{"id":"https://openalex.org/W2111358540","doi":"https://doi.org/10.1093/bioinformatics/btt043","title":"Bayesian analysis of gene essentiality based on sequencing of transposon insertion libraries","display_name":"Bayesian analysis of gene essentiality based on sequencing of transposon insertion libraries","publication_year":2013,"publication_date":"2013-01-29","ids":{"openalex":"https://openalex.org/W2111358540","doi":"https://doi.org/10.1093/bioinformatics/btt043","mag":"2111358540","pmid":"https://pubmed.ncbi.nlm.nih.gov/23361328"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btt043","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btt043","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/29/6/695/48902504/bioinformatics_29_6_695.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/29/6/695/48902504/bioinformatics_29_6_695.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038161872","display_name":"Michael A. DeJesus","orcid":"https://orcid.org/0000-0003-3867-0299"},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]},{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michael A. DeJesus","raw_affiliation_strings":["1 Department of Computer Science, Texas A&M University, College Station, TX 77843, 2Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, 3Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA 01655 and 4Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Computer Science, Texas A&M University, College Station, TX 77843, 2Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, 3Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA 01655 and 4Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843, USA","institution_ids":["https://openalex.org/I166722992","https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002728058","display_name":"Yanjia J. Zhang","orcid":"https://orcid.org/0000-0002-4043-5151"},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]},{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yanjia J. Zhang","raw_affiliation_strings":["1 Department of Computer Science, Texas A&M University, College Station, TX 77843, 2Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, 3Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA 01655 and 4Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Computer Science, Texas A&M University, College Station, TX 77843, 2Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, 3Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA 01655 and 4Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843, USA","institution_ids":["https://openalex.org/I166722992","https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062955181","display_name":"Christopher M. Sassetti","orcid":"https://orcid.org/0000-0001-6178-4329"},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]},{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher M. Sassetti","raw_affiliation_strings":["1 Department of Computer Science, Texas A&M University, College Station, TX 77843, 2Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, 3Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA 01655 and 4Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Computer Science, Texas A&M University, College Station, TX 77843, 2Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, 3Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA 01655 and 4Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843, USA","institution_ids":["https://openalex.org/I166722992","https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018392937","display_name":"Eric J. Rubin","orcid":"https://orcid.org/0000-0001-5120-962X"},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]},{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric J. Rubin","raw_affiliation_strings":["1 Department of Computer Science, Texas A&M University, College Station, TX 77843, 2Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, 3Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA 01655 and 4Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Computer Science, Texas A&M University, College Station, TX 77843, 2Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, 3Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA 01655 and 4Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843, USA","institution_ids":["https://openalex.org/I166722992","https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062257527","display_name":"James C. Sacchettini","orcid":"https://orcid.org/0000-0001-5767-2367"},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]},{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James C. Sacchettini","raw_affiliation_strings":["1 Department of Computer Science, Texas A&M University, College Station, TX 77843, 2Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, 3Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA 01655 and 4Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Computer Science, Texas A&M University, College Station, TX 77843, 2Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, 3Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA 01655 and 4Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843, USA","institution_ids":["https://openalex.org/I166722992","https://openalex.org/I91045830"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048876954","display_name":"Thomas R. Ioerger","orcid":"https://orcid.org/0000-0001-8702-9102"},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]},{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Thomas R. Ioerger","raw_affiliation_strings":["1 Department of Computer Science, Texas A&M University, College Station, TX 77843, 2Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, 3Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA 01655 and 4Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Computer Science, Texas A&M University, College Station, TX 77843, 2Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, 3Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA 01655 and 4Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843, USA","institution_ids":["https://openalex.org/I166722992","https://openalex.org/I91045830"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5038161872","https://openalex.org/A5048876954"],"corresponding_institution_ids":["https://openalex.org/I166722992","https://openalex.org/I91045830"],"apc_list":{"value":3989,"currency":"USD","value_usd":3989},"apc_paid":null,"fwci":6.1367,"has_fulltext":false,"cited_by_count":92,"citation_normalized_percentile":{"value":0.96764687,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"29","issue":"6","first_page":"695","last_page":"703"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.8553000092506409,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.8553000092506409,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.01600000075995922,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.01140000019222498,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transposable-element","display_name":"Transposable element","score":0.8085256218910217},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5336288809776306},{"id":"https://openalex.org/keywords/bayesian-probability","display_name":"Bayesian probability","score":0.514987051486969},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5060891509056091},{"id":"https://openalex.org/keywords/python","display_name":"Python (programming language)","score":0.43267545104026794},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.42793920636177063},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.39722007513046265},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.36088645458221436},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.2326887845993042},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.11322885751724243}],"concepts":[{"id":"https://openalex.org/C4918238","wikidata":"https://www.wikidata.org/wiki/Q121438","display_name":"Transposable element","level":4,"score":0.8085256218910217},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5336288809776306},{"id":"https://openalex.org/C107673813","wikidata":"https://www.wikidata.org/wiki/Q812534","display_name":"Bayesian probability","level":2,"score":0.514987051486969},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5060891509056091},{"id":"https://openalex.org/C519991488","wikidata":"https://www.wikidata.org/wiki/Q28865","display_name":"Python (programming language)","level":2,"score":0.43267545104026794},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.42793920636177063},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.39722007513046265},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.36088645458221436},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.2326887845993042},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.11322885751724243},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004251","descriptor_name":"DNA Transposable Elements","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004251","descriptor_name":"DNA Transposable Elements","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004251","descriptor_name":"DNA Transposable Elements","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005798","descriptor_name":"Genes, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005798","descriptor_name":"Genes, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005798","descriptor_name":"Genes, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015723","descriptor_name":"Gene Library","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015723","descriptor_name":"Gene Library","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015723","descriptor_name":"Gene Library","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016254","descriptor_name":"Mutagenesis, Insertional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016254","descriptor_name":"Mutagenesis, Insertional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016254","descriptor_name":"Mutagenesis, Insertional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020043","descriptor_name":"Genes, Essential","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020043","descriptor_name":"Genes, Essential","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020043","descriptor_name":"Genes, Essential","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1093/bioinformatics/btt043","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btt043","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/29/6/695/48902504/bioinformatics_29_6_695.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:23361328","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23361328","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2934689","is_oa":false,"landing_page_url":"http://europepmc.org/articles/PMC3597147","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3597147","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3597147","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btt043","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btt043","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/29/6/695/48902504/bioinformatics_29_6_695.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.44999998807907104}],"awards":[{"id":"https://openalex.org/G154268439","display_name":null,"funder_award_id":"P01 AI068135","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G259133391","display_name":null,"funder_award_id":"T32 AI007638","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G4479005546","display_name":null,"funder_award_id":"U01-GM094568","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G707340384","display_name":null,"funder_award_id":"T32GM007753","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W2111358540.pdf"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W109386094","https://openalex.org/W1779180564","https://openalex.org/W1864461701","https://openalex.org/W1906780201","https://openalex.org/W1966916880","https://openalex.org/W1967662130","https://openalex.org/W1973358006","https://openalex.org/W1996001643","https://openalex.org/W1996031884","https://openalex.org/W2013902051","https://openalex.org/W2017228544","https://openalex.org/W2020224454","https://openalex.org/W2022012591","https://openalex.org/W2026391318","https://openalex.org/W2030758065","https://openalex.org/W2067576392","https://openalex.org/W2071123953","https://openalex.org/W2081646044","https://openalex.org/W2094039729","https://openalex.org/W2099929909","https://openalex.org/W2102545353","https://openalex.org/W2104935223","https://openalex.org/W2105546078","https://openalex.org/W2108500436","https://openalex.org/W2116160060","https://openalex.org/W2117173394","https://openalex.org/W2119912157","https://openalex.org/W2125301421","https://openalex.org/W2128482141","https://openalex.org/W2140354550","https://openalex.org/W2141885858","https://openalex.org/W2146538795","https://openalex.org/W2152856606","https://openalex.org/W2158023121","https://openalex.org/W2169916860","https://openalex.org/W4210623056","https://openalex.org/W6604525207","https://openalex.org/W6677383815"],"related_works":["https://openalex.org/W4237591666","https://openalex.org/W2103833188","https://openalex.org/W2164152191","https://openalex.org/W2341492732","https://openalex.org/W68905254","https://openalex.org/W2387589589","https://openalex.org/W161778015","https://openalex.org/W3187193180","https://openalex.org/W1534300978","https://openalex.org/W106542691"],"abstract_inverted_index":{"Abstract":[0],"Motivation:":[1],"Next-generation":[2],"sequencing":[3],"affords":[4],"an":[5],"efficient":[6],"analysis":[7],"of":[8,38,52,75,137],"transposon":[9,91,131,150],"insertion":[10],"libraries,":[11],"which":[12],"can":[13,145],"be":[14,112,146],"used":[15,147],"to":[16,47,71,111,126],"identify":[17],"essential":[18,103,113,139],"genes":[19,104,109],"in":[20,114,152],"bacteria.":[21],"To":[22],"analyse":[23],"this":[24,99,133],"high-resolution":[25],"data,":[26],"we":[27,96,118],"present":[28],"a":[29,59,63,86,90],"formal":[30],"Bayesian":[31,100],"framework":[32],"for":[33,40,93,148,173],"estimating":[34],"the":[35,44,49,53,68,123,168],"posterior":[36,73],"probability":[37],"essentiality":[39,76,157],"each":[41],"gene,":[42],"using":[43,122],"extreme-value":[45,124],"distribution":[46,125],"characterize":[48,127],"statistical":[50,160],"significance":[51],"longest":[54],"region":[55],"lacking":[56,130],"insertions":[57],"within":[58,141],"gene.":[60],"We":[61],"describe":[62],"sampling":[64],"procedure":[65],"based":[66],"on":[67],"Metropolis\u2013Hastings":[69],"algorithm":[70],"calculate":[72],"probabilities":[74],"while":[77],"simultaneously":[78],"integrating":[79],"over":[80],"unknown":[81],"internal":[82],"parameters.":[83],"Results:":[84],"Using":[85],"sequence":[87],"dataset":[88],"from":[89,175],"library":[92],"Mycobacterium":[94],"tuberculosis,":[95],"show":[97,119],"that":[98,105,120],"approach":[101,144],"predicts":[102],"correspond":[106],"well":[107],"with":[108,159],"shown":[110],"previous":[115],"studies.":[116],"Furthermore,":[117],"by":[121],"genomic":[128],"regions":[129],"insertions,":[132],"method":[134,169],"is":[135,171],"capable":[136],"identifying":[138],"domains":[140],"genes.":[142],"This":[143],"analysing":[149],"libraries":[151],"other":[153],"organisms":[154],"and":[155],"augmenting":[156],"predictions":[158],"confidence":[161],"scores.":[162],"Availability:":[163],"A":[164],"python":[165],"script":[166],"implementing":[167],"described":[170],"available":[172,186],"download":[174],"http://saclab.tamu.edu/essentiality/.":[176],"Contact:":[177],"michael.dejesus@tamu.edu":[178],"or":[179],"ioerger@cs.tamu.edu":[180],"Supplementary":[181,183],"information:":[182],"data":[184],"are":[185],"at":[187],"Bioinformatics":[188],"online.":[189]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":6}],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2025-10-10T00:00:00"}
