{"id":"https://openalex.org/W2106855677","doi":"https://doi.org/10.1093/bioinformatics/btv146","title":"<i>Cardinal</i>: an R package for statistical analysis of mass spectrometry-based imaging experiments","display_name":"<i>Cardinal</i>: an R package for statistical analysis of mass spectrometry-based imaging experiments","publication_year":2015,"publication_date":"2015-03-15","ids":{"openalex":"https://openalex.org/W2106855677","doi":"https://doi.org/10.1093/bioinformatics/btv146","mag":"2106855677","pmid":"https://pubmed.ncbi.nlm.nih.gov/25777525"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btv146","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btv146","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/31/14/2418/49035281/bioinformatics_31_14_2418.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/31/14/2418/49035281/bioinformatics_31_14_2418.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000503708","display_name":"Kyle D. Bemis","orcid":null},"institutions":[{"id":"https://openalex.org/I4210152479","display_name":"Statistical Service","ror":"https://ror.org/05vydvf11","country_code":"CY","type":"government","lineage":["https://openalex.org/I4210152479"]}],"countries":["CY"],"is_corresponding":false,"raw_author_name":"Kyle D. Bemis","raw_affiliation_strings":["1 Department of Statistics and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Statistics and","institution_ids":["https://openalex.org/I4210152479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021894231","display_name":"April Harry","orcid":null},"institutions":[{"id":"https://openalex.org/I4210152479","display_name":"Statistical Service","ror":"https://ror.org/05vydvf11","country_code":"CY","type":"government","lineage":["https://openalex.org/I4210152479"]}],"countries":["CY"],"is_corresponding":false,"raw_author_name":"April Harry","raw_affiliation_strings":["1 Department of Statistics and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Statistics and","institution_ids":["https://openalex.org/I4210152479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038494195","display_name":"L\u00edvia S. Eberlin","orcid":"https://orcid.org/0000-0002-3885-3215"},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Livia S. Eberlin","raw_affiliation_strings":["2 Department of Chemistry, Purdue University, West Lafayette, IN 47907 USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2 Department of Chemistry, Purdue University, West Lafayette, IN 47907 USA,","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034795519","display_name":"Christina R. Ferreira","orcid":"https://orcid.org/0000-0003-3988-6454"},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christina Ferreira","raw_affiliation_strings":["2 Department of Chemistry, Purdue University, West Lafayette, IN 47907 USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2 Department of Chemistry, Purdue University, West Lafayette, IN 47907 USA,","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048845022","display_name":"Stephanie M.W.Y. van de Ven","orcid":"https://orcid.org/0000-0003-0861-0471"},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephanie M. van de Ven","raw_affiliation_strings":["3 Canary Center at Stanford for Cancer Early Detection, Stanford University School of Medicine, Palo Alto, CA 94304 USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3 Canary Center at Stanford for Cancer Early Detection, Stanford University School of Medicine, Palo Alto, CA 94304 USA,","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004807599","display_name":"Parag Mallick","orcid":"https://orcid.org/0000-0002-0505-2032"},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Parag Mallick","raw_affiliation_strings":["3 Canary Center at Stanford for Cancer Early Detection, Stanford University School of Medicine, Palo Alto, CA 94304 USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3 Canary Center at Stanford for Cancer Early Detection, Stanford University School of Medicine, Palo Alto, CA 94304 USA,","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074471874","display_name":"Mark L. Stolowitz","orcid":null},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark Stolowitz","raw_affiliation_strings":["3 Canary Center at Stanford for Cancer Early Detection, Stanford University School of Medicine, Palo Alto, CA 94304 USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3 Canary Center at Stanford for Cancer Early Detection, Stanford University School of Medicine, Palo Alto, CA 94304 USA,","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088073215","display_name":"Olga Vitek","orcid":"https://orcid.org/0000-0003-1728-1104"},"institutions":[{"id":"https://openalex.org/I12912129","display_name":"Northeastern University","ror":"https://ror.org/04t5xt781","country_code":"US","type":"education","lineage":["https://openalex.org/I12912129"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Olga Vitek","raw_affiliation_strings":["4 College of Science and","5 College of Computer and Information Science, Northeastern University, Boston, MA 02115 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4 College of Science and","institution_ids":[]},{"raw_affiliation_string":"5 College of Computer and Information Science, Northeastern University, Boston, MA 02115 USA","institution_ids":["https://openalex.org/I12912129"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5088073215"],"corresponding_institution_ids":["https://openalex.org/I12912129"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":{"value":3618,"currency":"USD","value_usd":3618},"fwci":8.2384,"has_fulltext":false,"cited_by_count":284,"citation_normalized_percentile":{"value":0.98700173,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"31","issue":"14","first_page":"2418","last_page":"2420"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9937999844551086,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10908","display_name":"Analytical Chemistry and Chromatography","score":0.9787999987602234,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mass-spectrometry-imaging","display_name":"Mass spectrometry imaging","score":0.6746607422828674},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6017192602157593},{"id":"https://openalex.org/keywords/mass-spectrometry","display_name":"Mass spectrometry","score":0.5555011630058289},{"id":"https://openalex.org/keywords/homogeneous","display_name":"Homogeneous","score":0.5320974588394165},{"id":"https://openalex.org/keywords/workflow","display_name":"Workflow","score":0.49507060647010803},{"id":"https://openalex.org/keywords/regularization","display_name":"Regularization (linguistics)","score":0.4514457583427429},{"id":"https://openalex.org/keywords/segmentation","display_name":"Segmentation","score":0.4240683913230896},{"id":"https://openalex.org/keywords/ionization","display_name":"Ionization","score":0.4181009531021118},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.41448843479156494},{"id":"https://openalex.org/keywords/image","display_name":"Image (mathematics)","score":0.41031134128570557},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.40601783990859985},{"id":"https://openalex.org/keywords/ion","display_name":"Ion","score":0.3788248300552368},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3405713140964508},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.33987534046173096},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.30002790689468384},{"id":"https://openalex.org/keywords/chromatography","display_name":"Chromatography","score":0.23930612206459045},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.0924692153930664}],"concepts":[{"id":"https://openalex.org/C24066741","wikidata":"https://www.wikidata.org/wiki/Q3796564","display_name":"Mass spectrometry imaging","level":3,"score":0.6746607422828674},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6017192602157593},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.5555011630058289},{"id":"https://openalex.org/C66882249","wikidata":"https://www.wikidata.org/wiki/Q169336","display_name":"Homogeneous","level":2,"score":0.5320974588394165},{"id":"https://openalex.org/C177212765","wikidata":"https://www.wikidata.org/wiki/Q627335","display_name":"Workflow","level":2,"score":0.49507060647010803},{"id":"https://openalex.org/C2776135515","wikidata":"https://www.wikidata.org/wiki/Q17143721","display_name":"Regularization (linguistics)","level":2,"score":0.4514457583427429},{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.4240683913230896},{"id":"https://openalex.org/C198291218","wikidata":"https://www.wikidata.org/wiki/Q190382","display_name":"Ionization","level":3,"score":0.4181009531021118},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.41448843479156494},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.41031134128570557},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.40601783990859985},{"id":"https://openalex.org/C145148216","wikidata":"https://www.wikidata.org/wiki/Q36496","display_name":"Ion","level":2,"score":0.3788248300552368},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3405713140964508},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.33987534046173096},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.30002790689468384},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.23930612206459045},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0924692153930664},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.0},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019032","descriptor_name":"Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019032","descriptor_name":"Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019032","descriptor_name":"Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D021241","descriptor_name":"Spectrometry, Mass, Electrospray Ionization","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D021241","descriptor_name":"Spectrometry, Mass, Electrospray Ionization","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D021241","descriptor_name":"Spectrometry, Mass, Electrospray Ionization","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/bioinformatics/btv146","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btv146","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/31/14/2418/49035281/bioinformatics_31_14_2418.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:25777525","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25777525","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:europepmc.org:3461082","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4495298","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:open-archive.highwire.org:bioinfo:31/14/2418","is_oa":false,"landing_page_url":"http://bioinformatics.oxfordjournals.org/cgi/content/short/31/14/2418","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btv146","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btv146","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/31/14/2418/49035281/bioinformatics_31_14_2418.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G8419798616","display_name":null,"funder_award_id":"UL1 TR001108","funder_id":"https://openalex.org/F4320337472","funder_display_name":"National Center for Advancing Translational Sciences"}],"funders":[{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":7,"referenced_works":["https://openalex.org/W1966626540","https://openalex.org/W2038856295","https://openalex.org/W2057652593","https://openalex.org/W2112523116","https://openalex.org/W2121767302","https://openalex.org/W2142372384","https://openalex.org/W2148430691"],"related_works":["https://openalex.org/W1981780420","https://openalex.org/W2182707996","https://openalex.org/W45233828","https://openalex.org/W2964988449","https://openalex.org/W188202134","https://openalex.org/W2397952901","https://openalex.org/W2029380707","https://openalex.org/W4255934811","https://openalex.org/W2465382974","https://openalex.org/W2039578808"],"abstract_inverted_index":{"Abstract":[0],"Cardinal":[1,21],"is":[2,136],"an":[3],"R":[4],"package":[5,135],"for":[6],"statistical":[7,105],"analysis":[8],"of":[9,15,56,63,68,92],"mass":[10],"spectrometry-based":[11],"imaging":[12],"(MSI)":[13],"experiments":[14,35],"biological":[16],"samples":[17],"such":[18],"as":[19],"tissues.":[20],"supports":[22],"both":[23],"Matrix-Assisted":[24],"Laser":[25],"Desorption/Ionization":[26],"(MALDI)":[27],"and":[28,34,39,65,71,76,95,112,117,123],"Desorption":[29],"Electrospray":[30],"Ionization-based":[31],"MSI":[32],"workflows,":[33],"with":[36],"multiple":[37],"tissues":[38],"complex":[40],"designs.":[41],"The":[42,104,119,134],"main":[43],"analytical":[44],"functionalities":[45],"include":[46],"(1)":[47],"image":[48,78],"segmentation,":[49],"which":[50,80],"partitions":[51],"a":[52],"tissue":[53,85],"into":[54],"regions":[55],"homogeneous":[57],"chemical":[58],"composition,":[59],"selects":[60,89],"the":[61,66,73,84,90,97,121,131],"number":[62],"segments":[64],"subset":[67,91],"informative":[69,93],"ions,":[70,94],"characterizes":[72],"associated":[74],"uncertainty":[75],"(2)":[77],"classification,":[79],"assigns":[81],"locations":[82],"on":[83,109],"to":[86],"pre-defined":[87],"classes,":[88],"estimates":[96],"resulting":[98],"classification":[99],"error":[100],"by":[101],"(cross-)":[102],"validation.":[103],"methods":[106],"are":[107,125],"based":[108],"mixture":[110],"modeling":[111],"regularization.":[113],"Contact:":[114],"o.vitek@neu.edu":[115],"Availability":[116],"implementation:":[118],"code,":[120],"documentation,":[122],"examples":[124],"available":[126,137],"open-source":[127],"at":[128,138],"www.cardinalmsi.org":[129],"under":[130],"Artistic-2.0":[132],"license.":[133],"www.bioconductor.org.":[139]},"counts_by_year":[{"year":2026,"cited_by_count":19},{"year":2025,"cited_by_count":28},{"year":2024,"cited_by_count":36},{"year":2023,"cited_by_count":35},{"year":2022,"cited_by_count":21},{"year":2021,"cited_by_count":38},{"year":2020,"cited_by_count":38},{"year":2019,"cited_by_count":19},{"year":2018,"cited_by_count":19},{"year":2017,"cited_by_count":13},{"year":2016,"cited_by_count":13},{"year":2015,"cited_by_count":5}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2016-06-24T00:00:00"}