{"id":"https://openalex.org/W2146276081","doi":"https://doi.org/10.1093/bioinformatics/btv023","title":"Bias in microRNA functional enrichment analysis","display_name":"Bias in microRNA functional enrichment analysis","publication_year":2015,"publication_date":"2015-01-20","ids":{"openalex":"https://openalex.org/W2146276081","doi":"https://doi.org/10.1093/bioinformatics/btv023","mag":"2146276081","pmid":"https://pubmed.ncbi.nlm.nih.gov/25609791"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btv023","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btv023","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/31/10/1592/17085526/btv023.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/31/10/1592/17085526/btv023.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085567517","display_name":"Thomas Bleazard","orcid":"https://orcid.org/0000-0002-5101-5726"},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Thomas Bleazard","raw_affiliation_strings":["1 Faculty of Medical and Human Sciences, and 2Faculty of Life Sciences, University of Manchester, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Faculty of Medical and Human Sciences, and 2Faculty of Life Sciences, University of Manchester, UK","institution_ids":["https://openalex.org/I28407311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080625220","display_name":"Janine A. Lamb","orcid":"https://orcid.org/0000-0002-7248-0539"},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Janine A Lamb","raw_affiliation_strings":["1 Faculty of Medical and Human Sciences, and 2Faculty of Life Sciences, University of Manchester, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Faculty of Medical and Human Sciences, and 2Faculty of Life Sciences, University of Manchester, UK","institution_ids":["https://openalex.org/I28407311"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001502247","display_name":"Sam Griffiths\u2010Jones","orcid":"https://orcid.org/0000-0001-6043-807X"},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Sam Griffiths-Jones","raw_affiliation_strings":["1 Faculty of Medical and Human Sciences, and 2Faculty of Life Sciences, University of Manchester, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Faculty of Medical and Human Sciences, and 2Faculty of Life Sciences, University of Manchester, UK","institution_ids":["https://openalex.org/I28407311"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5001502247","https://openalex.org/A5080625220"],"corresponding_institution_ids":["https://openalex.org/I28407311"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":{"value":3506,"currency":"EUR","value_usd":3781},"fwci":5.6513,"has_fulltext":true,"cited_by_count":115,"citation_normalized_percentile":{"value":0.97339846,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"31","issue":"10","first_page":"1592","last_page":"1598"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.7308826446533203},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.643499493598938},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.594582736492157},{"id":"https://openalex.org/keywords/gene-ontology","display_name":"Gene ontology","score":0.5472497940063477},{"id":"https://openalex.org/keywords/hypergeometric-distribution","display_name":"Hypergeometric distribution","score":0.5353992581367493},{"id":"https://openalex.org/keywords/functional-analysis","display_name":"Functional analysis","score":0.47716444730758667},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.44722476601600647},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3734622597694397},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.2899649143218994},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.1393212378025055},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.1361091434955597}],"concepts":[{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.7308826446533203},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.643499493598938},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.594582736492157},{"id":"https://openalex.org/C2987395477","wikidata":"https://www.wikidata.org/wiki/Q135085","display_name":"Gene ontology","level":4,"score":0.5472497940063477},{"id":"https://openalex.org/C176671685","wikidata":"https://www.wikidata.org/wiki/Q730600","display_name":"Hypergeometric distribution","level":2,"score":0.5353992581367493},{"id":"https://openalex.org/C55112680","wikidata":"https://www.wikidata.org/wiki/Q190549","display_name":"Functional analysis","level":3,"score":0.47716444730758667},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.44722476601600647},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3734622597694397},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2899649143218994},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.1393212378025055},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.1361091434955597}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D058977","descriptor_name":"Molecular Sequence Annotation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058977","descriptor_name":"Molecular Sequence Annotation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058977","descriptor_name":"Molecular Sequence Annotation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1093/bioinformatics/btv023","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btv023","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/31/10/1592/17085526/btv023.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:25609791","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25609791","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:pure.atira.dk:openaire/cea9b187-7fab-48d6-ae7d-8ffa277c554b","is_oa":true,"landing_page_url":"https://research.manchester.ac.uk/en/publications/cea9b187-7fab-48d6-ae7d-8ffa277c554b","pdf_url":null,"source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bleazard, T, Lamb, J & Griffiths-Jones, S 2015, 'Bias in microRNA functional enrichment analysis', Bioinformatics (Oxford, England), vol. 31, no. 10, pp. 1592-1598. https://doi.org/10.1093/bioinformatics/btv023","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:open-archive.highwire.org:bioinfo:31/10/1592","is_oa":false,"landing_page_url":"http://bioinformatics.oxfordjournals.org/cgi/content/short/31/10/1592","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"},{"id":"pmh:oai:pubmedcentral.nih.gov:4426843","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4426843","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btv023","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btv023","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/31/10/1592/17085526/btv023.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2146276081.pdf","grobid_xml":"https://content.openalex.org/works/W2146276081.grobid-xml"},"referenced_works_count":67,"referenced_works":["https://openalex.org/W1964351261","https://openalex.org/W1965568460","https://openalex.org/W1966486033","https://openalex.org/W1984146363","https://openalex.org/W1985313214","https://openalex.org/W1988925753","https://openalex.org/W1989373617","https://openalex.org/W1992512552","https://openalex.org/W1993576110","https://openalex.org/W2001707140","https://openalex.org/W2003816656","https://openalex.org/W2007381960","https://openalex.org/W2008521392","https://openalex.org/W2016700676","https://openalex.org/W2017426710","https://openalex.org/W2019907335","https://openalex.org/W2023027151","https://openalex.org/W2024511327","https://openalex.org/W2026570544","https://openalex.org/W2029943701","https://openalex.org/W2031621381","https://openalex.org/W2033926494","https://openalex.org/W2036171395","https://openalex.org/W2046773304","https://openalex.org/W2049339234","https://openalex.org/W2053143087","https://openalex.org/W2054244912","https://openalex.org/W2057025444","https://openalex.org/W2058809590","https://openalex.org/W2062836285","https://openalex.org/W2067260619","https://openalex.org/W2073315752","https://openalex.org/W2075716141","https://openalex.org/W2076281861","https://openalex.org/W2079904475","https://openalex.org/W2093323215","https://openalex.org/W2094048386","https://openalex.org/W2100084607","https://openalex.org/W2103017472","https://openalex.org/W2106222771","https://openalex.org/W2108541168","https://openalex.org/W2110065044","https://openalex.org/W2111143608","https://openalex.org/W2112187582","https://openalex.org/W2117802141","https://openalex.org/W2117977572","https://openalex.org/W2120456037","https://openalex.org/W2122866775","https://openalex.org/W2127838022","https://openalex.org/W2131054825","https://openalex.org/W2138473891","https://openalex.org/W2143284186","https://openalex.org/W2144177541","https://openalex.org/W2145460224","https://openalex.org/W2148141433","https://openalex.org/W2149785901","https://openalex.org/W2156564520","https://openalex.org/W2158217645","https://openalex.org/W2158671377","https://openalex.org/W2159482845","https://openalex.org/W2162674813","https://openalex.org/W2162940287","https://openalex.org/W2165019042","https://openalex.org/W2168173728","https://openalex.org/W4294216483","https://openalex.org/W6656336705","https://openalex.org/W6679936964"],"related_works":["https://openalex.org/W2737319532","https://openalex.org/W4392896533","https://openalex.org/W2062945643","https://openalex.org/W2050308539","https://openalex.org/W3151405604","https://openalex.org/W2565797512","https://openalex.org/W4241694095","https://openalex.org/W2330252996","https://openalex.org/W2793648706","https://openalex.org/W3043187607"],"abstract_inverted_index":{"Abstract":[0],"Motivation:":[1],"Many":[2],"studies":[3],"have":[4],"investigated":[5],"the":[6,34,61,73,83,97,119,147,164,187,202],"differential":[7],"expression":[8],"of":[9,26,50,56,63,85,87,110,123,146,151,153,163,186],"microRNAs":[10],"(miRNAs)":[11],"in":[12,60,102,118,143,172],"disease":[13],"states":[14],"and":[15,20,67,140,196],"between":[16],"different":[17],"treatments,":[18],"tissues":[19],"developmental":[21],"stages.":[22],"Given":[23],"a":[24,126,144],"list":[25],"perturbed":[27],"miRNAs,":[28,113],"it":[29],"is":[30,80,205],"common":[31],"to":[32,132],"predict":[33],"shared":[35],"pathways":[36],"on":[37],"which":[38,57],"they":[39],"act.":[40],"The":[41,92,160],"standard":[42,98,188],"test":[43,79],"for":[44,82,105,108,178,192],"functional":[45,53,77,106,174,189],"enrichment":[46,78,107,134,190],"typically":[47],"yields":[48],"dozens":[49],"significantly":[51,170],"enriched":[52,171],"categories,":[54],"many":[55],"appear":[58],"frequently":[59],"analysis":[62,84],"apparently":[64],"unrelated":[65],"diseases":[66],"conditions.":[68],"Results:":[69],"We":[70,128,180],"show":[71],"that":[72],"most":[74],"commonly":[75],"used":[76,95],"inappropriate":[81],"sets":[86,167],"genes":[88],"targeted":[89],"by":[90,96],"miRNAs.":[91],"hypergeometric":[93],"distribution":[94],"method":[99,191],"consistently":[100],"results":[101],"significant":[103],"P-values":[104],"targets":[109,122,152],"randomly":[111],"selected":[112],"reflecting":[114],"an":[115,130,136],"underlying":[116],"bias":[117],"predicted":[120],"gene":[121,148],"miRNAs":[124],"as":[125],"whole.":[127],"developed":[129],"algorithm":[131,204],"measure":[133],"using":[135],"empirical":[137,203],"sampling":[138],"approach,":[139],"applied":[141],"this":[142],"reanalysis":[145],"ontology":[149],"classes":[150],"miRNA":[154,165,193],"lists":[155],"from":[156],"44":[157],"published":[158],"studies.":[159],"vast":[161],"majority":[162],"target":[166],"were":[168],"not":[169],"any":[173],"category":[175],"after":[176],"correction":[177],"bias.":[179],"therefore":[181],"argue":[182],"against":[183],"continued":[184],"use":[185],"targets.":[194],"Availability":[195],"implementation:":[197],"A":[198],"Python":[199],"script":[200],"implementing":[201],"freely":[206],"available":[207,219],"at":[208,220],"http://sgjlab.org/empirical-go/.":[209],"Contact:":[210],"sam.griffiths-jones@manchester.ac.uk":[211],"or":[212],"janine.lamb@manchester.ac.uk":[213],"Supplementary":[214,216],"information:":[215],"data":[217],"are":[218],"Bioinformatics":[221],"online.":[222]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":16},{"year":2017,"cited_by_count":18},{"year":2016,"cited_by_count":12},{"year":2015,"cited_by_count":9}],"updated_date":"2026-08-04T08:18:43.703281","created_date":"2025-10-10T00:00:00"}