{"id":"https://openalex.org/W2136617988","doi":"https://doi.org/10.1093/bioinformatics/btu323","title":"Bioinformatics-driven discovery of rational combination for overcoming EGFR-mutant lung cancer resistance to EGFR therapy","display_name":"Bioinformatics-driven discovery of rational combination for overcoming EGFR-mutant lung cancer resistance to EGFR therapy","publication_year":2014,"publication_date":"2014-05-07","ids":{"openalex":"https://openalex.org/W2136617988","doi":"https://doi.org/10.1093/bioinformatics/btu323","mag":"2136617988","pmid":"https://pubmed.ncbi.nlm.nih.gov/24812339"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btu323","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btu323","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/30/17/2393/48927040/bioinformatics_30_17_2393.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/30/17/2393/48927040/bioinformatics_30_17_2393.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100384983","display_name":"Jihye Kim","orcid":"https://orcid.org/0000-0002-0338-2329"},"institutions":[{"id":"https://openalex.org/I3019586173","display_name":"National Jewish Health","ror":"https://ror.org/016z2bp30","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019586173"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]},{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz Medical Campus","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jihye Kim","raw_affiliation_strings":["1 \u00a01Division of Medical Oncology, Department of Medicine, Translational Bioinformatics and Cancer Systems Biology Laboratory, University of Colorado Anschutz Medical Campus, 80045 Aurora, 2Department of Medicine, National Jewish Health, 80206 Denver, 3Department of Craniofacial Biology, School of Dental Medicine, 4Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Anschutz Medical Campus, 80045 Aurora, CO, USA and 5Department of Computer Science and Engineering, Korea University, Seoul 136-713, Korea"],"affiliations":[{"raw_affiliation_string":"1 \u00a01Division of Medical Oncology, Department of Medicine, Translational Bioinformatics and Cancer Systems Biology Laboratory, University of Colorado Anschutz Medical Campus, 80045 Aurora, 2Department of Medicine, National Jewish Health, 80206 Denver, 3Department of Craniofacial Biology, School of Dental Medicine, 4Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Anschutz Medical Campus, 80045 Aurora, CO, USA and 5Department of Computer Science and Engineering, Korea University, Seoul 136-713, Korea","institution_ids":["https://openalex.org/I921990950","https://openalex.org/I3019586173","https://openalex.org/I51713134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085767473","display_name":"Vihas T. Vasu","orcid":"https://orcid.org/0000-0003-2275-2476"},"institutions":[{"id":"https://openalex.org/I3019586173","display_name":"National Jewish Health","ror":"https://ror.org/016z2bp30","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019586173"]},{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz Medical Campus","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vihas T. Vasu","raw_affiliation_strings":["1 \u00a01Division of Medical Oncology, Department of Medicine, Translational Bioinformatics and Cancer Systems Biology Laboratory, University of Colorado Anschutz Medical Campus, 80045 Aurora, 2Department of Medicine, National Jewish Health, 80206 Denver, 3Department of Craniofacial Biology, School of Dental Medicine, 4Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Anschutz Medical Campus, 80045 Aurora, CO, USA and 5Department of Computer Science and Engineering, Korea University, Seoul 136-713, Korea"],"affiliations":[{"raw_affiliation_string":"1 \u00a01Division of Medical Oncology, Department of Medicine, Translational Bioinformatics and Cancer Systems Biology Laboratory, University of Colorado Anschutz Medical Campus, 80045 Aurora, 2Department of Medicine, National Jewish Health, 80206 Denver, 3Department of Craniofacial Biology, School of Dental Medicine, 4Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Anschutz Medical Campus, 80045 Aurora, CO, USA and 5Department of Computer Science and Engineering, Korea University, Seoul 136-713, Korea","institution_ids":["https://openalex.org/I921990950","https://openalex.org/I3019586173","https://openalex.org/I51713134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039478974","display_name":"Rangnath Mishra","orcid":"https://orcid.org/0000-0001-7118-7114"},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz Medical Campus","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]},{"id":"https://openalex.org/I3019586173","display_name":"National Jewish Health","ror":"https://ror.org/016z2bp30","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019586173"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rangnath Mishra","raw_affiliation_strings":["1 \u00a01Division of Medical Oncology, Department of Medicine, Translational Bioinformatics and Cancer Systems Biology Laboratory, University of Colorado Anschutz Medical Campus, 80045 Aurora, 2Department of Medicine, National Jewish Health, 80206 Denver, 3Department of Craniofacial Biology, School of Dental Medicine, 4Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Anschutz Medical Campus, 80045 Aurora, CO, USA and 5Department of Computer Science and Engineering, Korea University, Seoul 136-713, Korea"],"affiliations":[{"raw_affiliation_string":"1 \u00a01Division of Medical Oncology, Department of Medicine, Translational Bioinformatics and Cancer Systems Biology Laboratory, University of Colorado Anschutz Medical Campus, 80045 Aurora, 2Department of Medicine, National Jewish Health, 80206 Denver, 3Department of Craniofacial Biology, School of Dental Medicine, 4Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Anschutz Medical Campus, 80045 Aurora, CO, USA and 5Department of Computer Science and Engineering, Korea University, Seoul 136-713, Korea","institution_ids":["https://openalex.org/I921990950","https://openalex.org/I3019586173","https://openalex.org/I51713134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019956651","display_name":"Katherine R. Singleton","orcid":null},"institutions":[{"id":"https://openalex.org/I3019586173","display_name":"National Jewish Health","ror":"https://ror.org/016z2bp30","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019586173"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]},{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz Medical Campus","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katherine R. Singleton","raw_affiliation_strings":["1 \u00a01Division of Medical Oncology, Department of Medicine, Translational Bioinformatics and Cancer Systems Biology Laboratory, University of Colorado Anschutz Medical Campus, 80045 Aurora, 2Department of Medicine, National Jewish Health, 80206 Denver, 3Department of Craniofacial Biology, School of Dental Medicine, 4Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Anschutz Medical Campus, 80045 Aurora, CO, USA and 5Department of Computer Science and Engineering, Korea University, Seoul 136-713, Korea"],"affiliations":[{"raw_affiliation_string":"1 \u00a01Division of Medical Oncology, Department of Medicine, Translational Bioinformatics and Cancer Systems Biology Laboratory, University of Colorado Anschutz Medical Campus, 80045 Aurora, 2Department of Medicine, National Jewish Health, 80206 Denver, 3Department of Craniofacial Biology, School of Dental Medicine, 4Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Anschutz Medical Campus, 80045 Aurora, CO, USA and 5Department of Computer Science and Engineering, Korea University, Seoul 136-713, Korea","institution_ids":["https://openalex.org/I921990950","https://openalex.org/I3019586173","https://openalex.org/I51713134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033144024","display_name":"Minjae Yoo","orcid":"https://orcid.org/0000-0002-1374-0791"},"institutions":[{"id":"https://openalex.org/I3019586173","display_name":"National Jewish Health","ror":"https://ror.org/016z2bp30","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019586173"]},{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz Medical Campus","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Minjae Yoo","raw_affiliation_strings":["1 \u00a01Division of Medical Oncology, Department of Medicine, Translational Bioinformatics and Cancer Systems Biology Laboratory, University of Colorado Anschutz Medical Campus, 80045 Aurora, 2Department of Medicine, National Jewish Health, 80206 Denver, 3Department of Craniofacial Biology, School of Dental Medicine, 4Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Anschutz Medical Campus, 80045 Aurora, CO, USA and 5Department of Computer Science and Engineering, Korea University, Seoul 136-713, Korea"],"affiliations":[{"raw_affiliation_string":"1 \u00a01Division of Medical Oncology, Department of Medicine, Translational Bioinformatics and Cancer Systems Biology Laboratory, University of Colorado Anschutz Medical Campus, 80045 Aurora, 2Department of Medicine, National Jewish Health, 80206 Denver, 3Department of Craniofacial Biology, School of Dental Medicine, 4Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Anschutz Medical Campus, 80045 Aurora, CO, USA and 5Department of Computer Science and Engineering, Korea University, Seoul 136-713, Korea","institution_ids":["https://openalex.org/I921990950","https://openalex.org/I3019586173","https://openalex.org/I51713134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041931115","display_name":"Sonia M. Leach","orcid":"https://orcid.org/0000-0003-2910-069X"},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz Medical Campus","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]},{"id":"https://openalex.org/I3019586173","display_name":"National Jewish Health","ror":"https://ror.org/016z2bp30","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019586173"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sonia M. Leach","raw_affiliation_strings":["1 \u00a01Division of Medical Oncology, Department of Medicine, Translational Bioinformatics and Cancer Systems Biology Laboratory, University of Colorado Anschutz Medical Campus, 80045 Aurora, 2Department of Medicine, National Jewish Health, 80206 Denver, 3Department of Craniofacial Biology, School of Dental Medicine, 4Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Anschutz Medical Campus, 80045 Aurora, CO, USA and 5Department of Computer Science and Engineering, Korea University, Seoul 136-713, Korea"],"affiliations":[{"raw_affiliation_string":"1 \u00a01Division of Medical Oncology, Department of Medicine, Translational Bioinformatics and Cancer Systems Biology Laboratory, University of Colorado Anschutz Medical Campus, 80045 Aurora, 2Department of Medicine, National Jewish Health, 80206 Denver, 3Department of Craniofacial Biology, School of Dental Medicine, 4Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Anschutz Medical Campus, 80045 Aurora, CO, USA and 5Department of Computer Science and Engineering, Korea University, Seoul 136-713, Korea","institution_ids":["https://openalex.org/I921990950","https://openalex.org/I3019586173","https://openalex.org/I51713134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081489957","display_name":"Eveline Farias\u2010Hesson","orcid":null},"institutions":[{"id":"https://openalex.org/I3019586173","display_name":"National Jewish Health","ror":"https://ror.org/016z2bp30","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019586173"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]},{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz Medical Campus","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eveline Farias-Hesson","raw_affiliation_strings":["1 \u00a01Division of Medical Oncology, Department of Medicine, Translational Bioinformatics and Cancer Systems Biology Laboratory, University of Colorado Anschutz Medical Campus, 80045 Aurora, 2Department of Medicine, National Jewish Health, 80206 Denver, 3Department of Craniofacial Biology, School of Dental Medicine, 4Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Anschutz Medical Campus, 80045 Aurora, CO, USA and 5Department of Computer Science and Engineering, Korea University, Seoul 136-713, Korea"],"affiliations":[{"raw_affiliation_string":"1 \u00a01Division of Medical Oncology, Department of Medicine, Translational Bioinformatics and Cancer Systems Biology Laboratory, University of Colorado Anschutz Medical Campus, 80045 Aurora, 2Department of Medicine, National Jewish Health, 80206 Denver, 3Department of Craniofacial Biology, School of Dental Medicine, 4Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Anschutz Medical Campus, 80045 Aurora, CO, USA and 5Department of Computer Science and Engineering, Korea University, Seoul 136-713, Korea","institution_ids":["https://openalex.org/I921990950","https://openalex.org/I3019586173","https://openalex.org/I51713134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102765411","display_name":"Robert J. Mason","orcid":"https://orcid.org/0000-0002-1784-2891"},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz Medical Campus","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]},{"id":"https://openalex.org/I3019586173","display_name":"National Jewish Health","ror":"https://ror.org/016z2bp30","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019586173"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert J. Mason","raw_affiliation_strings":["1 \u00a01Division of Medical Oncology, Department of Medicine, Translational Bioinformatics and Cancer Systems Biology Laboratory, University of Colorado Anschutz Medical Campus, 80045 Aurora, 2Department of Medicine, National Jewish Health, 80206 Denver, 3Department of Craniofacial Biology, School of Dental Medicine, 4Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Anschutz Medical Campus, 80045 Aurora, CO, USA and 5Department of Computer Science and Engineering, Korea University, Seoul 136-713, Korea"],"affiliations":[{"raw_affiliation_string":"1 \u00a01Division of Medical Oncology, Department of Medicine, Translational Bioinformatics and Cancer Systems Biology Laboratory, University of Colorado Anschutz Medical Campus, 80045 Aurora, 2Department of Medicine, National Jewish Health, 80206 Denver, 3Department of Craniofacial Biology, School of Dental Medicine, 4Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Anschutz Medical Campus, 80045 Aurora, CO, USA and 5Department of Computer Science and Engineering, Korea University, Seoul 136-713, Korea","institution_ids":["https://openalex.org/I921990950","https://openalex.org/I3019586173","https://openalex.org/I51713134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076917278","display_name":"Jaewoo Kang","orcid":"https://orcid.org/0000-0001-6798-9106"},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz Medical Campus","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I3019586173","display_name":"National Jewish Health","ror":"https://ror.org/016z2bp30","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019586173"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jaewoo Kang","raw_affiliation_strings":["1 \u00a01Division of Medical Oncology, Department of Medicine, Translational Bioinformatics and Cancer Systems Biology Laboratory, University of Colorado Anschutz Medical Campus, 80045 Aurora, 2Department of Medicine, National Jewish Health, 80206 Denver, 3Department of Craniofacial Biology, School of Dental Medicine, 4Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Anschutz Medical Campus, 80045 Aurora, CO, USA and 5Department of Computer Science and Engineering, Korea University, Seoul 136-713, Korea"],"affiliations":[{"raw_affiliation_string":"1 \u00a01Division of Medical Oncology, Department of Medicine, Translational Bioinformatics and Cancer Systems Biology Laboratory, University of Colorado Anschutz Medical Campus, 80045 Aurora, 2Department of Medicine, National Jewish Health, 80206 Denver, 3Department of Craniofacial Biology, School of Dental Medicine, 4Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Anschutz Medical Campus, 80045 Aurora, CO, USA and 5Department of Computer Science and Engineering, Korea University, Seoul 136-713, Korea","institution_ids":["https://openalex.org/I921990950","https://openalex.org/I3019586173","https://openalex.org/I51713134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017149867","display_name":"Preveen Ramamoorthy","orcid":null},"institutions":[{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]},{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz Medical Campus","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I3019586173","display_name":"National Jewish Health","ror":"https://ror.org/016z2bp30","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019586173"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Preveen Ramamoorthy","raw_affiliation_strings":["1 \u00a01Division of Medical Oncology, Department of Medicine, Translational Bioinformatics and Cancer Systems Biology Laboratory, University of Colorado Anschutz Medical Campus, 80045 Aurora, 2Department of Medicine, National Jewish Health, 80206 Denver, 3Department of Craniofacial Biology, School of Dental Medicine, 4Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Anschutz Medical Campus, 80045 Aurora, CO, USA and 5Department of Computer Science and Engineering, Korea University, Seoul 136-713, Korea"],"affiliations":[{"raw_affiliation_string":"1 \u00a01Division of Medical Oncology, Department of Medicine, Translational Bioinformatics and Cancer Systems Biology Laboratory, University of Colorado Anschutz Medical Campus, 80045 Aurora, 2Department of Medicine, National Jewish Health, 80206 Denver, 3Department of Craniofacial Biology, School of Dental Medicine, 4Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Anschutz Medical Campus, 80045 Aurora, CO, USA and 5Department of Computer Science and Engineering, Korea University, Seoul 136-713, Korea","institution_ids":["https://openalex.org/I921990950","https://openalex.org/I3019586173","https://openalex.org/I51713134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019506336","display_name":"Jeffrey A. Kern","orcid":"https://orcid.org/0000-0001-9709-9622"},"institutions":[{"id":"https://openalex.org/I3019586173","display_name":"National Jewish Health","ror":"https://ror.org/016z2bp30","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019586173"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]},{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz Medical Campus","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey A. Kern","raw_affiliation_strings":["1 \u00a01Division of Medical Oncology, Department of Medicine, Translational Bioinformatics and Cancer Systems Biology Laboratory, University of Colorado Anschutz Medical Campus, 80045 Aurora, 2Department of Medicine, National Jewish Health, 80206 Denver, 3Department of Craniofacial Biology, School of Dental Medicine, 4Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Anschutz Medical Campus, 80045 Aurora, CO, USA and 5Department of Computer Science and Engineering, Korea University, Seoul 136-713, Korea"],"affiliations":[{"raw_affiliation_string":"1 \u00a01Division of Medical Oncology, Department of Medicine, Translational Bioinformatics and Cancer Systems Biology Laboratory, University of Colorado Anschutz Medical Campus, 80045 Aurora, 2Department of Medicine, National Jewish Health, 80206 Denver, 3Department of Craniofacial Biology, School of Dental Medicine, 4Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Anschutz Medical Campus, 80045 Aurora, CO, USA and 5Department of Computer Science and Engineering, Korea University, Seoul 136-713, Korea","institution_ids":["https://openalex.org/I921990950","https://openalex.org/I3019586173","https://openalex.org/I51713134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057844697","display_name":"Lynn E. Heasley","orcid":"https://orcid.org/0000-0001-8056-0208"},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz Medical Campus","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]},{"id":"https://openalex.org/I3019586173","display_name":"National Jewish Health","ror":"https://ror.org/016z2bp30","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019586173"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lynn E. Heasley","raw_affiliation_strings":["1 \u00a01Division of Medical Oncology, Department of Medicine, Translational Bioinformatics and Cancer Systems Biology Laboratory, University of Colorado Anschutz Medical Campus, 80045 Aurora, 2Department of Medicine, National Jewish Health, 80206 Denver, 3Department of Craniofacial Biology, School of Dental Medicine, 4Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Anschutz Medical Campus, 80045 Aurora, CO, USA and 5Department of Computer Science and Engineering, Korea University, Seoul 136-713, Korea"],"affiliations":[{"raw_affiliation_string":"1 \u00a01Division of Medical Oncology, Department of Medicine, Translational Bioinformatics and Cancer Systems Biology Laboratory, University of Colorado Anschutz Medical Campus, 80045 Aurora, 2Department of Medicine, National Jewish Health, 80206 Denver, 3Department of Craniofacial Biology, School of Dental Medicine, 4Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Anschutz Medical Campus, 80045 Aurora, CO, USA and 5Department of Computer Science and Engineering, Korea University, Seoul 136-713, Korea","institution_ids":["https://openalex.org/I921990950","https://openalex.org/I3019586173","https://openalex.org/I51713134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056369871","display_name":"James H. Finigan","orcid":null},"institutions":[{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]},{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz Medical Campus","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I3019586173","display_name":"National Jewish Health","ror":"https://ror.org/016z2bp30","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019586173"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James H. Finigan","raw_affiliation_strings":["1 \u00a01Division of Medical Oncology, Department of Medicine, Translational Bioinformatics and Cancer Systems Biology Laboratory, University of Colorado Anschutz Medical Campus, 80045 Aurora, 2Department of Medicine, National Jewish Health, 80206 Denver, 3Department of Craniofacial Biology, School of Dental Medicine, 4Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Anschutz Medical Campus, 80045 Aurora, CO, USA and 5Department of Computer Science and Engineering, Korea University, Seoul 136-713, Korea"],"affiliations":[{"raw_affiliation_string":"1 \u00a01Division of Medical Oncology, Department of Medicine, Translational Bioinformatics and Cancer Systems Biology Laboratory, University of Colorado Anschutz Medical Campus, 80045 Aurora, 2Department of Medicine, National Jewish Health, 80206 Denver, 3Department of Craniofacial Biology, School of Dental Medicine, 4Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Anschutz Medical Campus, 80045 Aurora, CO, USA and 5Department of Computer Science and Engineering, Korea University, Seoul 136-713, Korea","institution_ids":["https://openalex.org/I921990950","https://openalex.org/I3019586173","https://openalex.org/I51713134"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019556057","display_name":"Aik Choon Tan","orcid":"https://orcid.org/0000-0003-2955-8369"},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz Medical Campus","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I3019586173","display_name":"National Jewish Health","ror":"https://ror.org/016z2bp30","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019586173"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aik Choon Tan","raw_affiliation_strings":["1 \u00a01Division of Medical Oncology, Department of Medicine, Translational Bioinformatics and Cancer Systems Biology Laboratory, University of Colorado Anschutz Medical Campus, 80045 Aurora, 2Department of Medicine, National Jewish Health, 80206 Denver, 3Department of Craniofacial Biology, School of Dental Medicine, 4Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Anschutz Medical Campus, 80045 Aurora, CO, USA and 5Department of Computer Science and Engineering, Korea University, Seoul 136-713, Korea"],"affiliations":[{"raw_affiliation_string":"1 \u00a01Division of Medical Oncology, Department of Medicine, Translational Bioinformatics and Cancer Systems Biology Laboratory, University of Colorado Anschutz Medical Campus, 80045 Aurora, 2Department of Medicine, National Jewish Health, 80206 Denver, 3Department of Craniofacial Biology, School of Dental Medicine, 4Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Anschutz Medical Campus, 80045 Aurora, CO, USA and 5Department of Computer Science and Engineering, Korea University, Seoul 136-713, Korea","institution_ids":["https://openalex.org/I921990950","https://openalex.org/I3019586173","https://openalex.org/I51713134"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":14,"corresponding_author_ids":["https://openalex.org/A5100384983"],"corresponding_institution_ids":["https://openalex.org/I3019586173","https://openalex.org/I51713134","https://openalex.org/I921990950"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":3.144,"has_fulltext":true,"cited_by_count":25,"citation_normalized_percentile":{"value":0.9178036,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"30","issue":"17","first_page":"2393","last_page":"2398"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13779","display_name":"Cancer Mechanisms and Therapy","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gefitinib","display_name":"Gefitinib","score":0.7302915453910828},{"id":"https://openalex.org/keywords/epidermal-growth-factor-receptor","display_name":"Epidermal growth factor receptor","score":0.6582293510437012},{"id":"https://openalex.org/keywords/erlotinib","display_name":"Erlotinib","score":0.6403743028640747},{"id":"https://openalex.org/keywords/egfr-inhibitors","display_name":"EGFR inhibitors","score":0.5819189548492432},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"Lung cancer","score":0.5702560544013977},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.5161257982254028},{"id":"https://openalex.org/keywords/kinase","display_name":"Kinase","score":0.48960310220718384},{"id":"https://openalex.org/keywords/drug-repositioning","display_name":"Drug repositioning","score":0.4750288128852844},{"id":"https://openalex.org/keywords/bosutinib","display_name":"Bosutinib","score":0.4722321033477783},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.4662821292877197},{"id":"https://openalex.org/keywords/repurposing","display_name":"Repurposing","score":0.4256397485733032},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3755072057247162},{"id":"https://openalex.org/keywords/tyrosine-kinase","display_name":"Tyrosine kinase","score":0.35673922300338745},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.349030077457428},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.2556339204311371},{"id":"https://openalex.org/keywords/oncology","display_name":"Oncology","score":0.24288243055343628},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"Signal transduction","score":0.2226448655128479},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.12395727634429932},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.12323486804962158},{"id":"https://openalex.org/keywords/dasatinib","display_name":"Dasatinib","score":0.09983828663825989}],"concepts":[{"id":"https://openalex.org/C2780580887","wikidata":"https://www.wikidata.org/wiki/Q417824","display_name":"Gefitinib","level":4,"score":0.7302915453910828},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.6582293510437012},{"id":"https://openalex.org/C2778087573","wikidata":"https://www.wikidata.org/wiki/Q418369","display_name":"Erlotinib","level":4,"score":0.6403743028640747},{"id":"https://openalex.org/C2777506169","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"EGFR inhibitors","level":4,"score":0.5819189548492432},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.5702560544013977},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5161257982254028},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.48960310220718384},{"id":"https://openalex.org/C103637391","wikidata":"https://www.wikidata.org/wiki/Q5308921","display_name":"Drug repositioning","level":3,"score":0.4750288128852844},{"id":"https://openalex.org/C2778208673","wikidata":"https://www.wikidata.org/wiki/Q894611","display_name":"Bosutinib","level":5,"score":0.4722321033477783},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4662821292877197},{"id":"https://openalex.org/C519536355","wikidata":"https://www.wikidata.org/wiki/Q21021151","display_name":"Repurposing","level":2,"score":0.4256397485733032},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3755072057247162},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.35673922300338745},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.349030077457428},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2556339204311371},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.24288243055343628},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2226448655128479},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12395727634429932},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.12323486804962158},{"id":"https://openalex.org/C2779536868","wikidata":"https://www.wikidata.org/wiki/Q419940","display_name":"Dasatinib","level":4,"score":0.09983828663825989},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077156","descriptor_name":"Gefitinib","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077156","descriptor_name":"Gefitinib","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077156","descriptor_name":"Gefitinib","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000814","descriptor_name":"Aniline Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000814","descriptor_name":"Aniline Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000814","descriptor_name":"Aniline Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009570","descriptor_name":"Nitriles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009570","descriptor_name":"Nitriles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009570","descriptor_name":"Nitriles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011799","descriptor_name":"Quinazolines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011799","descriptor_name":"Quinazolines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011799","descriptor_name":"Quinazolines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011804","descriptor_name":"Quinolines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011804","descriptor_name":"Quinolines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011804","descriptor_name":"Quinolines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bioinformatics/btu323","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btu323","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/30/17/2393/48927040/bioinformatics_30_17_2393.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:24812339","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24812339","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:4147888","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4147888","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btu323","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btu323","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/30/17/2393/48927040/bioinformatics_30_17_2393.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8199999928474426,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G1186755660","display_name":null,"funder_award_id":"CA046934","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G1496355663","display_name":null,"funder_award_id":"CA58187","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G1657669889","display_name":null,"funder_award_id":"P30CA046934","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2283353637","display_name":null,"funder_award_id":"HL111674","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3497591915","display_name":null,"funder_award_id":"(NIH)","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3743764273","display_name":null,"funder_award_id":"30CA046934","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3780238105","display_name":null,"funder_award_id":"W81XWH-11-1-","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G4119534169","display_name":null,"funder_award_id":"W81XWH","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G5850682332","display_name":null,"funder_award_id":"W81XWH","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6500554123","display_name":null,"funder_award_id":"P30CA046934","funder_id":"https://openalex.org/F4320311054","funder_display_name":"Cancer League of Colorado"}],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320311054","display_name":"Cancer League of Colorado","ror":"https://ror.org/03cy6xx05"},{"id":"https://openalex.org/F4320313443","display_name":"National Jewish Health","ror":"https://ror.org/016z2bp30"},{"id":"https://openalex.org/F4320321373","display_name":"Korea University","ror":"https://ror.org/047dqcg40"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2136617988.pdf","grobid_xml":"https://content.openalex.org/works/W2136617988.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W1587447328","https://openalex.org/W1980222592","https://openalex.org/W1988377311","https://openalex.org/W1989773675","https://openalex.org/W1989909503","https://openalex.org/W2021570316","https://openalex.org/W2027844138","https://openalex.org/W2039936465","https://openalex.org/W2045729702","https://openalex.org/W2054020870","https://openalex.org/W2054625493","https://openalex.org/W2075897300","https://openalex.org/W2081801534","https://openalex.org/W2086286404","https://openalex.org/W2090029719","https://openalex.org/W2099505694","https://openalex.org/W2106263664","https://openalex.org/W2110700041","https://openalex.org/W2111927373","https://openalex.org/W2114104545","https://openalex.org/W2115147179","https://openalex.org/W2121604817","https://openalex.org/W2124985265","https://openalex.org/W2132097639","https://openalex.org/W2138604360","https://openalex.org/W2140334822","https://openalex.org/W2143330861","https://openalex.org/W2152265294","https://openalex.org/W2154431984","https://openalex.org/W2161817637","https://openalex.org/W2163840470","https://openalex.org/W2171621406","https://openalex.org/W2408578196","https://openalex.org/W3102695902"],"related_works":["https://openalex.org/W1524782789","https://openalex.org/W2135117965","https://openalex.org/W4252130221","https://openalex.org/W2424009759","https://openalex.org/W2013573900","https://openalex.org/W2142436130","https://openalex.org/W2135761436","https://openalex.org/W2145580674","https://openalex.org/W2023820329","https://openalex.org/W2136617988"],"abstract_inverted_index":{"Supplementary":[0],"data":[1],"are":[2],"available":[3],"at":[4],"Bioinformatics":[5],"online.":[6]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":7}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}