{"id":"https://openalex.org/W2163532215","doi":"https://doi.org/10.1093/bioinformatics/btv138","title":"Hi-Jack: a novel computational framework for pathway-based inference of host\u2013pathogen interactions","display_name":"Hi-Jack: a novel computational framework for pathway-based inference of host\u2013pathogen interactions","publication_year":2015,"publication_date":"2015-03-09","ids":{"openalex":"https://openalex.org/W2163532215","doi":"https://doi.org/10.1093/bioinformatics/btv138","mag":"2163532215","pmid":"https://pubmed.ncbi.nlm.nih.gov/25758402"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btv138","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btv138","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/31/14/2332/17086841/btv138.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/31/14/2332/17086841/btv138.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064001499","display_name":"Dimitrios Kleftogiannis","orcid":"https://orcid.org/0000-0003-1086-821X"},"institutions":[{"id":"https://openalex.org/I71920554","display_name":"King Abdullah University of Science and Technology","ror":"https://ror.org/01q3tbs38","country_code":"SA","type":"education","lineage":["https://openalex.org/I71920554"]}],"countries":["SA"],"is_corresponding":true,"raw_author_name":"Dimitrios Kleftogiannis","raw_affiliation_strings":["1 Computer, Electrical and Mathematical Sciences and Engineering Division (CEMSE), King Abdullah University of Science and Technology (KAUST), Thuwal, Jeddah 23955-6900, Saudi Arabia,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Computer, Electrical and Mathematical Sciences and Engineering Division (CEMSE), King Abdullah University of Science and Technology (KAUST), Thuwal, Jeddah 23955-6900, Saudi Arabia,","institution_ids":["https://openalex.org/I71920554"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012381970","display_name":"Limsoon Wong","orcid":"https://orcid.org/0000-0003-1241-5441"},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Limsoon Wong","raw_affiliation_strings":["2 School of Computing, National University of Singapore, 13 Computing Drive, Singapore 117417, Singapore and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2 School of Computing, National University of Singapore, 13 Computing Drive, Singapore 117417, Singapore and","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110537576","display_name":"John A. C. Archer","orcid":"https://orcid.org/0000-0002-3302-3933"},"institutions":[{"id":"https://openalex.org/I71920554","display_name":"King Abdullah University of Science and Technology","ror":"https://ror.org/01q3tbs38","country_code":"SA","type":"education","lineage":["https://openalex.org/I71920554"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"John A.C. Archer","raw_affiliation_strings":["1 Computer, Electrical and Mathematical Sciences and Engineering Division (CEMSE), King Abdullah University of Science and Technology (KAUST), Thuwal, Jeddah 23955-6900, Saudi Arabia,","3 Computational Bioscience Research Center (CBRC), King Abdullah University of Science and Technology (KAUST), Thuwal, Jeddah 23955-6900, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Computer, Electrical and Mathematical Sciences and Engineering Division (CEMSE), King Abdullah University of Science and Technology (KAUST), Thuwal, Jeddah 23955-6900, Saudi Arabia,","institution_ids":["https://openalex.org/I71920554"]},{"raw_affiliation_string":"3 Computational Bioscience Research Center (CBRC), King Abdullah University of Science and Technology (KAUST), Thuwal, Jeddah 23955-6900, Saudi Arabia","institution_ids":["https://openalex.org/I71920554"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014399734","display_name":"Panos Kalnis","orcid":"https://orcid.org/0000-0002-5060-1360"},"institutions":[{"id":"https://openalex.org/I71920554","display_name":"King Abdullah University of Science and Technology","ror":"https://ror.org/01q3tbs38","country_code":"SA","type":"education","lineage":["https://openalex.org/I71920554"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Panos Kalnis","raw_affiliation_strings":["1 Computer, Electrical and Mathematical Sciences and Engineering Division (CEMSE), King Abdullah University of Science and Technology (KAUST), Thuwal, Jeddah 23955-6900, Saudi Arabia,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Computer, Electrical and Mathematical Sciences and Engineering Division (CEMSE), King Abdullah University of Science and Technology (KAUST), Thuwal, Jeddah 23955-6900, Saudi Arabia,","institution_ids":["https://openalex.org/I71920554"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5064001499"],"corresponding_institution_ids":["https://openalex.org/I71920554"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":{"value":3618,"currency":"USD","value_usd":3618},"fwci":0.6023,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.69545706,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":96},"biblio":{"volume":"31","issue":"14","first_page":"2332","last_page":"2339"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.43950000405311584,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.43950000405311584,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.26589998602867126,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.049300000071525574,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6770005822181702},{"id":"https://openalex.org/keywords/human-pathogen","display_name":"Human pathogen","score":0.6438641548156738},{"id":"https://openalex.org/keywords/host","display_name":"Host (biology)","score":0.6250296235084534},{"id":"https://openalex.org/keywords/pathogen","display_name":"Pathogen","score":0.6051549911499023},{"id":"https://openalex.org/keywords/metabolic-pathway","display_name":"Metabolic pathway","score":0.5889722108840942},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5475491285324097},{"id":"https://openalex.org/keywords/pentose-phosphate-pathway","display_name":"Pentose phosphate pathway","score":0.5193770527839661},{"id":"https://openalex.org/keywords/metabolic-network","display_name":"Metabolic network","score":0.460385799407959},{"id":"https://openalex.org/keywords/host\u2013pathogen-interaction","display_name":"Host\u2013pathogen interaction","score":0.45521801710128784},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3283199369907379},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.32180002331733704},{"id":"https://openalex.org/keywords/metabolism","display_name":"Metabolism","score":0.2939041554927826},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.23391887545585632},{"id":"https://openalex.org/keywords/virulence","display_name":"Virulence","score":0.15812042355537415},{"id":"https://openalex.org/keywords/glycolysis","display_name":"Glycolysis","score":0.14157193899154663}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6770005822181702},{"id":"https://openalex.org/C24527192","wikidata":"https://www.wikidata.org/wiki/Q17149729","display_name":"Human pathogen","level":3,"score":0.6438641548156738},{"id":"https://openalex.org/C126831891","wikidata":"https://www.wikidata.org/wiki/Q221673","display_name":"Host (biology)","level":2,"score":0.6250296235084534},{"id":"https://openalex.org/C2776460866","wikidata":"https://www.wikidata.org/wiki/Q170065","display_name":"Pathogen","level":2,"score":0.6051549911499023},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.5889722108840942},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5475491285324097},{"id":"https://openalex.org/C3409486","wikidata":"https://www.wikidata.org/wiki/Q827489","display_name":"Pentose phosphate pathway","level":4,"score":0.5193770527839661},{"id":"https://openalex.org/C101810790","wikidata":"https://www.wikidata.org/wiki/Q2263094","display_name":"Metabolic network","level":2,"score":0.460385799407959},{"id":"https://openalex.org/C2778375072","wikidata":"https://www.wikidata.org/wiki/Q5909198","display_name":"Host\u2013pathogen interaction","level":4,"score":0.45521801710128784},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3283199369907379},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.32180002331733704},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.2939041554927826},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23391887545585632},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.15812042355537415},{"id":"https://openalex.org/C20251656","wikidata":"https://www.wikidata.org/wiki/Q162643","display_name":"Glycolysis","level":3,"score":0.14157193899154663}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D054884","descriptor_name":"Host-Pathogen Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D054884","descriptor_name":"Host-Pathogen Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D054884","descriptor_name":"Host-Pathogen Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/bioinformatics/btv138","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btv138","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/31/14/2332/17086841/btv138.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:25758402","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25758402","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:open-archive.highwire.org:bioinfo:31/14/2332","is_oa":false,"landing_page_url":"http://bioinformatics.oxfordjournals.org/cgi/content/short/31/14/2332","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"},{"id":"pmh:oai:repository.kaust.edu.sa:10754/594174","is_oa":false,"landing_page_url":"http://hdl.handle.net/10754/594174","pdf_url":null,"source":{"id":"https://openalex.org/S4306401596","display_name":"King Abdullah University of Science and Technology Repository (King Abdullah University of Science and Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I71920554","host_organization_name":"King Abdullah University of Science and Technology","host_organization_lineage":["https://openalex.org/I71920554"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btv138","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btv138","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/31/14/2332/17086841/btv138.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322320","display_name":"King Abdullah University of Science and Technology","ror":"https://ror.org/01q3tbs38"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2163532215.pdf","grobid_xml":"https://content.openalex.org/works/W2163532215.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W1569155223","https://openalex.org/W1689761783","https://openalex.org/W1839665474","https://openalex.org/W1964572291","https://openalex.org/W1972902340","https://openalex.org/W1977392538","https://openalex.org/W1979537657","https://openalex.org/W1990660415","https://openalex.org/W2000351247","https://openalex.org/W2005936873","https://openalex.org/W2025060809","https://openalex.org/W2046163764","https://openalex.org/W2062685052","https://openalex.org/W2066135800","https://openalex.org/W2070587756","https://openalex.org/W2082344308","https://openalex.org/W2092899907","https://openalex.org/W2094999579","https://openalex.org/W2095521407","https://openalex.org/W2112303826","https://openalex.org/W2113140044","https://openalex.org/W2120550036","https://openalex.org/W2128482141","https://openalex.org/W2129860041","https://openalex.org/W2133319394","https://openalex.org/W2137896695","https://openalex.org/W2159482845","https://openalex.org/W2324055656","https://openalex.org/W4294216483","https://openalex.org/W4298203020","https://openalex.org/W4298226842","https://openalex.org/W6677955720"],"related_works":["https://openalex.org/W17595964","https://openalex.org/W2010579377","https://openalex.org/W2393779090","https://openalex.org/W2074892828","https://openalex.org/W1543402486","https://openalex.org/W2063475537","https://openalex.org/W2341681417","https://openalex.org/W1961707331","https://openalex.org/W3031598903","https://openalex.org/W2012938657"],"abstract_inverted_index":{"MOTIVATION:":[0],"Pathogens":[1],"infect":[2],"their":[3],"host":[4,8,24,87,128],"and":[5,88,106,108,123,175,200,233],"hijack":[6],"the":[7,23,36,39,62,70,94,127,134,139,155,188],"machinery":[9],"to":[10,25,33,66,178,184],"produce":[11],"more":[12],"progeny":[13],"pathogens.":[14],"Obligate":[15],"intracellular":[16],"pathogens,":[17,107],"in":[18,35,42,126,133,154,169,227],"particular,":[19],"require":[20],"resources":[21],"of":[22,38,44,51,53,96,205,213,219],"replicate.":[26],"Therefore,":[27],"infections":[28],"by":[29,187],"these":[30],"pathogens":[31],"lead":[32],"alterations":[34],"metabolism":[37,174],"host,":[40],"shifting":[41],"favor":[43],"pathogen":[45,90],"protein":[46],"production.":[47],"Some":[48],"computational":[49,78],"identification":[50],"mechanisms":[52],"host-pathogen":[54,147],"interactions":[55,84],"have":[56],"been":[57],"proposed,":[58],"but":[59],"it":[60],"seems":[61],"problem":[63],"has":[64],"yet":[65],"be":[67,152,185],"approached":[68],"from":[69,104],"metabolite-hijacking":[71],"angle.":[72],"RESULTS:":[73],"We":[74,144],"propose":[75],"a":[76,86,89],"novel":[77,116],"framework,":[79],"Hi-Jack,":[80],"for":[81,157],"inferring":[82],"pathway-based":[83],"between":[85,198],"that":[91,129,150],"relies":[92],"on":[93,163],"idea":[95],"metabolite":[97],"hijacking.":[98],"Hi-Jack":[99],"searches":[100],"metabolic":[101],"network":[102],"data":[103],"hosts":[105],"identifies":[109,124],"candidate":[110,120],"reactions":[111,122],"where":[112],"hijacking":[113],"occurs.":[114],"A":[115],"scoring":[117],"function":[118],"ranks":[119],"hijacked":[121,142,186],"pathways":[125,132,168,176],"interact":[130],"with":[131,210,224],"pathogen,":[135],"as":[136,138,203],"well":[137],"associated":[140],"frequent":[141],"metabolites.":[143],"also":[145],"describe":[146],"interaction":[148],"principles":[149],"can":[151],"used":[153],"future":[156],"subsequent":[158],"studies.":[159],"Our":[160],"case":[161],"study":[162],"Mycobacterium":[164],"tuberculosis":[165],"(Mtb)":[166],"revealed":[167],"human-e.g.":[170],"carbohydrate":[171],"metabolism,":[172],"lipids":[173],"related":[177],"amino":[179],"acids":[180],"metabolism-that":[181],"are":[182,235],"likely":[183],"pathogen.":[189],"In":[190],"addition,":[191],"we":[192],"report":[193],"interesting":[194],"potential":[195],"pathway":[196,223],"interconnections":[197],"human":[199,206,220],"Mtb":[201,211],"such":[202],"linkage":[204,218],"fatty":[207,215],"acid":[208],"biosynthesis":[209,212,226],"unsaturated":[214],"acids,":[216],"or":[217],"pentose":[221],"phosphate":[222],"lipopolysaccharide":[225],"Mtb.":[228],"AVAILABILITY":[229],"AND":[230],"IMPLEMENTATION:":[231],"Datasets":[232],"codes":[234],"available":[236],"at":[237],"http://cloud.kaust.edu.sa/Pages/Hi-Jack.aspx":[238]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}
