{"id":"https://openalex.org/W2101633640","doi":"https://doi.org/10.1093/bioinformatics/bts604","title":"Aragonite-associated biomineralization proteins are disordered and contain interactive motifs","display_name":"Aragonite-associated biomineralization proteins are disordered and contain interactive motifs","publication_year":2012,"publication_date":"2012-10-11","ids":{"openalex":"https://openalex.org/W2101633640","doi":"https://doi.org/10.1093/bioinformatics/bts604","mag":"2101633640","pmid":"https://pubmed.ncbi.nlm.nih.gov/23060620"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/bts604","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bts604","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/28/24/3182/16908670/bts604.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/28/24/3182/16908670/bts604.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001455892","display_name":"John Spencer Evans","orcid":"https://orcid.org/0000-0002-9565-7296"},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"John Spencer Evans","raw_affiliation_strings":["Laboratory for Chemical Physics, Department of Basic Sciences and Craniofacial Biology, New York University, New York, NY 10012, USA"],"affiliations":[{"raw_affiliation_string":"Laboratory for Chemical Physics, Department of Basic Sciences and Craniofacial Biology, New York University, New York, NY 10012, USA","institution_ids":["https://openalex.org/I57206974"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5001455892"],"corresponding_institution_ids":["https://openalex.org/I57206974"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":3.1435,"has_fulltext":false,"cited_by_count":69,"citation_normalized_percentile":{"value":0.9129141,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"28","issue":"24","first_page":"3182","last_page":"3185"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11278","display_name":"Calcium Carbonate Crystallization and Inhibition","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11278","display_name":"Calcium Carbonate Crystallization and Inhibition","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10109","display_name":"Paleontology and Stratigraphy of Fossils","score":0.9886000156402588,"subfield":{"id":"https://openalex.org/subfields/1911","display_name":"Paleontology"},"field":{"id":"https://openalex.org/fields/19","display_name":"Earth and Planetary Sciences"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11617","display_name":"Enzyme Production and Characterization","score":0.9620000123977661,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aragonite","display_name":"Aragonite","score":0.9651269316673279},{"id":"https://openalex.org/keywords/biomineralization","display_name":"Biomineralization","score":0.7892863154411316},{"id":"https://openalex.org/keywords/protein-sequencing","display_name":"Protein sequencing","score":0.5441840291023254},{"id":"https://openalex.org/keywords/mineralized-tissues","display_name":"Mineralized tissues","score":0.48583099246025085},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.4552217721939087},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.4447159767150879},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4443424940109253},{"id":"https://openalex.org/keywords/protein-structure","display_name":"Protein structure","score":0.43243762850761414},{"id":"https://openalex.org/keywords/intrinsically-disordered-proteins","display_name":"Intrinsically disordered proteins","score":0.41211166977882385},{"id":"https://openalex.org/keywords/peptide-sequence","display_name":"Peptide sequence","score":0.3893492817878723},{"id":"https://openalex.org/keywords/crystallography","display_name":"Crystallography","score":0.382573664188385},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.35048216581344604},{"id":"https://openalex.org/keywords/evolutionary-biology","display_name":"Evolutionary biology","score":0.34074413776397705},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.18339502811431885},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.17574340105056763},{"id":"https://openalex.org/keywords/mineralogy","display_name":"Mineralogy","score":0.14065513014793396},{"id":"https://openalex.org/keywords/calcite","display_name":"Calcite","score":0.137885183095932}],"concepts":[{"id":"https://openalex.org/C2779866092","wikidata":"https://www.wikidata.org/wiki/Q23775","display_name":"Aragonite","level":3,"score":0.9651269316673279},{"id":"https://openalex.org/C183586093","wikidata":"https://www.wikidata.org/wiki/Q610457","display_name":"Biomineralization","level":2,"score":0.7892863154411316},{"id":"https://openalex.org/C10010492","wikidata":"https://www.wikidata.org/wiki/Q3142557","display_name":"Protein sequencing","level":4,"score":0.5441840291023254},{"id":"https://openalex.org/C2777131851","wikidata":"https://www.wikidata.org/wiki/Q6864399","display_name":"Mineralized tissues","level":3,"score":0.48583099246025085},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4552217721939087},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4447159767150879},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4443424940109253},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.43243762850761414},{"id":"https://openalex.org/C2778815515","wikidata":"https://www.wikidata.org/wiki/Q3408242","display_name":"Intrinsically disordered proteins","level":2,"score":0.41211166977882385},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.3893492817878723},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.382573664188385},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.35048216581344604},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.34074413776397705},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18339502811431885},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.17574340105056763},{"id":"https://openalex.org/C199289684","wikidata":"https://www.wikidata.org/wiki/Q83353","display_name":"Mineralogy","level":1,"score":0.14065513014793396},{"id":"https://openalex.org/C2780191791","wikidata":"https://www.wikidata.org/wiki/Q171917","display_name":"Calcite","level":2,"score":0.137885183095932},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0},{"id":"https://openalex.org/C2779263046","wikidata":"https://www.wikidata.org/wiki/Q189637","display_name":"Dentin","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002113","descriptor_name":"Calcification, Physiologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002113","descriptor_name":"Calcification, Physiologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002113","descriptor_name":"Calcification, Physiologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002119","descriptor_name":"Calcium Carbonate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002119","descriptor_name":"Calcium Carbonate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002119","descriptor_name":"Calcium Carbonate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002119","descriptor_name":"Calcium Carbonate","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002119","descriptor_name":"Calcium Carbonate","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002119","descriptor_name":"Calcium Carbonate","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008974","descriptor_name":"Mollusca","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008974","descriptor_name":"Mollusca","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008974","descriptor_name":"Mollusca","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008974","descriptor_name":"Mollusca","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008974","descriptor_name":"Mollusca","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008974","descriptor_name":"Mollusca","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016326","descriptor_name":"Extracellular Matrix Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016326","descriptor_name":"Extracellular Matrix Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016326","descriptor_name":"Extracellular Matrix Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054730","descriptor_name":"Protein Interaction Domains and Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054730","descriptor_name":"Protein Interaction Domains and Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054730","descriptor_name":"Protein Interaction Domains and Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060734","descriptor_name":"Nacre","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D060734","descriptor_name":"Nacre","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D060734","descriptor_name":"Nacre","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/bioinformatics/bts604","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bts604","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/28/24/3182/16908670/bts604.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:23060620","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23060620","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/bts604","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bts604","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/28/24/3182/16908670/bts604.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Life below water","id":"https://metadata.un.org/sdg/14","score":0.5099999904632568}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2101633640.pdf","grobid_xml":"https://content.openalex.org/works/W2101633640.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W1970631212","https://openalex.org/W1997530993","https://openalex.org/W1997937079","https://openalex.org/W2009091242","https://openalex.org/W2010809008","https://openalex.org/W2030776726","https://openalex.org/W2034740400","https://openalex.org/W2037951645","https://openalex.org/W2037993016","https://openalex.org/W2055193239","https://openalex.org/W2059743959","https://openalex.org/W2060135702","https://openalex.org/W2063672911","https://openalex.org/W2084947738","https://openalex.org/W2091871958","https://openalex.org/W2094201044","https://openalex.org/W2104717117","https://openalex.org/W2120744225","https://openalex.org/W2126303237","https://openalex.org/W2132504786","https://openalex.org/W2132685021","https://openalex.org/W2132720084","https://openalex.org/W2133425057","https://openalex.org/W2141690555","https://openalex.org/W2149472608","https://openalex.org/W2156407548","https://openalex.org/W2157873167","https://openalex.org/W2161504862","https://openalex.org/W2162390984","https://openalex.org/W2313675008","https://openalex.org/W2330930725"],"related_works":["https://openalex.org/W2173214748","https://openalex.org/W4307420291","https://openalex.org/W2092404988","https://openalex.org/W2318565303","https://openalex.org/W2027008553","https://openalex.org/W2562533925","https://openalex.org/W2011758288","https://openalex.org/W3201931392","https://openalex.org/W4200426855","https://openalex.org/W2101633640"],"abstract_inverted_index":{"Of":[0],"39":[1],"mollusk":[2],"aragonite-associated":[3,57,97],"protein":[4,58,90],"sequences,":[5,43],"100%":[6],"contain":[7,63],"at":[8,64],"least":[9,65],"one":[10,66],"region":[11],"of":[12,55,68,104],"intrinsic":[13,105],"disorder":[14,106],"or":[15,70],"unfolding,":[16],"with":[17,49,79],"the":[18,29,56],"highest":[19],"percentages":[20],"found":[21,61],"in":[22,86,116],"framework":[23],"and":[24,44,76,82,107,119],"pearl-associated":[25],"proteins":[26,98],"relative":[27],"to":[28,62],"intracrystalline":[30],"proteins.":[31],"In":[32],"some":[33],"instances,":[34],"these":[35],"intrinsically":[36],"disordered":[37],"regions":[38,109],"were":[39,60],"identified":[40],"as":[41],"bind/fold":[42],"a":[45],"limited":[46],"number":[47],"correlate":[48],"known":[50,80],"biomineral-relevant":[51],"sequences.":[52,91],"Interestingly,":[53],"95%":[54],"sequences":[59],"occurrence":[67],"amyloid-like":[69],"cross-\u03b2":[71],"strand":[72],"aggregation-prone":[73,108],"supersecondary":[74],"motifs,":[75],"this":[77],"correlates":[78],"aggregation":[81],"aragonite":[83],"formation":[84],"functions":[85],"three":[87],"experimentally":[88],"tested":[89],"Collectively,":[92],"our":[93],"findings":[94],"indicate":[95],"that":[96,110],"have":[99],"evolved":[100],"signature":[101],"sequence":[102],"traits":[103],"are":[111],"important":[112],"for":[113],"their":[114],"role(s)":[115],"matrix":[117],"assembly":[118],"mineralization.":[120]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":16},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":4}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
