{"id":"https://openalex.org/W2132008404","doi":"https://doi.org/10.1093/bioinformatics/btu763","title":"Molecular principles of human virus protein\u2013protein interactions","display_name":"Molecular principles of human virus protein\u2013protein interactions","publication_year":2014,"publication_date":"2014-11-21","ids":{"openalex":"https://openalex.org/W2132008404","doi":"https://doi.org/10.1093/bioinformatics/btu763","mag":"2132008404","pmid":"https://pubmed.ncbi.nlm.nih.gov/25417202"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btu763","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btu763","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/31/7/1025/49013566/bioinformatics_31_7_1025.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/31/7/1025/49013566/bioinformatics_31_7_1025.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013271972","display_name":"Rachita Ramachandra Halehalli","orcid":null},"institutions":[{"id":"https://openalex.org/I164861460","display_name":"Manipal Academy of Higher Education","ror":"https://ror.org/02xzytt36","country_code":"IN","type":"education","lineage":["https://openalex.org/I164861460"]},{"id":"https://openalex.org/I78270026","display_name":"Centre for DNA Fingerprinting and Diagnostics","ror":"https://ror.org/04psbxy09","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I78270026"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Rachita Ramachandra Halehalli","raw_affiliation_strings":["1 Laboratory of Computational Biology, Centre for DNA Fingerprinting and Diagnostics, Hyderabad, Telangana, 500001, India and 2Graduate School, Manipal University, Manipal, 576104, Karnataka, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Laboratory of Computational Biology, Centre for DNA Fingerprinting and Diagnostics, Hyderabad, Telangana, 500001, India and 2Graduate School, Manipal University, Manipal, 576104, Karnataka, India","institution_ids":["https://openalex.org/I164861460","https://openalex.org/I78270026"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048834515","display_name":"Hampapathalu Adimurthy Nagarajaram","orcid":"https://orcid.org/0000-0001-8568-0620"},"institutions":[{"id":"https://openalex.org/I164861460","display_name":"Manipal Academy of Higher Education","ror":"https://ror.org/02xzytt36","country_code":"IN","type":"education","lineage":["https://openalex.org/I164861460"]},{"id":"https://openalex.org/I78270026","display_name":"Centre for DNA Fingerprinting and Diagnostics","ror":"https://ror.org/04psbxy09","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I78270026"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Hampapathalu Adimurthy Nagarajaram","raw_affiliation_strings":["1 Laboratory of Computational Biology, Centre for DNA Fingerprinting and Diagnostics, Hyderabad, Telangana, 500001, India and 2Graduate School, Manipal University, Manipal, 576104, Karnataka, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Laboratory of Computational Biology, Centre for DNA Fingerprinting and Diagnostics, Hyderabad, Telangana, 500001, India and 2Graduate School, Manipal University, Manipal, 576104, Karnataka, India","institution_ids":["https://openalex.org/I164861460","https://openalex.org/I78270026"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5048834515"],"corresponding_institution_ids":["https://openalex.org/I164861460","https://openalex.org/I78270026"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":1.0398,"has_fulltext":false,"cited_by_count":62,"citation_normalized_percentile":{"value":0.75755054,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"31","issue":"7","first_page":"1025","last_page":"1033"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.7059999704360962,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.7059999704360962,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.026200000196695328,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.014600000344216824,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5235528349876404},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4785376489162445},{"id":"https://openalex.org/keywords/virology","display_name":"Virology","score":0.3835653066635132},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.34241217374801636}],"concepts":[{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5235528349876404},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4785376489162445},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3835653066635132},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34241217374801636}],"mesh":[{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014777","descriptor_name":"Virus Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014777","descriptor_name":"Virus Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014777","descriptor_name":"Virus Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014777","descriptor_name":"Virus Diseases","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D014777","descriptor_name":"Virus Diseases","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D014777","descriptor_name":"Virus Diseases","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D014780","descriptor_name":"Viruses","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014780","descriptor_name":"Viruses","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014780","descriptor_name":"Viruses","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054730","descriptor_name":"Protein Interaction Domains and Motifs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D054730","descriptor_name":"Protein Interaction Domains and Motifs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D054730","descriptor_name":"Protein Interaction Domains and Motifs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D054884","descriptor_name":"Host-Pathogen Interactions","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D054884","descriptor_name":"Host-Pathogen Interactions","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D054884","descriptor_name":"Host-Pathogen Interactions","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1093/bioinformatics/btu763","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btu763","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/31/7/1025/49013566/bioinformatics_31_7_1025.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:25417202","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25417202","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btu763","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btu763","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/31/7/1025/49013566/bioinformatics_31_7_1025.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320336105","display_name":"Centre for DNA Fingerprinting and Diagnostics","ror":"https://ror.org/04psbxy09"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":84,"referenced_works":["https://openalex.org/W634123086","https://openalex.org/W1969941684","https://openalex.org/W1973582015","https://openalex.org/W1976844960","https://openalex.org/W1979601325","https://openalex.org/W1987378985","https://openalex.org/W1988463127","https://openalex.org/W1992983658","https://openalex.org/W1996076856","https://openalex.org/W2006192061","https://openalex.org/W2007199806","https://openalex.org/W2008620264","https://openalex.org/W2009285027","https://openalex.org/W2009465113","https://openalex.org/W2012441269","https://openalex.org/W2017161741","https://openalex.org/W2030482575","https://openalex.org/W2030776726","https://openalex.org/W2034858284","https://openalex.org/W2042072985","https://openalex.org/W2042143462","https://openalex.org/W2043816461","https://openalex.org/W2047091050","https://openalex.org/W2048222477","https://openalex.org/W2051349181","https://openalex.org/W2056990767","https://openalex.org/W2059325738","https://openalex.org/W2060592742","https://openalex.org/W2062725722","https://openalex.org/W2062860477","https://openalex.org/W2065769502","https://openalex.org/W2066812797","https://openalex.org/W2066937690","https://openalex.org/W2068880841","https://openalex.org/W2074166146","https://openalex.org/W2077797834","https://openalex.org/W2077865764","https://openalex.org/W2079635715","https://openalex.org/W2083498261","https://openalex.org/W2085656056","https://openalex.org/W2085963663","https://openalex.org/W2088422296","https://openalex.org/W2091448229","https://openalex.org/W2095387858","https://openalex.org/W2101330776","https://openalex.org/W2101998831","https://openalex.org/W2102545006","https://openalex.org/W2104437738","https://openalex.org/W2107040871","https://openalex.org/W2107055030","https://openalex.org/W2109108939","https://openalex.org/W2109788141","https://openalex.org/W2110335151","https://openalex.org/W2113985551","https://openalex.org/W2117161143","https://openalex.org/W2118608964","https://openalex.org/W2119098954","https://openalex.org/W2122403585","https://openalex.org/W2122863289","https://openalex.org/W2125957866","https://openalex.org/W2126064524","https://openalex.org/W2129482581","https://openalex.org/W2131858707","https://openalex.org/W2132720084","https://openalex.org/W2133177319","https://openalex.org/W2134024910","https://openalex.org/W2137513268","https://openalex.org/W2139119391","https://openalex.org/W2141368599","https://openalex.org/W2143399071","https://openalex.org/W2143593035","https://openalex.org/W2149472608","https://openalex.org/W2150515558","https://openalex.org/W2154335467","https://openalex.org/W2156564520","https://openalex.org/W2158173168","https://openalex.org/W2159482845","https://openalex.org/W2159675211","https://openalex.org/W2161189461","https://openalex.org/W2165489841","https://openalex.org/W2169806717","https://openalex.org/W2917375902","https://openalex.org/W3103071483","https://openalex.org/W4294216483"],"related_works":["https://openalex.org/W2748952813","https://openalex.org/W2082860237","https://openalex.org/W2119695867","https://openalex.org/W2130076355","https://openalex.org/W1990804418","https://openalex.org/W1993764875","https://openalex.org/W2046158694","https://openalex.org/W2788277189","https://openalex.org/W1971568933","https://openalex.org/W2013243191"],"abstract_inverted_index":{"MOTIVATION:":[0],"Viruses,":[1],"from":[2,85,271],"the":[3,26,31,45,101,116,190,194],"human":[4,32,195,224],"protein-protein":[5,52],"interaction":[6],"network":[7],"perspective,":[8],"target":[9],"hubs,":[10],"bottlenecks":[11],"and":[12,47,82,158,169,186,262],"interconnected":[13],"nodes":[14],"enriched":[15,147],"in":[16,79,138,143,148,223],"certain":[17],"biological":[18],"pathways.":[19,254],"However,":[20],"not":[21],"much":[22],"is":[23,104],"known":[24],"about":[25],"general":[27],"characteristic":[28,117,191],"features":[29,118,192],"of":[30,100,115,119,166,193,240],"proteins":[33,37,72,81,103,196,212],"interacting":[34],"with":[35,134,154,163],"viral":[36,71,80,199,211],"(referred":[38,54],"to":[39,55,89,219,221,232,243,246,250],"as":[40,42,44,56,113],"hVIPs)":[41],"well":[43],"motifs":[46,151,214,242],"domains":[48,222],"utilized":[49],"by":[50,198],"human-virus":[51,266],"interactions":[53,208],"Hu-Vir":[57,201,258],"PPIs).":[58],"RESULTS:":[59],"Our":[60],"study":[61],"has":[62],"revealed":[63],"that":[64,108,125,180,215],"hVIPs":[65,83,126],"are":[66,73,127,189,203,227,277],"mostly":[67,74,204],"disordered":[68,106],"proteins,":[69,131],"whereas":[70],"ordered":[75],"proteins.":[76,200,225],"Protein":[77],"disorder":[78,109],"varies":[84],"one":[86,99,114],"subcellular":[87],"location":[88],"another.":[90],"In":[91],"any":[92],"given":[93],"viral-human":[94],"PPI":[95,259,267],"pair,":[96],"at":[97,279],"least":[98],"two":[102],"structurally":[105],"suggesting":[107],"associated":[110,133,153,162],"conformational":[111,181],"flexibility":[112],"virus-host":[120],"interaction.":[121],"Further":[122],"analyses":[123],"reveal":[124],"(i)":[128],"slowly":[129],"evolving":[130],"(ii)":[132],"high":[135,164],"centrality":[136],"scores":[137],"human-PPI":[139],"network,":[140],"(iii)":[141],"involved":[142],"multiple":[144,174],"pathways,":[145],"(iv)":[146],"eukaryotic":[149],"linear":[150],"(ELMs)":[152],"protein":[155],"modification,":[156],"degradation":[157],"regulatory":[159],"processes,":[160],"(v)":[161],"number":[165],"splice":[167],"variants":[168],"(vi)":[170],"expressed":[171],"abundantly":[172],"across":[173],"tissues.":[175],"These":[176],"aforementioned":[177],"findings":[178],"suggest":[179],"flexibility,":[182],"spatial":[183],"diversity,":[184],"abundance":[185],"slow":[187],"evolution":[188,239],"targeted":[197],"PPIs":[202],"mediated":[205],"via":[206],"domain-motif":[207],"(DMIs)":[209],"where":[210],"employ":[213],"mimic":[216],"host":[217,252],"ELMs":[218],"bind":[220],"DMIs":[226],"shared":[228],"among":[229],"viruses":[230,245],"belonging":[231],"different":[233],"families":[234],"indicating":[235],"a":[236],"possible":[237],"convergent":[238],"these":[241],"help":[244],"adopt":[247],"common":[248],"strategies":[249],"subvert":[251],"cellular":[253],"AVAILABILITY":[255],"AND":[256],"IMPLEMENTATION:":[257],"data,":[260],"DDI":[261],"DMI":[263],"data":[264,276],"for":[265],"can":[268],"be":[269],"downloaded":[270],"http://cdfd.org.in/labpages/computational_biology_datasets.html.":[272],"SUPPLEMENTARY":[273],"INFORMATION:":[274],"Supplementary":[275],"available":[278],"Bioinformatics":[280],"online.":[281]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1}],"updated_date":"2026-07-22T07:51:19.307946","created_date":"2025-10-10T00:00:00"}