{"id":"https://openalex.org/W2102439908","doi":"https://doi.org/10.1093/bioinformatics/btu059","title":"Induction of T-cell memory by a dendritic cell vaccine: a computational model","display_name":"Induction of T-cell memory by a dendritic cell vaccine: a computational model","publication_year":2014,"publication_date":"2014-03-06","ids":{"openalex":"https://openalex.org/W2102439908","doi":"https://doi.org/10.1093/bioinformatics/btu059","mag":"2102439908","pmid":"https://pubmed.ncbi.nlm.nih.gov/24603984"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btu059","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btu059","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/11311/787321","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044340074","display_name":"Francesco Pappalardo","orcid":"https://orcid.org/0000-0003-1668-3320"},"institutions":[{"id":"https://openalex.org/I154387261","display_name":"Vita-Salute San Raffaele University","ror":"https://ror.org/01gmqr298","country_code":"IT","type":"education","lineage":["https://openalex.org/I154387261"]},{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesco Pappalardo","raw_affiliation_strings":["1 Department of Drug Science and 2Department of Mathematics and Computer Science, University of Catania, 95125 Catania, 3San Raffaele Scientific Institute and Universit\u00e0 Vita Salute San Raffaele, 20132 Milan, 4Politecnico di Milano, 20133 Milano and 5San Raffaele Scientific Institute, 20132 Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Drug Science and 2Department of Mathematics and Computer Science, University of Catania, 95125 Catania, 3San Raffaele Scientific Institute and Universit\u00e0 Vita Salute San Raffaele, 20132 Milan, 4Politecnico di Milano, 20133 Milano and 5San Raffaele Scientific Institute, 20132 Milan, Italy","institution_ids":["https://openalex.org/I154387261","https://openalex.org/I39063666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003874484","display_name":"Marzio Pennisi","orcid":"https://orcid.org/0000-0003-0231-7653"},"institutions":[{"id":"https://openalex.org/I154387261","display_name":"Vita-Salute San Raffaele University","ror":"https://ror.org/01gmqr298","country_code":"IT","type":"education","lineage":["https://openalex.org/I154387261"]},{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marzio Pennisi","raw_affiliation_strings":["1 Department of Drug Science and 2Department of Mathematics and Computer Science, University of Catania, 95125 Catania, 3San Raffaele Scientific Institute and Universit\u00e0 Vita Salute San Raffaele, 20132 Milan, 4Politecnico di Milano, 20133 Milano and 5San Raffaele Scientific Institute, 20132 Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Drug Science and 2Department of Mathematics and Computer Science, University of Catania, 95125 Catania, 3San Raffaele Scientific Institute and Universit\u00e0 Vita Salute San Raffaele, 20132 Milan, 4Politecnico di Milano, 20133 Milano and 5San Raffaele Scientific Institute, 20132 Milan, Italy","institution_ids":["https://openalex.org/I154387261","https://openalex.org/I39063666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068703055","display_name":"Alessia Ricupito","orcid":null},"institutions":[{"id":"https://openalex.org/I154387261","display_name":"Vita-Salute San Raffaele University","ror":"https://ror.org/01gmqr298","country_code":"IT","type":"education","lineage":["https://openalex.org/I154387261"]},{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alessia Ricupito","raw_affiliation_strings":["1 Department of Drug Science and 2Department of Mathematics and Computer Science, University of Catania, 95125 Catania, 3San Raffaele Scientific Institute and Universit\u00e0 Vita Salute San Raffaele, 20132 Milan, 4Politecnico di Milano, 20133 Milano and 5San Raffaele Scientific Institute, 20132 Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Drug Science and 2Department of Mathematics and Computer Science, University of Catania, 95125 Catania, 3San Raffaele Scientific Institute and Universit\u00e0 Vita Salute San Raffaele, 20132 Milan, 4Politecnico di Milano, 20133 Milano and 5San Raffaele Scientific Institute, 20132 Milan, Italy","institution_ids":["https://openalex.org/I154387261","https://openalex.org/I39063666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036488441","display_name":"Francesco Topputo","orcid":"https://orcid.org/0000-0002-5369-6887"},"institutions":[{"id":"https://openalex.org/I154387261","display_name":"Vita-Salute San Raffaele University","ror":"https://ror.org/01gmqr298","country_code":"IT","type":"education","lineage":["https://openalex.org/I154387261"]},{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesco Topputo","raw_affiliation_strings":["1 Department of Drug Science and 2Department of Mathematics and Computer Science, University of Catania, 95125 Catania, 3San Raffaele Scientific Institute and Universit\u00e0 Vita Salute San Raffaele, 20132 Milan, 4Politecnico di Milano, 20133 Milano and 5San Raffaele Scientific Institute, 20132 Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Drug Science and 2Department of Mathematics and Computer Science, University of Catania, 95125 Catania, 3San Raffaele Scientific Institute and Universit\u00e0 Vita Salute San Raffaele, 20132 Milan, 4Politecnico di Milano, 20133 Milano and 5San Raffaele Scientific Institute, 20132 Milan, Italy","institution_ids":["https://openalex.org/I154387261","https://openalex.org/I39063666"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020944852","display_name":"Matteo Bellone","orcid":"https://orcid.org/0000-0002-2586-2569"},"institutions":[{"id":"https://openalex.org/I154387261","display_name":"Vita-Salute San Raffaele University","ror":"https://ror.org/01gmqr298","country_code":"IT","type":"education","lineage":["https://openalex.org/I154387261"]},{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Matteo Bellone","raw_affiliation_strings":["1 Department of Drug Science and 2Department of Mathematics and Computer Science, University of Catania, 95125 Catania, 3San Raffaele Scientific Institute and Universit\u00e0 Vita Salute San Raffaele, 20132 Milan, 4Politecnico di Milano, 20133 Milano and 5San Raffaele Scientific Institute, 20132 Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Drug Science and 2Department of Mathematics and Computer Science, University of Catania, 95125 Catania, 3San Raffaele Scientific Institute and Universit\u00e0 Vita Salute San Raffaele, 20132 Milan, 4Politecnico di Milano, 20133 Milano and 5San Raffaele Scientific Institute, 20132 Milan, Italy","institution_ids":["https://openalex.org/I154387261","https://openalex.org/I39063666"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":2.3811,"has_fulltext":false,"cited_by_count":41,"citation_normalized_percentile":{"value":0.89043382,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"30","issue":"13","first_page":"1884","last_page":"1891"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.6651999950408936,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.6651999950408936,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.2614000141620636,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.01209999993443489,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cytotoxic-t-cell","display_name":"Cytotoxic T cell","score":0.6339743137359619},{"id":"https://openalex.org/keywords/context","display_name":"Context (archaeology)","score":0.631117045879364},{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.5685802698135376},{"id":"https://openalex.org/keywords/boosting","display_name":"Boosting (machine learning)","score":0.529998242855072},{"id":"https://openalex.org/keywords/vaccination","display_name":"Vaccination","score":0.5149096250534058},{"id":"https://openalex.org/keywords/antigen","display_name":"Antigen","score":0.4826505780220032},{"id":"https://openalex.org/keywords/t-cell","display_name":"T cell","score":0.46815991401672363},{"id":"https://openalex.org/keywords/dendritic-cell","display_name":"Dendritic cell","score":0.46185553073883057},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.45592784881591797},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4304938316345215},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.385574609041214},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3625979721546173},{"id":"https://openalex.org/keywords/immune-system","display_name":"Immune system","score":0.2900862693786621},{"id":"https://openalex.org/keywords/in-vitro","display_name":"In vitro","score":0.21352961659431458},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.13915035128593445},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.07726296782493591}],"concepts":[{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.6339743137359619},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.631117045879364},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.5685802698135376},{"id":"https://openalex.org/C46686674","wikidata":"https://www.wikidata.org/wiki/Q466303","display_name":"Boosting (machine learning)","level":2,"score":0.529998242855072},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.5149096250534058},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.4826505780220032},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.46815991401672363},{"id":"https://openalex.org/C2778170410","wikidata":"https://www.wikidata.org/wiki/Q506253","display_name":"Dendritic cell","level":3,"score":0.46185553073883057},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.45592784881591797},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4304938316345215},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.385574609041214},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3625979721546173},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2900862693786621},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.21352961659431458},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.13915035128593445},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07726296782493591},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000941","descriptor_name":"Antigens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000941","descriptor_name":"Antigens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000941","descriptor_name":"Antigens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007156","descriptor_name":"Immunologic Memory","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007156","descriptor_name":"Immunologic Memory","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007156","descriptor_name":"Immunologic Memory","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014612","descriptor_name":"Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014612","descriptor_name":"Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014612","descriptor_name":"Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D019496","descriptor_name":"Cancer Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D019496","descriptor_name":"Cancer Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D019496","descriptor_name":"Cancer Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bioinformatics/btu059","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btu059","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:24603984","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24603984","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:re.public.polimi.it:11311/787321","is_oa":true,"landing_page_url":"http://hdl.handle.net/11311/787321","pdf_url":null,"source":{"id":"https://openalex.org/S4306400312","display_name":"Virtual Community of Pathological Anatomy (University of Castilla La Mancha)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I79189158","host_organization_name":"University of Castilla-La Mancha","host_organization_lineage":["https://openalex.org/I79189158"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:re.public.polimi.it:11311/787321","is_oa":true,"landing_page_url":"http://hdl.handle.net/11311/787321","pdf_url":null,"source":{"id":"https://openalex.org/S4306400312","display_name":"Virtual Community of Pathological Anatomy (University of Castilla La Mancha)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I79189158","host_organization_name":"University of Castilla-La Mancha","host_organization_lineage":["https://openalex.org/I79189158"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.550000011920929,"id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W124478246","https://openalex.org/W1507160172","https://openalex.org/W1515234451","https://openalex.org/W1583482357","https://openalex.org/W1661544713","https://openalex.org/W1971201122","https://openalex.org/W1973291618","https://openalex.org/W1975655284","https://openalex.org/W1977489896","https://openalex.org/W1988136067","https://openalex.org/W1988620205","https://openalex.org/W1995062641","https://openalex.org/W1998319032","https://openalex.org/W2002069581","https://openalex.org/W2007186471","https://openalex.org/W2013167047","https://openalex.org/W2028633108","https://openalex.org/W2034810751","https://openalex.org/W2038669746","https://openalex.org/W2041691264","https://openalex.org/W2043514557","https://openalex.org/W2049491375","https://openalex.org/W2054822772","https://openalex.org/W2058158581","https://openalex.org/W2079604837","https://openalex.org/W2083052382","https://openalex.org/W2096866753","https://openalex.org/W2102264469","https://openalex.org/W2102742832","https://openalex.org/W2103959341","https://openalex.org/W2105218945","https://openalex.org/W2109963121","https://openalex.org/W2110518406","https://openalex.org/W2111733722","https://openalex.org/W2119896120","https://openalex.org/W2128112344","https://openalex.org/W2129046400","https://openalex.org/W2130815390","https://openalex.org/W2135360970","https://openalex.org/W2135899333","https://openalex.org/W2142715392","https://openalex.org/W2143853304","https://openalex.org/W2145494207","https://openalex.org/W2147763277","https://openalex.org/W2152803686","https://openalex.org/W2162742070","https://openalex.org/W2170904230","https://openalex.org/W3011730451","https://openalex.org/W4255758041","https://openalex.org/W4285719527","https://openalex.org/W6630369749","https://openalex.org/W6675447009","https://openalex.org/W6678920354"],"related_works":["https://openalex.org/W1540201991","https://openalex.org/W2928062689","https://openalex.org/W1967187870","https://openalex.org/W333207453","https://openalex.org/W1558312424","https://openalex.org/W2141418667","https://openalex.org/W2513589746","https://openalex.org/W2126367104","https://openalex.org/W1505169546","https://openalex.org/W1992915380"],"abstract_inverted_index":{"MOTIVATION:":[0],"Although":[1],"results":[2,139],"from":[3],"phase":[4],"III":[5],"clinical":[6],"trials":[7],"substantially":[8,176],"support":[9],"the":[10,54,103,109,123,128,132,150,156,192],"use":[11],"of":[12,56,61,105,111,134,140,160,181],"prophylactic":[13],"and":[14,28,38,63,67,97,101,130,143,158,175],"therapeutic":[15],"vaccines":[16],"against":[17,43],"cancer,":[18],"what":[19],"has":[20],"yet":[21],"to":[22,34,74,154,170],"be":[23,168],"defined":[24],"is":[25,48,152,188],"how":[26,29],"many":[27],"frequent":[30],"boosts":[31],"are":[32,64],"needed":[33],"sustain":[35],"a":[36,57,71,116],"long-lasting":[37],"protecting":[39],"memory":[40,98,107,135,162],"T-cell":[41],"response":[42],"tumor":[44],"antigens.":[45],"Common":[46],"experience":[47],"that":[49,86,149],"such":[50],"preclinical":[51],"tests":[52],"require":[53],"sacrifice":[55],"relatively":[58],"large":[59],"number":[60],"animals,":[62],"particularly":[65],"time-":[66],"money-consuming.":[68],"RESULTS:":[69],"As":[70],"first":[72],"step":[73],"overcome":[75],"these":[76],"hurdles,":[77],"we":[78,147],"have":[79,121],"developed":[80],"an":[81],"ordinary":[82],"differential":[83],"equation":[84],"model":[85,151,166,187],"includes":[87],"all":[88],"relevant":[89],"entities":[90],"(such":[91],"as":[92],"activated":[93],"cytotoxic":[94],"T":[95,99,136,163],"lymphocytes":[96],"cells),":[100],"investigated":[102],"induction":[104],"immunological":[106],"in":[108,127,131,144,177,191],"context":[110],"wild-type":[112],"mice":[113],"injected":[114],"with":[115],"dendritic":[117],"cell-based":[118],"vaccine.":[119],"We":[120],"simulated":[122],"biological":[124,179],"behavior":[125],"both":[126],"presence":[129],"absence":[133],"cells.":[137,164],"Comparing":[138],"ex":[141],"vivo":[142],"silico":[145],"experiments,":[146],"show":[148],"able":[153],"envisage":[155],"expansion":[157],"persistence":[159],"antigen-specific":[161],"The":[165,186],"might":[167],"applicable":[169],"more":[171],"complex":[172],"vaccination":[173],"schedules":[174],"any":[178],"condition":[180],"prime-boosting.":[182],"AVAILABILITY":[183],"AND":[184],"IMPLEMENTATION:":[185],"fully":[189],"described":[190],"article.":[193]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":5}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}
