{"id":"https://openalex.org/W2154164391","doi":"https://doi.org/10.1093/bioinformatics/btt610","title":"A pathway-based data integration framework for prediction of disease progression","display_name":"A pathway-based data integration framework for prediction of disease progression","publication_year":2013,"publication_date":"2013-10-24","ids":{"openalex":"https://openalex.org/W2154164391","doi":"https://doi.org/10.1093/bioinformatics/btt610","mag":"2154164391","pmid":"https://pubmed.ncbi.nlm.nih.gov/24162466"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btt610","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btt610","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/30/6/838/48919619/bioinformatics_30_6_838.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/30/6/838/48919619/bioinformatics_30_6_838.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015453378","display_name":"Jos\u00e9 A. Seoane","orcid":"https://orcid.org/0000-0002-3856-9177"},"institutions":[{"id":"https://openalex.org/I36234482","display_name":"University of Bristol","ror":"https://ror.org/0524sp257","country_code":"GB","type":"education","lineage":["https://openalex.org/I36234482"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Jos\u00e9 A. Seoane","raw_affiliation_strings":["1 MRC Centre for Causal Analyses in Translational Epidemiology, 2MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Clifton BS8 2BN, UK and 3Intelligent Systems Laboratory, University of Bristol, Bristol BS8 1UB, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 MRC Centre for Causal Analyses in Translational Epidemiology, 2MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Clifton BS8 2BN, UK and 3Intelligent Systems Laboratory, University of Bristol, Bristol BS8 1UB, UK","institution_ids":["https://openalex.org/I36234482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113733901","display_name":"Ian N.M. Day","orcid":null},"institutions":[{"id":"https://openalex.org/I36234482","display_name":"University of Bristol","ror":"https://ror.org/0524sp257","country_code":"GB","type":"education","lineage":["https://openalex.org/I36234482"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ian N. M. Day","raw_affiliation_strings":["1 MRC Centre for Causal Analyses in Translational Epidemiology, 2MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Clifton BS8 2BN, UK and 3Intelligent Systems Laboratory, University of Bristol, Bristol BS8 1UB, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 MRC Centre for Causal Analyses in Translational Epidemiology, 2MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Clifton BS8 2BN, UK and 3Intelligent Systems Laboratory, University of Bristol, Bristol BS8 1UB, UK","institution_ids":["https://openalex.org/I36234482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036589831","display_name":"Tom R. Gaunt","orcid":"https://orcid.org/0000-0003-0924-3247"},"institutions":[{"id":"https://openalex.org/I36234482","display_name":"University of Bristol","ror":"https://ror.org/0524sp257","country_code":"GB","type":"education","lineage":["https://openalex.org/I36234482"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Tom R. Gaunt","raw_affiliation_strings":["1 MRC Centre for Causal Analyses in Translational Epidemiology, 2MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Clifton BS8 2BN, UK and 3Intelligent Systems Laboratory, University of Bristol, Bristol BS8 1UB, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 MRC Centre for Causal Analyses in Translational Epidemiology, 2MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Clifton BS8 2BN, UK and 3Intelligent Systems Laboratory, University of Bristol, Bristol BS8 1UB, UK","institution_ids":["https://openalex.org/I36234482"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079342653","display_name":"Colin Campbell","orcid":"https://orcid.org/0000-0002-4775-9802"},"institutions":[{"id":"https://openalex.org/I36234482","display_name":"University of Bristol","ror":"https://ror.org/0524sp257","country_code":"GB","type":"education","lineage":["https://openalex.org/I36234482"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Colin Campbell","raw_affiliation_strings":["1 MRC Centre for Causal Analyses in Translational Epidemiology, 2MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Clifton BS8 2BN, UK and 3Intelligent Systems Laboratory, University of Bristol, Bristol BS8 1UB, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 MRC Centre for Causal Analyses in Translational Epidemiology, 2MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Clifton BS8 2BN, UK and 3Intelligent Systems Laboratory, University of Bristol, Bristol BS8 1UB, UK","institution_ids":["https://openalex.org/I36234482"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5015453378"],"corresponding_institution_ids":["https://openalex.org/I36234482"],"apc_list":{"value":3989,"currency":"USD","value_usd":3989},"apc_paid":{"value":3989,"currency":"USD","value_usd":3989},"fwci":1.806,"has_fulltext":true,"cited_by_count":86,"citation_normalized_percentile":{"value":0.85244681,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"30","issue":"6","first_page":"838","last_page":"845"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.41850000619888306,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.41850000619888306,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.12489999830722809,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.05249999836087227,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7157849669456482},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.6888863444328308},{"id":"https://openalex.org/keywords/feature-selection","display_name":"Feature selection","score":0.5941599011421204},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.576772928237915},{"id":"https://openalex.org/keywords/classifier","display_name":"Classifier (UML)","score":0.5599382519721985},{"id":"https://openalex.org/keywords/predictive-modelling","display_name":"Predictive modelling","score":0.4333907663822174},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.4237048625946045},{"id":"https://openalex.org/keywords/data-type","display_name":"Data type","score":0.4229119122028351}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7157849669456482},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.6888863444328308},{"id":"https://openalex.org/C148483581","wikidata":"https://www.wikidata.org/wiki/Q446488","display_name":"Feature selection","level":2,"score":0.5941599011421204},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.576772928237915},{"id":"https://openalex.org/C95623464","wikidata":"https://www.wikidata.org/wiki/Q1096149","display_name":"Classifier (UML)","level":2,"score":0.5599382519721985},{"id":"https://openalex.org/C45804977","wikidata":"https://www.wikidata.org/wiki/Q7239673","display_name":"Predictive modelling","level":2,"score":0.4333907663822174},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.4237048625946045},{"id":"https://openalex.org/C138958017","wikidata":"https://www.wikidata.org/wiki/Q190087","display_name":"Data type","level":2,"score":0.4229119122028351},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1093/bioinformatics/btt610","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btt610","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/30/6/838/48919619/bioinformatics_30_6_838.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:24162466","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24162466","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2938703","is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3957070","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3957070","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3957070","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"Text"},{"id":"pmh:oai:research-information.bris.ac.uk:openaire_cris_publications/de6ed015-1df9-4799-87b9-77ec03fc7202","is_oa":false,"landing_page_url":"https://research-information.bris.ac.uk/en/publications/de6ed015-1df9-4799-87b9-77ec03fc7202","pdf_url":null,"source":{"id":"https://openalex.org/S4306400895","display_name":"Bristol Research (University of Bristol)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I36234482","host_organization_name":"University of Bristol","host_organization_lineage":["https://openalex.org/I36234482"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Seoane, J A, Day, I N M, Gaunt, T R & Campbell, C 2014, 'A pathway-based data integration framework for prediction of disease progression', Bioinformatics, vol. 30, no. 6, pp. 838-845. https://doi.org/10.1093/bioinformatics/btt610","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:research-information.bris.ac.uk:publications/de6ed015-1df9-4799-87b9-77ec03fc7202","is_oa":false,"landing_page_url":"https://hdl.handle.net/1983/de6ed015-1df9-4799-87b9-77ec03fc7202","pdf_url":null,"source":{"id":"https://openalex.org/S4306400895","display_name":"Bristol Research (University of Bristol)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I36234482","host_organization_name":"University of Bristol","host_organization_lineage":["https://openalex.org/I36234482"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Seoane, J A, Day, I N M, Gaunt, T R & Campbell, C 2014, 'A pathway-based data integration framework for prediction of disease progression', Bioinformatics, vol. 30, no. 6, pp. 838-845. https://doi.org/10.1093/bioinformatics/btt610","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btt610","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btt610","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/30/6/838/48919619/bioinformatics_30_6_838.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5600000023841858}],"awards":[{"id":"https://openalex.org/G3573210925","display_name":null,"funder_award_id":"G1000427","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G5471577864","display_name":null,"funder_award_id":"EP/K008250/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G6641951221","display_name":"An Active Learning Approach to Network Inference","funder_award_id":"EP/K008250/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"}],"funders":[{"id":"https://openalex.org/F4320319985","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67"},{"id":"https://openalex.org/F4320320360","display_name":"University of Bristol","ror":"https://ror.org/0524sp257"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"},{"id":"https://openalex.org/F4320335036","display_name":"BC Cancer Agency","ror":"https://ror.org/03sfybe47"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2154164391.pdf","grobid_xml":"https://content.openalex.org/works/W2154164391.grobid-xml"},"referenced_works_count":56,"referenced_works":["https://openalex.org/W1506588750","https://openalex.org/W1510073064","https://openalex.org/W1549656520","https://openalex.org/W1565522942","https://openalex.org/W1618905105","https://openalex.org/W1629302677","https://openalex.org/W1678356000","https://openalex.org/W1971912363","https://openalex.org/W1980264541","https://openalex.org/W1995243908","https://openalex.org/W2005895632","https://openalex.org/W2008929650","https://openalex.org/W2013654014","https://openalex.org/W2031671719","https://openalex.org/W2031823405","https://openalex.org/W2040390955","https://openalex.org/W2048896634","https://openalex.org/W2052012933","https://openalex.org/W2070110479","https://openalex.org/W2089916965","https://openalex.org/W2092685308","https://openalex.org/W2096453387","https://openalex.org/W2097561421","https://openalex.org/W2101229103","https://openalex.org/W2103923312","https://openalex.org/W2108265780","https://openalex.org/W2109741660","https://openalex.org/W2109743529","https://openalex.org/W2110687186","https://openalex.org/W2112289645","https://openalex.org/W2120742047","https://openalex.org/W2135763142","https://openalex.org/W2135890487","https://openalex.org/W2136340483","https://openalex.org/W2145295623","https://openalex.org/W2155802351","https://openalex.org/W2156273110","https://openalex.org/W2157924629","https://openalex.org/W2158823144","https://openalex.org/W2161444669","https://openalex.org/W2163042952","https://openalex.org/W2171188027","https://openalex.org/W2171304795","https://openalex.org/W2231156824","https://openalex.org/W2587101915","https://openalex.org/W2911964244","https://openalex.org/W3023786531","https://openalex.org/W4285719527","https://openalex.org/W4299828299","https://openalex.org/W4300619116","https://openalex.org/W6630208708","https://openalex.org/W6633666095","https://openalex.org/W6636779317","https://openalex.org/W6645328661","https://openalex.org/W6683338691","https://openalex.org/W6685188343"],"related_works":["https://openalex.org/W2961085424","https://openalex.org/W2380784125","https://openalex.org/W2914806737","https://openalex.org/W2889085215","https://openalex.org/W3004057759","https://openalex.org/W1598207381","https://openalex.org/W3144599579","https://openalex.org/W3043432080","https://openalex.org/W4317600379","https://openalex.org/W3106528173"],"abstract_inverted_index":{"MOTIVATION:":[0],"Within":[1],"medical":[2],"research":[3],"there":[4],"is":[5,86,134,156,219],"an":[6],"increasing":[7],"trend":[8],"toward":[9],"deriving":[10],"multiple":[11,69],"types":[12],"of":[13,35,45,56,68,101,147,172,188,204,229],"data":[14,63,90,119,240],"from":[15,116,152],"the":[16,33,54,66,99,106,117,131,139,213,230],"same":[17],"individual.":[18],"The":[19],"most":[20],"effective":[21],"prognostic":[22],"prediction":[23,50,146,208],"methods":[24],"should":[25],"use":[26,55,67,138,163],"all":[27,57],"available":[28,58,242],"data,":[29],"as":[30,166,196],"this":[31,39,202],"maximizes":[32],"amount":[34],"information":[36],"used.":[37],"In":[38],"article,":[40],"we":[41,210],"consider":[42,62,98],"a":[43,77,102,123,186],"variety":[44],"learning":[46,71,73],"strategies":[47],"to":[48,110,121,206],"boost":[49],"performance":[51],"based":[52,191],"on":[53,192,216,227],"data.":[59],"IMPLEMENTATION:":[60],"We":[61,75,96,137,175],"integration":[64],"via":[65],"kernel":[70],"supervised":[72],"methods.":[74],"propose":[76],"scheme":[78],"in":[79],"which":[80,168],"feature":[81],"selection":[82],"by":[83,93,158,184],"statistical":[84],"score":[85],"performed":[87],"separately":[88],"per":[89],"type":[91],"and":[92,120],"pathway":[94],"membership.":[95],"further":[97,179],"introduction":[100],"confidence":[103,133],"measure":[104],"for":[105,142],"class":[107],"assignment,":[108],"both":[109],"remove":[111],"some":[112],"ambiguously":[113],"labeled":[114],"datapoints":[115],"training":[118],"implement":[122],"cautious":[124],"classifier":[125],"that":[126,161,177,212],"only":[127,225],"makes":[128],"predictions":[129,223],"when":[130],"associated":[132],"high.":[135],"RESULTS:":[136],"METABRIC":[140],"dataset":[141],"breast":[143],"cancer,":[144],"with":[145],"survival":[148],"at":[149,243],"2000":[150],"days":[151],"diagnosis.":[153],"Predictive":[154],"accuracy":[155,215],"improved":[157],"using":[159,185],"kernels":[160,190],"exclusively":[162],"those":[164],"genes,":[165],"features,":[167],"are":[169,224,241],"known":[170],"members":[171],"particular":[173],"pathways.":[174],"show":[176,211],"yet":[178],"improvements":[180],"can":[181],"be":[182],"made":[183,226],"range":[187,203],"additional":[189],"clinical":[193],"covariates":[194],"such":[195],"Estrogen":[197],"Receptor":[198],"(ER)":[199],"status.":[200],"Using":[201],"measures":[205],"improve":[207],"performance,":[209],"test":[214],"new":[217],"instances":[218],"nearly":[220],"80%,":[221],"though":[222],"69.2%":[228],"patient":[231],"cohort.":[232],"AVAILABILITY:":[233],"https://github.com/jseoane/FSMKL":[234],"CONTACT:":[235],"J.Seoane@bristol.ac.uk":[236],"SUPPLEMENTARY":[237],"INFORMATION:":[238],"Supplementary":[239],"Bioinformatics":[244],"online.":[245]},"counts_by_year":[{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":17},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":1}],"updated_date":"2026-08-26T07:47:46.906454","created_date":"2025-10-10T00:00:00"}