{"id":"https://openalex.org/W2165239068","doi":"https://doi.org/10.1093/bioinformatics/btu685","title":"MOST: a software environment for constraint-based metabolic modeling and strain design","display_name":"MOST: a software environment for constraint-based metabolic modeling and strain design","publication_year":2014,"publication_date":"2014-10-17","ids":{"openalex":"https://openalex.org/W2165239068","doi":"https://doi.org/10.1093/bioinformatics/btu685","mag":"2165239068","pmid":"https://pubmed.ncbi.nlm.nih.gov/25677126"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btu685","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btu685","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/31/4/610/49011494/bioinformatics_31_4_610.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/31/4/610/49011494/bioinformatics_31_4_610.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109812858","display_name":"James J. Kelley","orcid":null},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]},{"id":"https://openalex.org/I170239107","display_name":"University of South Australia","ror":"https://ror.org/01p93h210","country_code":"AU","type":"education","lineage":["https://openalex.org/I170239107"]}],"countries":["AU","US"],"is_corresponding":false,"raw_author_name":"James J. Kelley","raw_affiliation_strings":["1 \u00a01Center for Computational and Integrative Biology and Department of Computer Science, Rutgers University, Camden, NJ 08102, USA and 2Phenomics and Bioinformatics Research Centre and School of Mathematics and Statistics, University of South Australia, Mawson Lakes, SA 5095, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 \u00a01Center for Computational and Integrative Biology and Department of Computer Science, Rutgers University, Camden, NJ 08102, USA and 2Phenomics and Bioinformatics Research Centre and School of Mathematics and Statistics, University of South Australia, Mawson Lakes, SA 5095, Australia","institution_ids":["https://openalex.org/I102322142","https://openalex.org/I170239107"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072657569","display_name":"Anatoliy Lane","orcid":null},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]},{"id":"https://openalex.org/I170239107","display_name":"University of South Australia","ror":"https://ror.org/01p93h210","country_code":"AU","type":"education","lineage":["https://openalex.org/I170239107"]}],"countries":["AU","US"],"is_corresponding":false,"raw_author_name":"Anatoliy Lane","raw_affiliation_strings":["1 \u00a01Center for Computational and Integrative Biology and Department of Computer Science, Rutgers University, Camden, NJ 08102, USA and 2Phenomics and Bioinformatics Research Centre and School of Mathematics and Statistics, University of South Australia, Mawson Lakes, SA 5095, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 \u00a01Center for Computational and Integrative Biology and Department of Computer Science, Rutgers University, Camden, NJ 08102, USA and 2Phenomics and Bioinformatics Research Centre and School of Mathematics and Statistics, University of South Australia, Mawson Lakes, SA 5095, Australia","institution_ids":["https://openalex.org/I102322142","https://openalex.org/I170239107"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100368432","display_name":"Xiaowei Li","orcid":"https://orcid.org/0009-0008-2436-7524"},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]},{"id":"https://openalex.org/I170239107","display_name":"University of South Australia","ror":"https://ror.org/01p93h210","country_code":"AU","type":"education","lineage":["https://openalex.org/I170239107"]}],"countries":["AU","US"],"is_corresponding":false,"raw_author_name":"Xiaowei Li","raw_affiliation_strings":["1 \u00a01Center for Computational and Integrative Biology and Department of Computer Science, Rutgers University, Camden, NJ 08102, USA and 2Phenomics and Bioinformatics Research Centre and School of Mathematics and Statistics, University of South Australia, Mawson Lakes, SA 5095, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 \u00a01Center for Computational and Integrative Biology and Department of Computer Science, Rutgers University, Camden, NJ 08102, USA and 2Phenomics and Bioinformatics Research Centre and School of Mathematics and Statistics, University of South Australia, Mawson Lakes, SA 5095, Australia","institution_ids":["https://openalex.org/I102322142","https://openalex.org/I170239107"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087373652","display_name":"Brahmaji Mutthoju","orcid":null},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]},{"id":"https://openalex.org/I170239107","display_name":"University of South Australia","ror":"https://ror.org/01p93h210","country_code":"AU","type":"education","lineage":["https://openalex.org/I170239107"]}],"countries":["AU","US"],"is_corresponding":false,"raw_author_name":"Brahmaji Mutthoju","raw_affiliation_strings":["1 \u00a01Center for Computational and Integrative Biology and Department of Computer Science, Rutgers University, Camden, NJ 08102, USA and 2Phenomics and Bioinformatics Research Centre and School of Mathematics and Statistics, University of South Australia, Mawson Lakes, SA 5095, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 \u00a01Center for Computational and Integrative Biology and Department of Computer Science, Rutgers University, Camden, NJ 08102, USA and 2Phenomics and Bioinformatics Research Centre and School of Mathematics and Statistics, University of South Australia, Mawson Lakes, SA 5095, Australia","institution_ids":["https://openalex.org/I102322142","https://openalex.org/I170239107"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033452902","display_name":"Shay Maor","orcid":null},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]},{"id":"https://openalex.org/I170239107","display_name":"University of South Australia","ror":"https://ror.org/01p93h210","country_code":"AU","type":"education","lineage":["https://openalex.org/I170239107"]}],"countries":["AU","US"],"is_corresponding":false,"raw_author_name":"Shay Maor","raw_affiliation_strings":["1 \u00a01Center for Computational and Integrative Biology and Department of Computer Science, Rutgers University, Camden, NJ 08102, USA and 2Phenomics and Bioinformatics Research Centre and School of Mathematics and Statistics, University of South Australia, Mawson Lakes, SA 5095, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 \u00a01Center for Computational and Integrative Biology and Department of Computer Science, Rutgers University, Camden, NJ 08102, USA and 2Phenomics and Bioinformatics Research Centre and School of Mathematics and Statistics, University of South Australia, Mawson Lakes, SA 5095, Australia","institution_ids":["https://openalex.org/I102322142","https://openalex.org/I170239107"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086225254","display_name":"Dennis Egen","orcid":null},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]},{"id":"https://openalex.org/I170239107","display_name":"University of South Australia","ror":"https://ror.org/01p93h210","country_code":"AU","type":"education","lineage":["https://openalex.org/I170239107"]}],"countries":["AU","US"],"is_corresponding":false,"raw_author_name":"Dennis Egen","raw_affiliation_strings":["1 \u00a01Center for Computational and Integrative Biology and Department of Computer Science, Rutgers University, Camden, NJ 08102, USA and 2Phenomics and Bioinformatics Research Centre and School of Mathematics and Statistics, University of South Australia, Mawson Lakes, SA 5095, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 \u00a01Center for Computational and Integrative Biology and Department of Computer Science, Rutgers University, Camden, NJ 08102, USA and 2Phenomics and Bioinformatics Research Centre and School of Mathematics and Statistics, University of South Australia, Mawson Lakes, SA 5095, Australia","institution_ids":["https://openalex.org/I102322142","https://openalex.org/I170239107"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023722931","display_name":"Desmond S. Lun","orcid":"https://orcid.org/0000-0003-2276-2156"},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]},{"id":"https://openalex.org/I170239107","display_name":"University of South Australia","ror":"https://ror.org/01p93h210","country_code":"AU","type":"education","lineage":["https://openalex.org/I170239107"]}],"countries":["AU","US"],"is_corresponding":true,"raw_author_name":"Desmond S. Lun","raw_affiliation_strings":["1 \u00a01Center for Computational and Integrative Biology and Department of Computer Science, Rutgers University, Camden, NJ 08102, USA and 2Phenomics and Bioinformatics Research Centre and School of Mathematics and Statistics, University of South Australia, Mawson Lakes, SA 5095, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 \u00a01Center for Computational and Integrative Biology and Department of Computer Science, Rutgers University, Camden, NJ 08102, USA and 2Phenomics and Bioinformatics Research Centre and School of Mathematics and Statistics, University of South Australia, Mawson Lakes, SA 5095, Australia","institution_ids":["https://openalex.org/I102322142","https://openalex.org/I170239107"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5023722931"],"corresponding_institution_ids":["https://openalex.org/I102322142","https://openalex.org/I170239107"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":1.0398,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.75957498,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"31","issue":"4","first_page":"610","last_page":"611"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9896000027656555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9896000027656555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10791","display_name":"Advanced Control Systems Optimization","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2207","display_name":"Control and Systems Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12915","display_name":"Biochemical Acid Research Studies","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7680230140686035},{"id":"https://openalex.org/keywords/markup-language","display_name":"Markup language","score":0.6948738098144531},{"id":"https://openalex.org/keywords/documentation","display_name":"Documentation","score":0.6377674341201782},{"id":"https://openalex.org/keywords/software","display_name":"Software","score":0.6221795678138733},{"id":"https://openalex.org/keywords/software-engineering","display_name":"Software engineering","score":0.5850680470466614},{"id":"https://openalex.org/keywords/interface","display_name":"Interface (matter)","score":0.5632379055023193},{"id":"https://openalex.org/keywords/flux-balance-analysis","display_name":"Flux balance analysis","score":0.554609477519989},{"id":"https://openalex.org/keywords/programming-language","display_name":"Programming language","score":0.5235395431518555},{"id":"https://openalex.org/keywords/mit-license","display_name":"MIT License","score":0.5178033113479614},{"id":"https://openalex.org/keywords/application-programming-interface","display_name":"Application programming interface","score":0.473979651927948},{"id":"https://openalex.org/keywords/user-interface","display_name":"User interface","score":0.4349532127380371},{"id":"https://openalex.org/keywords/license","display_name":"License","score":0.4119487702846527},{"id":"https://openalex.org/keywords/operating-system","display_name":"Operating system","score":0.36195898056030273},{"id":"https://openalex.org/keywords/xml","display_name":"XML","score":0.18119388818740845},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.1626940667629242},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.0810285210609436}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7680230140686035},{"id":"https://openalex.org/C45874996","wikidata":"https://www.wikidata.org/wiki/Q37045","display_name":"Markup language","level":3,"score":0.6948738098144531},{"id":"https://openalex.org/C56666940","wikidata":"https://www.wikidata.org/wiki/Q788790","display_name":"Documentation","level":2,"score":0.6377674341201782},{"id":"https://openalex.org/C2777904410","wikidata":"https://www.wikidata.org/wiki/Q7397","display_name":"Software","level":2,"score":0.6221795678138733},{"id":"https://openalex.org/C115903868","wikidata":"https://www.wikidata.org/wiki/Q80993","display_name":"Software engineering","level":1,"score":0.5850680470466614},{"id":"https://openalex.org/C113843644","wikidata":"https://www.wikidata.org/wiki/Q901882","display_name":"Interface (matter)","level":4,"score":0.5632379055023193},{"id":"https://openalex.org/C167091322","wikidata":"https://www.wikidata.org/wiki/Q5463029","display_name":"Flux balance analysis","level":2,"score":0.554609477519989},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.5235395431518555},{"id":"https://openalex.org/C174183944","wikidata":"https://www.wikidata.org/wiki/Q334661","display_name":"MIT License","level":3,"score":0.5178033113479614},{"id":"https://openalex.org/C99613125","wikidata":"https://www.wikidata.org/wiki/Q165194","display_name":"Application programming interface","level":2,"score":0.473979651927948},{"id":"https://openalex.org/C89505385","wikidata":"https://www.wikidata.org/wiki/Q47146","display_name":"User interface","level":2,"score":0.4349532127380371},{"id":"https://openalex.org/C2780560020","wikidata":"https://www.wikidata.org/wiki/Q79719","display_name":"License","level":2,"score":0.4119487702846527},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.36195898056030273},{"id":"https://openalex.org/C8797682","wikidata":"https://www.wikidata.org/wiki/Q2115","display_name":"XML","level":2,"score":0.18119388818740845},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.1626940667629242},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0810285210609436},{"id":"https://openalex.org/C129307140","wikidata":"https://www.wikidata.org/wiki/Q6795880","display_name":"Maximum bubble pressure method","level":3,"score":0.0},{"id":"https://openalex.org/C157915830","wikidata":"https://www.wikidata.org/wiki/Q2928001","display_name":"Bubble","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055786","descriptor_name":"Gene Knockout Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055786","descriptor_name":"Gene Knockout Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055786","descriptor_name":"Gene Knockout Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D064688","descriptor_name":"Metabolic Flux Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D064688","descriptor_name":"Metabolic Flux Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D064688","descriptor_name":"Metabolic Flux Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/bioinformatics/btu685","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btu685","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/31/4/610/49011494/bioinformatics_31_4_610.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:25677126","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25677126","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btu685","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btu685","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/31/4/610/49011494/bioinformatics_31_4_610.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2165239068.pdf","grobid_xml":"https://content.openalex.org/works/W2165239068.grobid-xml"},"referenced_works_count":8,"referenced_works":["https://openalex.org/W1976812345","https://openalex.org/W2078355959","https://openalex.org/W2096097217","https://openalex.org/W2100818174","https://openalex.org/W2130364940","https://openalex.org/W2130832653","https://openalex.org/W2150908245","https://openalex.org/W2156409537"],"related_works":["https://openalex.org/W2036021480","https://openalex.org/W2546377002","https://openalex.org/W4285209474","https://openalex.org/W22571951","https://openalex.org/W2046541848","https://openalex.org/W4384009753","https://openalex.org/W2791776396","https://openalex.org/W4286531993","https://openalex.org/W2964820744","https://openalex.org/W4247858078"],"abstract_inverted_index":{"SUMMARY:":[0],"MOST":[1,95],"(metabolic":[2],"optimization":[3],"and":[4,18,37,43,108],"simulation":[5],"tool)":[6],"is":[7,48,78,96],"a":[8,73],"software":[9,107],"package":[10],"that":[11],"implements":[12],"GDBB":[13,47,67],"(genetic":[14],"design":[15],"through":[16],"branch":[17],"bound)":[19],"in":[20],"an":[21],"intuitive":[22],"user-friendly":[23],"interface":[24],"with":[25],"excel-like":[26],"editing":[27],"functionality,":[28],"as":[29,31],"well":[30],"implementing":[32],"FBA":[33,59],"(flux":[34],"balance":[35],"analysis),":[36],"supporting":[38],"systems":[39],"biology":[40],"markup":[41],"language":[42],"comma-separated":[44],"values":[45],"files.":[46],"currently":[49],"the":[50,88,101],"fastest":[51],"algorithm":[52],"for":[53,82,98],"finding":[54],"gene":[55],"knockouts":[56],"predicted":[57],"by":[58],"to":[60,80],"increase":[61],"production":[62],"of":[63,90],"desired":[64],"products,":[65],"but":[66],"has":[68],"only":[69],"been":[70],"available":[71,112],"on":[72,100],"command":[74],"line":[75],"interface,":[76],"which":[77],"difficult":[79],"use":[81],"those":[83],"without":[84],"programming":[85],"knowledge,":[86],"until":[87],"release":[89],"MOST.":[91],"AVAILABILITY":[92],"AND":[93],"IMPLEMENTATION:":[94],"distributed":[97],"free":[99],"GNU":[102],"General":[103],"Public":[104],"License.":[105],"The":[106],"full":[109],"documentation":[110],"are":[111],"at":[113],"http://most.ccib.rutgers.edu/.":[114],"CONTACT:":[115],"dslun@rutgers.edu.":[116]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3}],"updated_date":"2026-07-22T07:51:19.307946","created_date":"2025-10-10T00:00:00"}