{"id":"https://openalex.org/W2119377277","doi":"https://doi.org/10.1093/bioinformatics/bts624","title":"Distinction immune genes of hepatitis-induced heptatocellular carcinoma","display_name":"Distinction immune genes of hepatitis-induced heptatocellular carcinoma","publication_year":2012,"publication_date":"2012-10-25","ids":{"openalex":"https://openalex.org/W2119377277","doi":"https://doi.org/10.1093/bioinformatics/bts624","mag":"2119377277","pmid":"https://pubmed.ncbi.nlm.nih.gov/23104883"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/bts624","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bts624","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/28/24/3191/48879381/bioinformatics_28_24_3191.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/28/24/3191/48879381/bioinformatics_28_24_3191.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035215097","display_name":"Jinyu Hu","orcid":"https://orcid.org/0000-0003-1263-5225"},"institutions":[{"id":"https://openalex.org/I32394136","display_name":"Northumbria University","ror":"https://ror.org/049e6bc10","country_code":"GB","type":"education","lineage":["https://openalex.org/I32394136"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Jinyu Hu","raw_affiliation_strings":["1 Department of Automation, School of Electrical Engineering and Automation, Tianjin University, Tianjin 300072, China and 2Division of Electric Engineering and Physics, School of Computing, Engineering and Information Sciences, Northumbria University, Newcastle Upon Tyne, NE1 8ST, UK"],"affiliations":[{"raw_affiliation_string":"1 Department of Automation, School of Electrical Engineering and Automation, Tianjin University, Tianjin 300072, China and 2Division of Electric Engineering and Physics, School of Computing, Engineering and Information Sciences, Northumbria University, Newcastle Upon Tyne, NE1 8ST, UK","institution_ids":["https://openalex.org/I32394136"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002055009","display_name":"Zhiwei Gao","orcid":"https://orcid.org/0000-0001-5464-3288"},"institutions":[{"id":"https://openalex.org/I32394136","display_name":"Northumbria University","ror":"https://ror.org/049e6bc10","country_code":"GB","type":"education","lineage":["https://openalex.org/I32394136"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"David Zhiwei Gao","raw_affiliation_strings":["1 Department of Automation, School of Electrical Engineering and Automation, Tianjin University, Tianjin 300072, China and 2Division of Electric Engineering and Physics, School of Computing, Engineering and Information Sciences, Northumbria University, Newcastle Upon Tyne, NE1 8ST, UK"],"affiliations":[{"raw_affiliation_string":"1 Department of Automation, School of Electrical Engineering and Automation, Tianjin University, Tianjin 300072, China and 2Division of Electric Engineering and Physics, School of Computing, Engineering and Information Sciences, Northumbria University, Newcastle Upon Tyne, NE1 8ST, UK","institution_ids":["https://openalex.org/I32394136"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5035215097"],"corresponding_institution_ids":["https://openalex.org/I32394136"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":{"value":3618,"currency":"USD","value_usd":3618},"fwci":0.596,"has_fulltext":true,"cited_by_count":98,"citation_normalized_percentile":{"value":0.68963006,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":100},"biblio":{"volume":"28","issue":"24","first_page":"3191","last_page":"3194"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.9943000078201294,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/immune-system","display_name":"Immune system","score":0.727613627910614},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"Hepatocellular carcinoma","score":0.723188042640686},{"id":"https://openalex.org/keywords/hepatitis-b-virus","display_name":"Hepatitis B virus","score":0.6625813841819763},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.6010759472846985},{"id":"https://openalex.org/keywords/virology","display_name":"Virology","score":0.5618884563446045},{"id":"https://openalex.org/keywords/antigen","display_name":"Antigen","score":0.5257371664047241},{"id":"https://openalex.org/keywords/hepatitis-c-virus","display_name":"Hepatitis C virus","score":0.4960084855556488},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.48256364464759827},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.4816790521144867},{"id":"https://openalex.org/keywords/virus","display_name":"Virus","score":0.47208118438720703},{"id":"https://openalex.org/keywords/hepatitis-b","display_name":"Hepatitis B","score":0.4364200830459595},{"id":"https://openalex.org/keywords/major-histocompatibility-complex","display_name":"Major histocompatibility complex","score":0.41646888852119446},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.2793275713920593},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.1491779386997223}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.727613627910614},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.723188042640686},{"id":"https://openalex.org/C2780593183","wikidata":"https://www.wikidata.org/wiki/Q6844","display_name":"Hepatitis B virus","level":3,"score":0.6625813841819763},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6010759472846985},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5618884563446045},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5257371664047241},{"id":"https://openalex.org/C2776408679","wikidata":"https://www.wikidata.org/wiki/Q708693","display_name":"Hepatitis C virus","level":3,"score":0.4960084855556488},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48256364464759827},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4816790521144867},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.47208118438720703},{"id":"https://openalex.org/C2777382497","wikidata":"https://www.wikidata.org/wiki/Q6853","display_name":"Hepatitis B","level":2,"score":0.4364200830459595},{"id":"https://openalex.org/C207936829","wikidata":"https://www.wikidata.org/wiki/Q423163","display_name":"Major histocompatibility complex","level":3,"score":0.41646888852119446},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.2793275713920593},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1491779386997223}],"mesh":[{"descriptor_ui":"D006509","descriptor_name":"Hepatitis B","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D006509","descriptor_name":"Hepatitis B","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D006509","descriptor_name":"Hepatitis B","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D006526","descriptor_name":"Hepatitis C","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D006526","descriptor_name":"Hepatitis C","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D006526","descriptor_name":"Hepatitis C","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007109","descriptor_name":"Immunity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007109","descriptor_name":"Immunity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007109","descriptor_name":"Immunity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/bioinformatics/bts624","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bts624","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/28/24/3191/48879381/bioinformatics_28_24_3191.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:23104883","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23104883","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:nrl.northumbria.ac.uk:10541","is_oa":false,"landing_page_url":"http://nrl.northumbria.ac.uk/10541/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401884","display_name":"Northumbria Research Link (Northumbria University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I32394136","host_organization_name":"Northumbria University","host_organization_lineage":["https://openalex.org/I32394136"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:nrl.northumbria.ac.uk:10542","is_oa":false,"landing_page_url":"http://nrl.northumbria.ac.uk/10542/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401884","display_name":"Northumbria Research Link (Northumbria University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I32394136","host_organization_name":"Northumbria University","host_organization_lineage":["https://openalex.org/I32394136"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/bts624","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bts624","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/28/24/3191/48879381/bioinformatics_28_24_3191.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8500000238418579,"id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2119377277.pdf","grobid_xml":"https://content.openalex.org/works/W2119377277.grobid-xml"},"referenced_works_count":17,"referenced_works":["https://openalex.org/W200764996","https://openalex.org/W257177699","https://openalex.org/W1965037168","https://openalex.org/W1985680307","https://openalex.org/W1989993810","https://openalex.org/W1998256808","https://openalex.org/W2026452787","https://openalex.org/W2031285070","https://openalex.org/W2070622584","https://openalex.org/W2071267501","https://openalex.org/W2094356158","https://openalex.org/W2105912300","https://openalex.org/W2129287973","https://openalex.org/W2153346747","https://openalex.org/W2167744756","https://openalex.org/W2168132716","https://openalex.org/W2481490887"],"related_works":["https://openalex.org/W2417822880","https://openalex.org/W628600844","https://openalex.org/W1570838273","https://openalex.org/W2410885201","https://openalex.org/W2385390897","https://openalex.org/W3015095084","https://openalex.org/W2369572641","https://openalex.org/W2147058584","https://openalex.org/W2040973434","https://openalex.org/W2362454490"],"abstract_inverted_index":{"To":[0],"distinguish":[1],"the":[2,17,44,51,86,107,124,131,138,142,145,161,169,181,194,200],"immune":[3,21,56,62,76,91,201],"genes":[4,45,63,88],"with":[5,39],"low-level":[6],"expression":[7,13,162],"in":[8,14,96,101,184],"HBV-induced":[9,102,185,207],"HCC,":[10,16,98,106,208],"but":[11,99,180],"high-level":[12],"HCV-induced":[15,97,105,148],"concept":[18],"of":[19,53,109,134,141,147,164,203],"distinction":[20,55,61],"gene":[22,36],"is":[23,27,83,127,152,197],"proposed.":[24],"A":[25],"filter":[26],"then":[28],"designed":[29],"to":[30,49,118,129,155,167,171,198,206],"screen":[31],"these":[32],"genes.":[33,57],"By":[34],"using":[35],"positive":[37],"network":[38],"strong":[40],"correlations":[41],"between":[42],"genes,":[43,92],"are":[46,64,67,89,94,116],"further":[47],"filtered":[48],"form":[50],"set":[52],"key":[54,60],"The":[58],"23":[59],"screened,":[65],"which":[66,93],"divided":[68],"into":[69],"four":[70],"clusters,":[71],"T":[72,157,165,213],"cells,":[73,75],"B":[74,216],"signalling":[77],"and":[78,215,218],"major":[79],"histocompatibility":[80],"complex.":[81],"It":[82],"evident":[84],"that":[85,114],"screened":[87],"important":[90],"activated":[95],"inactivated":[100],"HCC.":[103,149],"In":[104,175],"structures":[108],"HCV":[110],"adaptively":[111],"update,":[112],"so":[113,219],"they":[115],"difficult":[117],"be":[119],"identified":[120],"by":[121],"antigens.":[122],"Therefore,":[123],"clinic":[125,195],"advice":[126,196],"either":[128],"increase":[130],"update":[132,139],"speed":[133,140],"antigens":[135],"or":[136,159],"reduce":[137],"viruses":[143],"during":[144],"treatment":[146],"Moreover,":[150],"it":[151],"also":[153],"advised":[154],"add":[156,160],"cells":[158,166,214,217],"levels":[163],"strengthen":[168],"ability":[170,202],"kill":[172],"cancer":[173],"cells.":[174],"contrast,":[176],"HBV":[177],"updates":[178],"slowly,":[179],"immunity":[182],"system":[183],"HCC":[186],"has":[187],"been":[188],"damaged":[189],"seriously.":[190],"As":[191],"a":[192],"result,":[193],"improve":[199],"patients":[204],"subjected":[205],"such":[209],"as":[210],"increasing":[211],"immunoglobulin,":[212],"forth.":[220]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":75},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-04-04T16:13:02.066488","created_date":"2025-10-10T00:00:00"}
