{"id":"https://openalex.org/W2115212074","doi":"https://doi.org/10.1093/bioinformatics/btu186","title":"A fast and powerful tree-based association test for detecting complex joint effects in case\u2013control studies","display_name":"A fast and powerful tree-based association test for detecting complex joint effects in case\u2013control studies","publication_year":2014,"publication_date":"2014-04-11","ids":{"openalex":"https://openalex.org/W2115212074","doi":"https://doi.org/10.1093/bioinformatics/btu186","mag":"2115212074","pmid":"https://pubmed.ncbi.nlm.nih.gov/24794927"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btu186","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btu186","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/30/15/2171/48924268/bioinformatics_30_15_2171.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/30/15/2171/48924268/bioinformatics_30_15_2171.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100399263","display_name":"Han Zhang","orcid":"https://orcid.org/0000-0001-7977-9616"},"institutions":[{"id":"https://openalex.org/I4210110061","display_name":"Information Management Services","ror":"https://ror.org/020k7fn51","country_code":"US","type":"company","lineage":["https://openalex.org/I4210110061"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4391012607","display_name":"Division of Cancer Epidemiology and Genetics","ror":"https://ror.org/00vkwep27","country_code":null,"type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4391012607"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Han Zhang","raw_affiliation_strings":["1 Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20850, USA, 2 Information Management Services, Inc., Silver Spring, Maryland 20904, USA, and 3 Cancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Gaithersburg, Maryland 20877, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20850, USA, 2 Information Management Services, Inc., Silver Spring, Maryland 20904, USA, and 3 Cancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Gaithersburg, Maryland 20877, USA","institution_ids":["https://openalex.org/I4210140884","https://openalex.org/I4210110061","https://openalex.org/I4391012607"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109125285","display_name":"William Wheeler","orcid":null},"institutions":[{"id":"https://openalex.org/I4210110061","display_name":"Information Management Services","ror":"https://ror.org/020k7fn51","country_code":"US","type":"company","lineage":["https://openalex.org/I4210110061"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4391012607","display_name":"Division of Cancer Epidemiology and Genetics","ror":"https://ror.org/00vkwep27","country_code":null,"type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4391012607"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William Wheeler","raw_affiliation_strings":["1 Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20850, USA, 2 Information Management Services, Inc., Silver Spring, Maryland 20904, USA, and 3 Cancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Gaithersburg, Maryland 20877, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20850, USA, 2 Information Management Services, Inc., Silver Spring, Maryland 20904, USA, and 3 Cancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Gaithersburg, Maryland 20877, USA","institution_ids":["https://openalex.org/I4210140884","https://openalex.org/I4210110061","https://openalex.org/I4391012607"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Zhaoming Wang","orcid":null},"institutions":[{"id":"https://openalex.org/I4210110061","display_name":"Information Management Services","ror":"https://ror.org/020k7fn51","country_code":"US","type":"company","lineage":["https://openalex.org/I4210110061"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4391012607","display_name":"Division of Cancer Epidemiology and Genetics","ror":"https://ror.org/00vkwep27","country_code":null,"type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4391012607"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhaoming Wang","raw_affiliation_strings":["1 Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20850, USA, 2 Information Management Services, Inc., Silver Spring, Maryland 20904, USA, and 3 Cancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Gaithersburg, Maryland 20877, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20850, USA, 2 Information Management Services, Inc., Silver Spring, Maryland 20904, USA, and 3 Cancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Gaithersburg, Maryland 20877, USA","institution_ids":["https://openalex.org/I4210140884","https://openalex.org/I4210110061","https://openalex.org/I4391012607"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080559639","display_name":"Philip R. Taylor","orcid":"https://orcid.org/0000-0003-0163-1421"},"institutions":[{"id":"https://openalex.org/I4210110061","display_name":"Information Management Services","ror":"https://ror.org/020k7fn51","country_code":"US","type":"company","lineage":["https://openalex.org/I4210110061"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4391012607","display_name":"Division of Cancer Epidemiology and Genetics","ror":"https://ror.org/00vkwep27","country_code":null,"type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4391012607"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Philip R. Taylor","raw_affiliation_strings":["1 Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20850, USA, 2 Information Management Services, Inc., Silver Spring, Maryland 20904, USA, and 3 Cancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Gaithersburg, Maryland 20877, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20850, USA, 2 Information Management Services, Inc., Silver Spring, Maryland 20904, USA, and 3 Cancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Gaithersburg, Maryland 20877, USA","institution_ids":["https://openalex.org/I4210140884","https://openalex.org/I4210110061","https://openalex.org/I4391012607"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100758006","display_name":"Kai Yu","orcid":"https://orcid.org/0000-0002-5337-137X"},"institutions":[{"id":"https://openalex.org/I4210110061","display_name":"Information Management Services","ror":"https://ror.org/020k7fn51","country_code":"US","type":"company","lineage":["https://openalex.org/I4210110061"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4391012607","display_name":"Division of Cancer Epidemiology and Genetics","ror":"https://ror.org/00vkwep27","country_code":null,"type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4391012607"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kai Yu","raw_affiliation_strings":["1 Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20850, USA, 2 Information Management Services, Inc., Silver Spring, Maryland 20904, USA, and 3 Cancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Gaithersburg, Maryland 20877, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20850, USA, 2 Information Management Services, Inc., Silver Spring, Maryland 20904, USA, and 3 Cancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Gaithersburg, Maryland 20877, USA","institution_ids":["https://openalex.org/I4210140884","https://openalex.org/I4210110061","https://openalex.org/I4391012607"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5100758006"],"corresponding_institution_ids":["https://openalex.org/I4210110061","https://openalex.org/I4210140884","https://openalex.org/I4391012607"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":0.9082,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.784009,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"30","issue":"15","first_page":"2171","last_page":"2178"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.251800000667572,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.251800000667572,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10619","display_name":"Esophageal Cancer Research and Treatment","score":0.2053000032901764,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.06030000001192093,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6081916689872742},{"id":"https://openalex.org/keywords/association","display_name":"Association (psychology)","score":0.5796329975128174},{"id":"https://openalex.org/keywords/tree","display_name":"Tree (set theory)","score":0.5454526543617249},{"id":"https://openalex.org/keywords/joint","display_name":"Joint (building)","score":0.5342791080474854},{"id":"https://openalex.org/keywords/test","display_name":"Test (biology)","score":0.49511805176734924},{"id":"https://openalex.org/keywords/control","display_name":"Control (management)","score":0.4417755603790283},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.36871621012687683},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.328683465719223},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.3255006670951843},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.21828007698059082},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.13916587829589844},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.13795599341392517},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.10595366358757019}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6081916689872742},{"id":"https://openalex.org/C142853389","wikidata":"https://www.wikidata.org/wiki/Q744778","display_name":"Association (psychology)","level":2,"score":0.5796329975128174},{"id":"https://openalex.org/C113174947","wikidata":"https://www.wikidata.org/wiki/Q2859736","display_name":"Tree (set theory)","level":2,"score":0.5454526543617249},{"id":"https://openalex.org/C18555067","wikidata":"https://www.wikidata.org/wiki/Q8375051","display_name":"Joint (building)","level":2,"score":0.5342791080474854},{"id":"https://openalex.org/C2777267654","wikidata":"https://www.wikidata.org/wiki/Q3519023","display_name":"Test (biology)","level":2,"score":0.49511805176734924},{"id":"https://openalex.org/C2775924081","wikidata":"https://www.wikidata.org/wiki/Q55608371","display_name":"Control (management)","level":2,"score":0.4417755603790283},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.36871621012687683},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.328683465719223},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.3255006670951843},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.21828007698059082},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13916587829589844},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.13795599341392517},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.10595366358757019},{"id":"https://openalex.org/C542102704","wikidata":"https://www.wikidata.org/wiki/Q183257","display_name":"Psychotherapist","level":1,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C170154142","wikidata":"https://www.wikidata.org/wiki/Q150737","display_name":"Architectural engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003663","descriptor_name":"Decision Trees","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003663","descriptor_name":"Decision Trees","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003663","descriptor_name":"Decision Trees","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004938","descriptor_name":"Esophageal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004938","descriptor_name":"Esophageal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004938","descriptor_name":"Esophageal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016015","descriptor_name":"Logistic Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016015","descriptor_name":"Logistic Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016015","descriptor_name":"Logistic Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050762","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p15","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050762","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p15","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050762","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p15","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bioinformatics/btu186","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btu186","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/30/15/2171/48924268/bioinformatics_30_15_2171.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:24794927","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24794927","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:4103596","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4103596","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btu186","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btu186","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/30/15/2171/48924268/bioinformatics_30_15_2171.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Partnerships for the goals","score":0.4399999976158142,"id":"https://metadata.un.org/sdg/17"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2115212074.pdf","grobid_xml":"https://content.openalex.org/works/W2115212074.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W1493790738","https://openalex.org/W1510900750","https://openalex.org/W1553500812","https://openalex.org/W1594031697","https://openalex.org/W1822695366","https://openalex.org/W1975600230","https://openalex.org/W1983202164","https://openalex.org/W1992436001","https://openalex.org/W2002052115","https://openalex.org/W2014530124","https://openalex.org/W2040280877","https://openalex.org/W2041953582","https://openalex.org/W2075972745","https://openalex.org/W2087467445","https://openalex.org/W2095827770","https://openalex.org/W2096791516","https://openalex.org/W2100909778","https://openalex.org/W2105518356","https://openalex.org/W2113381189","https://openalex.org/W2117138514","https://openalex.org/W2127236929","https://openalex.org/W2136167691","https://openalex.org/W2150000105","https://openalex.org/W4233278386","https://openalex.org/W6629461242","https://openalex.org/W6653881643","https://openalex.org/W6682308145"],"related_works":["https://openalex.org/W2352440174","https://openalex.org/W4309440960","https://openalex.org/W2748574964","https://openalex.org/W1996130883","https://openalex.org/W2062168445","https://openalex.org/W2348940229","https://openalex.org/W2888483922","https://openalex.org/W2363046693","https://openalex.org/W2389491697","https://openalex.org/W4301044699"],"abstract_inverted_index":{"MOTIVATION:":[0],"Multivariate":[1],"tests":[2,28],"derived":[3],"from":[4],"the":[5,14,33,41,61,78,83,89,100,120,125,157,171],"logistic":[6],"regression":[7],"model":[8,46,63,102,115,123],"are":[9,214],"widely":[10],"used":[11,65,179],"to":[12,56,118],"assess":[13],"joint":[15,34,126],"effect":[16,35],"of":[17,77,143,174],"multiple":[18],"predictors":[19],"on":[20,136,201],"a":[21,95,105,132,141,151],"disease":[22],"outcome":[23],"in":[24,140,195],"case-control":[25],"studies.":[26],"These":[27],"become":[29],"less":[30],"optimal":[31,121],"if":[32],"cannot":[36],"be":[37],"approximated":[38],"adequately":[39],"by":[40],"additive":[42],"model.":[43],"The":[44,184],"tree-structure":[45,101],"is":[47,53,64,187],"an":[48,113],"attractive":[49],"alternative,":[50],"as":[51,131],"it":[52],"more":[54],"apt":[55],"capture":[57],"non-additive":[58],"effects.":[59],"However,":[60],"tree":[62,122],"most":[66],"commonly":[67,178],"for":[68,72,87,98,190],"prediction":[69],"and":[70,103,149,160,197,199,204],"seldom":[71],"hypothesis":[73],"testing,":[74],"mainly":[75],"because":[76],"computational":[79],"burden":[80],"associated":[81],"with":[82],"resampling-based":[84],"procedure":[85,117],"required":[86],"estimating":[88],"significance":[90],"level.":[91],"RESULTS:":[92],"We":[93,128,165],"designed":[94],"fast":[96],"algorithm":[97],"building":[99],"proposed":[104],"robust":[106],"TREe-based":[107],"Association":[108],"Test":[109],"(TREAT)":[110],"that":[111],"incorporates":[112],"adaptive":[114],"selection":[116],"identify":[119],"representing":[124],"effect.":[127],"applied":[129],"TREAT":[130,175,186],"multilocus":[133],"association":[134,155],"test":[135],">20":[137],"000":[138],"genes/regions":[139],"study":[142],"esophageal":[144],"squamous":[145],"cell":[146],"carcinoma":[147],"(ESCC)":[148],"detected":[150],"highly":[152],"significant":[153],"novel":[154],"between":[156],"gene":[158],"CDKN2B":[159],"ESCC":[161],"([Formula:":[162],"see":[163],"text]).":[164],"also":[166],"demonstrated,":[167],"through":[168],"simulation":[169],"studies,":[170],"power":[172],"advantage":[173],"over":[176],"other":[177],"tests.":[180],"AVAILABILITY":[181],"AND":[182],"IMPLEMENTATION:":[183],"package":[185],"freely":[188],"available":[189,215],"download":[191],"at":[192,216],"http://www.hanzhang.name/softwares/treat,":[193],"implemented":[194],"C++":[196],"R":[198],"supported":[200],"64-bit":[202,205],"Linux":[203],"MS":[206],"Windows.":[207],"CONTACT:":[208],"yuka@mail.nih.gov":[209],"SUPPLEMENTARY":[210],"INFORMATION:":[211],"Supplementary":[212],"data":[213],"Bioinformatics":[217],"online.":[218]},"counts_by_year":[{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}