{"id":"https://openalex.org/W2102089979","doi":"https://doi.org/10.1093/bioinformatics/btu453","title":"Effects of small particle numbers on long-term behaviour in discrete biochemical systems","display_name":"Effects of small particle numbers on long-term behaviour in discrete biochemical systems","publication_year":2014,"publication_date":"2014-08-22","ids":{"openalex":"https://openalex.org/W2102089979","doi":"https://doi.org/10.1093/bioinformatics/btu453","mag":"2102089979","pmid":"https://pubmed.ncbi.nlm.nih.gov/25161236"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btu453","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btu453","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/30/17/i475/17149982/btu453.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/30/17/i475/17149982/btu453.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087323230","display_name":"Peter Kreyssig","orcid":null},"institutions":[{"id":"https://openalex.org/I13469542","display_name":"Vrije Universiteit Brussel","ror":"https://ror.org/006e5kg04","country_code":"BE","type":"education","lineage":["https://openalex.org/I13469542"]},{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I4210145958","display_name":"Instituto de Filosof\u00eda y Ciencias de la Complejidad","ror":"https://ror.org/0447jv934","country_code":"CL","type":"facility","lineage":["https://openalex.org/I4210145958"]},{"id":"https://openalex.org/I76198965","display_name":"Friedrich Schiller University Jena","ror":"https://ror.org/05qpz1x62","country_code":"DE","type":"education","lineage":["https://openalex.org/I76198965"]}],"countries":["BE","CA","CL","DE"],"is_corresponding":false,"raw_author_name":"Peter Kreyssig","raw_affiliation_strings":["1 Bio Systems Analysis Group, Department of Mathematics and Computer Science and Jena Centre for Bioinformatics, Friedrich Schiller University Jena, 07743 Jena, Germany, 2Mathematics Department, University of British Columbia, Kelowna, BC V1V 1V7, Canada, 3Instituto de Filosof\u00eda y Ciencias de la Complejidad - IFICC, Los Alerces 3024 \u00d1u\u00f1oa, Santiago, Chile, 4Center Leo Apostel, Vrije Universiteit Brussel, B-1160 Brussels, Belgium, 5Umm Al-Qura University, 1109 Makkah Al-Mukarramah and 6Al-Qunfudah Center for Scientific Research (QCSR), 21912 Al-Qunfudah, Kingdom of Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Bio Systems Analysis Group, Department of Mathematics and Computer Science and Jena Centre for Bioinformatics, Friedrich Schiller University Jena, 07743 Jena, Germany, 2Mathematics Department, University of British Columbia, Kelowna, BC V1V 1V7, Canada, 3Instituto de Filosof\u00eda y Ciencias de la Complejidad - IFICC, Los Alerces 3024 \u00d1u\u00f1oa, Santiago, Chile, 4Center Leo Apostel, Vrije Universiteit Brussel, B-1160 Brussels, Belgium, 5Umm Al-Qura University, 1109 Makkah Al-Mukarramah and 6Al-Qunfudah Center for Scientific Research (QCSR), 21912 Al-Qunfudah, Kingdom of Saudi Arabia","institution_ids":["https://openalex.org/I13469542","https://openalex.org/I141945490","https://openalex.org/I4210145958","https://openalex.org/I76198965"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022925357","display_name":"Christian Wozar","orcid":null},"institutions":[{"id":"https://openalex.org/I13469542","display_name":"Vrije Universiteit Brussel","ror":"https://ror.org/006e5kg04","country_code":"BE","type":"education","lineage":["https://openalex.org/I13469542"]},{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I4210145958","display_name":"Instituto de Filosof\u00eda y Ciencias de la Complejidad","ror":"https://ror.org/0447jv934","country_code":"CL","type":"facility","lineage":["https://openalex.org/I4210145958"]},{"id":"https://openalex.org/I76198965","display_name":"Friedrich Schiller University Jena","ror":"https://ror.org/05qpz1x62","country_code":"DE","type":"education","lineage":["https://openalex.org/I76198965"]}],"countries":["BE","CA","CL","DE"],"is_corresponding":false,"raw_author_name":"Christian Wozar","raw_affiliation_strings":["1 Bio Systems Analysis Group, Department of Mathematics and Computer Science and Jena Centre for Bioinformatics, Friedrich Schiller University Jena, 07743 Jena, Germany, 2Mathematics Department, University of British Columbia, Kelowna, BC V1V 1V7, Canada, 3Instituto de Filosof\u00eda y Ciencias de la Complejidad - IFICC, Los Alerces 3024 \u00d1u\u00f1oa, Santiago, Chile, 4Center Leo Apostel, Vrije Universiteit Brussel, B-1160 Brussels, Belgium, 5Umm Al-Qura University, 1109 Makkah Al-Mukarramah and 6Al-Qunfudah Center for Scientific Research (QCSR), 21912 Al-Qunfudah, Kingdom of Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Bio Systems Analysis Group, Department of Mathematics and Computer Science and Jena Centre for Bioinformatics, Friedrich Schiller University Jena, 07743 Jena, Germany, 2Mathematics Department, University of British Columbia, Kelowna, BC V1V 1V7, Canada, 3Instituto de Filosof\u00eda y Ciencias de la Complejidad - IFICC, Los Alerces 3024 \u00d1u\u00f1oa, Santiago, Chile, 4Center Leo Apostel, Vrije Universiteit Brussel, B-1160 Brussels, Belgium, 5Umm Al-Qura University, 1109 Makkah Al-Mukarramah and 6Al-Qunfudah Center for Scientific Research (QCSR), 21912 Al-Qunfudah, Kingdom of Saudi Arabia","institution_ids":["https://openalex.org/I13469542","https://openalex.org/I141945490","https://openalex.org/I4210145958","https://openalex.org/I76198965"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084087535","display_name":"Stephan Peter","orcid":"https://orcid.org/0000-0003-1540-190X"},"institutions":[{"id":"https://openalex.org/I13469542","display_name":"Vrije Universiteit Brussel","ror":"https://ror.org/006e5kg04","country_code":"BE","type":"education","lineage":["https://openalex.org/I13469542"]},{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I4210145958","display_name":"Instituto de Filosof\u00eda y Ciencias de la Complejidad","ror":"https://ror.org/0447jv934","country_code":"CL","type":"facility","lineage":["https://openalex.org/I4210145958"]},{"id":"https://openalex.org/I76198965","display_name":"Friedrich Schiller University Jena","ror":"https://ror.org/05qpz1x62","country_code":"DE","type":"education","lineage":["https://openalex.org/I76198965"]}],"countries":["BE","CA","CL","DE"],"is_corresponding":false,"raw_author_name":"Stephan Peter","raw_affiliation_strings":["1 Bio Systems Analysis Group, Department of Mathematics and Computer Science and Jena Centre for Bioinformatics, Friedrich Schiller University Jena, 07743 Jena, Germany, 2Mathematics Department, University of British Columbia, Kelowna, BC V1V 1V7, Canada, 3Instituto de Filosof\u00eda y Ciencias de la Complejidad - IFICC, Los Alerces 3024 \u00d1u\u00f1oa, Santiago, Chile, 4Center Leo Apostel, Vrije Universiteit Brussel, B-1160 Brussels, Belgium, 5Umm Al-Qura University, 1109 Makkah Al-Mukarramah and 6Al-Qunfudah Center for Scientific Research (QCSR), 21912 Al-Qunfudah, Kingdom of Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Bio Systems Analysis Group, Department of Mathematics and Computer Science and Jena Centre for Bioinformatics, Friedrich Schiller University Jena, 07743 Jena, Germany, 2Mathematics Department, University of British Columbia, Kelowna, BC V1V 1V7, Canada, 3Instituto de Filosof\u00eda y Ciencias de la Complejidad - IFICC, Los Alerces 3024 \u00d1u\u00f1oa, Santiago, Chile, 4Center Leo Apostel, Vrije Universiteit Brussel, B-1160 Brussels, Belgium, 5Umm Al-Qura University, 1109 Makkah Al-Mukarramah and 6Al-Qunfudah Center for Scientific Research (QCSR), 21912 Al-Qunfudah, Kingdom of Saudi Arabia","institution_ids":["https://openalex.org/I13469542","https://openalex.org/I141945490","https://openalex.org/I4210145958","https://openalex.org/I76198965"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026723884","display_name":"Tom\u00e1s Veloz","orcid":"https://orcid.org/0000-0003-3014-8340"},"institutions":[{"id":"https://openalex.org/I13469542","display_name":"Vrije Universiteit Brussel","ror":"https://ror.org/006e5kg04","country_code":"BE","type":"education","lineage":["https://openalex.org/I13469542"]},{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I4210145958","display_name":"Instituto de Filosof\u00eda y Ciencias de la Complejidad","ror":"https://ror.org/0447jv934","country_code":"CL","type":"facility","lineage":["https://openalex.org/I4210145958"]},{"id":"https://openalex.org/I76198965","display_name":"Friedrich Schiller University Jena","ror":"https://ror.org/05qpz1x62","country_code":"DE","type":"education","lineage":["https://openalex.org/I76198965"]}],"countries":["BE","CA","CL","DE"],"is_corresponding":false,"raw_author_name":"Tom\u00e1s Veloz","raw_affiliation_strings":["1 Bio Systems Analysis Group, Department of Mathematics and Computer Science and Jena Centre for Bioinformatics, Friedrich Schiller University Jena, 07743 Jena, Germany, 2Mathematics Department, University of British Columbia, Kelowna, BC V1V 1V7, Canada, 3Instituto de Filosof\u00eda y Ciencias de la Complejidad - IFICC, Los Alerces 3024 \u00d1u\u00f1oa, Santiago, Chile, 4Center Leo Apostel, Vrije Universiteit Brussel, B-1160 Brussels, Belgium, 5Umm Al-Qura University, 1109 Makkah Al-Mukarramah and 6Al-Qunfudah Center for Scientific Research (QCSR), 21912 Al-Qunfudah, Kingdom of Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Bio Systems Analysis Group, Department of Mathematics and Computer Science and Jena Centre for Bioinformatics, Friedrich Schiller University Jena, 07743 Jena, Germany, 2Mathematics Department, University of British Columbia, Kelowna, BC V1V 1V7, Canada, 3Instituto de Filosof\u00eda y Ciencias de la Complejidad - IFICC, Los Alerces 3024 \u00d1u\u00f1oa, Santiago, Chile, 4Center Leo Apostel, Vrije Universiteit Brussel, B-1160 Brussels, Belgium, 5Umm Al-Qura University, 1109 Makkah Al-Mukarramah and 6Al-Qunfudah Center for Scientific Research (QCSR), 21912 Al-Qunfudah, Kingdom of Saudi Arabia","institution_ids":["https://openalex.org/I13469542","https://openalex.org/I141945490","https://openalex.org/I4210145958","https://openalex.org/I76198965"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072586926","display_name":"Bashar Ibrahim","orcid":"https://orcid.org/0000-0001-7773-0122"},"institutions":[{"id":"https://openalex.org/I13469542","display_name":"Vrije Universiteit Brussel","ror":"https://ror.org/006e5kg04","country_code":"BE","type":"education","lineage":["https://openalex.org/I13469542"]},{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I4210145958","display_name":"Instituto de Filosof\u00eda y Ciencias de la Complejidad","ror":"https://ror.org/0447jv934","country_code":"CL","type":"facility","lineage":["https://openalex.org/I4210145958"]},{"id":"https://openalex.org/I76198965","display_name":"Friedrich Schiller University Jena","ror":"https://ror.org/05qpz1x62","country_code":"DE","type":"education","lineage":["https://openalex.org/I76198965"]}],"countries":["BE","CA","CL","DE"],"is_corresponding":true,"raw_author_name":"Bashar Ibrahim","raw_affiliation_strings":["1 Bio Systems Analysis Group, Department of Mathematics and Computer Science and Jena Centre for Bioinformatics, Friedrich Schiller University Jena, 07743 Jena, Germany, 2Mathematics Department, University of British Columbia, Kelowna, BC V1V 1V7, Canada, 3Instituto de Filosof\u00eda y Ciencias de la Complejidad - IFICC, Los Alerces 3024 \u00d1u\u00f1oa, Santiago, Chile, 4Center Leo Apostel, Vrije Universiteit Brussel, B-1160 Brussels, Belgium, 5Umm Al-Qura University, 1109 Makkah Al-Mukarramah and 6Al-Qunfudah Center for Scientific Research (QCSR), 21912 Al-Qunfudah, Kingdom of Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Bio Systems Analysis Group, Department of Mathematics and Computer Science and Jena Centre for Bioinformatics, Friedrich Schiller University Jena, 07743 Jena, Germany, 2Mathematics Department, University of British Columbia, Kelowna, BC V1V 1V7, Canada, 3Instituto de Filosof\u00eda y Ciencias de la Complejidad - IFICC, Los Alerces 3024 \u00d1u\u00f1oa, Santiago, Chile, 4Center Leo Apostel, Vrije Universiteit Brussel, B-1160 Brussels, Belgium, 5Umm Al-Qura University, 1109 Makkah Al-Mukarramah and 6Al-Qunfudah Center for Scientific Research (QCSR), 21912 Al-Qunfudah, Kingdom of Saudi Arabia","institution_ids":["https://openalex.org/I13469542","https://openalex.org/I141945490","https://openalex.org/I4210145958","https://openalex.org/I76198965"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018987403","display_name":"Peter Dittrich","orcid":"https://orcid.org/0000-0002-2541-6745"},"institutions":[{"id":"https://openalex.org/I13469542","display_name":"Vrije Universiteit Brussel","ror":"https://ror.org/006e5kg04","country_code":"BE","type":"education","lineage":["https://openalex.org/I13469542"]},{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I4210145958","display_name":"Instituto de Filosof\u00eda y Ciencias de la Complejidad","ror":"https://ror.org/0447jv934","country_code":"CL","type":"facility","lineage":["https://openalex.org/I4210145958"]},{"id":"https://openalex.org/I76198965","display_name":"Friedrich Schiller University Jena","ror":"https://ror.org/05qpz1x62","country_code":"DE","type":"education","lineage":["https://openalex.org/I76198965"]}],"countries":["BE","CA","CL","DE"],"is_corresponding":true,"raw_author_name":"Peter Dittrich","raw_affiliation_strings":["1 Bio Systems Analysis Group, Department of Mathematics and Computer Science and Jena Centre for Bioinformatics, Friedrich Schiller University Jena, 07743 Jena, Germany, 2Mathematics Department, University of British Columbia, Kelowna, BC V1V 1V7, Canada, 3Instituto de Filosof\u00eda y Ciencias de la Complejidad - IFICC, Los Alerces 3024 \u00d1u\u00f1oa, Santiago, Chile, 4Center Leo Apostel, Vrije Universiteit Brussel, B-1160 Brussels, Belgium, 5Umm Al-Qura University, 1109 Makkah Al-Mukarramah and 6Al-Qunfudah Center for Scientific Research (QCSR), 21912 Al-Qunfudah, Kingdom of Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Bio Systems Analysis Group, Department of Mathematics and Computer Science and Jena Centre for Bioinformatics, Friedrich Schiller University Jena, 07743 Jena, Germany, 2Mathematics Department, University of British Columbia, Kelowna, BC V1V 1V7, Canada, 3Instituto de Filosof\u00eda y Ciencias de la Complejidad - IFICC, Los Alerces 3024 \u00d1u\u00f1oa, Santiago, Chile, 4Center Leo Apostel, Vrije Universiteit Brussel, B-1160 Brussels, Belgium, 5Umm Al-Qura University, 1109 Makkah Al-Mukarramah and 6Al-Qunfudah Center for Scientific Research (QCSR), 21912 Al-Qunfudah, Kingdom of Saudi Arabia","institution_ids":["https://openalex.org/I13469542","https://openalex.org/I141945490","https://openalex.org/I4210145958","https://openalex.org/I76198965"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5018987403","https://openalex.org/A5072586926"],"corresponding_institution_ids":["https://openalex.org/I13469542","https://openalex.org/I141945490","https://openalex.org/I4210145958","https://openalex.org/I76198965"],"apc_list":{"value":3989,"currency":"USD","value_usd":3989},"apc_paid":{"value":3989,"currency":"USD","value_usd":3989},"fwci":2.2566,"has_fulltext":true,"cited_by_count":37,"citation_normalized_percentile":{"value":0.87243229,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"30","issue":"17","first_page":"i475","last_page":"i481"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.8496000170707703,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.8496000170707703,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11445","display_name":"Origins and Evolution of Life","score":0.04100000113248825,"subfield":{"id":"https://openalex.org/subfields/3103","display_name":"Astronomy and Astrophysics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.01769999973475933,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/markup-language","display_name":"Markup language","score":0.7610915899276733},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6971264481544495},{"id":"https://openalex.org/keywords/term","display_name":"Term (time)","score":0.6067942976951599},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.47465425729751587},{"id":"https://openalex.org/keywords/extension","display_name":"Extension (predicate logic)","score":0.4643773138523102},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.4370706379413605},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3332972228527069},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.24103322625160217},{"id":"https://openalex.org/keywords/xml","display_name":"XML","score":0.20569807291030884},{"id":"https://openalex.org/keywords/programming-language","display_name":"Programming language","score":0.17866939306259155},{"id":"https://openalex.org/keywords/world-wide-web","display_name":"World Wide Web","score":0.12121585011482239},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.11721095442771912}],"concepts":[{"id":"https://openalex.org/C45874996","wikidata":"https://www.wikidata.org/wiki/Q37045","display_name":"Markup language","level":3,"score":0.7610915899276733},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6971264481544495},{"id":"https://openalex.org/C61797465","wikidata":"https://www.wikidata.org/wiki/Q1188986","display_name":"Term (time)","level":2,"score":0.6067942976951599},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.47465425729751587},{"id":"https://openalex.org/C2778029271","wikidata":"https://www.wikidata.org/wiki/Q5421931","display_name":"Extension (predicate logic)","level":2,"score":0.4643773138523102},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.4370706379413605},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3332972228527069},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24103322625160217},{"id":"https://openalex.org/C8797682","wikidata":"https://www.wikidata.org/wiki/Q2115","display_name":"XML","level":2,"score":0.20569807291030884},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.17866939306259155},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.12121585011482239},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.11721095442771912},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D008941","descriptor_name":"Spindle Apparatus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008941","descriptor_name":"Spindle Apparatus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008941","descriptor_name":"Spindle Apparatus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/bioinformatics/btu453","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btu453","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/30/17/i475/17149982/btu453.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:25161236","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25161236","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4147906","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4147906","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"Text"},{"id":"pmh:oai:vubissmart:VUBISSMART:2000:92252","is_oa":false,"landing_page_url":"https://biblio.vub.ac.be/vubir/effects-of-small-particle-numbers-on-longterm-behaviour-in-discrete-biochemical-systems(2ada89c0-aaeb-468b-87d0-e979ecdf9a14).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306402573","display_name":"VUBIR (Vrije Universiteit Brussel)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I13469542","host_organization_name":"Vrije Universiteit Brussel","host_organization_lineage":["https://openalex.org/I13469542"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btu453","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btu453","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/30/17/i475/17149982/btu453.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1244000712","display_name":null,"funder_award_id":"SPP1183","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G2169288157","display_name":null,"funder_award_id":"SPP1395","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G4114176512","display_name":null,"funder_award_id":"DI 852/4-3","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G941128329","display_name":null,"funder_award_id":"Di852/10-1","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2102089979.pdf","grobid_xml":"https://content.openalex.org/works/W2102089979.grobid-xml"},"referenced_works_count":61,"referenced_works":["https://openalex.org/W34476357","https://openalex.org/W174102300","https://openalex.org/W224340457","https://openalex.org/W344947223","https://openalex.org/W568941435","https://openalex.org/W581916199","https://openalex.org/W592696926","https://openalex.org/W1482646691","https://openalex.org/W1510249251","https://openalex.org/W1569581113","https://openalex.org/W1592379908","https://openalex.org/W1849431597","https://openalex.org/W1892851289","https://openalex.org/W1978486653","https://openalex.org/W1986649132","https://openalex.org/W1996109622","https://openalex.org/W2010445459","https://openalex.org/W2011214280","https://openalex.org/W2021767817","https://openalex.org/W2023205416","https://openalex.org/W2026541477","https://openalex.org/W2026993027","https://openalex.org/W2032570525","https://openalex.org/W2032700586","https://openalex.org/W2035045968","https://openalex.org/W2042321087","https://openalex.org/W2045628352","https://openalex.org/W2046760236","https://openalex.org/W2055401277","https://openalex.org/W2057788561","https://openalex.org/W2094097101","https://openalex.org/W2097242011","https://openalex.org/W2110823478","https://openalex.org/W2112185150","https://openalex.org/W2113372190","https://openalex.org/W2114202040","https://openalex.org/W2117863812","https://openalex.org/W2118274513","https://openalex.org/W2122902581","https://openalex.org/W2135411055","https://openalex.org/W2145600675","https://openalex.org/W2148895036","https://openalex.org/W2149567454","https://openalex.org/W2150766477","https://openalex.org/W2150908245","https://openalex.org/W2155418451","https://openalex.org/W2156458781","https://openalex.org/W2159875969","https://openalex.org/W2165360511","https://openalex.org/W2324660040","https://openalex.org/W2402709285","https://openalex.org/W2404429251","https://openalex.org/W2944782266","https://openalex.org/W3101205262","https://openalex.org/W3102310679","https://openalex.org/W4245558686","https://openalex.org/W6601398114","https://openalex.org/W6653242640","https://openalex.org/W6656953575","https://openalex.org/W6713458472","https://openalex.org/W7009171728"],"related_works":["https://openalex.org/W4385386698","https://openalex.org/W4388119604","https://openalex.org/W2954418080","https://openalex.org/W3121570353","https://openalex.org/W818235636","https://openalex.org/W4388119676","https://openalex.org/W1566913699","https://openalex.org/W2150908245","https://openalex.org/W2211443823","https://openalex.org/W2043776573"],"abstract_inverted_index":{"MOTIVATION:":[0],"The":[1,108],"functioning":[2],"of":[3,11,16,24,36,38,65,72,104,113,133,149],"many":[4],"biological":[5,51,73],"processes":[6],"depends":[7],"on":[8,68],"the":[9,22,29,63,69,99,105,127,131,146,150],"appearance":[10],"only":[12],"a":[13,17,33,80,89],"small":[14],"number":[15,35],"single":[18,46,66],"molecular":[19,25],"species.":[20],"Additionally,":[21],"observation":[23],"crowding":[26],"leads":[27],"to":[28,49,91,101,145],"insight":[30],"that":[31],"even":[32],"high":[34],"copies":[37],"species":[39],"do":[40],"not":[41,54],"guarantee":[42],"their":[43],"interaction.":[44],"How":[45],"particles":[47],"contribute":[48],"stabilizing":[50],"systems":[52],"is":[53,110],"well":[55],"understood":[56],"yet.":[57],"Hence,":[58],"we":[59,118,125,141],"aim":[60],"at":[61,166],"determining":[62],"influence":[64],"molecules":[67],"long-term":[70],"behaviour":[71],"systems,":[74],"i.e.":[75],"whether":[76],"they":[77],"can":[78],"reach":[79],"steady":[81],"state.":[82],"RESULTS:":[83],"We":[84],"provide":[85],"theoretical":[86],"considerations":[87],"and":[88],"tool":[90],"analyse":[92],"Systems":[93],"Biology":[94],"Markup":[95],"Language":[96],"models":[97],"for":[98,130],"possibility":[100],"stabilize":[102],"because":[103],"described":[106],"effects.":[107],"theory":[109],"an":[111,143],"extension":[112],"chemical":[114,121,135],"organization":[115,122],"theory,":[116],"which":[117],"called":[119],"discrete":[120,134],"theory.":[123],"Furthermore":[124],"scanned":[126],"BioModels":[128],"Database":[129],"occurrence":[132],"organizations.":[136],"To":[137],"exemplify":[138],"our":[139],"method,":[140],"describe":[142],"application":[144],"Template":[147],"model":[148],"mitotic":[151],"spindle":[152],"assembly":[153],"checkpoint":[154],"mechanism.":[155],"AVAILABILITY":[156],"AND":[157],"IMPLEMENTATION:":[158],"http://www.biosys.uni-jena.de/Services.html.":[159],"SUPPLEMENTARY":[160],"INFORMATION:":[161],"Supplementary":[162],"data":[163],"are":[164],"available":[165],"Bioinformatics":[167],"online.":[168]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2}],"updated_date":"2026-08-27T14:10:00.468798","created_date":"2025-10-10T00:00:00"}