{"id":"https://openalex.org/W2124211388","doi":"https://doi.org/10.1093/bioinformatics/btu528","title":"Thresher: an improved algorithm for peak height thresholding of microbial community profiles","display_name":"Thresher: an improved algorithm for peak height thresholding of microbial community profiles","publication_year":2014,"publication_date":"2014-08-05","ids":{"openalex":"https://openalex.org/W2124211388","doi":"https://doi.org/10.1093/bioinformatics/btu528","mag":"2124211388","pmid":"https://pubmed.ncbi.nlm.nih.gov/25095881"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btu528","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btu528","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/30/22/3257/48931051/bioinformatics_30_22_3257.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/30/22/3257/48931051/bioinformatics_30_22_3257.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014012185","display_name":"V. Starke","orcid":null},"institutions":[{"id":"https://openalex.org/I4210150103","display_name":"Geophysical Laboratory","ror":"https://ror.org/05qyye271","country_code":"US","type":"facility","lineage":["https://openalex.org/I196817621","https://openalex.org/I4210150103"]},{"id":"https://openalex.org/I196817621","display_name":"Carnegie Institution for Science","ror":"https://ror.org/04jr01610","country_code":"US","type":"funder","lineage":["https://openalex.org/I196817621"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Verena Starke","raw_affiliation_strings":["Carnegie Institution of Washington, Geophysical Laboratory, Washington DC 20015, USA","Carnegie Institution of Washington, Geophysical Laboratory, Washington, DC 20015, USA"],"affiliations":[{"raw_affiliation_string":"Carnegie Institution of Washington, Geophysical Laboratory, Washington DC 20015, USA","institution_ids":["https://openalex.org/I196817621","https://openalex.org/I4210150103"]},{"raw_affiliation_string":"Carnegie Institution of Washington, Geophysical Laboratory, Washington, DC 20015, USA","institution_ids":["https://openalex.org/I196817621","https://openalex.org/I4210150103"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026238093","display_name":"A. Steele","orcid":"https://orcid.org/0000-0001-9643-2841"},"institutions":[{"id":"https://openalex.org/I4210150103","display_name":"Geophysical Laboratory","ror":"https://ror.org/05qyye271","country_code":"US","type":"facility","lineage":["https://openalex.org/I196817621","https://openalex.org/I4210150103"]},{"id":"https://openalex.org/I196817621","display_name":"Carnegie Institution for Science","ror":"https://ror.org/04jr01610","country_code":"US","type":"funder","lineage":["https://openalex.org/I196817621"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew Steele","raw_affiliation_strings":["Carnegie Institution of Washington, Geophysical Laboratory, Washington DC 20015, USA","Carnegie Institution of Washington, Geophysical Laboratory, Washington, DC 20015, USA"],"affiliations":[{"raw_affiliation_string":"Carnegie Institution of Washington, Geophysical Laboratory, Washington DC 20015, USA","institution_ids":["https://openalex.org/I196817621","https://openalex.org/I4210150103"]},{"raw_affiliation_string":"Carnegie Institution of Washington, Geophysical Laboratory, Washington, DC 20015, USA","institution_ids":["https://openalex.org/I196817621","https://openalex.org/I4210150103"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5014012185"],"corresponding_institution_ids":["https://openalex.org/I196817621","https://openalex.org/I4210150103"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.09712172,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"30","issue":"22","first_page":"3257","last_page":"3263"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11791","display_name":"Microbial Community Ecology and Physiology","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/2303","display_name":"Ecology"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11791","display_name":"Microbial Community Ecology and Physiology","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/2303","display_name":"Ecology"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9914000034332275,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/replicate","display_name":"Replicate","score":0.8595422506332397},{"id":"https://openalex.org/keywords/thresholding","display_name":"Thresholding","score":0.8143556118011475},{"id":"https://openalex.org/keywords/sample","display_name":"Sample (material)","score":0.6545131206512451},{"id":"https://openalex.org/keywords/outlier","display_name":"Outlier","score":0.6512649655342102},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5839468240737915},{"id":"https://openalex.org/keywords/similarity","display_name":"Similarity (geometry)","score":0.5592333674430847},{"id":"https://openalex.org/keywords/software","display_name":"Software","score":0.5293486714363098},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.42027774453163147},{"id":"https://openalex.org/keywords/species-richness","display_name":"Species richness","score":0.4160473942756653},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.394543319940567},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.39314860105514526},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.33976322412490845},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.3232163190841675},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.2871144413948059},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.1701078712940216},{"id":"https://openalex.org/keywords/image","display_name":"Image (mathematics)","score":0.16941094398498535},{"id":"https://openalex.org/keywords/ecology","display_name":"Ecology","score":0.09015887975692749}],"concepts":[{"id":"https://openalex.org/C2781162219","wikidata":"https://www.wikidata.org/wiki/Q26250693","display_name":"Replicate","level":2,"score":0.8595422506332397},{"id":"https://openalex.org/C191178318","wikidata":"https://www.wikidata.org/wiki/Q2256906","display_name":"Thresholding","level":3,"score":0.8143556118011475},{"id":"https://openalex.org/C198531522","wikidata":"https://www.wikidata.org/wiki/Q485146","display_name":"Sample (material)","level":2,"score":0.6545131206512451},{"id":"https://openalex.org/C79337645","wikidata":"https://www.wikidata.org/wiki/Q779824","display_name":"Outlier","level":2,"score":0.6512649655342102},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5839468240737915},{"id":"https://openalex.org/C103278499","wikidata":"https://www.wikidata.org/wiki/Q254465","display_name":"Similarity (geometry)","level":3,"score":0.5592333674430847},{"id":"https://openalex.org/C2777904410","wikidata":"https://www.wikidata.org/wiki/Q7397","display_name":"Software","level":2,"score":0.5293486714363098},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.42027774453163147},{"id":"https://openalex.org/C53565203","wikidata":"https://www.wikidata.org/wiki/Q17146659","display_name":"Species richness","level":2,"score":0.4160473942756653},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.394543319940567},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.39314860105514526},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.33976322412490845},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3232163190841675},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.2871144413948059},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1701078712940216},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.16941094398498535},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.09015887975692749},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004783","descriptor_name":"Environmental Microbiology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004783","descriptor_name":"Environmental Microbiology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004783","descriptor_name":"Environmental Microbiology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021903","descriptor_name":"DNA, Ribosomal Spacer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D021903","descriptor_name":"DNA, Ribosomal Spacer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D021903","descriptor_name":"DNA, Ribosomal Spacer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1093/bioinformatics/btu528","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btu528","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/30/22/3257/48931051/bioinformatics_30_22_3257.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:25095881","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25095881","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btu528","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btu528","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/30/22/3257/48931051/bioinformatics_30_22_3257.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1391051816","display_name":null,"funder_award_id":"NNA09DA81A","funder_id":"https://openalex.org/F4320306101","funder_display_name":"National Aeronautics and Space Administration"},{"id":"https://openalex.org/G5953166597","display_name":"RETURNING SAMPLES FROM MARS HAS BEEN A KEY PART OF THE MARS PROGRAMS EXPLORATION GOALS. THIS MISSION IS CHALLENGED BY HIGH COSTS AND A HOST OF TECHNO","funder_award_id":"NNX12AP77G","funder_id":"https://openalex.org/F4320306101","funder_display_name":"National Aeronautics and Space Administration"},{"id":"https://openalex.org/G6956911564","display_name":"ARCTIC MARS ANALOGUE SVALBARD EXPEDITION (AMASE) SAMPLE RETURN:THIS PROPOSAL SEEKS TO ASSESS SAMPLE TARGETING / ACQUISITION / CONTAINMENT / SAMPLE H","funder_award_id":"NNX09AB74G","funder_id":"https://openalex.org/F4320306101","funder_display_name":"National Aeronautics and Space Administration"},{"id":"https://openalex.org/G7085615209","display_name":null,"funder_award_id":"NNA09DA81A","funder_id":"https://openalex.org/F4320331934","funder_display_name":"NASA Astrobiology Institute"}],"funders":[{"id":"https://openalex.org/F4320306101","display_name":"National Aeronautics and Space Administration","ror":"https://ror.org/027ka1x80"},{"id":"https://openalex.org/F4320306159","display_name":"W. M. Keck Foundation","ror":"https://ror.org/000dswa46"},{"id":"https://openalex.org/F4320331934","display_name":"NASA Astrobiology Institute","ror":"https://ror.org/01qxmdg18"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2124211388.pdf","grobid_xml":"https://content.openalex.org/works/W2124211388.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W1786737416","https://openalex.org/W1980587537","https://openalex.org/W1989103000","https://openalex.org/W2028829346","https://openalex.org/W2034939341","https://openalex.org/W2060850085","https://openalex.org/W2067752346","https://openalex.org/W2068861508","https://openalex.org/W2070743843","https://openalex.org/W2084072969","https://openalex.org/W2106964832","https://openalex.org/W2109823990","https://openalex.org/W2117683904","https://openalex.org/W2121456362","https://openalex.org/W2132088881","https://openalex.org/W2135403073","https://openalex.org/W2139297528","https://openalex.org/W2145166062","https://openalex.org/W2147618390","https://openalex.org/W2147926010","https://openalex.org/W2155162332","https://openalex.org/W2155531834","https://openalex.org/W2156257686","https://openalex.org/W2319824271","https://openalex.org/W2582743722","https://openalex.org/W4285719527","https://openalex.org/W6772461537"],"related_works":["https://openalex.org/W4254851101","https://openalex.org/W3171007296","https://openalex.org/W22115721","https://openalex.org/W2211931904","https://openalex.org/W2321234655","https://openalex.org/W2065444835","https://openalex.org/W2022250864","https://openalex.org/W4385061579","https://openalex.org/W1855418621","https://openalex.org/W2470062578"],"abstract_inverted_index":{"Supplementary":[0],"data":[1],"are":[2],"available":[3],"at":[4],"Bioinformatics":[5],"online.":[6]},"counts_by_year":[],"updated_date":"2026-03-14T08:43:22.919905","created_date":"2025-10-10T00:00:00"}