{"id":"https://openalex.org/W2139028820","doi":"https://doi.org/10.1093/bioinformatics/btt646","title":"Development of a domain-specific genetic language to design <i>Chlamydomonas reinhardtii</i> expression vectors","display_name":"Development of a domain-specific genetic language to design <i>Chlamydomonas reinhardtii</i> expression vectors","publication_year":2013,"publication_date":"2013-11-08","ids":{"openalex":"https://openalex.org/W2139028820","doi":"https://doi.org/10.1093/bioinformatics/btt646","mag":"2139028820","pmid":"https://pubmed.ncbi.nlm.nih.gov/24215020"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btt646","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btt646","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/30/2/251/48914989/bioinformatics_30_2_251.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/30/2/251/48914989/bioinformatics_30_2_251.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073411729","display_name":"Mandy Wilson","orcid":"https://orcid.org/0000-0002-4778-5744"},"institutions":[{"id":"https://openalex.org/I4210155419","display_name":"Center for Systems Biology","ror":"https://ror.org/05r3dyn47","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210155419","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mandy L. Wilson","raw_affiliation_strings":["1 Virginia Bioinformatics Institute, 2Department of Plant Pathology, Physiology, and Weed Science and 3ICTAS Center for Systems Biology of Engineered Tissues, MC 0193, Virginia Tech, Blacksburg, VA 24061, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Virginia Bioinformatics Institute, 2Department of Plant Pathology, Physiology, and Weed Science and 3ICTAS Center for Systems Biology of Engineered Tissues, MC 0193, Virginia Tech, Blacksburg, VA 24061, USA","institution_ids":["https://openalex.org/I4210155419","https://openalex.org/I859038795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090590370","display_name":"Sakiko Okumoto","orcid":"https://orcid.org/0000-0003-1451-5446"},"institutions":[{"id":"https://openalex.org/I4210155419","display_name":"Center for Systems Biology","ror":"https://ror.org/05r3dyn47","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210155419","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sakiko Okumoto","raw_affiliation_strings":["1 Virginia Bioinformatics Institute, 2Department of Plant Pathology, Physiology, and Weed Science and 3ICTAS Center for Systems Biology of Engineered Tissues, MC 0193, Virginia Tech, Blacksburg, VA 24061, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Virginia Bioinformatics Institute, 2Department of Plant Pathology, Physiology, and Weed Science and 3ICTAS Center for Systems Biology of Engineered Tissues, MC 0193, Virginia Tech, Blacksburg, VA 24061, USA","institution_ids":["https://openalex.org/I4210155419","https://openalex.org/I859038795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044552858","display_name":"Laura Adam","orcid":"https://orcid.org/0000-0002-4822-2695"},"institutions":[{"id":"https://openalex.org/I4210155419","display_name":"Center for Systems Biology","ror":"https://ror.org/05r3dyn47","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210155419","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laura Adam","raw_affiliation_strings":["1 Virginia Bioinformatics Institute, 2Department of Plant Pathology, Physiology, and Weed Science and 3ICTAS Center for Systems Biology of Engineered Tissues, MC 0193, Virginia Tech, Blacksburg, VA 24061, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Virginia Bioinformatics Institute, 2Department of Plant Pathology, Physiology, and Weed Science and 3ICTAS Center for Systems Biology of Engineered Tissues, MC 0193, Virginia Tech, Blacksburg, VA 24061, USA","institution_ids":["https://openalex.org/I4210155419","https://openalex.org/I859038795"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086336387","display_name":"Jean Peccoud","orcid":"https://orcid.org/0000-0001-7649-6127"},"institutions":[{"id":"https://openalex.org/I4210155419","display_name":"Center for Systems Biology","ror":"https://ror.org/05r3dyn47","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210155419","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jean Peccoud","raw_affiliation_strings":["1 Virginia Bioinformatics Institute, 2Department of Plant Pathology, Physiology, and Weed Science and 3ICTAS Center for Systems Biology of Engineered Tissues, MC 0193, Virginia Tech, Blacksburg, VA 24061, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Virginia Bioinformatics Institute, 2Department of Plant Pathology, Physiology, and Weed Science and 3ICTAS Center for Systems Biology of Engineered Tissues, MC 0193, Virginia Tech, Blacksburg, VA 24061, USA","institution_ids":["https://openalex.org/I4210155419","https://openalex.org/I859038795"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5086336387"],"corresponding_institution_ids":["https://openalex.org/I4210155419","https://openalex.org/I859038795"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":0.59,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.69254252,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"30","issue":"2","first_page":"251","last_page":"257"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10303","display_name":"Photosynthetic Processes and Mechanisms","score":0.5404000282287598,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10303","display_name":"Photosynthetic Processes and Mechanisms","score":0.5404000282287598,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10476","display_name":"Algal biology and biofuel production","score":0.2013999968767166,"subfield":{"id":"https://openalex.org/subfields/2105","display_name":"Renewable Energy, Sustainability and the Environment"},"field":{"id":"https://openalex.org/fields/21","display_name":"Energy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.02250000089406967,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chlamydomonas-reinhardtii","display_name":"Chlamydomonas reinhardtii","score":0.819530725479126},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6759599447250366},{"id":"https://openalex.org/keywords/context","display_name":"Context (archaeology)","score":0.5422630310058594},{"id":"https://openalex.org/keywords/programming-language","display_name":"Programming language","score":0.5104652643203735},{"id":"https://openalex.org/keywords/synthetic-biology","display_name":"Synthetic biology","score":0.5017838478088379},{"id":"https://openalex.org/keywords/expression-cassette","display_name":"Expression cassette","score":0.4816531240940094},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.48059412837028503},{"id":"https://openalex.org/keywords/domain-specific-language","display_name":"Domain-specific language","score":0.4765627682209015},{"id":"https://openalex.org/keywords/domain","display_name":"Domain (mathematical analysis)","score":0.4540891647338867},{"id":"https://openalex.org/keywords/source-code","display_name":"Source code","score":0.43063434958457947},{"id":"https://openalex.org/keywords/code-generation","display_name":"Code generation","score":0.41632869839668274},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3614688813686371},{"id":"https://openalex.org/keywords/vector","display_name":"Vector (molecular biology)","score":0.3119780719280243},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.260432630777359},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.2541543245315552},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.10574528574943542}],"concepts":[{"id":"https://openalex.org/C2777727519","wikidata":"https://www.wikidata.org/wiki/Q291827","display_name":"Chlamydomonas reinhardtii","level":4,"score":0.819530725479126},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6759599447250366},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5422630310058594},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.5104652643203735},{"id":"https://openalex.org/C191908910","wikidata":"https://www.wikidata.org/wiki/Q862838","display_name":"Synthetic biology","level":2,"score":0.5017838478088379},{"id":"https://openalex.org/C100012643","wikidata":"https://www.wikidata.org/wiki/Q1384844","display_name":"Expression cassette","level":5,"score":0.4816531240940094},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.48059412837028503},{"id":"https://openalex.org/C135257023","wikidata":"https://www.wikidata.org/wiki/Q691358","display_name":"Domain-specific language","level":2,"score":0.4765627682209015},{"id":"https://openalex.org/C36503486","wikidata":"https://www.wikidata.org/wiki/Q11235244","display_name":"Domain (mathematical analysis)","level":2,"score":0.4540891647338867},{"id":"https://openalex.org/C43126263","wikidata":"https://www.wikidata.org/wiki/Q128751","display_name":"Source code","level":2,"score":0.43063434958457947},{"id":"https://openalex.org/C133162039","wikidata":"https://www.wikidata.org/wiki/Q1061077","display_name":"Code generation","level":3,"score":0.41632869839668274},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3614688813686371},{"id":"https://openalex.org/C92087593","wikidata":"https://www.wikidata.org/wiki/Q427389","display_name":"Vector (molecular biology)","level":4,"score":0.3119780719280243},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.260432630777359},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2541543245315552},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.10574528574943542},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.0},{"id":"https://openalex.org/C38652104","wikidata":"https://www.wikidata.org/wiki/Q3510521","display_name":"Computer security","level":1,"score":0.0},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C26517878","wikidata":"https://www.wikidata.org/wiki/Q228039","display_name":"Key (lock)","level":2,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002736","descriptor_name":"Chloroplasts","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002736","descriptor_name":"Chloroplasts","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002736","descriptor_name":"Chloroplasts","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009876","descriptor_name":"Operon","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009876","descriptor_name":"Operon","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009876","descriptor_name":"Operon","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011995","descriptor_name":"Recombination, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011995","descriptor_name":"Recombination, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011995","descriptor_name":"Recombination, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012045","descriptor_name":"Regulatory Sequences, Nucleic Acid","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012045","descriptor_name":"Regulatory Sequences, Nucleic Acid","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012045","descriptor_name":"Regulatory Sequences, Nucleic Acid","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016825","descriptor_name":"Chlamydomonas reinhardtii","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016825","descriptor_name":"Chlamydomonas reinhardtii","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016825","descriptor_name":"Chlamydomonas reinhardtii","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017343","descriptor_name":"Genes, Plant","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017343","descriptor_name":"Genes, Plant","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017343","descriptor_name":"Genes, Plant","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018506","descriptor_name":"Gene Expression Regulation, Plant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018506","descriptor_name":"Gene Expression Regulation, Plant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018506","descriptor_name":"Gene Expression Regulation, Plant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018745","descriptor_name":"Genome, Plant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018745","descriptor_name":"Genome, Plant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018745","descriptor_name":"Genome, Plant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020121","descriptor_name":"5' Untranslated Regions","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020121","descriptor_name":"5' Untranslated Regions","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020121","descriptor_name":"5' Untranslated Regions","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/bioinformatics/btt646","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btt646","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/30/2/251/48914989/bioinformatics_30_2_251.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:24215020","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24215020","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btt646","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btt646","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/30/2/251/48914989/bioinformatics_30_2_251.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/4","score":0.5699999928474426,"display_name":"Quality Education"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1550904083","https://openalex.org/W1550975773","https://openalex.org/W1760665500","https://openalex.org/W1983849957","https://openalex.org/W1998044371","https://openalex.org/W2006607348","https://openalex.org/W2037613071","https://openalex.org/W2039589107","https://openalex.org/W2050728725","https://openalex.org/W2109906206","https://openalex.org/W2116497687","https://openalex.org/W2137758003","https://openalex.org/W2138182334","https://openalex.org/W2153517004","https://openalex.org/W2158654912","https://openalex.org/W2161783808","https://openalex.org/W2915446286","https://openalex.org/W2916791310","https://openalex.org/W4285719527","https://openalex.org/W4324088634","https://openalex.org/W6632751421","https://openalex.org/W6759746820"],"related_works":["https://openalex.org/W2794657471","https://openalex.org/W1970499202","https://openalex.org/W2924423935","https://openalex.org/W818898529","https://openalex.org/W4245356976","https://openalex.org/W1963927741","https://openalex.org/W307712065","https://openalex.org/W2052246585","https://openalex.org/W4240313326","https://openalex.org/W2044764227"],"abstract_inverted_index":{"MOTIVATION:":[0],"Expression":[1],"vectors":[2,57,153],"used":[3],"in":[4,74,86],"different":[5,75],"biotechnology":[6,50],"applications":[7],"are":[8,23,161],"designed":[9,154],"with":[10,155,163],"domain-specific":[11,107],"rules.":[12],"For":[13],"instance,":[14],"promoters,":[15],"origins":[16],"of":[17,31,54,81,89,115,143,158,167,179,186],"replication":[18],"or":[19,28],"homologous":[20],"recombination":[21],"sites":[22],"host-specific.":[24],"Similarly,":[25],"chromosomal":[26],"integration":[27],"viral":[29],"delivery":[30],"an":[32,93],"expression":[33,56],"cassette":[34],"imposes":[35],"specific":[36],"structural":[37],"constraints.":[38],"As":[39],"de":[40],"novo":[41],"gene":[42],"synthesis":[43],"and":[44,199],"synthetic":[45],"biology":[46],"methods":[47],"permeate":[48],"many":[49],"specialties,":[51],"the":[52,59,79,87,141,159,164,168,180,202],"design":[53,71,80,100,138],"application-specific":[55],"becomes":[58],"new":[60],"norm.":[61],"In":[62],"this":[63],"context,":[64],"it":[65,130],"is":[66,147,177,188,195],"desirable":[67],"to":[68,83,124,134,150],"formalize":[69],"vector":[70,99],"strategies":[72,139],"applicable":[73],"domains.":[76],"RESULTS:":[77],"Using":[78],"constructs":[82],"express":[84],"genes":[85],"chloroplast":[88],"Chlamydomonas":[90],"reinhardtii":[91],"as":[92,105],"example,":[94],"we":[95],"show":[96],"that":[97,152],"a":[98,106,112,144],"strategy":[101],"can":[102],"be":[103],"formalized":[104],"language.":[108,169],"We":[109],"have":[110],"developed":[111],"graphical":[113],"editor":[114,176],"context-free":[116,174],"grammars":[117],"usable":[118],"by":[119],"biologists":[120,133],"without":[121],"prior":[122],"exposure":[123],"language":[125,160],"theory.":[126],"This":[127],"environment":[128],"makes":[129],"possible":[131,149],"for":[132],"iteratively":[135],"improve":[136],"their":[137],"throughout":[140],"course":[142],"project.":[145],"It":[146],"also":[148],"ensure":[151],"early":[156],"iterations":[157],"consistent":[162],"latest":[165],"iteration":[166],"AVAILABILITY":[170],"AND":[171],"IMPLEMENTATION:":[172],"The":[173],"grammar":[175],"part":[178],"GenoCAD":[181,187,192],"application.":[182],"A":[183],"public":[184],"instance":[185],"available":[189,196],"at":[190],"http://www.genocad.org.":[191],"source":[193,206],"code":[194],"from":[197],"SourceForge":[198],"licensed":[200],"under":[201],"Apache":[203],"v2.0":[204],"open":[205],"license.":[207]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1}],"updated_date":"2026-06-23T06:36:01.041984","created_date":"2016-06-24T00:00:00"}