{"id":"https://openalex.org/W2100539413","doi":"https://doi.org/10.1093/bioinformatics/btt075","title":"Accounting for non-genetic factors by low-rank representation and sparse regression for eQTL mapping","display_name":"Accounting for non-genetic factors by low-rank representation and sparse regression for eQTL mapping","publication_year":2013,"publication_date":"2013-02-17","ids":{"openalex":"https://openalex.org/W2100539413","doi":"https://doi.org/10.1093/bioinformatics/btt075","mag":"2100539413","pmid":"https://pubmed.ncbi.nlm.nih.gov/23419377"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btt075","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btt075","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/29/8/1026/17104705/btt075.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/29/8/1026/17104705/btt075.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046831784","display_name":"Can Yang","orcid":"https://orcid.org/0000-0003-3368-3082"},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Can Yang","raw_affiliation_strings":["1 Department of Biostatistics, Yale School of Public Health, New Haven, CT 06520, USA, 2Center for Theoretical Biology, Peking University, Beijing 100871 and 3Center for Computational Systems Biology, School of Mathematical Sciences, Fudan University, Shanghai 200433, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Biostatistics, Yale School of Public Health, New Haven, CT 06520, USA, 2Center for Theoretical Biology, Peking University, Beijing 100871 and 3Center for Computational Systems Biology, School of Mathematical Sciences, Fudan University, Shanghai 200433, China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I24943067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100403169","display_name":"Lin Wang","orcid":"https://orcid.org/0000-0002-4905-3432"},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lin Wang","raw_affiliation_strings":["1 Department of Biostatistics, Yale School of Public Health, New Haven, CT 06520, USA, 2Center for Theoretical Biology, Peking University, Beijing 100871 and 3Center for Computational Systems Biology, School of Mathematical Sciences, Fudan University, Shanghai 200433, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Biostatistics, Yale School of Public Health, New Haven, CT 06520, USA, 2Center for Theoretical Biology, Peking University, Beijing 100871 and 3Center for Computational Systems Biology, School of Mathematical Sciences, Fudan University, Shanghai 200433, China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I24943067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024866341","display_name":"Shuqin Zhang","orcid":"https://orcid.org/0000-0001-8223-844X"},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuqin Zhang","raw_affiliation_strings":["1 Department of Biostatistics, Yale School of Public Health, New Haven, CT 06520, USA, 2Center for Theoretical Biology, Peking University, Beijing 100871 and 3Center for Computational Systems Biology, School of Mathematical Sciences, Fudan University, Shanghai 200433, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Biostatistics, Yale School of Public Health, New Haven, CT 06520, USA, 2Center for Theoretical Biology, Peking University, Beijing 100871 and 3Center for Computational Systems Biology, School of Mathematical Sciences, Fudan University, Shanghai 200433, China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I24943067"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074828414","display_name":"Hongyu Zhao","orcid":"https://orcid.org/0000-0003-1195-9607"},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hongyu Zhao","raw_affiliation_strings":["1 Department of Biostatistics, Yale School of Public Health, New Haven, CT 06520, USA, 2Center for Theoretical Biology, Peking University, Beijing 100871 and 3Center for Computational Systems Biology, School of Mathematical Sciences, Fudan University, Shanghai 200433, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Biostatistics, Yale School of Public Health, New Haven, CT 06520, USA, 2Center for Theoretical Biology, Peking University, Beijing 100871 and 3Center for Computational Systems Biology, School of Mathematical Sciences, Fudan University, Shanghai 200433, China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I24943067"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5074828414"],"corresponding_institution_ids":["https://openalex.org/I20231570","https://openalex.org/I24943067"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":4.4989,"has_fulltext":true,"cited_by_count":47,"citation_normalized_percentile":{"value":0.947178,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"29","issue":"8","first_page":"1026","last_page":"1034"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9437999725341797,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9437999725341797,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.03590000048279762,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10136","display_name":"Statistical Methods and Inference","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/spurious-relationship","display_name":"Spurious relationship","score":0.7698785066604614},{"id":"https://openalex.org/keywords/expression-quantitative-trait-loci","display_name":"Expression quantitative trait loci","score":0.7610986232757568},{"id":"https://openalex.org/keywords/covariate","display_name":"Covariate","score":0.6111571788787842},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6107092499732971},{"id":"https://openalex.org/keywords/regression","display_name":"Regression","score":0.5180047154426575},{"id":"https://openalex.org/keywords/representation","display_name":"Representation (politics)","score":0.4858414828777313},{"id":"https://openalex.org/keywords/consistency","display_name":"Consistency (knowledge bases)","score":0.48355910181999207},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.480714350938797},{"id":"https://openalex.org/keywords/rank","display_name":"Rank (graph theory)","score":0.46406325697898865},{"id":"https://openalex.org/keywords/confounding","display_name":"Confounding","score":0.45436930656433105},{"id":"https://openalex.org/keywords/software","display_name":"Software","score":0.41366612911224365},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphism","display_name":"Single-nucleotide polymorphism","score":0.4047195017337799},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3950631022453308},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.374845027923584},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3411266803741455},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.273881733417511},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.2059047818183899},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.17779049277305603},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.15933528542518616},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.14950695633888245},{"id":"https://openalex.org/keywords/genotype","display_name":"Genotype","score":0.08656615018844604}],"concepts":[{"id":"https://openalex.org/C97256817","wikidata":"https://www.wikidata.org/wiki/Q1462316","display_name":"Spurious relationship","level":2,"score":0.7698785066604614},{"id":"https://openalex.org/C168393362","wikidata":"https://www.wikidata.org/wiki/Q5421706","display_name":"Expression quantitative trait loci","level":5,"score":0.7610986232757568},{"id":"https://openalex.org/C119043178","wikidata":"https://www.wikidata.org/wiki/Q320723","display_name":"Covariate","level":2,"score":0.6111571788787842},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6107092499732971},{"id":"https://openalex.org/C83546350","wikidata":"https://www.wikidata.org/wiki/Q1139051","display_name":"Regression","level":2,"score":0.5180047154426575},{"id":"https://openalex.org/C2776359362","wikidata":"https://www.wikidata.org/wiki/Q2145286","display_name":"Representation (politics)","level":3,"score":0.4858414828777313},{"id":"https://openalex.org/C2776436953","wikidata":"https://www.wikidata.org/wiki/Q5163215","display_name":"Consistency (knowledge bases)","level":2,"score":0.48355910181999207},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.480714350938797},{"id":"https://openalex.org/C164226766","wikidata":"https://www.wikidata.org/wiki/Q7293202","display_name":"Rank (graph theory)","level":2,"score":0.46406325697898865},{"id":"https://openalex.org/C77350462","wikidata":"https://www.wikidata.org/wiki/Q1125472","display_name":"Confounding","level":2,"score":0.45436930656433105},{"id":"https://openalex.org/C2777904410","wikidata":"https://www.wikidata.org/wiki/Q7397","display_name":"Software","level":2,"score":0.41366612911224365},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.4047195017337799},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3950631022453308},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.374845027923584},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3411266803741455},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.273881733417511},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.2059047818183899},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.17779049277305603},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15933528542518616},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14950695633888245},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.08656615018844604},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.0},{"id":"https://openalex.org/C94625758","wikidata":"https://www.wikidata.org/wiki/Q7163","display_name":"Politics","level":2,"score":0.0},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1093/bioinformatics/btt075","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btt075","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/29/8/1026/17104705/btt075.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:23419377","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23419377","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:europepmc.org:2965020","is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3624800","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:repository.hkust.edu.hk:1783.1-86992","is_oa":false,"landing_page_url":"http://repository.hkust.edu.hk/ir/Record/1783.1-86992","pdf_url":null,"source":{"id":"https://openalex.org/S4306401796","display_name":"Rare & Special e-Zone (The Hong Kong University of Science and Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I200769079","host_organization_name":"Hong Kong University of Science and Technology","host_organization_lineage":["https://openalex.org/I200769079"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btt075","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btt075","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/29/8/1026/17104705/btt075.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1018933286","display_name":"\u77e9\u9635\u5206\u89e3\u5728\u57fa\u56e0\u7ec4\u5173\u8054\u7814\u7a76\u4e2d\u7684\u5e94\u7528","funder_award_id":"10901042","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G1800865264","display_name":null,"funder_award_id":"R01 GM59507","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4503107416","display_name":null,"funder_award_id":"R01 GM59507","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4941990141","display_name":null,"funder_award_id":"10971075","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5737903045","display_name":null,"funder_award_id":"91130032","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G630330811","display_name":null,"funder_award_id":"GM59507","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7217317707","display_name":null,"funder_award_id":"DMS 1106738","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2100539413.pdf","grobid_xml":"https://content.openalex.org/works/W2100539413.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W1502922572","https://openalex.org/W1973455222","https://openalex.org/W1990987722","https://openalex.org/W1992088789","https://openalex.org/W1997494129","https://openalex.org/W2010637767","https://openalex.org/W2038225430","https://openalex.org/W2048612325","https://openalex.org/W2056014573","https://openalex.org/W2056636001","https://openalex.org/W2074682976","https://openalex.org/W2079927753","https://openalex.org/W2088486634","https://openalex.org/W2094248448","https://openalex.org/W2096192437","https://openalex.org/W2097360283","https://openalex.org/W2099788003","https://openalex.org/W2100417824","https://openalex.org/W2102751249","https://openalex.org/W2107636757","https://openalex.org/W2107665951","https://openalex.org/W2116650193","https://openalex.org/W2118550318","https://openalex.org/W2131847331","https://openalex.org/W2135046866","https://openalex.org/W2137499573","https://openalex.org/W2142260323","https://openalex.org/W2146130798","https://openalex.org/W2148541040","https://openalex.org/W2154560360","https://openalex.org/W2158217645","https://openalex.org/W2160299056","https://openalex.org/W2169043705","https://openalex.org/W3003365835","https://openalex.org/W3098745759","https://openalex.org/W4211049957","https://openalex.org/W4243337323","https://openalex.org/W4294541781","https://openalex.org/W6682042988"],"related_works":["https://openalex.org/W3113091479","https://openalex.org/W2162899405","https://openalex.org/W941090075","https://openalex.org/W2044987316","https://openalex.org/W3134374554","https://openalex.org/W2237480245","https://openalex.org/W2075065631","https://openalex.org/W2169619449","https://openalex.org/W2948749495","https://openalex.org/W3125058662"],"abstract_inverted_index":{"MOTIVATION:":[0],"Expression":[1],"quantitative":[2],"trait":[3],"loci":[4],"(eQTL)":[5],"studies":[6,173],"investigate":[7],"how":[8],"gene":[9,98],"expression":[10,43],"levels":[11],"are":[12,206],"affected":[13],"by":[14],"DNA":[15],"variants.":[16],"A":[17],"major":[18],"challenge":[19],"in":[20,93],"inferring":[21],"eQTL":[22,78],"is":[23,111,129,156,198],"that":[24,154,185],"a":[25,63,90,112],"number":[26],"of":[27,74],"factors,":[28],"such":[29],"as":[30],"unobserved":[31],"covariates,":[32],"experimental":[33],"artifacts":[34],"and":[35,51,71,86,97,126,142],"unknown":[36],"environmental":[37],"perturbations,":[38],"may":[39,46],"confound":[40],"the":[41,83,105],"observed":[42],"levels.":[44],"This":[45],"both":[47],"mask":[48],"real":[49,149],"associations":[50,168],"lead":[52],"to":[53,66,122,135,146,160],"spurious":[54],"association":[55],"findings.":[56],"RESULTS:":[57],"In":[58],"this":[59,124],"article,":[60],"we":[61,179],"introduce":[62],"LOw-Rank":[64],"representation":[65,85],"account":[67,136,161],"for":[68,77,137,162,192],"confounding":[69],"factors":[70],"make":[72],"use":[73],"Sparse":[75],"regression":[76,88],"mapping":[79],"(LORS).":[80],"We":[81,116,131],"integrate":[82],"low-rank":[84],"sparse":[87],"into":[89],"unified":[91],"framework,":[92],"which":[94],"single-nucleotide":[95],"polymorphisms":[96],"probes":[99],"can":[100,186],"be":[101,188],"jointly":[102],"analyzed.":[103],"Given":[104],"two":[106,147],"model":[107],"parameters,":[108],"our":[109,166],"formulation":[110],"convex":[113],"optimization":[114],"problem.":[115],"have":[117,180],"developed":[118],"an":[119,157],"efficient":[120],"algorithm":[121],"solve":[123],"problem":[125],"its":[127,133],"convergence":[128],"guaranteed.":[130],"demonstrate":[132],"ability":[134],"non-genetic":[138,163,193],"effects":[139],"using":[140],"simulation,":[141],"then":[143],"apply":[144],"it":[145],"independent":[148],"datasets.":[150],"Our":[151],"results":[152],"indicate":[153],"LORS":[155],"effective":[158],"tool":[159],"effects.":[164,194],"First,":[165],"detected":[167],"show":[169],"higher":[170],"consistency":[171],"between":[172],"than":[174],"recently":[175],"proposed":[176],"methods.":[177],"Second,":[178],"identified":[181,189],"some":[182],"new":[183],"hotspots":[184],"not":[187],"without":[190],"accounting":[191],"AVAILABILITY:":[195],"The":[196],"software":[197],"available":[199,207],"at:":[200],"http://bioinformatics.med.yale.edu/software.aspx.":[201],"SUPPLEMENTARY":[202],"INFORMATION:":[203],"Supplementary":[204],"data":[205],"at":[208],"Bioinformatics":[209],"online.":[210]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-06-23T06:36:01.041984","created_date":"2025-10-10T00:00:00"}