{"id":"https://openalex.org/W2103459989","doi":"https://doi.org/10.1093/bioinformatics/btt691","title":"mCSM: predicting the effects of mutations in proteins using graph-based signatures","display_name":"mCSM: predicting the effects of mutations in proteins using graph-based signatures","publication_year":2013,"publication_date":"2013-11-26","ids":{"openalex":"https://openalex.org/W2103459989","doi":"https://doi.org/10.1093/bioinformatics/btt691","mag":"2103459989","pmid":"https://pubmed.ncbi.nlm.nih.gov/24281696"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btt691","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btt691","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/30/3/335/48916234/bioinformatics_30_3_335.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/30/3/335/48916234/bioinformatics_30_3_335.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071950872","display_name":"Douglas E. V. Pires","orcid":"https://orcid.org/0000-0002-3004-2119"},"institutions":[{"id":"https://openalex.org/I77826658","display_name":"St Vincents Institute of Medical Research","ror":"https://ror.org/02k3cxs74","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I77826658"]},{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["AU","GB"],"is_corresponding":true,"raw_author_name":"Douglas E. V. Pires","raw_affiliation_strings":["1 Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, UK and 2ACRF Rational Drug Discovery Centre and Biota Structural Biology Laboratory, St Vincents Institute of Medical Research, Fitzroy, VIC, 3065, Australia"],"affiliations":[{"raw_affiliation_string":"1 Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, UK and 2ACRF Rational Drug Discovery Centre and Biota Structural Biology Laboratory, St Vincents Institute of Medical Research, Fitzroy, VIC, 3065, Australia","institution_ids":["https://openalex.org/I77826658","https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091903225","display_name":"David B. Ascher","orcid":"https://orcid.org/0000-0003-2948-2413"},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I77826658","display_name":"St Vincents Institute of Medical Research","ror":"https://ror.org/02k3cxs74","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I77826658"]}],"countries":["AU","GB"],"is_corresponding":false,"raw_author_name":"David B. Ascher","raw_affiliation_strings":["1 Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, UK and 2ACRF Rational Drug Discovery Centre and Biota Structural Biology Laboratory, St Vincents Institute of Medical Research, Fitzroy, VIC, 3065, Australia"],"affiliations":[{"raw_affiliation_string":"1 Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, UK and 2ACRF Rational Drug Discovery Centre and Biota Structural Biology Laboratory, St Vincents Institute of Medical Research, Fitzroy, VIC, 3065, Australia","institution_ids":["https://openalex.org/I77826658","https://openalex.org/I241749"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001029093","display_name":"Tom L. Blundell","orcid":"https://orcid.org/0000-0002-2708-8992"},"institutions":[{"id":"https://openalex.org/I77826658","display_name":"St Vincents Institute of Medical Research","ror":"https://ror.org/02k3cxs74","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I77826658"]},{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["AU","GB"],"is_corresponding":false,"raw_author_name":"Tom L. Blundell","raw_affiliation_strings":["1 Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, UK and 2ACRF Rational Drug Discovery Centre and Biota Structural Biology Laboratory, St Vincents Institute of Medical Research, Fitzroy, VIC, 3065, Australia"],"affiliations":[{"raw_affiliation_string":"1 Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, UK and 2ACRF Rational Drug Discovery Centre and Biota Structural Biology Laboratory, St Vincents Institute of Medical Research, Fitzroy, VIC, 3065, Australia","institution_ids":["https://openalex.org/I77826658","https://openalex.org/I241749"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5071950872"],"corresponding_institution_ids":["https://openalex.org/I241749","https://openalex.org/I77826658"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":{"value":2565,"currency":"EUR","value_usd":2766},"fwci":13.0275,"has_fulltext":true,"cited_by_count":1089,"citation_normalized_percentile":{"value":0.99247333,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"30","issue":"3","first_page":"335","last_page":"342"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9977999925613403,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9958999752998352,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/missense-mutation","display_name":"Missense mutation","score":0.814510703086853},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.5761426091194153},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5594009757041931},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5474007725715637},{"id":"https://openalex.org/keywords/mutation","display_name":"Mutation","score":0.47839415073394775},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.4665731191635132},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3402218222618103}],"concepts":[{"id":"https://openalex.org/C75563809","wikidata":"https://www.wikidata.org/wiki/Q2656896","display_name":"Missense mutation","level":4,"score":0.814510703086853},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5761426091194153},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5594009757041931},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5474007725715637},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.47839415073394775},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4665731191635132},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3402218222618103}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003196","descriptor_name":"Computer Graphics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003196","descriptor_name":"Computer Graphics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003196","descriptor_name":"Computer Graphics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020125","descriptor_name":"Mutation, Missense","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020125","descriptor_name":"Mutation, Missense","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020125","descriptor_name":"Mutation, Missense","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D046912","descriptor_name":"Multiprotein Complexes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D046912","descriptor_name":"Multiprotein Complexes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D046912","descriptor_name":"Multiprotein Complexes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055550","descriptor_name":"Protein Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055550","descriptor_name":"Protein Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055550","descriptor_name":"Protein Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1093/bioinformatics/btt691","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btt691","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/30/3/335/48916234/bioinformatics_30_3_335.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:24281696","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24281696","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:jupiter.its.unimelb.edu.au:11343/216427","is_oa":true,"landing_page_url":"http://hdl.handle.net/11343/216427","pdf_url":"http://hdl.handle.net/11343/216427","source":{"id":"https://openalex.org/S4377196259","display_name":"Minerva Access (University of Melbourne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I165779595","host_organization_name":"The University of Melbourne","host_organization_lineage":["https://openalex.org/I165779595"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2888624","is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3904523","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3904523","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3904523","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btt691","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btt691","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/30/3/335/48916234/bioinformatics_30_3_335.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2103459989.pdf","grobid_xml":"https://content.openalex.org/works/W2103459989.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W1595131347","https://openalex.org/W1967209541","https://openalex.org/W1979965027","https://openalex.org/W1982190126","https://openalex.org/W1985999867","https://openalex.org/W2011402521","https://openalex.org/W2011441819","https://openalex.org/W2034227568","https://openalex.org/W2035876071","https://openalex.org/W2047151046","https://openalex.org/W2059145105","https://openalex.org/W2063669247","https://openalex.org/W2064308761","https://openalex.org/W2072052957","https://openalex.org/W2073576377","https://openalex.org/W2085277871","https://openalex.org/W2089106375","https://openalex.org/W2089289562","https://openalex.org/W2092387745","https://openalex.org/W2092902276","https://openalex.org/W2096679774","https://openalex.org/W2099672241","https://openalex.org/W2110947069","https://openalex.org/W2117541321","https://openalex.org/W2121519777","https://openalex.org/W2122287089","https://openalex.org/W2123400824","https://openalex.org/W2135503340","https://openalex.org/W2136513422","https://openalex.org/W2141823032","https://openalex.org/W2142765738","https://openalex.org/W2143238378","https://openalex.org/W2145644903","https://openalex.org/W2148768886","https://openalex.org/W2149580316","https://openalex.org/W2150192011","https://openalex.org/W2152279845","https://openalex.org/W2152830137","https://openalex.org/W2152949473","https://openalex.org/W2153457180","https://openalex.org/W2157807259","https://openalex.org/W2172034373","https://openalex.org/W2312641146"],"related_works":["https://openalex.org/W3004443428","https://openalex.org/W4361004911","https://openalex.org/W1971719088","https://openalex.org/W2625862723","https://openalex.org/W2594013754","https://openalex.org/W2612068534","https://openalex.org/W4289526060","https://openalex.org/W2388990391","https://openalex.org/W2069150591","https://openalex.org/W4232163425"],"abstract_inverted_index":{"A":[0],"web":[1],"server":[2],"is":[3],"available":[4],"at":[5],"http://structure.bioc.cam.ac.uk/mcsm.":[6]},"counts_by_year":[{"year":2026,"cited_by_count":33},{"year":2025,"cited_by_count":124},{"year":2024,"cited_by_count":134},{"year":2023,"cited_by_count":129},{"year":2022,"cited_by_count":112},{"year":2021,"cited_by_count":137},{"year":2020,"cited_by_count":133},{"year":2019,"cited_by_count":98},{"year":2018,"cited_by_count":60},{"year":2017,"cited_by_count":41},{"year":2016,"cited_by_count":46},{"year":2015,"cited_by_count":32},{"year":2014,"cited_by_count":9}],"updated_date":"2026-04-14T08:04:32.555800","created_date":"2025-10-10T00:00:00"}
