{"id":"https://openalex.org/W2105064756","doi":"https://doi.org/10.1093/bioinformatics/btt566","title":"MMAD: microarray microdissection with analysis of differences is a computational tool for deconvoluting cell type-specific contributions from tissue samples","display_name":"MMAD: microarray microdissection with analysis of differences is a computational tool for deconvoluting cell type-specific contributions from tissue samples","publication_year":2013,"publication_date":"2013-10-01","ids":{"openalex":"https://openalex.org/W2105064756","doi":"https://doi.org/10.1093/bioinformatics/btt566","mag":"2105064756","pmid":"https://pubmed.ncbi.nlm.nih.gov/24085566"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btt566","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btt566","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/30/5/682/48918142/bioinformatics_30_5_682.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/30/5/682/48918142/bioinformatics_30_5_682.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069135591","display_name":"David A. Liebner","orcid":"https://orcid.org/0000-0002-7657-4137"},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David A. Liebner","raw_affiliation_strings":["1 Division of Medical Oncology, Department of Internal Medicine, 2Department of Biomedical Informatics and 3Comprehensive Cancer Center, Biomedical Informatics Shared Resource, The Ohio State University, Columbus OH 43210, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Division of Medical Oncology, Department of Internal Medicine, 2Department of Biomedical Informatics and 3Comprehensive Cancer Center, Biomedical Informatics Shared Resource, The Ohio State University, Columbus OH 43210, USA","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057366605","display_name":"Kun Huang","orcid":"https://orcid.org/0000-0002-8530-370X"},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kun Huang","raw_affiliation_strings":["1 Division of Medical Oncology, Department of Internal Medicine, 2Department of Biomedical Informatics and 3Comprehensive Cancer Center, Biomedical Informatics Shared Resource, The Ohio State University, Columbus OH 43210, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Division of Medical Oncology, Department of Internal Medicine, 2Department of Biomedical Informatics and 3Comprehensive Cancer Center, Biomedical Informatics Shared Resource, The Ohio State University, Columbus OH 43210, USA","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023251641","display_name":"Jeffrey D. Parvin","orcid":"https://orcid.org/0000-0001-5616-1928"},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey D. Parvin","raw_affiliation_strings":["1 Division of Medical Oncology, Department of Internal Medicine, 2Department of Biomedical Informatics and 3Comprehensive Cancer Center, Biomedical Informatics Shared Resource, The Ohio State University, Columbus OH 43210, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Division of Medical Oncology, Department of Internal Medicine, 2Department of Biomedical Informatics and 3Comprehensive Cancer Center, Biomedical Informatics Shared Resource, The Ohio State University, Columbus OH 43210, USA","institution_ids":["https://openalex.org/I52357470"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5069135591"],"corresponding_institution_ids":["https://openalex.org/I52357470"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":2.2124,"has_fulltext":false,"cited_by_count":87,"citation_normalized_percentile":{"value":0.87995376,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"30","issue":"5","first_page":"682","last_page":"689"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.8873999714851379,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.8873999714851379,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11970","display_name":"Molecular Biology Techniques and Applications","score":0.04670000076293945,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.04340000078082085,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/laser-capture-microdissection","display_name":"Laser capture microdissection","score":0.7191296219825745},{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.6639202833175659},{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.5485898852348328},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.47485020756721497},{"id":"https://openalex.org/keywords/microarray-analysis-techniques","display_name":"Microarray analysis techniques","score":0.4712558090686798},{"id":"https://openalex.org/keywords/microarray","display_name":"Microarray","score":0.46324649453163147},{"id":"https://openalex.org/keywords/normalization","display_name":"Normalization (sociology)","score":0.43120288848876953},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.41879719495773315},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.27571552991867065},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.2489883303642273},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.21938422322273254},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.15923401713371277}],"concepts":[{"id":"https://openalex.org/C125965507","wikidata":"https://www.wikidata.org/wiki/Q1516595","display_name":"Laser capture microdissection","level":4,"score":0.7191296219825745},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.6639202833175659},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.5485898852348328},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.47485020756721497},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.4712558090686798},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.46324649453163147},{"id":"https://openalex.org/C136886441","wikidata":"https://www.wikidata.org/wiki/Q926129","display_name":"Normalization (sociology)","level":2,"score":0.43120288848876953},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.41879719495773315},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27571552991867065},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2489883303642273},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.21938422322273254},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15923401713371277},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C19165224","wikidata":"https://www.wikidata.org/wiki/Q23404","display_name":"Anthropology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D042282","descriptor_name":"Microdissection","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D042282","descriptor_name":"Microdissection","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D042282","descriptor_name":"Microdissection","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D046888","descriptor_name":"Tissue Array Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D046888","descriptor_name":"Tissue Array Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D046888","descriptor_name":"Tissue Array Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bioinformatics/btt566","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btt566","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/30/5/682/48918142/bioinformatics_30_5_682.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:24085566","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24085566","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:europepmc.org:3306963","is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3933869","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btt566","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btt566","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/30/5/682/48918142/bioinformatics_30_5_682.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Decent work and economic growth","id":"https://metadata.un.org/sdg/8","score":0.44999998807907104}],"awards":[{"id":"https://openalex.org/G4751356441","display_name":null,"funder_award_id":"5R01CA141090","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5573027316","display_name":null,"funder_award_id":"P30 CA016058","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6926031907","display_name":null,"funder_award_id":"5T32CA009338-34","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8798717920","display_name":null,"funder_award_id":"5T32CA009338-33","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W1599494094","https://openalex.org/W1651215666","https://openalex.org/W1754646916","https://openalex.org/W1773728303","https://openalex.org/W1819302943","https://openalex.org/W1968371014","https://openalex.org/W1977843291","https://openalex.org/W1981390480","https://openalex.org/W1990802950","https://openalex.org/W1995086037","https://openalex.org/W2000771269","https://openalex.org/W2028426093","https://openalex.org/W2032980774","https://openalex.org/W2033642329","https://openalex.org/W2036902495","https://openalex.org/W2041199873","https://openalex.org/W2048867608","https://openalex.org/W2081319583","https://openalex.org/W2090326649","https://openalex.org/W2090384073","https://openalex.org/W2096269949","https://openalex.org/W2097255042","https://openalex.org/W2103146144","https://openalex.org/W2116642156","https://openalex.org/W2119192314","https://openalex.org/W2120865735","https://openalex.org/W2128985829","https://openalex.org/W2129631522","https://openalex.org/W2131994307","https://openalex.org/W2137605677","https://openalex.org/W2140802251","https://openalex.org/W2147246240","https://openalex.org/W2147730364","https://openalex.org/W2155388222","https://openalex.org/W2157795344","https://openalex.org/W2158549544","https://openalex.org/W2161643019","https://openalex.org/W2162871532","https://openalex.org/W2164683872","https://openalex.org/W2168649860","https://openalex.org/W4285719527","https://openalex.org/W4294107304","https://openalex.org/W6638751971"],"related_works":["https://openalex.org/W2096302356","https://openalex.org/W2088284538","https://openalex.org/W2041540252","https://openalex.org/W2796636403","https://openalex.org/W4362392254","https://openalex.org/W2415545834","https://openalex.org/W170658859","https://openalex.org/W1483316219","https://openalex.org/W4310366902","https://openalex.org/W3023720143"],"abstract_inverted_index":{"BACKGROUND:":[0],"One":[1],"of":[2,9,36,47,66,81,88,129,145,161,191,198,213,226],"the":[3,7,100,162,224],"significant":[4],"obstacles":[5],"in":[6,72,124,178,218,234],"development":[8],"clinically":[10],"relevant":[11],"microarray-derived":[12],"biomarkers":[13],"and":[14,27,43,84,111,119,131,141,155,193,220],"classifiers":[15],"is":[16,211,236],"tissue":[17,133,180,216],"heterogeneity.":[18],"Physical":[19],"cell":[20,25,34,52,82,90,120,157,164,194],"separation":[21],"techniques,":[22],"such":[23],"as":[24,148,150,232],"sorting":[26],"laser-capture":[28],"microdissection,":[29],"can":[30,44,222],"enrich":[31],"samples":[32,123,181],"for":[33,78,94,115,159,239],"types":[35],"interest,":[37],"but":[38],"are":[39],"costly,":[40],"labor":[41],"intensive":[42],"limit":[45],"investigation":[46],"important":[48],"interactions":[49],"between":[50,122,139,153],"different":[51,125],"types.":[53,165],"RESULTS:":[54],"We":[55,201],"developed":[56,203],"a":[57,204],"new":[58,205],"computational":[59,206],"approach,":[60],"called":[61,208],"microarray":[62,95],"microdissection":[63,71,128,217],"with":[64,184],"analysis":[65,190,197],"differences":[67],"(MMAD),":[68],"which":[69,210,221],"performs":[70],"silico.":[73],"Notably,":[74],"MMAD":[75,169,230],"(i)":[76],"allows":[77],"simultaneous":[79],"estimation":[80],"fractions":[83,121],"gene":[85,117,143],"expression":[86,118,144],"profiles":[87],"contributing":[89],"types,":[91],"(ii)":[92],"adjusts":[93],"normalization":[96],"bias,":[97],"(iii)":[98],"uses":[99],"corrected":[101],"Akaike":[102],"information":[103],"criterion":[104],"during":[105],"model":[106],"optimization":[107],"to":[108,173],"minimize":[109],"overfitting":[110],"(iv)":[112],"provides":[113],"mechanisms":[114],"comparing":[116],"classes.":[126],"Computational":[127],"simulated":[130],"experimental":[132],"mixture":[134],"datasets":[135],"showed":[136,170],"tight":[137,151],"correlations":[138,152],"predicted":[140],"measured":[142],"pure":[146],"tissues":[147],"well":[149],"reported":[154],"estimated":[156],"fraction":[158],"each":[160],"individual":[163],"In":[166],"simulation":[167],"studies,":[168],"superior":[171],"ability":[172],"detect":[174],"differentially":[175,227],"expressed":[176,228],"genes":[177],"mixed":[179],"when":[182],"compared":[183],"standard":[185],"metrics,":[186],"including":[187],"both":[188],"significance":[189,196],"microarrays":[192],"type-specific":[195],"microarrays.":[199],"CONCLUSIONS:":[200],"have":[202],"tool":[207],"MMAD,":[209],"capable":[212],"performing":[214],"robust":[215],"silico,":[219],"improve":[223],"detection":[225],"genes.":[229],"software":[231],"implemented":[233],"MATLAB":[235],"publically":[237],"available":[238],"download":[240],"at":[241],"http://sourceforge.net/projects/mmad/.":[242]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":15},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":12},{"year":2015,"cited_by_count":3}],"updated_date":"2026-07-13T07:31:44.756512","created_date":"2025-10-10T00:00:00"}
