{"id":"https://openalex.org/W2150705458","doi":"https://doi.org/10.1093/bioinformatics/btu768","title":"Evolutionary non-linear modelling for selecting vaccines against antigenically variable viruses","display_name":"Evolutionary non-linear modelling for selecting vaccines against antigenically variable viruses","publication_year":2014,"publication_date":"2014-11-19","ids":{"openalex":"https://openalex.org/W2150705458","doi":"https://doi.org/10.1093/bioinformatics/btu768","mag":"2150705458","pmid":"https://pubmed.ncbi.nlm.nih.gov/25414361"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btu768","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btu768","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/31/6/834/49011714/bioinformatics_31_6_834.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/31/6/834/49011714/bioinformatics_31_6_834.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109599470","display_name":"Tameera Rahman","orcid":null},"institutions":[{"id":"https://openalex.org/I1287548271","display_name":"The Pirbright Institute","ror":"https://ror.org/04xv01a59","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1287548271","https://openalex.org/I2799693246","https://openalex.org/I4210087105"]},{"id":"https://openalex.org/I28290843","display_name":"University of Surrey","ror":"https://ror.org/00ks66431","country_code":"GB","type":"education","lineage":["https://openalex.org/I28290843"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Tameera Rahman","raw_affiliation_strings":["1 Department of Computing, University of Surrey, Guildford GU2 7XH, UK, 2The Pirbright Institute, Pirbright GU24 0NF, UK and 3Department of Microbial and Cellular Sciences, University of Surrey, Guildford GU2 7XH, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Computing, University of Surrey, Guildford GU2 7XH, UK, 2The Pirbright Institute, Pirbright GU24 0NF, UK and 3Department of Microbial and Cellular Sciences, University of Surrey, Guildford GU2 7XH, UK","institution_ids":["https://openalex.org/I1287548271","https://openalex.org/I28290843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011937644","display_name":"Mana Mahapatra","orcid":"https://orcid.org/0000-0002-3977-1465"},"institutions":[{"id":"https://openalex.org/I1287548271","display_name":"The Pirbright Institute","ror":"https://ror.org/04xv01a59","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1287548271","https://openalex.org/I2799693246","https://openalex.org/I4210087105"]},{"id":"https://openalex.org/I28290843","display_name":"University of Surrey","ror":"https://ror.org/00ks66431","country_code":"GB","type":"education","lineage":["https://openalex.org/I28290843"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mana Mahapatra","raw_affiliation_strings":["1 Department of Computing, University of Surrey, Guildford GU2 7XH, UK, 2The Pirbright Institute, Pirbright GU24 0NF, UK and 3Department of Microbial and Cellular Sciences, University of Surrey, Guildford GU2 7XH, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Computing, University of Surrey, Guildford GU2 7XH, UK, 2The Pirbright Institute, Pirbright GU24 0NF, UK and 3Department of Microbial and Cellular Sciences, University of Surrey, Guildford GU2 7XH, UK","institution_ids":["https://openalex.org/I1287548271","https://openalex.org/I28290843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040416265","display_name":"Emma Laing","orcid":"https://orcid.org/0000-0002-2095-2442"},"institutions":[{"id":"https://openalex.org/I1287548271","display_name":"The Pirbright Institute","ror":"https://ror.org/04xv01a59","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1287548271","https://openalex.org/I2799693246","https://openalex.org/I4210087105"]},{"id":"https://openalex.org/I28290843","display_name":"University of Surrey","ror":"https://ror.org/00ks66431","country_code":"GB","type":"education","lineage":["https://openalex.org/I28290843"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Emma Laing","raw_affiliation_strings":["1 Department of Computing, University of Surrey, Guildford GU2 7XH, UK, 2The Pirbright Institute, Pirbright GU24 0NF, UK and 3Department of Microbial and Cellular Sciences, University of Surrey, Guildford GU2 7XH, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Computing, University of Surrey, Guildford GU2 7XH, UK, 2The Pirbright Institute, Pirbright GU24 0NF, UK and 3Department of Microbial and Cellular Sciences, University of Surrey, Guildford GU2 7XH, UK","institution_ids":["https://openalex.org/I1287548271","https://openalex.org/I28290843"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032314861","display_name":"Yaochu Jin","orcid":"https://orcid.org/0000-0003-1100-0631"},"institutions":[{"id":"https://openalex.org/I1287548271","display_name":"The Pirbright Institute","ror":"https://ror.org/04xv01a59","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1287548271","https://openalex.org/I2799693246","https://openalex.org/I4210087105"]},{"id":"https://openalex.org/I28290843","display_name":"University of Surrey","ror":"https://ror.org/00ks66431","country_code":"GB","type":"education","lineage":["https://openalex.org/I28290843"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Yaochu Jin","raw_affiliation_strings":["1 Department of Computing, University of Surrey, Guildford GU2 7XH, UK, 2The Pirbright Institute, Pirbright GU24 0NF, UK and 3Department of Microbial and Cellular Sciences, University of Surrey, Guildford GU2 7XH, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Computing, University of Surrey, Guildford GU2 7XH, UK, 2The Pirbright Institute, Pirbright GU24 0NF, UK and 3Department of Microbial and Cellular Sciences, University of Surrey, Guildford GU2 7XH, UK","institution_ids":["https://openalex.org/I1287548271","https://openalex.org/I28290843"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5032314861","https://openalex.org/A5040416265"],"corresponding_institution_ids":["https://openalex.org/I1287548271","https://openalex.org/I28290843"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":1.0715,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.80404262,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"31","issue":"6","first_page":"834","last_page":"840"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11560","display_name":"Animal Disease Management and Epidemiology","score":0.9470999836921692,"subfield":{"id":"https://openalex.org/subfields/1102","display_name":"Agronomy and Crop Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11560","display_name":"Animal Disease Management and Epidemiology","score":0.9470999836921692,"subfield":{"id":"https://openalex.org/subfields/1102","display_name":"Agronomy and Crop Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11112","display_name":"Viral Infections and Immunology Research","score":0.032499998807907104,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11135","display_name":"Virology and Viral Diseases","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/weighting","display_name":"Weighting","score":0.5781925916671753},{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.5756199359893799},{"id":"https://openalex.org/keywords/foot-and-mouth-disease-virus","display_name":"Foot-and-mouth disease virus","score":0.551194429397583},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.520199716091156},{"id":"https://openalex.org/keywords/linear-regression","display_name":"Linear regression","score":0.5116658210754395},{"id":"https://openalex.org/keywords/linear-model","display_name":"Linear model","score":0.504475474357605},{"id":"https://openalex.org/keywords/capsid","display_name":"Capsid","score":0.4860992431640625},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4307393431663513},{"id":"https://openalex.org/keywords/lasso","display_name":"Lasso (programming language)","score":0.42571014165878296},{"id":"https://openalex.org/keywords/similarity","display_name":"Similarity (geometry)","score":0.4254509210586548},{"id":"https://openalex.org/keywords/virology","display_name":"Virology","score":0.3611513078212738},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3553391695022583},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.34845393896102905},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.26071393489837646},{"id":"https://openalex.org/keywords/virus","display_name":"Virus","score":0.23595565557479858},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.15950587391853333},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.15580511093139648},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.09327587485313416}],"concepts":[{"id":"https://openalex.org/C183115368","wikidata":"https://www.wikidata.org/wiki/Q856577","display_name":"Weighting","level":2,"score":0.5781925916671753},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.5756199359893799},{"id":"https://openalex.org/C2776151397","wikidata":"https://www.wikidata.org/wiki/Q1911079","display_name":"Foot-and-mouth disease virus","level":3,"score":0.551194429397583},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.520199716091156},{"id":"https://openalex.org/C48921125","wikidata":"https://www.wikidata.org/wiki/Q10861030","display_name":"Linear regression","level":2,"score":0.5116658210754395},{"id":"https://openalex.org/C163175372","wikidata":"https://www.wikidata.org/wiki/Q3339222","display_name":"Linear model","level":2,"score":0.504475474357605},{"id":"https://openalex.org/C202878990","wikidata":"https://www.wikidata.org/wiki/Q830465","display_name":"Capsid","level":3,"score":0.4860992431640625},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4307393431663513},{"id":"https://openalex.org/C37616216","wikidata":"https://www.wikidata.org/wiki/Q3218363","display_name":"Lasso (programming language)","level":2,"score":0.42571014165878296},{"id":"https://openalex.org/C103278499","wikidata":"https://www.wikidata.org/wiki/Q254465","display_name":"Similarity (geometry)","level":3,"score":0.4254509210586548},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3611513078212738},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3553391695022583},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34845393896102905},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.26071393489837646},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.23595565557479858},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15950587391853333},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15580511093139648},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09327587485313416},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.0},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.0},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000940","descriptor_name":"Antigenic Variation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000940","descriptor_name":"Antigenic Variation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000940","descriptor_name":"Antigenic Variation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000940","descriptor_name":"Antigenic Variation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000956","descriptor_name":"Antigens, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000956","descriptor_name":"Antigens, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000956","descriptor_name":"Antigens, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000956","descriptor_name":"Antigens, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005536","descriptor_name":"Foot-and-Mouth Disease","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005536","descriptor_name":"Foot-and-Mouth Disease","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005536","descriptor_name":"Foot-and-Mouth Disease","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005536","descriptor_name":"Foot-and-Mouth Disease","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005536","descriptor_name":"Foot-and-Mouth Disease","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D005536","descriptor_name":"Foot-and-Mouth Disease","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D005536","descriptor_name":"Foot-and-Mouth Disease","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D005536","descriptor_name":"Foot-and-Mouth Disease","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D007252","descriptor_name":"Influenza Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007252","descriptor_name":"Influenza Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007252","descriptor_name":"Influenza Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007252","descriptor_name":"Influenza Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D017711","descriptor_name":"Nonlinear Dynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017711","descriptor_name":"Nonlinear Dynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017711","descriptor_name":"Nonlinear Dynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017711","descriptor_name":"Nonlinear Dynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029544","descriptor_name":"Foot-and-Mouth Disease Virus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029544","descriptor_name":"Foot-and-Mouth Disease Virus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029544","descriptor_name":"Foot-and-Mouth Disease Virus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029544","descriptor_name":"Foot-and-Mouth Disease Virus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029544","descriptor_name":"Foot-and-Mouth Disease Virus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D029544","descriptor_name":"Foot-and-Mouth Disease Virus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D029544","descriptor_name":"Foot-and-Mouth Disease Virus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D029544","descriptor_name":"Foot-and-Mouth Disease Virus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D036022","descriptor_name":"Capsid Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D036022","descriptor_name":"Capsid Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D036022","descriptor_name":"Capsid Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D036022","descriptor_name":"Capsid Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D057134","descriptor_name":"Antibodies, Neutralizing","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D057134","descriptor_name":"Antibodies, Neutralizing","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D057134","descriptor_name":"Antibodies, Neutralizing","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D057134","descriptor_name":"Antibodies, Neutralizing","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1093/bioinformatics/btu768","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btu768","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/31/6/834/49011714/bioinformatics_31_6_834.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:25414361","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25414361","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:alma.44SUR_INST:11138801320002346","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":{"id":"https://openalex.org/S4210197018","display_name":"Open Research (University of Surrey)","issn_l":"2688-268X","issn":["2688-268X","2688-3988"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":""},{"id":"pmh:oai:epubs.surrey.ac.uk:807838","is_oa":false,"landing_page_url":"http://epubs.surrey.ac.uk/807838/7/BioinformaticsDraft_RahmanEtal.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4306400680","display_name":"Surrey Research Insight Open Access (The University of Surrey)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I28290843","host_organization_name":"University of Surrey","host_organization_lineage":["https://openalex.org/I28290843"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:pub.uni-bielefeld.de:2978532","is_oa":false,"landing_page_url":"https://pub.uni-bielefeld.de/record/2978532","pdf_url":null,"source":{"id":"https://openalex.org/S4306401671","display_name":"PUB \u2013 Publications at Bielefeld University (Bielefeld University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I20121455","host_organization_name":"Bielefeld University","host_organization_lineage":["https://openalex.org/I20121455"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"http://purl.org/coar/resource_type/c_6501"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btu768","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btu768","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/31/6/834/49011714/bioinformatics_31_6_834.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5299999713897705}],"awards":[{"id":"https://openalex.org/G2293299777","display_name":null,"funder_award_id":"BB/H009175/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G5026567654","display_name":"Improving the quality of FMD vaccines by understanding the correlation of vaccine-induced protection with humoral and cellular immune responses","funder_award_id":"BB/H009175/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G7835317536","display_name":null,"funder_award_id":"BB/F009186/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G991203670","display_name":"Identifying epitopes that induce antibody mediated protection against foot-and-mouth disease using reverse genetics","funder_award_id":"BB/F009186/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"}],"funders":[{"id":"https://openalex.org/F4320321979","display_name":"University of Surrey","ror":"https://ror.org/00ks66431"},{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2150705458.pdf","grobid_xml":"https://content.openalex.org/works/W2150705458.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W225560312","https://openalex.org/W568631482","https://openalex.org/W606510174","https://openalex.org/W1480376833","https://openalex.org/W1512414139","https://openalex.org/W1515226261","https://openalex.org/W1526255571","https://openalex.org/W1546341583","https://openalex.org/W1547343431","https://openalex.org/W1570276276","https://openalex.org/W1573534773","https://openalex.org/W1580819266","https://openalex.org/W1587907511","https://openalex.org/W1591480310","https://openalex.org/W1639032689","https://openalex.org/W1659842140","https://openalex.org/W1911984885","https://openalex.org/W1979769287","https://openalex.org/W1984037251","https://openalex.org/W1995648971","https://openalex.org/W1998954852","https://openalex.org/W2015986646","https://openalex.org/W2041646166","https://openalex.org/W2044162698","https://openalex.org/W2079129173","https://openalex.org/W2079778884","https://openalex.org/W2144636407","https://openalex.org/W2144983829","https://openalex.org/W2171288396","https://openalex.org/W2600349519","https://openalex.org/W2904250082","https://openalex.org/W3023540311","https://openalex.org/W4206694472","https://openalex.org/W4237628923","https://openalex.org/W6608886761","https://openalex.org/W6630657875","https://openalex.org/W6630786662"],"related_works":["https://openalex.org/W2137572138","https://openalex.org/W2968050865","https://openalex.org/W2076921277","https://openalex.org/W2079290149","https://openalex.org/W2769051567","https://openalex.org/W2347733161","https://openalex.org/W2169851782","https://openalex.org/W2034511141","https://openalex.org/W2296480322","https://openalex.org/W2804784031"],"abstract_inverted_index":{"MOTIVATION:":[0],"In":[1,128,254],"vitro":[2],"and":[3,13,52,66,94,108,115,147,180,243,295],"in":[4,76,103,109,144,198,209],"vivo":[5],"selection":[6],"of":[7,28,57,64,92,117,140,169,175,183,193,227,267,278,280],"vaccines":[8,16,65,70],"is":[9,196],"time":[10],"consuming,":[11],"expensive":[12],"the":[14,55,86,90,100,113,118,138,145,162,186,210,219,228,236,241,251,257,296],"selected":[15],"may":[17],"not":[18],"be":[19],"able":[20,300],"to":[21,98,301],"provide":[22],"protection":[23],"against":[24],"broad-spectrum":[25],"viruses":[26],"because":[27],"emerging":[29],"antigenically":[30,49],"novel":[31],"disease":[32,105],"strains.":[33],"A":[34,177,225],"powerful":[35],"computational":[36],"model":[37,120,298],"that":[38,217],"incorporates":[39],"these":[40],"protein/DNA":[41],"or":[42],"RNA":[43],"level":[44],"fluctuations":[45],"can":[46,53],"effectively":[47],"predict":[48,99],"variant":[50],"strains,":[51,111],"minimize":[54],"amount":[56],"resources":[58],"spent":[59],"on":[60,166,190,207,289],"exclusive":[61],"serological":[62],"testing":[63],"make":[67],"wide":[68],"spectrum":[69],"possible":[71],"for":[72,136,256],"many":[73],"diseases.":[74],"However,":[75],"silico":[77],"vaccine":[78],"prediction":[79,164],"remains":[80],"a":[81,201,275],"grand":[82],"challenge.":[83],"To":[84],"address":[85],"challenge,":[87],"we":[88,130],"investigate":[89],"use":[91],"linear":[93,146,242,272],"non-linear":[95,119,148,202,229,244,263,276],"regression":[96,203,230,264],"models":[97,154,231,245,265,285],"antigenic":[101,211],"similarity":[102],"foot-and-mouth":[104],"virus":[106],"strains":[107],"influenza":[110,184],"where":[112],"structure":[114],"parameters":[116,247],"are":[121,248],"optimized":[122],"using":[123,250],"an":[124,303],"evolutionary":[125],"algorithm":[126],"(EA).":[127],"addition,":[129,255],"examine":[131],"two":[132,173,181],"different":[133],"scoring":[134,187],"methods":[135],"weighting":[137],"type":[139],"amino":[141,194,281],"acid":[142,282],"substitutions":[143,208],"models.":[149],"We":[150,160],"also":[151,287],"test":[152],"our":[153],"with":[155,200,235],"some":[156],"unseen":[157],"data.":[158],"RESULTS:":[159],"achieved":[161],"best":[163,258,297],"results":[165],"three":[167],"datasets":[168,174,182,294],"SAT2":[170],"(Foot-and-Mouth":[171,178],"disease),":[172],"serotype":[176],"disease)":[179],"when":[185],"method":[188],"based":[189,206],"biochemical":[191],"properties":[192],"acids":[195],"employed":[197],"combination":[199],"model.":[204],"Models":[205],"areas":[212],"performed":[213,238],"better":[214,239],"than":[215,240,270],"those":[216],"took":[218],"entire":[220],"exposed":[221],"viral":[222],"capsid":[223],"proteins.":[224],"majority":[226],"optimi":[232,260],"Z:":[233,261],"ed":[234,262],"EA:":[237],"whose":[246],"estimated":[249],"least-squares":[252],"method.":[253],"models,":[259],"consist":[266],"more":[268],"terms":[269],"their":[271],"counterparts,":[273],"implying":[274],"nature":[277],"influences":[279],"substitutions.":[283],"Our":[284],"were":[286],"tested":[288],"five":[290],"recently":[291],"generated":[292],"FMDV":[293],"was":[299],"achieve":[302],"80%":[304],"agreement":[305],"rate.":[306]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-08-06T08:24:18.245995","created_date":"2025-10-10T00:00:00"}