{"id":"https://openalex.org/W2149625704","doi":"https://doi.org/10.1093/bioinformatics/btu769","title":"Achievements and challenges in structural bioinformatics and computational biophysics","display_name":"Achievements and challenges in structural bioinformatics and computational biophysics","publication_year":2014,"publication_date":"2014-12-08","ids":{"openalex":"https://openalex.org/W2149625704","doi":"https://doi.org/10.1093/bioinformatics/btu769","mag":"2149625704","pmid":"https://pubmed.ncbi.nlm.nih.gov/25488929"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btu769","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btu769","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/31/1/146/49011142/bioinformatics_31_1_146.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/31/1/146/49011142/bioinformatics_31_1_146.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084686775","display_name":"Ilan Samish","orcid":"https://orcid.org/0000-0002-0299-9124"},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I231622532","display_name":"Braude College of Engineering Karmiel","ror":"https://ror.org/004af2v94","country_code":"IL","type":"education","lineage":["https://openalex.org/I231622532"]},{"id":"https://openalex.org/I4210091794","display_name":"Office of the Director","ror":"https://ror.org/00fj8a872","country_code":"US","type":"other","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210091794"]},{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL","US"],"is_corresponding":false,"raw_author_name":"Ilan Samish","raw_affiliation_strings":["1 Department of Plant Sciences, Weizmann Institute of Science, Rehovot, 76100, Israel, 2 Ort Braude College, Karmiel, 2161002, Israel, 3 Office of the Director, National Institutes of Health, Bethesda, MD 20814, USA and 4 Department of Biochemistry, University of Sherbrooke, Sherbrooke, J1H 5N4, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Plant Sciences, Weizmann Institute of Science, Rehovot, 76100, Israel, 2 Ort Braude College, Karmiel, 2161002, Israel, 3 Office of the Director, National Institutes of Health, Bethesda, MD 20814, USA and 4 Department of Biochemistry, University of Sherbrooke, Sherbrooke, J1H 5N4, Canada","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I231622532","https://openalex.org/I4210091794","https://openalex.org/I53964585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075833022","display_name":"Philip E. Bourne","orcid":"https://orcid.org/0000-0002-7618-7292"},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I231622532","display_name":"Braude College of Engineering Karmiel","ror":"https://ror.org/004af2v94","country_code":"IL","type":"education","lineage":["https://openalex.org/I231622532"]},{"id":"https://openalex.org/I4210091794","display_name":"Office of the Director","ror":"https://ror.org/00fj8a872","country_code":"US","type":"other","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210091794"]},{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL","US"],"is_corresponding":false,"raw_author_name":"Philip E. Bourne","raw_affiliation_strings":["1 Department of Plant Sciences, Weizmann Institute of Science, Rehovot, 76100, Israel, 2 Ort Braude College, Karmiel, 2161002, Israel, 3 Office of the Director, National Institutes of Health, Bethesda, MD 20814, USA and 4 Department of Biochemistry, University of Sherbrooke, Sherbrooke, J1H 5N4, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Plant Sciences, Weizmann Institute of Science, Rehovot, 76100, Israel, 2 Ort Braude College, Karmiel, 2161002, Israel, 3 Office of the Director, National Institutes of Health, Bethesda, MD 20814, USA and 4 Department of Biochemistry, University of Sherbrooke, Sherbrooke, J1H 5N4, Canada","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I231622532","https://openalex.org/I4210091794","https://openalex.org/I53964585"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019812910","display_name":"Rafa\u00ebl Najmanovich","orcid":"https://orcid.org/0000-0002-6971-7224"},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I231622532","display_name":"Braude College of Engineering Karmiel","ror":"https://ror.org/004af2v94","country_code":"IL","type":"education","lineage":["https://openalex.org/I231622532"]},{"id":"https://openalex.org/I4210091794","display_name":"Office of the Director","ror":"https://ror.org/00fj8a872","country_code":"US","type":"other","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210091794"]},{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL","US"],"is_corresponding":true,"raw_author_name":"Rafael J. Najmanovich","raw_affiliation_strings":["1 Department of Plant Sciences, Weizmann Institute of Science, Rehovot, 76100, Israel, 2 Ort Braude College, Karmiel, 2161002, Israel, 3 Office of the Director, National Institutes of Health, Bethesda, MD 20814, USA and 4 Department of Biochemistry, University of Sherbrooke, Sherbrooke, J1H 5N4, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Plant Sciences, Weizmann Institute of Science, Rehovot, 76100, Israel, 2 Ort Braude College, Karmiel, 2161002, Israel, 3 Office of the Director, National Institutes of Health, Bethesda, MD 20814, USA and 4 Department of Biochemistry, University of Sherbrooke, Sherbrooke, J1H 5N4, Canada","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I231622532","https://openalex.org/I4210091794","https://openalex.org/I53964585"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5019812910"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I231622532","https://openalex.org/I4210091794","https://openalex.org/I53964585"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":{"value":3618,"currency":"USD","value_usd":3618},"fwci":1.9496,"has_fulltext":true,"cited_by_count":28,"citation_normalized_percentile":{"value":0.86516032,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"31","issue":"1","first_page":"146","last_page":"150"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.4490000009536743,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.4490000009536743,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.06880000233650208,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.06469999998807907,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/field","display_name":"Field (mathematics)","score":0.568725049495697},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5658196210861206},{"id":"https://openalex.org/keywords/computational-model","display_name":"Computational model","score":0.5185871124267578},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.4855899214744568},{"id":"https://openalex.org/keywords/structural-bioinformatics","display_name":"Structural bioinformatics","score":0.42589694261550903},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.37995877861976624},{"id":"https://openalex.org/keywords/management-science","display_name":"Management science","score":0.35110747814178467},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.254965603351593},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.22409886121749878},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.15798044204711914},{"id":"https://openalex.org/keywords/protein-structure","display_name":"Protein structure","score":0.15648820996284485},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.11842519044876099}],"concepts":[{"id":"https://openalex.org/C9652623","wikidata":"https://www.wikidata.org/wiki/Q190109","display_name":"Field (mathematics)","level":2,"score":0.568725049495697},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5658196210861206},{"id":"https://openalex.org/C66024118","wikidata":"https://www.wikidata.org/wiki/Q1122506","display_name":"Computational model","level":2,"score":0.5185871124267578},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.4855899214744568},{"id":"https://openalex.org/C69131567","wikidata":"https://www.wikidata.org/wiki/Q2068215","display_name":"Structural bioinformatics","level":3,"score":0.42589694261550903},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.37995877861976624},{"id":"https://openalex.org/C539667460","wikidata":"https://www.wikidata.org/wiki/Q2414942","display_name":"Management science","level":1,"score":0.35110747814178467},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.254965603351593},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.22409886121749878},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.15798044204711914},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.15648820996284485},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.11842519044876099},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C202444582","wikidata":"https://www.wikidata.org/wiki/Q837863","display_name":"Pure mathematics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000124","descriptor_name":"Achievement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000124","descriptor_name":"Achievement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000124","descriptor_name":"Achievement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001703","descriptor_name":"Biophysics","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D001703","descriptor_name":"Biophysics","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D001703","descriptor_name":"Biophysics","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D035843","descriptor_name":"Biomedical Research","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D035843","descriptor_name":"Biomedical Research","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D035843","descriptor_name":"Biomedical Research","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bioinformatics/btu769","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btu769","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/31/1/146/49011142/bioinformatics_31_1_146.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:25488929","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25488929","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:europepmc.org:3256913","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4271151","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btu769","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btu769","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/31/1/146/49011142/bioinformatics_31_1_146.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Industry, innovation and infrastructure","id":"https://metadata.un.org/sdg/9","score":0.41999998688697815}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2149625704.pdf","grobid_xml":"https://content.openalex.org/works/W2149625704.grobid-xml"},"referenced_works_count":84,"referenced_works":["https://openalex.org/W95014119","https://openalex.org/W1532494422","https://openalex.org/W1542243497","https://openalex.org/W1548178570","https://openalex.org/W1898130445","https://openalex.org/W1973858832","https://openalex.org/W1978159078","https://openalex.org/W1981190811","https://openalex.org/W1982834739","https://openalex.org/W1984030577","https://openalex.org/W1986240377","https://openalex.org/W1991637889","https://openalex.org/W1995164506","https://openalex.org/W1997803213","https://openalex.org/W1998063251","https://openalex.org/W2006253061","https://openalex.org/W2014095962","https://openalex.org/W2019974881","https://openalex.org/W2023170820","https://openalex.org/W2024334224","https://openalex.org/W2024725429","https://openalex.org/W2026043555","https://openalex.org/W2031772330","https://openalex.org/W2035929563","https://openalex.org/W2036318837","https://openalex.org/W2041746984","https://openalex.org/W2044322490","https://openalex.org/W2047026361","https://openalex.org/W2048871574","https://openalex.org/W2050918141","https://openalex.org/W2051783184","https://openalex.org/W2053845649","https://openalex.org/W2061042699","https://openalex.org/W2067763399","https://openalex.org/W2070630797","https://openalex.org/W2073338313","https://openalex.org/W2075243501","https://openalex.org/W2076764146","https://openalex.org/W2084527991","https://openalex.org/W2088417711","https://openalex.org/W2089102241","https://openalex.org/W2091734240","https://openalex.org/W2100029668","https://openalex.org/W2101335101","https://openalex.org/W2109801072","https://openalex.org/W2114981306","https://openalex.org/W2115921407","https://openalex.org/W2117486996","https://openalex.org/W2117897850","https://openalex.org/W2120513776","https://openalex.org/W2120634113","https://openalex.org/W2121895929","https://openalex.org/W2126466006","https://openalex.org/W2128653811","https://openalex.org/W2130479394","https://openalex.org/W2132696400","https://openalex.org/W2133737475","https://openalex.org/W2136640709","https://openalex.org/W2137167381","https://openalex.org/W2139754669","https://openalex.org/W2141783940","https://openalex.org/W2142863519","https://openalex.org/W2145682943","https://openalex.org/W2146030191","https://openalex.org/W2146731001","https://openalex.org/W2147526198","https://openalex.org/W2147700328","https://openalex.org/W2152500739","https://openalex.org/W2157925921","https://openalex.org/W2160544821","https://openalex.org/W2161644181","https://openalex.org/W2162943526","https://openalex.org/W2170471837","https://openalex.org/W2170776141","https://openalex.org/W2409199570","https://openalex.org/W2914356985","https://openalex.org/W2951264695","https://openalex.org/W2995121509","https://openalex.org/W4210584619","https://openalex.org/W4237017626","https://openalex.org/W4245744705","https://openalex.org/W4246407778","https://openalex.org/W6632380914","https://openalex.org/W7006001029"],"related_works":["https://openalex.org/W2371931285","https://openalex.org/W4299638067","https://openalex.org/W4377966303","https://openalex.org/W4384825963","https://openalex.org/W4296405299","https://openalex.org/W2393484506","https://openalex.org/W2965177120","https://openalex.org/W2060237576","https://openalex.org/W1971098996","https://openalex.org/W2952785685"],"abstract_inverted_index":{"MOTIVATION:":[0],"The":[1,87],"field":[2,88],"of":[3,53,59,70],"structural":[4],"bioinformatics":[5],"and":[6,41,51,56,68,83,96],"computational":[7,39,82],"biophysics":[8,95],"has":[9,43],"undergone":[10],"a":[11],"revolution":[12],"in":[13,35,45,48],"the":[14,24,36,49,57,60,66,71,111],"last":[15],"10":[16],"years.":[17],"Developments":[18],"that":[19],"are":[20],"captured":[21],"annually":[22],"through":[23],"3DSIG":[25],"meeting,":[26],"upon":[27],"which":[28],"this":[29,100],"article":[30],"reflects.":[31],"RESULTS:":[32],"An":[33],"increase":[34,47],"accessible":[37],"data,":[38],"resources":[40],"methodology":[42],"resulted":[44],"an":[46,90],"size":[50],"resolution":[52],"studied":[54],"systems":[55],"complexity":[58],"questions":[61],"amenable":[62],"to":[63],"research.":[64],"Concomitantly,":[65],"parameterization":[67],"efficiency":[69],"methods":[72],"have":[73],"markedly":[74],"improved":[75],"along":[76,106],"with":[77,80,93,107],"their":[78],"cross-validation":[79],"other":[81,97],"experimental":[84],"results.":[85],"CONCLUSION:":[86],"exhibits":[89],"ever-increasing":[91],"integration":[92],"biochemistry,":[94],"disciplines.":[98],"In":[99],"article,":[101],"we":[102],"discuss":[103],"recent":[104],"achievements":[105],"current":[108],"challenges":[109],"within":[110],"field.":[112]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":4}],"updated_date":"2026-07-30T17:31:21.811387","created_date":"2025-10-10T00:00:00"}