{"id":"https://openalex.org/W2108276306","doi":"https://doi.org/10.1093/bioinformatics/btt751","title":"Prediction of therapeutic microRNA based on the human metabolic network","display_name":"Prediction of therapeutic microRNA based on the human metabolic network","publication_year":2014,"publication_date":"2014-01-07","ids":{"openalex":"https://openalex.org/W2108276306","doi":"https://doi.org/10.1093/bioinformatics/btt751","mag":"2108276306","pmid":"https://pubmed.ncbi.nlm.nih.gov/24403541"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btt751","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btt751","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/30/8/1163/48922558/bioinformatics_30_8_1163.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/30/8/1163/48922558/bioinformatics_30_8_1163.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056912122","display_name":"Ming\u2010Tsang Wu","orcid":"https://orcid.org/0000-0001-7307-7816"},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ming Wu","raw_affiliation_strings":["1 Department of Computer Science and Engineering, 2Department of Chemical Engineering and Materials Science and 3Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Computer Science and Engineering, 2Department of Chemical Engineering and Materials Science and 3Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824, USA","institution_ids":["https://openalex.org/I87216513"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102757744","display_name":"Christina Chan","orcid":"https://orcid.org/0009-0003-7693-8206"},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Christina Chan","raw_affiliation_strings":["1 Department of Computer Science and Engineering, 2Department of Chemical Engineering and Materials Science and 3Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Computer Science and Engineering, 2Department of Chemical Engineering and Materials Science and 3Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824, USA","institution_ids":["https://openalex.org/I87216513"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5102757744"],"corresponding_institution_ids":["https://openalex.org/I87216513"],"apc_list":{"value":3989,"currency":"USD","value_usd":3989},"apc_paid":{"value":3989,"currency":"USD","value_usd":3989},"fwci":0.5988,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.65819813,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"30","issue":"8","first_page":"1163","last_page":"1171"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.46889999508857727,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.46889999508857727,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.3596999943256378,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.026200000196695328,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.695111095905304},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6157832741737366},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5786986351013184},{"id":"https://openalex.org/keywords/metabolic-network","display_name":"Metabolic network","score":0.4846263825893402},{"id":"https://openalex.org/keywords/biological-network","display_name":"Biological network","score":0.41385048627853394},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3416891098022461},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.27510443329811096},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.14215457439422607},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.12102305889129639}],"concepts":[{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.695111095905304},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6157832741737366},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5786986351013184},{"id":"https://openalex.org/C101810790","wikidata":"https://www.wikidata.org/wiki/Q2263094","display_name":"Metabolic network","level":2,"score":0.4846263825893402},{"id":"https://openalex.org/C28225019","wikidata":"https://www.wikidata.org/wiki/Q4915005","display_name":"Biological network","level":2,"score":0.41385048627853394},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3416891098022461},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27510443329811096},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14215457439422607},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12102305889129639}],"mesh":[{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1093/bioinformatics/btt751","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btt751","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/30/8/1163/48922558/bioinformatics_30_8_1163.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:24403541","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24403541","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:3358964","is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3982155","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btt751","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btt751","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/30/8/1163/48922558/bioinformatics_30_8_1163.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.4300000071525574,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G2349230937","display_name":null,"funder_award_id":"R01 GM079688","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G2496828974","display_name":"CDI-Type II: Discovery of Biophysical Mechanisms Inducing Signaling and Cytotoxicity: An Experimental Approach Enabled by Cyber Tools","funder_award_id":"0941055","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G2691469609","display_name":null,"funder_award_id":"R21 CA176854","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4056497535","display_name":null,"funder_award_id":"R01GM089866","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6490296102","display_name":null,"funder_award_id":"0941055","funder_id":"https://openalex.org/F4320337390","funder_display_name":"Division of Chemical, Bioengineering, Environmental, and Transport Systems"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337390","display_name":"Division of Chemical, Bioengineering, Environmental, and Transport Systems","ror":"https://ror.org/0471zv972"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2108276306.pdf","grobid_xml":"https://content.openalex.org/works/W2108276306.grobid-xml"},"referenced_works_count":84,"referenced_works":["https://openalex.org/W858887","https://openalex.org/W122736534","https://openalex.org/W144423133","https://openalex.org/W202353055","https://openalex.org/W1540036510","https://openalex.org/W1551169986","https://openalex.org/W1574470162","https://openalex.org/W1643243445","https://openalex.org/W1669342046","https://openalex.org/W1865124038","https://openalex.org/W1969067437","https://openalex.org/W1970073870","https://openalex.org/W1977372263","https://openalex.org/W1985517408","https://openalex.org/W1987586561","https://openalex.org/W1997062226","https://openalex.org/W2004576498","https://openalex.org/W2005712021","https://openalex.org/W2008676682","https://openalex.org/W2010622876","https://openalex.org/W2014058353","https://openalex.org/W2014460958","https://openalex.org/W2015207840","https://openalex.org/W2019974881","https://openalex.org/W2026570544","https://openalex.org/W2029845869","https://openalex.org/W2031492751","https://openalex.org/W2033969079","https://openalex.org/W2037631027","https://openalex.org/W2043642817","https://openalex.org/W2061873339","https://openalex.org/W2062290101","https://openalex.org/W2064034649","https://openalex.org/W2064135947","https://openalex.org/W2067928373","https://openalex.org/W2069009920","https://openalex.org/W2069269337","https://openalex.org/W2072096798","https://openalex.org/W2072451938","https://openalex.org/W2075343129","https://openalex.org/W2076262841","https://openalex.org/W2078355959","https://openalex.org/W2088349621","https://openalex.org/W2097259163","https://openalex.org/W2098450614","https://openalex.org/W2099787654","https://openalex.org/W2101752169","https://openalex.org/W2103950919","https://openalex.org/W2104108767","https://openalex.org/W2109761160","https://openalex.org/W2116201681","https://openalex.org/W2121053107","https://openalex.org/W2122493934","https://openalex.org/W2123218517","https://openalex.org/W2125592780","https://openalex.org/W2126524529","https://openalex.org/W2128601422","https://openalex.org/W2130979840","https://openalex.org/W2135314242","https://openalex.org/W2136707042","https://openalex.org/W2141360045","https://openalex.org/W2142355441","https://openalex.org/W2143632660","https://openalex.org/W2144038313","https://openalex.org/W2147472054","https://openalex.org/W2149848115","https://openalex.org/W2151024276","https://openalex.org/W2154061034","https://openalex.org/W2155492529","https://openalex.org/W2159807040","https://openalex.org/W2159888101","https://openalex.org/W2162666840","https://openalex.org/W2163841023","https://openalex.org/W2170974939","https://openalex.org/W2524141079","https://openalex.org/W2910065277","https://openalex.org/W4230392683","https://openalex.org/W4238101851","https://openalex.org/W4243903519","https://openalex.org/W4250090323","https://openalex.org/W6600040151","https://openalex.org/W6636807666","https://openalex.org/W6639379679","https://openalex.org/W6653313199"],"related_works":["https://openalex.org/W2737319532","https://openalex.org/W3151405604","https://openalex.org/W2565797512","https://openalex.org/W2050308539","https://openalex.org/W2133150343","https://openalex.org/W2350653470","https://openalex.org/W2171305205","https://openalex.org/W2786774244","https://openalex.org/W2005673176","https://openalex.org/W2061627113"],"abstract_inverted_index":{"MOTIVATION:":[0],"MicroRNA":[1],"(miRNA)":[2],"expression":[3,74],"has":[4,47],"been":[5,48],"found":[6],"to":[7,16,39,51,76,93,111,115,153,163,180],"be":[8,33],"deregulated":[9],"in":[10,14,23,59,125,143,192],"human":[11,100,185],"cancer,":[12],"contributing,":[13],"part,":[15],"the":[17,20,52,83,127,144,155,168,175,196,201,215],"interest":[18],"of":[19,45,85,106,135,170],"research":[21],"community":[22],"using":[24],"miRNAs":[25,31,38,79,128,159,183],"as":[26],"alternative":[27],"therapeutic":[28,78,182],"targets.":[29],"Although":[30],"could":[32,81,130],"potential":[34],"targets,":[35],"identifying":[36],"which":[37,158],"target":[40],"for":[41,99,184,206],"a":[42,90,95,151],"particular":[43],"type":[44],"cancer":[46,117,137,165,186,193],"difficult":[49],"due":[50],"limited":[53],"knowledge":[54],"on":[55,139,188],"their":[56,113,189],"regulatory":[57],"roles":[58],"cancer.":[60,86],"We":[61,88],"address":[62],"this":[63,173],"challenge":[64],"by":[65,157,200,214],"integrating":[66],"miRNA-target":[67],"prediction,":[68],"metabolic":[69,97,148,161,197,203],"modeling":[70],"and":[71,133,209,223],"context-specific":[72],"gene":[73],"data":[75,230],"predict":[77,112,181],"that":[80,129,211],"reduce":[82,116],"growth":[84,208],"RESULTS:":[87],"developed":[89],"novel":[91],"approach":[92,121,178],"simulate":[94],"condition-specific":[96,147],"system":[98,149],"hepatocellular":[101],"carcinoma":[102],"(HCC)":[103],"wherein":[104],"overexpression":[105],"each":[107],"miRNA":[108],"was":[109],"simulated":[110],"ability":[114],"cell":[118,207],"growth.":[119,166],"Our":[120],"achieved":[122],">80%":[123],"accuracy":[124],"predicting":[126],"suppress":[131],"metastasis":[132],"progression":[134],"liver":[136],"based":[138,187],"various":[140],"experimental":[141],"evidences":[142],"literature.":[145],"This":[146],"provides":[150],"framework":[152],"explore":[154],"mechanisms":[156],"modulate":[160],"functions":[162,198],"affect":[164],"To":[167],"best":[169],"our":[171],"knowledge,":[172],"is":[174],"first":[176],"computational":[177],"implemented":[179],"functional":[190],"role":[191],"metabolism.":[194],"Analyzing":[195],"altered":[199],"miRNA-identified":[202],"genes":[204],"essential":[205],"proliferation":[210],"are":[212,231],"targeted":[213],"miRNAs.":[216],"AVAILABILITY":[217],"AND":[218],"IMPLEMENTATION:":[219],"See":[220],"supplementary":[221],"protocols":[222],"http://www.egr.msu.edu/changroup/Protocols%20Index.html":[224],"CONTACT:":[225],"krischan@egr.msu.edu":[226],"Supplementary":[227,229],"information:":[228],"available":[232],"at":[233],"Bioinformatics":[234],"online.":[235]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2}],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2025-10-10T00:00:00"}
