{"id":"https://openalex.org/W2146317031","doi":"https://doi.org/10.1093/bioinformatics/btt768","title":"Inference with viral quasispecies diversity indices: clonal and NGS approaches","display_name":"Inference with viral quasispecies diversity indices: clonal and NGS approaches","publication_year":2014,"publication_date":"2014-01-02","ids":{"openalex":"https://openalex.org/W2146317031","doi":"https://doi.org/10.1093/bioinformatics/btt768","mag":"2146317031","pmid":"https://pubmed.ncbi.nlm.nih.gov/24389655"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btt768","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btt768","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087236325","display_name":"Josep Gregori","orcid":"https://orcid.org/0000-0002-4253-8015"},"institutions":[{"id":"https://openalex.org/I123044942","display_name":"Universitat Aut\u00f2noma de Barcelona","ror":"https://ror.org/052g8jq94","country_code":"ES","type":"education","lineage":["https://openalex.org/I123044942"]},{"id":"https://openalex.org/I2801357902","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886","country_code":"ES","type":"funder","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210102407","display_name":"Vall d'Hebron Institut de Recerca","ror":"https://ror.org/01d5vx451","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210102407","https://openalex.org/I4387153040"]},{"id":"https://openalex.org/I4210132431","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas","ror":"https://ror.org/03cn6tr16","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210132431"]},{"id":"https://openalex.org/I63634437","display_name":"Universidad Aut\u00f3noma de Madrid","ror":"https://ror.org/01cby8j38","country_code":"ES","type":"education","lineage":["https://openalex.org/I63634437"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Josep Gregori","raw_affiliation_strings":["1 Liver Unit, Internal Medicine Lab Malalties Hep\u00e0tiques, Vall d\u2019Hebron Institut Recerca (VHIR-HUVH), 08035 Barcelona, Spain, 2Roche Diagnostics SL, 08174, Sant Cugat del Vall\u00e8s, Spain, 3Statistics Department, Biology Faculty, Barcelona University, 08028, Barcelona, Spain, 4CIBER de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd) del Instituto de Salud Carlos III, 28029 Madrid, Spain, 5Centro de Biolog\u00eda Molecular Severo Ochoa (CSIC-UAM), Campus de Cantoblanco, 28049, Madrid, Spain, 6Bioinformatics and Statistics Unit, Vall d\u2019Hebron Institut Recerca (VHIR-HUVH), 08035, Barcelona, Spain, 7Universitat Aut\u00f2noma de Barcelona, 08193 Bellaterra, Barcelona, Spain and 8Biochemistry Unit. Virology Unit/Microbiology Department, HUVH, 08035 Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Liver Unit, Internal Medicine Lab Malalties Hep\u00e0tiques, Vall d\u2019Hebron Institut Recerca (VHIR-HUVH), 08035 Barcelona, Spain, 2Roche Diagnostics SL, 08174, Sant Cugat del Vall\u00e8s, Spain, 3Statistics Department, Biology Faculty, Barcelona University, 08028, Barcelona, Spain, 4CIBER de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd) del Instituto de Salud Carlos III, 28029 Madrid, Spain, 5Centro de Biolog\u00eda Molecular Severo Ochoa (CSIC-UAM), Campus de Cantoblanco, 28049, Madrid, Spain, 6Bioinformatics and Statistics Unit, Vall d\u2019Hebron Institut Recerca (VHIR-HUVH), 08035, Barcelona, Spain, 7Universitat Aut\u00f2noma de Barcelona, 08193 Bellaterra, Barcelona, Spain and 8Biochemistry Unit. Virology Unit/Microbiology Department, HUVH, 08035 Barcelona, Spain","institution_ids":["https://openalex.org/I4210102407","https://openalex.org/I2801357902","https://openalex.org/I4210132431","https://openalex.org/I123044942","https://openalex.org/I63634437"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081149067","display_name":"Miquel Salicr\u00fa","orcid":"https://orcid.org/0000-0001-9644-5626"},"institutions":[{"id":"https://openalex.org/I123044942","display_name":"Universitat Aut\u00f2noma de Barcelona","ror":"https://ror.org/052g8jq94","country_code":"ES","type":"education","lineage":["https://openalex.org/I123044942"]},{"id":"https://openalex.org/I2801357902","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886","country_code":"ES","type":"funder","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210102407","display_name":"Vall d'Hebron Institut de Recerca","ror":"https://ror.org/01d5vx451","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210102407","https://openalex.org/I4387153040"]},{"id":"https://openalex.org/I4210132431","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas","ror":"https://ror.org/03cn6tr16","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210132431"]},{"id":"https://openalex.org/I63634437","display_name":"Universidad Aut\u00f3noma de Madrid","ror":"https://ror.org/01cby8j38","country_code":"ES","type":"education","lineage":["https://openalex.org/I63634437"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Miquel Salicr\u00fa","raw_affiliation_strings":["1 Liver Unit, Internal Medicine Lab Malalties Hep\u00e0tiques, Vall d\u2019Hebron Institut Recerca (VHIR-HUVH), 08035 Barcelona, Spain, 2Roche Diagnostics SL, 08174, Sant Cugat del Vall\u00e8s, Spain, 3Statistics Department, Biology Faculty, Barcelona University, 08028, Barcelona, Spain, 4CIBER de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd) del Instituto de Salud Carlos III, 28029 Madrid, Spain, 5Centro de Biolog\u00eda Molecular Severo Ochoa (CSIC-UAM), Campus de Cantoblanco, 28049, Madrid, Spain, 6Bioinformatics and Statistics Unit, Vall d\u2019Hebron Institut Recerca (VHIR-HUVH), 08035, Barcelona, Spain, 7Universitat Aut\u00f2noma de Barcelona, 08193 Bellaterra, Barcelona, Spain and 8Biochemistry Unit. Virology Unit/Microbiology Department, HUVH, 08035 Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Liver Unit, Internal Medicine Lab Malalties Hep\u00e0tiques, Vall d\u2019Hebron Institut Recerca (VHIR-HUVH), 08035 Barcelona, Spain, 2Roche Diagnostics SL, 08174, Sant Cugat del Vall\u00e8s, Spain, 3Statistics Department, Biology Faculty, Barcelona University, 08028, Barcelona, Spain, 4CIBER de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd) del Instituto de Salud Carlos III, 28029 Madrid, Spain, 5Centro de Biolog\u00eda Molecular Severo Ochoa (CSIC-UAM), Campus de Cantoblanco, 28049, Madrid, Spain, 6Bioinformatics and Statistics Unit, Vall d\u2019Hebron Institut Recerca (VHIR-HUVH), 08035, Barcelona, Spain, 7Universitat Aut\u00f2noma de Barcelona, 08193 Bellaterra, Barcelona, Spain and 8Biochemistry Unit. Virology Unit/Microbiology Department, HUVH, 08035 Barcelona, Spain","institution_ids":["https://openalex.org/I4210102407","https://openalex.org/I2801357902","https://openalex.org/I4210132431","https://openalex.org/I123044942","https://openalex.org/I63634437"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010609839","display_name":"Esteban Domingo","orcid":"https://orcid.org/0000-0002-0573-1676"},"institutions":[{"id":"https://openalex.org/I123044942","display_name":"Universitat Aut\u00f2noma de Barcelona","ror":"https://ror.org/052g8jq94","country_code":"ES","type":"education","lineage":["https://openalex.org/I123044942"]},{"id":"https://openalex.org/I2801357902","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886","country_code":"ES","type":"funder","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210102407","display_name":"Vall d'Hebron Institut de Recerca","ror":"https://ror.org/01d5vx451","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210102407","https://openalex.org/I4387153040"]},{"id":"https://openalex.org/I4210132431","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas","ror":"https://ror.org/03cn6tr16","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210132431"]},{"id":"https://openalex.org/I63634437","display_name":"Universidad Aut\u00f3noma de Madrid","ror":"https://ror.org/01cby8j38","country_code":"ES","type":"education","lineage":["https://openalex.org/I63634437"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Esteban Domingo","raw_affiliation_strings":["1 Liver Unit, Internal Medicine Lab Malalties Hep\u00e0tiques, Vall d\u2019Hebron Institut Recerca (VHIR-HUVH), 08035 Barcelona, Spain, 2Roche Diagnostics SL, 08174, Sant Cugat del Vall\u00e8s, Spain, 3Statistics Department, Biology Faculty, Barcelona University, 08028, Barcelona, Spain, 4CIBER de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd) del Instituto de Salud Carlos III, 28029 Madrid, Spain, 5Centro de Biolog\u00eda Molecular Severo Ochoa (CSIC-UAM), Campus de Cantoblanco, 28049, Madrid, Spain, 6Bioinformatics and Statistics Unit, Vall d\u2019Hebron Institut Recerca (VHIR-HUVH), 08035, Barcelona, Spain, 7Universitat Aut\u00f2noma de Barcelona, 08193 Bellaterra, Barcelona, Spain and 8Biochemistry Unit. Virology Unit/Microbiology Department, HUVH, 08035 Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Liver Unit, Internal Medicine Lab Malalties Hep\u00e0tiques, Vall d\u2019Hebron Institut Recerca (VHIR-HUVH), 08035 Barcelona, Spain, 2Roche Diagnostics SL, 08174, Sant Cugat del Vall\u00e8s, Spain, 3Statistics Department, Biology Faculty, Barcelona University, 08028, Barcelona, Spain, 4CIBER de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd) del Instituto de Salud Carlos III, 28029 Madrid, Spain, 5Centro de Biolog\u00eda Molecular Severo Ochoa (CSIC-UAM), Campus de Cantoblanco, 28049, Madrid, Spain, 6Bioinformatics and Statistics Unit, Vall d\u2019Hebron Institut Recerca (VHIR-HUVH), 08035, Barcelona, Spain, 7Universitat Aut\u00f2noma de Barcelona, 08193 Bellaterra, Barcelona, Spain and 8Biochemistry Unit. Virology Unit/Microbiology Department, HUVH, 08035 Barcelona, Spain","institution_ids":["https://openalex.org/I4210102407","https://openalex.org/I2801357902","https://openalex.org/I4210132431","https://openalex.org/I123044942","https://openalex.org/I63634437"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075738659","display_name":"\u00c1lex S\u00e1nchez\u2010Pla","orcid":"https://orcid.org/0000-0002-8673-7737"},"institutions":[{"id":"https://openalex.org/I123044942","display_name":"Universitat Aut\u00f2noma de Barcelona","ror":"https://ror.org/052g8jq94","country_code":"ES","type":"education","lineage":["https://openalex.org/I123044942"]},{"id":"https://openalex.org/I2801357902","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886","country_code":"ES","type":"funder","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210102407","display_name":"Vall d'Hebron Institut de Recerca","ror":"https://ror.org/01d5vx451","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210102407","https://openalex.org/I4387153040"]},{"id":"https://openalex.org/I4210132431","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas","ror":"https://ror.org/03cn6tr16","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210132431"]},{"id":"https://openalex.org/I63634437","display_name":"Universidad Aut\u00f3noma de Madrid","ror":"https://ror.org/01cby8j38","country_code":"ES","type":"education","lineage":["https://openalex.org/I63634437"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Alex Sanchez","raw_affiliation_strings":["1 Liver Unit, Internal Medicine Lab Malalties Hep\u00e0tiques, Vall d\u2019Hebron Institut Recerca (VHIR-HUVH), 08035 Barcelona, Spain, 2Roche Diagnostics SL, 08174, Sant Cugat del Vall\u00e8s, Spain, 3Statistics Department, Biology Faculty, Barcelona University, 08028, Barcelona, Spain, 4CIBER de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd) del Instituto de Salud Carlos III, 28029 Madrid, Spain, 5Centro de Biolog\u00eda Molecular Severo Ochoa (CSIC-UAM), Campus de Cantoblanco, 28049, Madrid, Spain, 6Bioinformatics and Statistics Unit, Vall d\u2019Hebron Institut Recerca (VHIR-HUVH), 08035, Barcelona, Spain, 7Universitat Aut\u00f2noma de Barcelona, 08193 Bellaterra, Barcelona, Spain and 8Biochemistry Unit. Virology Unit/Microbiology Department, HUVH, 08035 Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Liver Unit, Internal Medicine Lab Malalties Hep\u00e0tiques, Vall d\u2019Hebron Institut Recerca (VHIR-HUVH), 08035 Barcelona, Spain, 2Roche Diagnostics SL, 08174, Sant Cugat del Vall\u00e8s, Spain, 3Statistics Department, Biology Faculty, Barcelona University, 08028, Barcelona, Spain, 4CIBER de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd) del Instituto de Salud Carlos III, 28029 Madrid, Spain, 5Centro de Biolog\u00eda Molecular Severo Ochoa (CSIC-UAM), Campus de Cantoblanco, 28049, Madrid, Spain, 6Bioinformatics and Statistics Unit, Vall d\u2019Hebron Institut Recerca (VHIR-HUVH), 08035, Barcelona, Spain, 7Universitat Aut\u00f2noma de Barcelona, 08193 Bellaterra, Barcelona, Spain and 8Biochemistry Unit. Virology Unit/Microbiology Department, HUVH, 08035 Barcelona, Spain","institution_ids":["https://openalex.org/I4210102407","https://openalex.org/I2801357902","https://openalex.org/I4210132431","https://openalex.org/I123044942","https://openalex.org/I63634437"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069448022","display_name":"Juan Ignacio Esteban","orcid":"https://orcid.org/0000-0001-5085-917X"},"institutions":[{"id":"https://openalex.org/I123044942","display_name":"Universitat Aut\u00f2noma de Barcelona","ror":"https://ror.org/052g8jq94","country_code":"ES","type":"education","lineage":["https://openalex.org/I123044942"]},{"id":"https://openalex.org/I2801357902","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886","country_code":"ES","type":"funder","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210102407","display_name":"Vall d'Hebron Institut de Recerca","ror":"https://ror.org/01d5vx451","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210102407","https://openalex.org/I4387153040"]},{"id":"https://openalex.org/I4210132431","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas","ror":"https://ror.org/03cn6tr16","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210132431"]},{"id":"https://openalex.org/I63634437","display_name":"Universidad Aut\u00f3noma de Madrid","ror":"https://ror.org/01cby8j38","country_code":"ES","type":"education","lineage":["https://openalex.org/I63634437"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Juan I. Esteban","raw_affiliation_strings":["1 Liver Unit, Internal Medicine Lab Malalties Hep\u00e0tiques, Vall d\u2019Hebron Institut Recerca (VHIR-HUVH), 08035 Barcelona, Spain, 2Roche Diagnostics SL, 08174, Sant Cugat del Vall\u00e8s, Spain, 3Statistics Department, Biology Faculty, Barcelona University, 08028, Barcelona, Spain, 4CIBER de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd) del Instituto de Salud Carlos III, 28029 Madrid, Spain, 5Centro de Biolog\u00eda Molecular Severo Ochoa (CSIC-UAM), Campus de Cantoblanco, 28049, Madrid, Spain, 6Bioinformatics and Statistics Unit, Vall d\u2019Hebron Institut Recerca (VHIR-HUVH), 08035, Barcelona, Spain, 7Universitat Aut\u00f2noma de Barcelona, 08193 Bellaterra, Barcelona, Spain and 8Biochemistry Unit. Virology Unit/Microbiology Department, HUVH, 08035 Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Liver Unit, Internal Medicine Lab Malalties Hep\u00e0tiques, Vall d\u2019Hebron Institut Recerca (VHIR-HUVH), 08035 Barcelona, Spain, 2Roche Diagnostics SL, 08174, Sant Cugat del Vall\u00e8s, Spain, 3Statistics Department, Biology Faculty, Barcelona University, 08028, Barcelona, Spain, 4CIBER de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd) del Instituto de Salud Carlos III, 28029 Madrid, Spain, 5Centro de Biolog\u00eda Molecular Severo Ochoa (CSIC-UAM), Campus de Cantoblanco, 28049, Madrid, Spain, 6Bioinformatics and Statistics Unit, Vall d\u2019Hebron Institut Recerca (VHIR-HUVH), 08035, Barcelona, Spain, 7Universitat Aut\u00f2noma de Barcelona, 08193 Bellaterra, Barcelona, Spain and 8Biochemistry Unit. Virology Unit/Microbiology Department, HUVH, 08035 Barcelona, Spain","institution_ids":["https://openalex.org/I4210102407","https://openalex.org/I2801357902","https://openalex.org/I4210132431","https://openalex.org/I123044942","https://openalex.org/I63634437"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058669821","display_name":"Francisco Rodr\u00edguez\u2010Frias","orcid":"https://orcid.org/0000-0002-9128-7013"},"institutions":[{"id":"https://openalex.org/I123044942","display_name":"Universitat Aut\u00f2noma de Barcelona","ror":"https://ror.org/052g8jq94","country_code":"ES","type":"education","lineage":["https://openalex.org/I123044942"]},{"id":"https://openalex.org/I2801357902","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886","country_code":"ES","type":"funder","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210102407","display_name":"Vall d'Hebron Institut de Recerca","ror":"https://ror.org/01d5vx451","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210102407","https://openalex.org/I4387153040"]},{"id":"https://openalex.org/I4210132431","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas","ror":"https://ror.org/03cn6tr16","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210132431"]},{"id":"https://openalex.org/I63634437","display_name":"Universidad Aut\u00f3noma de Madrid","ror":"https://ror.org/01cby8j38","country_code":"ES","type":"education","lineage":["https://openalex.org/I63634437"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Francisco Rodr\u00edguez-Fr\u00edas","raw_affiliation_strings":["1 Liver Unit, Internal Medicine Lab Malalties Hep\u00e0tiques, Vall d\u2019Hebron Institut Recerca (VHIR-HUVH), 08035 Barcelona, Spain, 2Roche Diagnostics SL, 08174, Sant Cugat del Vall\u00e8s, Spain, 3Statistics Department, Biology Faculty, Barcelona University, 08028, Barcelona, Spain, 4CIBER de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd) del Instituto de Salud Carlos III, 28029 Madrid, Spain, 5Centro de Biolog\u00eda Molecular Severo Ochoa (CSIC-UAM), Campus de Cantoblanco, 28049, Madrid, Spain, 6Bioinformatics and Statistics Unit, Vall d\u2019Hebron Institut Recerca (VHIR-HUVH), 08035, Barcelona, Spain, 7Universitat Aut\u00f2noma de Barcelona, 08193 Bellaterra, Barcelona, Spain and 8Biochemistry Unit. Virology Unit/Microbiology Department, HUVH, 08035 Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Liver Unit, Internal Medicine Lab Malalties Hep\u00e0tiques, Vall d\u2019Hebron Institut Recerca (VHIR-HUVH), 08035 Barcelona, Spain, 2Roche Diagnostics SL, 08174, Sant Cugat del Vall\u00e8s, Spain, 3Statistics Department, Biology Faculty, Barcelona University, 08028, Barcelona, Spain, 4CIBER de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd) del Instituto de Salud Carlos III, 28029 Madrid, Spain, 5Centro de Biolog\u00eda Molecular Severo Ochoa (CSIC-UAM), Campus de Cantoblanco, 28049, Madrid, Spain, 6Bioinformatics and Statistics Unit, Vall d\u2019Hebron Institut Recerca (VHIR-HUVH), 08035, Barcelona, Spain, 7Universitat Aut\u00f2noma de Barcelona, 08193 Bellaterra, Barcelona, Spain and 8Biochemistry Unit. Virology Unit/Microbiology Department, HUVH, 08035 Barcelona, Spain","institution_ids":["https://openalex.org/I4210102407","https://openalex.org/I2801357902","https://openalex.org/I4210132431","https://openalex.org/I123044942","https://openalex.org/I63634437"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054578489","display_name":"Josep Quer","orcid":"https://orcid.org/0000-0003-0014-084X"},"institutions":[{"id":"https://openalex.org/I123044942","display_name":"Universitat Aut\u00f2noma de Barcelona","ror":"https://ror.org/052g8jq94","country_code":"ES","type":"education","lineage":["https://openalex.org/I123044942"]},{"id":"https://openalex.org/I2801357902","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886","country_code":"ES","type":"funder","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210102407","display_name":"Vall d'Hebron Institut de Recerca","ror":"https://ror.org/01d5vx451","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210102407","https://openalex.org/I4387153040"]},{"id":"https://openalex.org/I4210132431","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas","ror":"https://ror.org/03cn6tr16","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210132431"]},{"id":"https://openalex.org/I63634437","display_name":"Universidad Aut\u00f3noma de Madrid","ror":"https://ror.org/01cby8j38","country_code":"ES","type":"education","lineage":["https://openalex.org/I63634437"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Josep Quer","raw_affiliation_strings":["1 Liver Unit, Internal Medicine Lab Malalties Hep\u00e0tiques, Vall d\u2019Hebron Institut Recerca (VHIR-HUVH), 08035 Barcelona, Spain, 2Roche Diagnostics SL, 08174, Sant Cugat del Vall\u00e8s, Spain, 3Statistics Department, Biology Faculty, Barcelona University, 08028, Barcelona, Spain, 4CIBER de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd) del Instituto de Salud Carlos III, 28029 Madrid, Spain, 5Centro de Biolog\u00eda Molecular Severo Ochoa (CSIC-UAM), Campus de Cantoblanco, 28049, Madrid, Spain, 6Bioinformatics and Statistics Unit, Vall d\u2019Hebron Institut Recerca (VHIR-HUVH), 08035, Barcelona, Spain, 7Universitat Aut\u00f2noma de Barcelona, 08193 Bellaterra, Barcelona, Spain and 8Biochemistry Unit. Virology Unit/Microbiology Department, HUVH, 08035 Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Liver Unit, Internal Medicine Lab Malalties Hep\u00e0tiques, Vall d\u2019Hebron Institut Recerca (VHIR-HUVH), 08035 Barcelona, Spain, 2Roche Diagnostics SL, 08174, Sant Cugat del Vall\u00e8s, Spain, 3Statistics Department, Biology Faculty, Barcelona University, 08028, Barcelona, Spain, 4CIBER de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd) del Instituto de Salud Carlos III, 28029 Madrid, Spain, 5Centro de Biolog\u00eda Molecular Severo Ochoa (CSIC-UAM), Campus de Cantoblanco, 28049, Madrid, Spain, 6Bioinformatics and Statistics Unit, Vall d\u2019Hebron Institut Recerca (VHIR-HUVH), 08035, Barcelona, Spain, 7Universitat Aut\u00f2noma de Barcelona, 08193 Bellaterra, Barcelona, Spain and 8Biochemistry Unit. Virology Unit/Microbiology Department, HUVH, 08035 Barcelona, Spain","institution_ids":["https://openalex.org/I4210102407","https://openalex.org/I2801357902","https://openalex.org/I4210132431","https://openalex.org/I123044942","https://openalex.org/I63634437"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":6.0496,"has_fulltext":false,"cited_by_count":69,"citation_normalized_percentile":{"value":0.96632675,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"30","issue":"8","first_page":"1104","last_page":"1111"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.6751000285148621,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.6751000285148621,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.19169999659061432,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12090","display_name":"Language and cultural evolution","score":0.019999999552965164,"subfield":{"id":"https://openalex.org/subfields/3316","display_name":"Cultural Studies"},"field":{"id":"https://openalex.org/fields/33","display_name":"Social Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/viral-quasispecies","display_name":"Viral quasispecies","score":0.9557862281799316},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5080056190490723},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5030061602592468},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.4492800831794739},{"id":"https://openalex.org/keywords/inference","display_name":"Inference","score":0.4354982376098633},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.41318368911743164},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.3940684199333191},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.29270821809768677},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.29023534059524536},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.20789626240730286},{"id":"https://openalex.org/keywords/hepatitis-c-virus","display_name":"Hepatitis C virus","score":0.18278679251670837},{"id":"https://openalex.org/keywords/virus","display_name":"Virus","score":0.17051160335540771},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.09449100494384766}],"concepts":[{"id":"https://openalex.org/C14500911","wikidata":"https://www.wikidata.org/wiki/Q3413375","display_name":"Viral quasispecies","level":4,"score":0.9557862281799316},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5080056190490723},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5030061602592468},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4492800831794739},{"id":"https://openalex.org/C2776214188","wikidata":"https://www.wikidata.org/wiki/Q408386","display_name":"Inference","level":2,"score":0.4354982376098633},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.41318368911743164},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.3940684199333191},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.29270821809768677},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.29023534059524536},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.20789626240730286},{"id":"https://openalex.org/C2776408679","wikidata":"https://www.wikidata.org/wiki/Q708693","display_name":"Hepatitis C virus","level":3,"score":0.18278679251670837},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.17051160335540771},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09449100494384766},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016174","descriptor_name":"Hepacivirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016174","descriptor_name":"Hepacivirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016174","descriptor_name":"Hepacivirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1093/bioinformatics/btt768","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btt768","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:24389655","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24389655","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.932.7350","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.932.7350","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://bioinformatics.oxfordjournals.org/content/early/2014/01/19/bioinformatics.btt768.full.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.948.6355","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.948.6355","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://bioinformatics.oxfordjournals.org/content/30/8/1104.full.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322850","display_name":"National Academy of Sciences of Ukraine","ror":"https://ror.org/00je4t102"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":78,"referenced_works":["https://openalex.org/W93588716","https://openalex.org/W1968225289","https://openalex.org/W1972260831","https://openalex.org/W1973635629","https://openalex.org/W1974839791","https://openalex.org/W1975553990","https://openalex.org/W1980355960","https://openalex.org/W1993562512","https://openalex.org/W1995875735","https://openalex.org/W2003574450","https://openalex.org/W2010880827","https://openalex.org/W2014444740","https://openalex.org/W2015216410","https://openalex.org/W2022825068","https://openalex.org/W2026721694","https://openalex.org/W2029003567","https://openalex.org/W2029853992","https://openalex.org/W2036711150","https://openalex.org/W2043519223","https://openalex.org/W2046374009","https://openalex.org/W2048260165","https://openalex.org/W2048499136","https://openalex.org/W2048818637","https://openalex.org/W2050783057","https://openalex.org/W2062250105","https://openalex.org/W2068050458","https://openalex.org/W2068310350","https://openalex.org/W2073918065","https://openalex.org/W2075082570","https://openalex.org/W2075557802","https://openalex.org/W2089728879","https://openalex.org/W2097173970","https://openalex.org/W2097528039","https://openalex.org/W2106651885","https://openalex.org/W2107683172","https://openalex.org/W2110501857","https://openalex.org/W2113135059","https://openalex.org/W2114075052","https://openalex.org/W2114870795","https://openalex.org/W2116601594","https://openalex.org/W2119284644","https://openalex.org/W2120474334","https://openalex.org/W2122158190","https://openalex.org/W2123009189","https://openalex.org/W2125963799","https://openalex.org/W2126948011","https://openalex.org/W2130077037","https://openalex.org/W2130924724","https://openalex.org/W2134007392","https://openalex.org/W2135590074","https://openalex.org/W2138240824","https://openalex.org/W2140849404","https://openalex.org/W2143559032","https://openalex.org/W2146209885","https://openalex.org/W2148399664","https://openalex.org/W2148735094","https://openalex.org/W2151265018","https://openalex.org/W2156502917","https://openalex.org/W2157012071","https://openalex.org/W2158028643","https://openalex.org/W2159641034","https://openalex.org/W2160697532","https://openalex.org/W2163314170","https://openalex.org/W2165308292","https://openalex.org/W2166323995","https://openalex.org/W2170200856","https://openalex.org/W2171783890","https://openalex.org/W2181112653","https://openalex.org/W2297100025","https://openalex.org/W2405432308","https://openalex.org/W2510474575","https://openalex.org/W2582743722","https://openalex.org/W2726651211","https://openalex.org/W2914081640","https://openalex.org/W3106047961","https://openalex.org/W6673289328","https://openalex.org/W6674669923","https://openalex.org/W6685465097"],"related_works":["https://openalex.org/W2370565492","https://openalex.org/W2016766059","https://openalex.org/W2029741357","https://openalex.org/W2144907742","https://openalex.org/W1748700469","https://openalex.org/W2620872782","https://openalex.org/W2086431635","https://openalex.org/W2009366069","https://openalex.org/W2073918065","https://openalex.org/W2077505157"],"abstract_inverted_index":{"Given":[0],"the":[1,13,26,51,70,95,102,106,112,119,124,150,184],"inherent":[2],"dynamics":[3],"of":[4,15,18,21,28,31,35,114,118,137,153,159,183,196],"a":[5,22,38,65,135,138],"viral":[6,82,143,160],"quasispecies,":[7],"we":[8,73,100,110,145],"are":[9,206],"often":[10,77],"interested":[11],"in":[12,25,33,37,123],"comparison":[14,27],"diversity":[16,29,52],"indices":[17,30,76,155],"sequential":[19],"samples":[20],"patient,":[23],"or":[24],"virus":[32,142],"groups":[34],"patients":[36],"treated":[39],"versus":[40],"control":[41],"design.":[42],"It":[43],"is":[44],"then":[45],"important":[46],"to":[47,181],"make":[48],"sure":[49],"that":[50],"measures":[53,80],"from":[54,94],"each":[55,182],"sample":[56],"may":[57],"be":[58],"compared":[59],"with":[60],"no":[61],"bias":[62,197],"and":[63,85,105,109,170,188],"within":[64],"consistent":[66],"statistical":[67,89,151],"framework.":[68],"In":[69,98],"present":[71],"report,":[72],"review":[74],"some":[75],"used":[78],"as":[79,134,175,194,198],"for":[81,88],"quasispecies":[83,161],"complexity":[84],"provide":[86],"means":[87],"inference,":[90],"applying":[91],"procedures":[92],"taken":[93],"ecology":[96],"field.":[97],"particular,":[99],"examine":[101],"Shannon":[103,120],"entropy":[104,121],"mutation":[107],"frequency,":[108],"discuss":[111],"appropriateness":[113],"different":[115],"normalization":[116],"methods":[117,158],"found":[122],"literature.":[125],"By":[126],"taking":[127],"amplicons":[128],"ultra-deep":[129],"pyrosequencing":[130],"(UDPS)":[131],"raw":[132],"data":[133,205],"surrogate":[136],"real":[139],"hepatitis":[140],"C":[141],"population,":[144],"study":[146],"through":[147],"in-silico":[148],"sampling":[149,186],"properties":[152],"these":[154],"under":[156],"two":[157,185],"sampling,":[162],"classical":[163],"cloning":[164],"followed":[165],"by":[166],"Sanger":[167],"sequencing":[168,172],"(CCSS)":[169],"next-generation":[171],"(NGS)":[173],"such":[174],"UDPS.":[176],"We":[177],"propose":[178],"solutions":[179],"specific":[180],"methods-CCSS":[187],"NGS-to":[189],"guarantee":[190],"statistically":[191],"conforming":[192],"conclusions":[193],"free":[195],"possible.":[199],"CONTACT:":[200],"josep.gregori@gmail.com":[201],"Supplementary":[202,204],"information:":[203],"available":[207],"at":[208],"Bioinformatics":[209],"online.":[210]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":7}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}