{"id":"https://openalex.org/W2105136962","doi":"https://doi.org/10.1093/bioinformatics/btu811","title":"Identifying cancer-related microRNAs based on gene expression data","display_name":"Identifying cancer-related microRNAs based on gene expression data","publication_year":2014,"publication_date":"2014-12-12","ids":{"openalex":"https://openalex.org/W2105136962","doi":"https://doi.org/10.1093/bioinformatics/btu811","mag":"2105136962","pmid":"https://pubmed.ncbi.nlm.nih.gov/25505085"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btu811","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btu811","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101736200","display_name":"Xing-Ming Zhao","orcid":"https://orcid.org/0000-0002-3335-6439"},"institutions":[{"id":"https://openalex.org/I113940042","display_name":"Shanghai University","ror":"https://ror.org/006teas31","country_code":"CN","type":"education","lineage":["https://openalex.org/I113940042"]},{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210106477","display_name":"Shanghai Institutes for Biological Sciences","ror":"https://ror.org/011rf9d86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106477"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xing-Ming Zhao","raw_affiliation_strings":["1 School of Electronics and Information Engineering, Tongji University, Shanghai 201804, China, 2Center for Bioinformatics and Systems Biology, Department of Radiology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA, 3LERIA, University of Angers, 49045 Angers Cedex 01, France, 4Department of Mathematics, Shanghai University, Shanghai 200444, China and 5Key Laboratory of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 School of Electronics and Information Engineering, Tongji University, Shanghai 201804, China, 2Center for Bioinformatics and Systems Biology, Department of Radiology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA, 3LERIA, University of Angers, 49045 Angers Cedex 01, France, 4Department of Mathematics, Shanghai University, Shanghai 200444, China and 5Key Laboratory of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I113940042","https://openalex.org/I19820366","https://openalex.org/I4210106477"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090833521","display_name":"Ke-Qin Liu","orcid":null},"institutions":[{"id":"https://openalex.org/I113940042","display_name":"Shanghai University","ror":"https://ror.org/006teas31","country_code":"CN","type":"education","lineage":["https://openalex.org/I113940042"]},{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210106477","display_name":"Shanghai Institutes for Biological Sciences","ror":"https://ror.org/011rf9d86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106477"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ke-Qin Liu","raw_affiliation_strings":["1 School of Electronics and Information Engineering, Tongji University, Shanghai 201804, China, 2Center for Bioinformatics and Systems Biology, Department of Radiology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA, 3LERIA, University of Angers, 49045 Angers Cedex 01, France, 4Department of Mathematics, Shanghai University, Shanghai 200444, China and 5Key Laboratory of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 School of Electronics and Information Engineering, Tongji University, Shanghai 201804, China, 2Center for Bioinformatics and Systems Biology, Department of Radiology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA, 3LERIA, University of Angers, 49045 Angers Cedex 01, France, 4Department of Mathematics, Shanghai University, Shanghai 200444, China and 5Key Laboratory of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I113940042","https://openalex.org/I19820366","https://openalex.org/I4210106477"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100713942","display_name":"Guanghui Zhu","orcid":"https://orcid.org/0000-0003-1418-2768"},"institutions":[{"id":"https://openalex.org/I113940042","display_name":"Shanghai University","ror":"https://ror.org/006teas31","country_code":"CN","type":"education","lineage":["https://openalex.org/I113940042"]},{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210106477","display_name":"Shanghai Institutes for Biological Sciences","ror":"https://ror.org/011rf9d86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106477"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guanghui Zhu","raw_affiliation_strings":["1 School of Electronics and Information Engineering, Tongji University, Shanghai 201804, China, 2Center for Bioinformatics and Systems Biology, Department of Radiology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA, 3LERIA, University of Angers, 49045 Angers Cedex 01, France, 4Department of Mathematics, Shanghai University, Shanghai 200444, China and 5Key Laboratory of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 School of Electronics and Information Engineering, Tongji University, Shanghai 201804, China, 2Center for Bioinformatics and Systems Biology, Department of Radiology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA, 3LERIA, University of Angers, 49045 Angers Cedex 01, France, 4Department of Mathematics, Shanghai University, Shanghai 200444, China and 5Key Laboratory of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I113940042","https://openalex.org/I19820366","https://openalex.org/I4210106477"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5119268524","display_name":"Feng He","orcid":"https://orcid.org/0000-0002-9858-4141"},"institutions":[{"id":"https://openalex.org/I113940042","display_name":"Shanghai University","ror":"https://ror.org/006teas31","country_code":"CN","type":"education","lineage":["https://openalex.org/I113940042"]},{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210106477","display_name":"Shanghai Institutes for Biological Sciences","ror":"https://ror.org/011rf9d86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106477"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Feng He","raw_affiliation_strings":["1 School of Electronics and Information Engineering, Tongji University, Shanghai 201804, China, 2Center for Bioinformatics and Systems Biology, Department of Radiology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA, 3LERIA, University of Angers, 49045 Angers Cedex 01, France, 4Department of Mathematics, Shanghai University, Shanghai 200444, China and 5Key Laboratory of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 School of Electronics and Information Engineering, Tongji University, Shanghai 201804, China, 2Center for Bioinformatics and Systems Biology, Department of Radiology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA, 3LERIA, University of Angers, 49045 Angers Cedex 01, France, 4Department of Mathematics, Shanghai University, Shanghai 200444, China and 5Key Laboratory of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I113940042","https://openalex.org/I19820366","https://openalex.org/I4210106477"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011361507","display_name":"B\u00e9atrice Duval","orcid":"https://orcid.org/0000-0002-1400-4163"},"institutions":[{"id":"https://openalex.org/I113940042","display_name":"Shanghai University","ror":"https://ror.org/006teas31","country_code":"CN","type":"education","lineage":["https://openalex.org/I113940042"]},{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210106477","display_name":"Shanghai Institutes for Biological Sciences","ror":"https://ror.org/011rf9d86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106477"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"B\u00e9atrice Duval","raw_affiliation_strings":["1 School of Electronics and Information Engineering, Tongji University, Shanghai 201804, China, 2Center for Bioinformatics and Systems Biology, Department of Radiology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA, 3LERIA, University of Angers, 49045 Angers Cedex 01, France, 4Department of Mathematics, Shanghai University, Shanghai 200444, China and 5Key Laboratory of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 School of Electronics and Information Engineering, Tongji University, Shanghai 201804, China, 2Center for Bioinformatics and Systems Biology, Department of Radiology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA, 3LERIA, University of Angers, 49045 Angers Cedex 01, France, 4Department of Mathematics, Shanghai University, Shanghai 200444, China and 5Key Laboratory of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I113940042","https://openalex.org/I19820366","https://openalex.org/I4210106477"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049497041","display_name":"Jean\u2010Michel Richer","orcid":null},"institutions":[{"id":"https://openalex.org/I113940042","display_name":"Shanghai University","ror":"https://ror.org/006teas31","country_code":"CN","type":"education","lineage":["https://openalex.org/I113940042"]},{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210106477","display_name":"Shanghai Institutes for Biological Sciences","ror":"https://ror.org/011rf9d86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106477"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jean-Michel Richer","raw_affiliation_strings":["1 School of Electronics and Information Engineering, Tongji University, Shanghai 201804, China, 2Center for Bioinformatics and Systems Biology, Department of Radiology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA, 3LERIA, University of Angers, 49045 Angers Cedex 01, France, 4Department of Mathematics, Shanghai University, Shanghai 200444, China and 5Key Laboratory of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 School of Electronics and Information Engineering, Tongji University, Shanghai 201804, China, 2Center for Bioinformatics and Systems Biology, Department of Radiology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA, 3LERIA, University of Angers, 49045 Angers Cedex 01, France, 4Department of Mathematics, Shanghai University, Shanghai 200444, China and 5Key Laboratory of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I113940042","https://openalex.org/I19820366","https://openalex.org/I4210106477"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060381913","display_name":"De-Shuang Huang","orcid":"https://orcid.org/0000-0002-6759-2691"},"institutions":[{"id":"https://openalex.org/I113940042","display_name":"Shanghai University","ror":"https://ror.org/006teas31","country_code":"CN","type":"education","lineage":["https://openalex.org/I113940042"]},{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210106477","display_name":"Shanghai Institutes for Biological Sciences","ror":"https://ror.org/011rf9d86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106477"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"De-Shuang Huang","raw_affiliation_strings":["1 School of Electronics and Information Engineering, Tongji University, Shanghai 201804, China, 2Center for Bioinformatics and Systems Biology, Department of Radiology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA, 3LERIA, University of Angers, 49045 Angers Cedex 01, France, 4Department of Mathematics, Shanghai University, Shanghai 200444, China and 5Key Laboratory of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 School of Electronics and Information Engineering, Tongji University, Shanghai 201804, China, 2Center for Bioinformatics and Systems Biology, Department of Radiology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA, 3LERIA, University of Angers, 49045 Angers Cedex 01, France, 4Department of Mathematics, Shanghai University, Shanghai 200444, China and 5Key Laboratory of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I113940042","https://openalex.org/I19820366","https://openalex.org/I4210106477"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Chang-Jun Jiang","orcid":null},"institutions":[{"id":"https://openalex.org/I113940042","display_name":"Shanghai University","ror":"https://ror.org/006teas31","country_code":"CN","type":"education","lineage":["https://openalex.org/I113940042"]},{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210106477","display_name":"Shanghai Institutes for Biological Sciences","ror":"https://ror.org/011rf9d86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106477"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chang-Jun Jiang","raw_affiliation_strings":["1 School of Electronics and Information Engineering, Tongji University, Shanghai 201804, China, 2Center for Bioinformatics and Systems Biology, Department of Radiology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA, 3LERIA, University of Angers, 49045 Angers Cedex 01, France, 4Department of Mathematics, Shanghai University, Shanghai 200444, China and 5Key Laboratory of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 School of Electronics and Information Engineering, Tongji University, Shanghai 201804, China, 2Center for Bioinformatics and Systems Biology, Department of Radiology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA, 3LERIA, University of Angers, 49045 Angers Cedex 01, France, 4Department of Mathematics, Shanghai University, Shanghai 200444, China and 5Key Laboratory of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I113940042","https://openalex.org/I19820366","https://openalex.org/I4210106477"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016332970","display_name":"Jin\u2010Kao Hao","orcid":"https://orcid.org/0000-0001-8813-4377"},"institutions":[{"id":"https://openalex.org/I113940042","display_name":"Shanghai University","ror":"https://ror.org/006teas31","country_code":"CN","type":"education","lineage":["https://openalex.org/I113940042"]},{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210106477","display_name":"Shanghai Institutes for Biological Sciences","ror":"https://ror.org/011rf9d86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106477"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jin-Kao Hao","raw_affiliation_strings":["1 School of Electronics and Information Engineering, Tongji University, Shanghai 201804, China, 2Center for Bioinformatics and Systems Biology, Department of Radiology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA, 3LERIA, University of Angers, 49045 Angers Cedex 01, France, 4Department of Mathematics, Shanghai University, Shanghai 200444, China and 5Key Laboratory of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 School of Electronics and Information Engineering, Tongji University, Shanghai 201804, China, 2Center for Bioinformatics and Systems Biology, Department of Radiology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA, 3LERIA, University of Angers, 49045 Angers Cedex 01, France, 4Department of Mathematics, Shanghai University, Shanghai 200444, China and 5Key Laboratory of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I113940042","https://openalex.org/I19820366","https://openalex.org/I4210106477"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012283696","display_name":"Luonan Chen","orcid":"https://orcid.org/0000-0002-3960-0068"},"institutions":[{"id":"https://openalex.org/I113940042","display_name":"Shanghai University","ror":"https://ror.org/006teas31","country_code":"CN","type":"education","lineage":["https://openalex.org/I113940042"]},{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210106477","display_name":"Shanghai Institutes for Biological Sciences","ror":"https://ror.org/011rf9d86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106477"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Luonan Chen","raw_affiliation_strings":["1 School of Electronics and Information Engineering, Tongji University, Shanghai 201804, China, 2Center for Bioinformatics and Systems Biology, Department of Radiology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA, 3LERIA, University of Angers, 49045 Angers Cedex 01, France, 4Department of Mathematics, Shanghai University, Shanghai 200444, China and 5Key Laboratory of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 School of Electronics and Information Engineering, Tongji University, Shanghai 201804, China, 2Center for Bioinformatics and Systems Biology, Department of Radiology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA, 3LERIA, University of Angers, 49045 Angers Cedex 01, France, 4Department of Mathematics, Shanghai University, Shanghai 200444, China and 5Key Laboratory of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I113940042","https://openalex.org/I19820366","https://openalex.org/I4210106477"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5012283696","https://openalex.org/A5016332970","https://openalex.org/A5101736200"],"corresponding_institution_ids":["https://openalex.org/I113940042","https://openalex.org/I116953780","https://openalex.org/I19820366","https://openalex.org/I4210106477"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":2.9828,"has_fulltext":false,"cited_by_count":86,"citation_normalized_percentile":{"value":0.91391806,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":100},"biblio":{"volume":"31","issue":"8","first_page":"1226","last_page":"1234"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.965399980545044,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.965399980545044,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.004800000227987766,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11765","display_name":"Circular RNAs in diseases","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.8465120792388916},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6138656139373779},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.5314971804618835},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5085541009902954},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.4958425462245941},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.47633057832717896},{"id":"https://openalex.org/keywords/regulation-of-gene-expression","display_name":"Regulation of gene expression","score":0.46923547983169556},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3653976321220398},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.24177634716033936}],"concepts":[{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.8465120792388916},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6138656139373779},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5314971804618835},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5085541009902954},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4958425462245941},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.47633057832717896},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.46923547983169556},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3653976321220398},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.24177634716033936}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bioinformatics/btu811","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btu811","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:25505085","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25505085","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:HAL:hal-01392209v1","is_oa":false,"landing_page_url":"https://hal.science/hal-01392209","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics, 2015, 31(8), pp.1226-1234. &#x27E8;10.1093/bioinformatics/btu811&#x27E9;","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":66,"referenced_works":["https://openalex.org/W144423133","https://openalex.org/W202353055","https://openalex.org/W1563316806","https://openalex.org/W1971904680","https://openalex.org/W1972626324","https://openalex.org/W1973816411","https://openalex.org/W1978337436","https://openalex.org/W1978545732","https://openalex.org/W1986782449","https://openalex.org/W1990933893","https://openalex.org/W1992127683","https://openalex.org/W1999895438","https://openalex.org/W2002995168","https://openalex.org/W2006797972","https://openalex.org/W2007227595","https://openalex.org/W2008945738","https://openalex.org/W2010215928","https://openalex.org/W2010457001","https://openalex.org/W2014209078","https://openalex.org/W2015939604","https://openalex.org/W2017199818","https://openalex.org/W2020541351","https://openalex.org/W2027769492","https://openalex.org/W2029102827","https://openalex.org/W2035487684","https://openalex.org/W2040191060","https://openalex.org/W2043797012","https://openalex.org/W2046759180","https://openalex.org/W2047967134","https://openalex.org/W2050079849","https://openalex.org/W2050245934","https://openalex.org/W2050869737","https://openalex.org/W2056506538","https://openalex.org/W2061873339","https://openalex.org/W2066195414","https://openalex.org/W2070544303","https://openalex.org/W2070777085","https://openalex.org/W2074664629","https://openalex.org/W2075329854","https://openalex.org/W2076118448","https://openalex.org/W2083381199","https://openalex.org/W2085555782","https://openalex.org/W2103177465","https://openalex.org/W2110095004","https://openalex.org/W2110666579","https://openalex.org/W2112192177","https://openalex.org/W2117641610","https://openalex.org/W2117692326","https://openalex.org/W2123060905","https://openalex.org/W2126108346","https://openalex.org/W2127594372","https://openalex.org/W2129158737","https://openalex.org/W2130979840","https://openalex.org/W2135314242","https://openalex.org/W2140469676","https://openalex.org/W2144038313","https://openalex.org/W2144896290","https://openalex.org/W2148108295","https://openalex.org/W2151100414","https://openalex.org/W2156205933","https://openalex.org/W2156268500","https://openalex.org/W2162038712","https://openalex.org/W2166658616","https://openalex.org/W2170951627","https://openalex.org/W2170989872","https://openalex.org/W6652492101"],"related_works":["https://openalex.org/W2128583238","https://openalex.org/W2049907435","https://openalex.org/W2057742104","https://openalex.org/W2034377088","https://openalex.org/W4283692078","https://openalex.org/W2613929436","https://openalex.org/W2347793859","https://openalex.org/W3151254369","https://openalex.org/W46113340","https://openalex.org/W2016183850"],"abstract_inverted_index":{"MOTIVATION:":[0],"MicroRNAs":[1],"(miRNAs)":[2],"are":[3,27,42,100,108,196,228,245,255],"short":[4],"non-coding":[5],"RNAs":[6],"that":[7,25,107,173],"play":[8],"important":[9,18],"roles":[10],"in":[11,30,52,121,230],"post-transcriptional":[12],"regulations":[13],"as":[14,16],"well":[15],"other":[17,97,187],"biological":[19],"processes.":[20],"Recently,":[21],"accumulating":[22],"evidences":[23,204],"indicate":[24],"miRNAs":[26,41,128,145,181,202,227],"extensively":[28],"involved":[29,51,229],"cancer.":[31,231],"However,":[32],"it":[33],"is":[34,91],"a":[35,137,219],"big":[36],"challenge":[37],"to":[38,44,141],"identify":[39,84,126,142,179],"which":[40,45,222],"related":[43],"cancer":[46,122,127,170],"considering":[47],"the":[48,96,115,143,159,208,242],"complex":[49],"processes":[50],"tumors,":[53],"where":[54],"one":[55,66],"miRNA":[56,79,155,163],"may":[57,68],"target":[58],"hundreds":[59],"or":[60,158],"even":[61],"thousands":[62],"of":[63,75,89,103,117,192,211],"genes":[64],"and":[65,78,162,203,238],"gene":[67,77,104,131,149,161],"regulate":[69],"multiple":[70,169],"miRNAs.":[71],"Despite":[72],"integrative":[73],"analysis":[74],"matched":[76,160],"expression":[80,105,132,150,156,164],"data":[81,90,106,157,239,254],"can":[82,125,177,223],"help":[83,224],"cancer-associated":[85],"miRNAs,":[86],"such":[87],"kind":[88],"not":[92],"commonly":[93],"available.":[94],"On":[95],"hand,":[98],"there":[99],"huge":[101],"amount":[102],"publicly":[109],"accessible.":[110],"It":[111],"will":[112],"significantly":[113],"improve":[114],"efficiency":[116],"characterizing":[118],"miRNA's":[119],"function":[120],"if":[123],"we":[124,217],"directly":[129],"from":[130,205],"data.":[133,165],"RESULTS:":[134],"We":[135],"present":[136],"novel":[138,194],"computational":[139],"framework":[140],"cancer-related":[144,180],"based":[146],"solely":[147],"on":[148,168],"profiles":[151],"without":[152],"requiring":[153],"either":[154],"The":[166,235],"results":[167],"datasets":[171],"show":[172],"our":[174,193,212],"proposed":[175,213,243],"method":[176,244],"effectively":[178],"with":[182,186],"higher":[183],"precision":[184],"compared":[185],"popular":[188],"approaches.":[189],"Furthermore,":[190],"some":[191],"predictions":[195],"validated":[197],"by":[198],"both":[199],"differentially":[200],"expressed":[201],"literature,":[206],"implying":[207],"predictive":[209],"power":[210],"method.":[214],"In":[215],"addition,":[216],"construct":[218],"cancer-miRNA-pathway":[220],"network,":[221],"explain":[225],"how":[226],"AVAILABILITY":[232],"AND":[233],"IMPLEMENTATION:":[234],"R":[236],"code":[237],"files":[240],"for":[241],"available":[246,256],"at":[247,257],"http://comp-sysbio.org/miR_Path/":[248],"CONTACT:":[249],"liukeq@gmail.com":[250],"SUPPLEMENTARY":[251],"INFORMATION:":[252],"supplementary":[253],"Bioinformatics":[258],"online.":[259]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":16},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":6}],"updated_date":"2026-06-23T06:36:01.041984","created_date":"2025-10-10T00:00:00"}
