"presents":[76],"itself":[77],"as":[78],"solution":[80],"this":[82],"problem,":[83],"systematically":[84],"analyzing":[85],"and":[86,154,182,186],"sorting":[87],"from":[90,149],"most":[92],"least":[94],"likely":[95],"be":[97],"disease-causing":[99],"gene,":[100],"in":[101,140],"fraction":[103],"time":[106],"it":[107],"would":[108],"take":[109],"researcher":[111],"perform":[113],"queries":[115],"manually.":[116],"RESULTS:":[117],"Here,":[118],"we":[119],"present":[120],"Gene":[121],"TIssue":[122],"Expression":[123],"Ranker":[124],"(GeneTIER),":[125],"new":[127],"web-based":[128],"application":[129],"for":[130],"prioritization.":[133],"GeneTIER":[134],"replaces":[135],"knowledge-based":[136],"inference":[137],"traditionally":[138],"used":[139],"disease":[142],"applications":[145],"data":[148,207],"tissue-specific":[150],"expression":[152],"datasets":[153],"thus":[155],"largely":[156],"overcomes":[157],"bias":[159],"toward":[160],"better":[162],"characterized":[163],"genes/diseases":[164],"that":[165,172],"commonly":[166],"afflict":[167],"other":[168],"methods.":[169],"We":[170],"show":[171],"our":[173],"capable":[176],"accurate":[178],"illustrate":[183],"its":[184],"strengths":[185],"weaknesses":[187],"using":[188],"case":[189],"study":[190],"examples.":[191],"AVAILABILITY":[192],"AND":[193],"IMPLEMENTATION:":[194],"Freely":[195],"available":[196,209],"on":[197],"web":[199],"at":[200,210],"http://dna.leeds.ac.uk/GeneTIER/.":[201],"CONTACT:":[202],"umaan@leeds.ac.uk":[203],"SUPPLEMENTARY":[204],"INFORMATION:":[205],"Supplementary":[206],"Bioinformatics":[211],"online.":[212]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-06-23T06:36:01.041984","created_date":"2025-10-10T00:00:00"}
