{"id":"https://openalex.org/W2127372456","doi":"https://doi.org/10.1093/bioinformatics/btt688","title":"RNA-seq differential expression studies: more sequence or more replication?","display_name":"RNA-seq differential expression studies: more sequence or more replication?","publication_year":2013,"publication_date":"2013-12-04","ids":{"openalex":"https://openalex.org/W2127372456","doi":"https://doi.org/10.1093/bioinformatics/btt688","mag":"2127372456","pmid":"https://pubmed.ncbi.nlm.nih.gov/24319002"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btt688","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btt688","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/30/3/301/48914472/bioinformatics_30_3_301.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/30/3/301/48914472/bioinformatics_30_3_301.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101706394","display_name":"Yuwen Liu","orcid":"https://orcid.org/0000-0003-3769-1784"},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yuwen Liu","raw_affiliation_strings":["1 Institute of Genomics and Systems Biology, 2Committee on Development, Regeneration, and Stem Cell Biology and 3Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA"],"affiliations":[{"raw_affiliation_string":"1 Institute of Genomics and Systems Biology, 2Committee on Development, Regeneration, and Stem Cell Biology and 3Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019232233","display_name":"Jie Zhou","orcid":"https://orcid.org/0000-0002-9113-800X"},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jie Zhou","raw_affiliation_strings":["1 Institute of Genomics and Systems Biology, 2Committee on Development, Regeneration, and Stem Cell Biology and 3Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA"],"affiliations":[{"raw_affiliation_string":"1 Institute of Genomics and Systems Biology, 2Committee on Development, Regeneration, and Stem Cell Biology and 3Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006842195","display_name":"Kevin P. White","orcid":"https://orcid.org/0000-0001-6934-5793"},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin P. White","raw_affiliation_strings":["1 Institute of Genomics and Systems Biology, 2Committee on Development, Regeneration, and Stem Cell Biology and 3Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA"],"affiliations":[{"raw_affiliation_string":"1 Institute of Genomics and Systems Biology, 2Committee on Development, Regeneration, and Stem Cell Biology and 3Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA","institution_ids":["https://openalex.org/I40347166"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5101706394"],"corresponding_institution_ids":["https://openalex.org/I40347166"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":16.5636,"has_fulltext":true,"cited_by_count":514,"citation_normalized_percentile":{"value":0.99477853,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"30","issue":"3","first_page":"301","last_page":"304"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/replication","display_name":"Replication (statistics)","score":0.6919870376586914},{"id":"https://openalex.org/keywords/sequence","display_name":"Sequence (biology)","score":0.6808889508247375},{"id":"https://openalex.org/keywords/rna","display_name":"RNA","score":0.5692008137702942},{"id":"https://openalex.org/keywords/expression","display_name":"Expression (computer science)","score":0.535912811756134},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5308055877685547},{"id":"https://openalex.org/keywords/differential","display_name":"Differential (mechanical device)","score":0.5115402936935425},{"id":"https://openalex.org/keywords/sequence-analysis","display_name":"Sequence analysis","score":0.42752254009246826},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.38790634274482727},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3785317838191986},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3572210371494293},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.17047277092933655},{"id":"https://openalex.org/keywords/virology","display_name":"Virology","score":0.12362286448478699},{"id":"https://openalex.org/keywords/programming-language","display_name":"Programming language","score":0.09134048223495483}],"concepts":[{"id":"https://openalex.org/C12590798","wikidata":"https://www.wikidata.org/wiki/Q3933199","display_name":"Replication (statistics)","level":2,"score":0.6919870376586914},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.6808889508247375},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.5692008137702942},{"id":"https://openalex.org/C90559484","wikidata":"https://www.wikidata.org/wiki/Q778379","display_name":"Expression (computer science)","level":2,"score":0.535912811756134},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5308055877685547},{"id":"https://openalex.org/C93226319","wikidata":"https://www.wikidata.org/wiki/Q193137","display_name":"Differential (mechanical device)","level":2,"score":0.5115402936935425},{"id":"https://openalex.org/C61053724","wikidata":"https://www.wikidata.org/wiki/Q1154615","display_name":"Sequence analysis","level":3,"score":0.42752254009246826},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.38790634274482727},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3785317838191986},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3572210371494293},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17047277092933655},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.12362286448478699},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.09134048223495483},{"id":"https://openalex.org/C146978453","wikidata":"https://www.wikidata.org/wiki/Q3798668","display_name":"Aerospace engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D018401","descriptor_name":"Sample Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018401","descriptor_name":"Sample Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018401","descriptor_name":"Sample Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D061986","descriptor_name":"MCF-7 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061986","descriptor_name":"MCF-7 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061986","descriptor_name":"MCF-7 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bioinformatics/btt688","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btt688","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/30/3/301/48914472/bioinformatics_30_3_301.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:24319002","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24319002","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:europepmc.org:3280232","is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3904521","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btt688","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btt688","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/30/3/301/48914472/bioinformatics_30_3_301.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G6929605419","display_name":null,"funder_award_id":"P50GM081892","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306278","display_name":"Chicago Community Trust","ror":"https://ror.org/01fcdd135"},{"id":"https://openalex.org/F4320317058","display_name":"Chicago Biomedical Consortium","ror":null},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2127372456.pdf","grobid_xml":"https://content.openalex.org/works/W2127372456.grobid-xml"},"referenced_works_count":17,"referenced_works":["https://openalex.org/W27628499","https://openalex.org/W1974611660","https://openalex.org/W1983275320","https://openalex.org/W1995070233","https://openalex.org/W2060842569","https://openalex.org/W2061537056","https://openalex.org/W2100305481","https://openalex.org/W2102619694","https://openalex.org/W2114104545","https://openalex.org/W2118532317","https://openalex.org/W2121211805","https://openalex.org/W2139754521","https://openalex.org/W2152239989","https://openalex.org/W2155371242","https://openalex.org/W2161106528","https://openalex.org/W2161318011","https://openalex.org/W2167364244"],"related_works":["https://openalex.org/W4404501470","https://openalex.org/W4205713785","https://openalex.org/W3016766501","https://openalex.org/W4398287560","https://openalex.org/W4398914716","https://openalex.org/W4404562765","https://openalex.org/W4398619072","https://openalex.org/W4398556994","https://openalex.org/W4398472861","https://openalex.org/W4398934068"],"abstract_inverted_index":{"The":[0,10],"code":[1],"used":[2],"in":[3,15],"this":[4],"paper":[5],"is":[6,13],"provided":[7],"on:":[8],"http://home.uchicago.edu/\u223cjiezhou/replication/.":[9],"expression":[11],"data":[12],"deposited":[14],"the":[16,21],"Gene":[17],"Expression":[18],"Omnibus":[19],"under":[20],"accession":[22],"ID":[23],"GSE51403.":[24]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":24},{"year":2024,"cited_by_count":27},{"year":2023,"cited_by_count":29},{"year":2022,"cited_by_count":37},{"year":2021,"cited_by_count":53},{"year":2020,"cited_by_count":54},{"year":2019,"cited_by_count":50},{"year":2018,"cited_by_count":43},{"year":2017,"cited_by_count":52},{"year":2016,"cited_by_count":66},{"year":2015,"cited_by_count":52},{"year":2014,"cited_by_count":24}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}
